Académique Documents
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of Nappy Rash
Title of Guideline (must include the word Guideline Guideline for the Management of Nappy
(not protocol, policy, procedure etc) Rash
Contact Name and Job Title (author) Sandra Lawton, Nurse Consultant
Dermatology
Barbara Howard, PDM Neonates
Directorate & Speciality Dermatology
This guideline has been registered with the trust. However, clinical guidelines are guidelines
only. The interpretation and application of clinical guidelines will remain the responsibility of
the individual clinician. If in doubt contact a senior colleague or expert. Caution is advised
when using guidelines after the review date.
INTRODUCTION 3
ASSESSMENT 4
DIFFERENTIAL DIAGNOSIS 4-5
PRINCIPLES OF NAPPY CARE 6-7
TREATMENT UNCOMPLICATED 8
TREATMENT COMPLICATED 8-9
REFERRAL 9-10
AUDIT 10
REFERENCES 11
APPENDIX 1 FLOW CHART 12
2) EVIDENCE BASE
Further information is available from Clinical Knowledge Summaries, a service provided by the
National Institute for Health and Care Excellence (NICE):
http://www.cks.library.nhs.uk/nappy_rash/view_whole_guidance
This guidance is for use when an individual is being treated for nappy rash or it is suspected.
It aims to provide information about what nappy rash is and how it is treated effectively.
Contraindications
Nappy rash treatment requires the prescriber to be aware of the contraindications when
considering treatments, ensuring that the correct products are then prescribed.
4) HAZARDS
See under contraindications
5) EQUIPMENT LIST
Prescribed medication please refer to applying treatment section.
Hygiene practices (for example how often the area is cleaned and the nappy changed) - lack
of hygiene and prolonged contact with urine / faeces predisposes to irritant dermatitis.
Type of nappy used- disposable nappies or reusable cotton nappies.
Exposure to irritants when cleaning - such as soaps, detergents, or alcohol/ perfume based
baby wipes.
Trauma - for example, friction from nappies or over-vigorous cleaning.
Recent antibiotic use antibiotics predispose to candida colonization and diarrhoea
Nappy rash is diagnosed from the characteristic appearance of the rash and by excluding other
diagnoses of rash in the nappy area (especially in neonates, as nappy rash is uncommon in this age
group). Typically there is redness over convex surfaces closest to the nappy (buttocks, genitals, pubic
area, and upper thighs) with sparing (no redness) in the deeper skin creases. The rash has a glazed
appearance if acute, or fine scaling if more long-standing and hypopigmentation in some dark-skinned
infants (Atherton 2004). There are usually no symptoms (scratching or systemic upset) however, if the
nappy rash is severe or painful, the child may be distressed or uncomfortable. A skin swab is not
necessary to make a diagnosis and is only indicated if bacterial infection (marked redness with
exudate, and vesicular and pustular lesions) is suspected particularly when the nappy rash is severe,
or persists despite treatment (Brook 1992, NHS CKS 2009).
Although there is no universally recommended or validated method for assessing severity, the
following classification may be a useful guide and will influence the management (Odio et al, 2000):
Mild nappy rash faint to definite pink rash of less than 10% of the area covered by the
nappy, with or without a few scattered papules, with or without slight scaling and dryness. Mild
nappy rash is unlikely to distress the infant and can usually be managed with simple nappy
skin care measures.
Moderate to severe nappy rash moderate to severe redness covering an area greater
than 10% of the area covered by the nappy, with or without papules, oedema, or ulceration.
Moderate to severe nappy rash is more likely to be distressing and secondarily infected with
Candida albicans.
Differential Diagnosis (Atherton 2001, 2004, NHS CKS 2009, DermNet NZ 2012)
There is a wide variety of disorders to consider in an infant presenting with an inflamed rash in the
nappy area. Other diagnosis should be considered when a nappy rash fails to respond to what is
regarded as adequate therapy, this may include infections, primary skin conditions, rare conditions
affecting the nappy area and issues of neglect and abuse:
Candida albicans: The clinical features of nappy rash predominantly caused by Candida
albicans (candidiasis) most commonly include, erythema initially developing around the
perianal skin and later, erythema spreading to involve the perineum and sometimes the upper
thighs. It develops into sharply marginated confluent zones with papules, pustules involving
the skin creases of the nappy area. Satellite lesions, papules and small pustules or erosions
Perianal streptococcal dermatitis: Presents as a bright red, sharply demarcated rash that is
commonly misdiagnosed and treated as a fungal infection. It occurs most commonly in
children 34 years of age. It remains unresponsive to treatment with topical steroids and
antifungal creams. Perianal pain and itching are common and blood-streaked stools occur in
up to a third of cases.
Skin Conditions
Infantile seborrhoeic dermatitis: usually affects the scalp, ears, eyebrows, neck, and axillae,
but may also affect the nappy area. It presents as well-defined areas of redness and scaling,
which do not seem to disturb the child. It most commonly starts between the second week and
sixth month of life; it usually clears within a few weeks and does not recur. Unlike nappy
dermatitis which spares the deeper skin creases, all of the skin is involved in seborrhoeic
dermatitis.
Atopic eczema: a tendency to dry skin, a positive family history of atopic eczema, and rash
affecting other skin areas help to distinguish it from a primary nappy rash (often the nappy
area is spared as this area is so well hydrated and not accessible to excoriation).
Psoriasis: Infantile psoriasis is uncommon, and when it occurs it most typically affects the
nappy area. The rash may have a well-demarcated edge and characteristic adherent scales,
although in the nappy area this typical appearance is usually significantly modified by
occlusion and friction. Psoriasis may start as early as the second month of life. Affected
infants have a greater chance of developing psoriasis in adulthood.
Allergic contact dermatitis: Other types of contact dermatitis are uncommon causes of
nappy rash. They are distinguished by their characteristic patterns of distribution following
exposure to potential irritants or allergens such as nappy dyes, detergents, drug reactions
(such as antibiotics), and baby wipes with perfumes and fragrances added.
Scabies- is an itchy rash caused by a little mite that burrows in the skin surface. Scabies
burrows appear as tiny grey irregular tracks between the fingers and on the wrists. They may
also be found in armpits, buttocks, on the penis, insteps and backs of the heels. Scabies rash
appears as tiny red intensely itchy bumps on the limbs and trunk. It can easily be confused
with dermatitis or hives (and may be accompanied by these). Blisters and pustules on the
palms and soles are characteristic of scabies in infants (DermNet NZ 2012)
Langerhans' cell histiocytosis: commonly presents in the third month of life with persistent
intertrigo. Initially small, yellow papules develop which become confluent and subsequently
ulcerate.
ACTION RATIONALE
Good nappy care will generally prevent nappy rash. There is little available evidence on which aspects
of skin care can improve or prevent nappy rash. Advice is based on consensus and common sense
measures to reduce the time that urine and faeces are in contact with the skin. Parental preference,
practical issues and cost should be considered (NHS CKS 2009). The principles of good nappy care
include:
Reduce interval between nappy changes. Reduces skin exposure time to urine / faeces.
(Occurrence of nappy rash demonstrated to be
significantly lower in one study (n=1089) when
mean number of nappy changes was above
average (i.e. >8 changes per day) irrespective of
nappy type (Jordan et al 1986).
Use, and frequent changing of, a disposable The gel-core of modern disposable nappies
gel-core nappy. (The use of other types of absorbs and retains fluid, keeping it away from the
nappy is not prohibited and parents/ carers may skin and preventing mixing with faeces. There is
prefer to use alternatives. Given the variety of however not enough evidence from good quality
products available the appropriateness of the randomised controlled trials to support or refute the
nappy would need to be assessed on a case to use and type of disposable napkins for the
case basis depending on the childs prevention of napkin dermatitis in infants (Baer et al
circumstances) 2006).
Thorough cleansing of the nappy area with Baby wipes had an equivalent effect on skin
warm water and / or a water-soluble emollient hydration when compared with cotton wool and
(see emollient formulary) or fragrance-free and water and showed no evidence of any adverse
alcohol-free baby wipes after soiling. effects of using these wipes. (Lavender et al 2012).
Use fragrance- free and alcohol- free wipes (NHS
CKS 2009).
Talcum powder or equivalent should not be Talcum powder forms a paste when wet which
used causes friction and irritation (Atherton 2004). This
paste can also clog nappies limiting absorption. In
infants and neonates inhalation of powder residue
in the air may lead to respiratory complications
(Pfenninger and DApuzzo 1977, Mofenson et al
1981, Cotton and Davidson 1985).
Exposing the skin to the air for periods of time Air exposure allows the skin to dry and reduces
may be beneficial in the prevention of nappy persistent exposure to urine/ faeces (NHS CKS
rash 2009).
If exposing the nappy area to air, do not lay the Incontinence pads have a paper pulp core, which is
child on incontinence pads. Use a gel core less absorbent than gel core nappies and is unable
nappy laid flat under the child to retain fluid potentially leading to greater
exposure to urine/ faeces.
If a child is embarking on a treatment regimen Timely prophylactic intervention should avoid the
(e.g. antibiotic or chemo-therapy) that is onset of tissue damage.
expected to alter bowel habit (e.g. causing
changes to frequency, consistency, enzyme or Cavilon barrier film single use applicators
acid content of faeces) then Cavilon barrier should be used to apply the film.
film should be introduced before damage
occurs.
Please refer to Specific Product Characteristics and BNF when prescribing the
products listed below
Barrier Products
Barrier preparations are offered to provide a protective layer between the skin and urine/faeces.
There is no evidence to support the use of branded preparations containing water-repellent
substances (dimeticone). Many contain antiseptics, fragrances, and perfumes which may exacerbate
irritant dermatitis (NHS CKS 2009). Suitable preparations from the local formularies include ointment
based emollients and the products listed below:
Zinc and castor oil ointment BP contains pharmaceutical grade arachis (peanut) oil. This is
highly refined, and therefore, effectively, the peanut oil should have been removed. As a
precaution, however the Committee on the Safety of Medicines advises that people with a
known allergy to peanuts or soya (possible cross-sensitivity) should not use medicines
containing peanut oil (NHS CKS 2009).(for prevention)
Cavilon Durable Barrier Cream
Metanium Ointment
Cavilon Barrier Film (Applicators)
Emollients
Suitable choices from Emollient Formulary:
http://www.nottsapc.nhs.uk/attachments/article/8/emollient%20formulary.pdf
Liquid Paraffin and White Soft Paraffin Ointment (50:50)
Cetraben Emollient Cream
Hydromol Ointment
and
Yellow Soft Paraffin 15 g
White Soft Paraffin 15 g
Combination Therapies
It is best to prescribe a topical corticosteroid and topical anti-candidal separately rather than as a
combined preparation, as this minimises exposure to topical corticosteroids and their potential adverse
effect (NHS CKS 2009):
Topical corticosteroids need only be applied once a day, whereas topical antifungals need to
be applied two to three times a day.
Topical corticosteroids should be stopped as soon as the rash clears, whereas it is
recommended that antifungals are continued for 710 days after the rash has cleared to
ensure complete mycological eradication.
Treat with oral antibiotics if there are features of severe or recurrent secondary bacterial infection. Oral
antibiotics should be used cautiously in nappy rash, as broad-spectrum antibiotics may cause
worsening of candidal infection (NHS CKS 2009).
Flucloxacillin is a good empirical first-line antibiotic as it will cover both staphylococcal and
streptococcal species.
Erythromycin as an alternative if known to be allergic to penicillin.
http://nuhnet/diagnostics_clinical_support/antibiotics/Pages/Home.aspx
Further Management
Follow-up advice
For all children with persistent nappy rash (NHS CKS 2009):
Review after 710 days of treatment if the rash has not resolved, or sooner if there is
deterioration. Daily if inpatient.
Review skin care of the nappy area and effective use of treatments.
If the child has persistent moderate to severe nappy rash despite 710 days of anti-
candidal treatment, consider changing to a different anti-candidal treatment, e.g. from an
imidazole to nystatin (or vice versa).
Fungal Infections unresponsive to topical antifungals. Swab and request fungal as well as
routine culture on microbiology request card.
Referral
http://www.cks.library.nhs.uk/nappy_rash/view_whole_guidance
http://www.dermnetnz.org/dermatitis/napkin-dermatitis-imgs.html
(Skin disease information and photographs)
10) UPDATING
This guidance will be reviewed every three years earlier if evidence indicates an earlier review.
11) MEASUREMENT
Component Yes No
1. Was appropriate treatment prescribed?
2. Were emollient creams used to cleanse the skin?
3. Was treatment kept on the skin for the appropriate length of time?
4. Were the rashes reviewed 7-10 days following treatment?
5. Was the referral appropriate?
6. What investigations were undertaken if any?
Adalat, S, Wall, D and Goodyear, H (2007) Diaper Dermatitis- Frequency and Contributory Factors in
Hospital Attending Children. Pediatric Dermatology.Vol.24:No.5: 483-488
Atherton, DJ. (2001) The aetiology and management of irritant diaper dermatitis. European Academy
of Dermatology and Venereology. 15. Supp 1:1-4.
Atherton DJ. (2004) A review of the pathophysiology, prevention and treatment of irritant diaper
dermatitis. Current Medical Research and Opinion. 20. 5:645-9.
Baer EL, Davies MW, Easterbrook KJ (2006). Disposable nappies for preventing napkin dermatitis in
infants. Cochrane Database of Systematic Reviews 2006, Issue 3. Art. No.: CD004262. DOI:
10.1002/14651858.CD004262.pub2
British National Formulary for Children 2012-2013 (2012) British London, British Medical Association
and Royal Pharmaceutical Society of Great Britain.
Cotton WH, Davidson PJ. (1985). Aspiration of baby powder. New England Journal of Medicine.
313.26:1662.
Gfatter R, Hackl P, Braun F. (1997). Effects of soap and detergents on skin surface pH, stratum
corneum hydration and fat content in infants. Dermatology 195.3:258-62.
Holden C. (1998). Infant napkin dermatitis. Journal of Wound Care. 7.8: 417-418
Jordan, W.E., Lawson, K.D., Berg, R.W. et al (1986) Diaper dermatitis: frequency and severity among
a general infant population. Pediatric Dermatology 3(3), 198-207.
Lavender,T., Furber,C., Campbell,M., Victor,S., Roberts,I., Bedwell,C and Cork,M.J (2012) Effect on
skin hydration of using baby wipes to clean the napkin area of newborn babies: assessor-blinded
randomised controlled equivalence trial. BMC Pediatrics: Jun 1;12:59
http://www.biomedcentral.com/content/pdf/1471-2431-12-59.pdf [Accessed 02/1013]
Mofenson HC, Greensher J, DiTomasso A, Okun S. (1981). Baby powder--a hazard! Pediatrics. 68.
2:265-6.
Odio, M.R., O'Connor, R.J., Sarbaugh, F. and Baldwin, S. (2000) Continuous topical administration of
a petrolatum formulation by a novel disposable diaper. 2. Effect on skin condition. Dermatology
200(3), 238-243.
Pfenninger J, D'Apuzzo V. (1977). Powder aspiration in children. Report of two cases. Archives of
disease in Childhood. 52.2:157-9
NHS Clinical Knowledge Summaries (2009) Nappy rash Management. Available at:
www.cks.nhs.uk/nappy_rash [Accessed 02/10/13]
Rowe, J., McCall, E and Kent, B (2008) Clinical effectiveness of barrier preparations in the prevention
and treatment of nappy dermatitis in infants and preschool children of nappy age. International Journal
Evidence Based Healthcare. 6: 323
Scheinfeld, N. (2005) Diaper dermatitis: a review and brief survey of eruptions of the diaper area.
American Journal of Clinical Dermatology 6(5), 273-281.
Nappy rash which remains moderate to severe or distressing despite treatment. Medical Teams
Extension of rash onto areas of skin not in contact with faeces /urine Tissue Viability
Signed off by: Angela Horsley, Kerry Webb and Rachel Keay
N03 2013