Lampiran 1

Perhitungan Pembakuan I2 0,1 N dengan Arsen Trioksida

Normalitas I2 dapat dihitung dengan rumus :

Berat arsen trioksida x 0,1

Normalitas I2 =
Volume titran x kesetaraan

Dimana:

1 ml I2 0,1 N setara dengan 4,946 mg arsen trioksida

Berat As2O3 I = 150,20 mg

Berat As2O3 II = 150,82 mg

Berat As2O3 III = 151,15 mg

Volume titran I = 29,40 ml

Volume titran II = 29,40 ml

Volume titran III = 29,50 ml

150,20 mg x 0,1
Normalitas I2 1 (N1) =
29,40 ml x 4,946 mg
= 0,1032 N

150,82 mg x 0,1
Normalitas I2 2 (N2) =
29,40 ml x 4,946 mg
= 0,1037 N

Normalitas I2 3 (N3) = 151,15 mg x 0,1

29,50 ml x 4,946 mg
= 0,1035 N

Universitas Sumatera Utara

 N1 + N2 + N3
Normalitas I2 rata-rata =
3
0,1032 + 0,1037 + 0,1036
=
3
= 0,1035 N

Universitas Sumatera Utara

Lampiran 2

Perhitungan Penetapan Kadar Bahan Baku Antalgin

Tabel 2. Data Perhitungan

No. LOD Bt (mg) Vt (ml) K (%)

1. 5,5 199 10,9 94,50
2. 5,5 201 10,95 93,99
3. 5,5 202 11,0 93,95
4. 5,5 201 10,95 93,99
5. 5,39 199 10,9 94,50
6. 5,5 202 11,0 93,95
7. 5,5 200 10,9 94,03
8. 5,37 198 10,85 94,54
9. 5,5 201 11,0 94,42
10. 5,5 199 10,9 94,50
11. 5,5 201 11,0 94,42
12. 5,48 199 10,9 94,50
13. 5,5 201 10,95 93,99
14. 5,5 201 10,95 93,99
15. 5,5 199 10,9 94,50
16. 5,5 201 11,0 94,42
17. 5,26 200 11,0 94,89
18. 5,5 199 10,95 94,93
19. 5,47 201 11,0 94,42
20. 5,5 202 11,0 93,95
21. 5,5 199 10,9 94,50

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Rumus Perhitungan Penetapan Kadar Bahan Baku Antalgin

Vt x N I2 x 16,67
K = x 100%
Ns x Bt

100
KS = x K
100 - LOD

Keterangan:

Vt : Volume titran (ml)

N I2 : Normalitas pentiter (0,1035 N)

Ns : Normalitas standart (0,1 N)

Bt : Berat serbuk ditimbang (200mg)

LOD : Lost of Dry (%)

K : Kadar awal (%)

KS : Kadar sebenarnya. (%)

1 ml Iodium 0,1 N setara dengan 16,67 C13H16N3NaO4S.

Universitas Sumatera Utara

Kadar Bahan Baku Antalgin 1:

10,9 x 0,1035 x 16,67

K = x 100% = 94,50%
0,1 x 199

100
KS1 = x 94,50% = 100,0%
1005,5

Kadar Bahan Baku Antalgin 2:

10,95 x 0,1035 x 16,67

K = x 100% = 93,99%
0,1 x 201

100
KS2 = x 93,99% = 99,46%
1005,5

Kadar Bahan Baku Antalgin 3:

11,0 x 0,1035 x 16,67

K = x 100% = 93,95%
0,1 x 202

100
KS3 = x 93,95% = 99,41%
1005,5

Kadar Bahan Baku Antalgin 4:

10,95 x 0,1035 x 16,67

K = x 100% = 93,99%
0,1 x 201

100
KS4 = x 93,99% = 99,46%
1005,5

Kadar Bahan Baku Antalgin 5:

10,9 x 0,1035 x 16,67

K = x 100% = 94,50%
0,1 x 199

100
KS5 = x 94,50% = 99,88%
1005,39

Universitas Sumatera Utara

Kadar Bahan Baku Antalgin 6:

11,0 x 0,1035 x 16,67

K = x 100% = 93,95%
0,1 x 202

100
KS6 = x 93,95% = 99,41%
1005,5

Kadar Bahan Baku Antalgin 7:

10,9 x 0,1035 x 16,67

K = x 100% = 94,03 %
0,1 x 200

100
KS7 = x 94,03% = 99,50%
1005,5

Kadar Bahan Baku Antalgin 8:

10,85 x 0,1035 x 16,67

K = x 100% = 94,54%
0,1 x 198

100
KS8 = x 94,54% = 99,90%
1005,37

Kadar Bahan Baku Antalgin 9:

11,0 x 0,1035 x 16,67

K = x 100% = 94,42%
0,1 x 201

100
KS9 = x 94,42% = 99,91%
1005,5

Kadar Bahan Baku Antalgin 10:

10,9 x 0,1035 x 16,67

K = x 100% = 94,50%
0,1 x 199

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 100
KS10 = x 94,50% = 100,0%
1005,5

Kadar Bahan Baku Antalgin 11:

11,0 x 0,1035 x 16,67

K = x 100% = 94,42%
0,1 x 201

100
KS11 = x 94,42% = 99,91%
1005,5

Kadar Bahan Baku Antalgin 12:

10,9 x 0,1035 x 16,67

K = x 100% = 94,50%
0,1 x 199

100
KS12 = x 94,50% = 99,97%
1005,48

Kadar Bahan Baku Antalgin 13:

10,95 x 0,1035 x 16,67

K = x 100% = 93,99%
0,1 x 201

100
KS13 = x 93,99% = 99,46%
1005,5

Kadar Bahan Baku Antalgin 14:

10,95 x 0,1035 x 16,67

K = x 100% = 93,99%
0,1 x 201

100
KS14 = x 93,99% = 99,46%
1005,5

Kadar Bahan Baku Antalgin 15:

10,9 x 0,1035 x 16,67

K = x 100% = 94,50%
0,1 x 199

Universitas Sumatera Utara

 100
KS15 = x 94,50% = 100,0%
1005,5

Kadar Bahan Baku Antalgin 16:

11,0 x 0,1035 x 16,67

K = x 100% = 94,42%
0,1 x 201

100
KS16 = x 94,42% = 99,91%
1005,5

Kadar Bahan Baku Antalgin 17:

11,0 x 0,1035 x 16,67

K = x 100% = 94,89%
0,1 x 200

100
KS17 = x 94,89% = 100,15%
1005,26

Kadar Bahan Baku Antalgin 18:

10,95 x 0,1035 x 16,67

K = x 100% = 94,93%
0,1 x 200,18

100
KS18 = x 94,93% = 100,32%
1005,5

Kadar Bahan Baku Antalgin 19:

11,0 x 0,1035 x 16,67

K = x 100% = 94,42%
0,1 x 201

100
KS19 = x 94,42% = 99,88%
1005,47

Universitas Sumatera Utara

Kadar Bahan Baku Antalgin 20:

11,0 x 0,1035 x 16,67

K = x 100% = 93,95%
0,1 x 202

100
KS20 = x 93,95% = 99,41%
1005,5

Kadar Bahan Baku Antalgin 21:

10,9 x 0,1035 x 16,67

K = x 100% = 94,50%
0,1 x 199

100
KS21 = x 94,50% = 100,0%
1005,5

Universitas Sumatera Utara