DR EJAZ WARIS - PROFESSOR OF HISTOPATHOLOGY , ASMDC
1. An abnormal increase in interstitial fluid within tissues is called edema, while
fluid collections in the different body 2. cavities are variously designated hydrothorax, hydropericardium, and hydroperitoneum (the last is more commonly called ascites). Anasarca is a severe and generalized edema with widespread subcutaneous tissue swelling. 3. Edema caused by increased hydrostatic pressure or reduced plasma protein is typically a protein-poor fluid called a transudate 4. In contrast, inflammatory edema is a protein-rich exudate that is a result of increased vascular permeability. 5. Reduced plasma osmotic pressure occurs when albumin, the major plasma protein, is not synthesized in adequate amounts or is lost from the circulation. An important cause of albumin loss is the nephrotic syndrome 6. Hyperemia is an active process in which arteriolar dilation (e.g., at sites of inflammation or in skeletal muscle during exercise) leads to increased blood flow. 7. Congestion is a passive process resulting from reduced outflow of blood from a tissue. It can be systemic, as in cardiac failure, or local, as in isolated venous obstruction 8. In chronic pulmonary congestion the septa are thickened and fibrotic, and the alveoli often contain numerous hemosiderin-laden macrophages called heart failure cells 9. In chronic passive hepatic congestion the centrilobular regions are grossly red- brown and slightly depressed (because of cell death) and are accentuated against the surrounding zones of uncongested tan liver (nutmeg liver) .Microscopically, there is centrilobular hemorrhage, hemosiderin-laden macrophages, and degeneration of hepatocytes 10. Minute 1- to 2-mm hemorrhages into skin, mucous membranes, or serosal surfaces are called petechiae 11. Slightly larger hemorrhages (3 mm) hemorrhages are called purpura. 12. Larger hemorrhages (>1 to 2 cm) subcutaneous hematomas (i.e., bruises) are called ecchymoses. 13. three primary abnormalities that lead to thrombus formation (called Virchow's triad): (1) endothelial injury, (2) stasis or turbulent blood flow, and (3) hypercoagulability of the blood 14. Of the inherited causes of hypercoagulability, point mutations in the factor V gene and prothrombin gene are the most common. 15. Elevated levels of homocysteine contribute to arterial and venous thrombosis, as well as the development of atherosclerosis 16. Antiphospholipid antibody syndrome(previously called the lupus anticoagulant syndrome). This syndrome has protean clinical manifestations, including recurrent thromboses, repeated miscarriages, cardiac valve vegetations, and thrombocytopenia. 17. Thrombi often have grossly and microscopically apparent laminations called lines of Zahn; these represent pale platelet and fibrin deposits alternating with darker red cellrich layers. 18. Arterial thrombi are frequently occlusive; the most common sites in decreasing order of frequency are the coronary, cerebral, and femoral arteries 19. Postmortem clots can sometimes be mistaken for antemortem venous thrombi. However, postmortem clots are gelatinous with a dark red dependent portion where red cells have settled by gravity and a yellow chicken fat upper portion; they are usually not attached to the underlying wall. In comparison, red thrombi are firmer and are focally attached, and sectioning typically reveals gross and/or microscopic lines of Zahn 20. Fate of thrombus include : propogation ,embolization , dissolution and organization / recanalization 21. Microthrombi of fibrin are seen in DIC. 22. An embolus is a detached intravascular solid, liquid, or gaseous mass that is carried by the blood to a site distant from its point of origin ( Word literally means bottle stopper) 23. Rarely, an embolus can pass through an interatrial or interventricular defect and gain access to the systemic circulation (paradoxical embolism) 24. epending on the size of the embolus, it can occlude the main pulmonary artery, straddle the pulmonary artery bifurcation (saddle embolus 25. Microscopic fat globules ( fat emboli)with or without associated hematopoietic marrow elementscan be found in the circulation and impacted in the pulmonary vasculature after fractures of long bones (which have fatty marrow) or, rarely, in the setting of soft tissue trauma and burns 26. A particular form of gas embolism, called decompression sickness, occurs when individuals experience sudden decreases in atmospheric pressure. 27. The rapid formation of gas bubbles within skeletal muscles and supporting tissues in and about joints is responsible for the painful condition called the bends 28. in the lungs, gas bubbles in the vasculature cause edema, hemorrhage, and focal atelectasis or emphysema, leading to a form of respiratory distress called the chokes 29. A more chronic form of decompression sickness is called caisson disease (named for the pressurized vessels used in the bridge construction; workers in these vessels suffered both acute and chronic forms of decompression sickness 30. An infarct is an area of ischemic necrosis caused by occlusion of either the arterial supply or the venous drainage. 31. Infarcts are classified according to color and the presence or absence of infection; they are either red (hemorrhagic) or white (anemic) and may be septic or bland. 32. Shock is characterized by systemic hypotension due either to reduced cardiac output or to reduced effective circulating blood volume. The consequences are impaired tissue perfusion and cellular hypoxia. 33. Cardiogenic shock results from low cardiac output due to myocardial pump failure. This can be due to intrinsic myocardial damage (infarction), ventricular arrhythmias, extrinsic compression , or outflow obstruction (e.g., pulmonary embolism). 34. Hypovolemic shock results from low cardiac output due to the loss of blood or plasma volume, such as can occur with massive hemorrhage or fluid loss from severe burns. 35. Septic shock results from vasodilation and peripheral pooling of blood as part of a systemic immune reaction to bacterial or fungal infection. Its complex pathogenesis is discussed in further detail below. 36. Toll-like receptors (TLRs) recognize microbial elements and trigger the responses that initiate sepsis.