Académique Documents
Professionnel Documents
Culture Documents
Numerous nanoparticle-based experimental therapeutics for lung cancer utilize a combinatorial approach balancing the design with targeting and
tracking moieties and anticancer agents. For example, silica nanoparticles in their amorphous state have the potential to cause inflammatory
reactions on target organs resulting in apoptotic cell death [ 78 ]. Abstract We propose a nanomedical device for the classification of lung cancer
LC histology. Mesoporous silica nanoparticles MSNs have been increasingly used in anticancer drug delivery research due to their dynamic
capacity for drug loading, controlled drug release property, and multifunctional ability. The leaky vasculature and dysfunctional lymphatics of solid
tumors allow the preferential accumulation and retention of colloidal nanoparticles in contrast to the tight vasculature of normal tissue, which
excludes nanoparticles. In this model, MSNs were able to hold the radionuclide without release and withstand long irradiation times. Additionally,
Ho -carrying MSNs predominantly accumulated in the tumor tissue following intraperitoneal administration in tumor-bearing mice. In this study, a
nanomedical device that profiles volatile organic compounds VOCs in lung cancer cells is investigated, using a matrix of gold nanoparticle GNP
sensors that are suitable for detecting lung cancer LC specific patterns of VOC profiles. Moreover, active targeting of nanoparticles is
accomplished by decorating the surface of the nanoparticle with specific ligands to promote the binding and interaction with overexpressed protein
receptors on cancer cell surfaces. These systems are already helping to address key issues with traditional anticancer agents such as nonspecific
targeting, low therapeutic efficiencies, untoward side effects, and drug resistance as well as surpassing their predecessors with the ability to detect
early metastasis. View at Google Scholar P. Nature has produced a well-stocked arsenal of potent cancer-fighting compounds, including Taxol,
first isolated from the Pacific yew tree, and rapamycin, borrowed from a soil-dwelling bacterium. Unfortunately, most of them are not as good as
they may seem, or as you'd hope they would be. The ability of nanoparticles to be tailored for a personalized medicine strategy makes them ideal
vehicles for the treatment of lung cancer. Nutritional benefits may vary from one person to another. At present Lipusu, a paclitaxel-liposome, is
commercially available with several other formulations under clinical investigation [ 27 ]. While a large number of multifunctional nanoparticles, such
as theranostic systems targeted to lung cancer are under development, Aurimune CYT is currently the only known multifunctional nanoparticle
system with diagnostic and therapeutic properties that has entered the clinical setting [ 76 ]. A new study from the scientists in Edinburgh UK
shows that little flecks of gold can be used to help boost the effectiveness of lung cancer treatments. In , Boulikas developed a liposome-based
cisplatin drug called Lipoplatin to reduce systemic toxicity of cisplatin [ 22 ]. The team believe that the careful, tailored assembly of micelle cores,
as well as considered design of the surrounding protective outer shell, will help improve the efficacy of nanocarriers. Magnetic hyperthermia is a
noninvasive therapeutic approach for lung cancer that entails the heat-induced ablation of desired tumor tissue. To safely and effectively use gold
nanoparticles, therefore, we need to investigate and quantify the enhanced impact of radiation that they cause. Drag according to your
convenience. Tiny wires are required to connect these to an electrical circuit at the nano level. Meshes made from fibers with nanometer-scale
diameters have a wide range of potential applications, including tissue engineering, water filtration, solar cells, and even body armor.
Pharmacokinetics PK and biodistribution are known to be effected by small compositional differences in nanoparticles [ 81 ]. The increasing
miniaturisation in electronics will result in components which consist of only a few molecules, or even just one molecule. You can proceed from one
strategy to the next by clicking on the NEXT buttons at the end of each page. Militant Secularists 'Want Your Kids'. Literally thousands of people
have walked this path before you, and have used the recommendations in this report to beat their cancer and live happy normal lives. Magnetic
nanoparticles conjugated with the epithelial tumor cell marker pan-cytokeratin efficiently isolated circulating tumor cells CTCs from patients
diagnosed with lung cancer. While this has not yet been tested on humans, it is hoped such a device could one day be used to reduce side effects
of current chemotherapy treatments by precisely targeting diseased cells without damaging healthy tissue. In another study, paclitaxel-loaded
PLGA nanoparticles decorated with anti-EGFR demonstrated high binding affinity to EGFR expressing cells in a mouse lung tumor model
indicating the potential of these nanoparticles for targeted lung cancer therapy [ 53 ]. Taking advantage of gold's biocompatibility, nanoparticles can
be injected intravenously and will naturally accumulate in any area of leaking vascularity such as tumours. Reduction of the number of lipid bilayers
reduces the size of the liposomes to nanosize increasing the circulation time and tumor localization properties of encapsulated drugs [ 16 ].
Nanoparticle-based therapeutic systems have gained immense popularity due to their ability to overcome biological barriers, effectively deliver
hydrophobic therapies, and preferentially target disease sites. This will alert our moderators to take action. This will prevent the mistake of using
supplements that sound good but aren't good enough -- in all too many cases, to beat a tough cancer. There are many many testimonies, and this
can be quite inspiring. While many nanoparticle-based therapies have been developed, such as Abraxane, an albumin-bound paclitaxel
nanoformulation for the treatment of metastatic NSCLC [ 15 ], few have been translated into clinical success. Recently, gold nanoparticles have
also successfully been tested as sensors for discriminating and classifying different lung cancer histologies. My Saved Articles Sign in Sign up.
Conceptually nanoparticle-based therapy must overcome the same hurdles faced by any new drug: In lung cancer, nanoparticle-based therapeutics
is paving the way in the diagnosis, imaging, screening, and treatment of primary and metastatic tumors. The nanoparticle system carrying siRNA
inhibited targeted mRNA causing suppression of cellular resistance to the chemotherapeutics accomplishing an enhanced therapeutic efficacy of
cisplatin and doxorubicin. Particle-particle interactions and aggregation tendencies are largely dependent on the zeta potential of the nanoparticles.
Therefore, stringent in vitro and in vivo toxicity studies for each of the novel nanoparticle systems must be conducted to ensure safety prior to their
application in humans.