San Beda College

COLLEGE OF NURSING

DRUG STUDY

GENERIC NAME: Amoxicillin Dosage: Adults and children 40 kg BRAND NAME: Amoxil
Route of Administration: P.O. and over: 500mg Available Stock: Capsules: 250mg; 500mg
DRUG CLASS MODE OF ACTION INDICATION/ ADVERSE DRUG NURSING HEALTH TEACHING
CONTRAINDICATION REACTIONS TO INTERACTIONS CONSIDERATIONS
WATCH OUT FOR
Antibiotic, Semisynthetic broad- Indications: Hypersensitivity, N&V, Probenecid decreases Child’s dose should not Take entire prescription;
penicillin spectrum penicillin Indicated in the treatment gastritis, stomatitis. the renal tubular exceed maximum adult don’t stop if feeling
closely related to of infections due to secretion of dose. ‘better’; creates antibiotic
ampicillin. Binds to susceptible (only β- amoxicillin. Concurrent resistance.
penicillin-binding lactamase- negative) use of amoxicillin and Clients on hemodialysis
proteins (PBP-1 and strains of the designated probenecid may result should receive 250 or For school-age child
PBP-3) in the microorganisms. in increased and 500 mg q 24 hr, space evenly over 24-hr
cytoplasmic prolonged blood levels depending on infection period; give before
membranes of Contraindiacations: of amoxicillin. severity; should receive school, upon arrival
bacteria, thus A history of allergic an additional dose both home, at bedtime.
inhibiting cell wall reaction to any of the Chloramphenicol, during and at end of
synthesis. Destroyed penicillins is a macrolides, dialysis. Report unusual
the penicillinase, acid contraindication. sulfonamides, and symptoms, i.e.,
stable, and better tetracyclines may List reasons for therapy; brusising/bleeding, sore
absorbed than interfere with the C&S results. Identify throat, rash, diarrhea,
ampicillin bactericidal effects onset, symptoms, worsening of symptoms,
of penicillin. severity, location, other or lack of response.
associated factors.

Assess for previous

reactions to penicillins,
cephalosporins or other
antibiotics.

GENERIC NAME: Cefuroxime Dosage: Adult: 250mg
Route of Administration: P.O., IM
DRUG CLASS MODE OF ACTION INDICATION/
CONTRAINDICATION
Cephalosprotin Acts on blood Indications:
vessels, GI system, Pharyngitis, tonsillitis,
respiratory system, acutre bacteria otitis media, fever, sore throat, and
by competing with acute bacterial maxillary
histamine H1 sinusitis, acute bacterial
-receptor site exacerbations of chronic
decreases allergic bronchitis, uncomplicated
response by blocking skn and skin structure
histamine. infections, uncomplicated
urethral and endocervical
gonorrhea
Contraindications:
Contraindicated in patients
with known allergy to the
cephalosporin group of
antibiotics
San Beda College
COLLEGE OF NURSING
DRUG STUDY
BRAND NAME: Ceftin
Children: 125 mg Available Stock: Tablets: 125 mg, 250 mg, 500 mg
ADVERSE DRUG NURSING HEALTH TEACHING
REACTIONS TO INTERACTIONS CONSIDERATIONS
WATCH OUT FOR
Diarrhea/ loose stools, Probenecid, with Do not confuse Swallow tablets whole;
N&V, abdominal pain, cefuroxime axetil cefuromixe with do not chew or crushed
tablets increases the deferoxamine. tablet has strong, bitter,
headache with a severe area under the serum persistent taste. Tablets
blistering, peeling, and concentration versus Cefuroxime axetel for may be taken without
red skin rash. time curve by 50%. PO use is available in regard for food; the
tablet and suspention suspension must be taken
Drugs that reduce forms. Swallow tablets with food. Store
gastric acidity may whole, do not crush; suspension at room
result in a lower crushed tablet has a temperature or
bioavailability of strong, bitter, persistent refrigerate. Discard after
Ceftin compared with taste. The tablets may be 10 days. Protect tablets
that of fasting state and taken without regard for from excessive moisture.
tend to cancel the effect food; however, the
of postprandial suspension must be taken Report lack of response,
absorption. with food. Protect tablet persistent diarrhea or
from excessive moisture. S&S of anemia
Cefuroxime axetil may immediately.
affect the gut flora,
leading to lower
estrogen reabsorption
and reduced efficacy of
combined oral
estrogen/progesterone
contraceptives.
 San Beda College
COLLEGE OF NURSING

DRUG STUDY

GENERIC NAME: Ferrous Sulfate Dosage: Adult: 200 mg/day BRAND NAME: Feosol
Route of Administration: P.O. Pediatric: 5 mg/kg/day Available Stock: Tablets: 200 mg, 300 mg
DRUG CLASS MODE OF ACTION INDICATION/ ADVERSE DRUG NURSING HEALTH TEACHING
CONTRAINDICATION REACTIONS TO INTERACTIONS CONSIDERATIONS
WATCH OUT FOR
Antianemic, The normal daily Indications: Constipation, gastritis Antacids, oral/ Substitution of one iron Adhere to prescribed
iron intake for males is To prevent and treat iron irritation, nausea, decreases iron salt for another without regimen; report any
12-20 mg and for deficiency anemia abdominal cramps, absorption from GI proper adjustment may problems immediately.
females is 8-15 mg, anorexia, diarrhea, tract result in serious over or Coated tablets may
although only about Contraindications: dark-colored stools. under dosing. diminish GI effects such
10% (1-2 mg) of iron Hemosiderosis, Ascorbic acid/ as nausea, constipation or
is absorbed. Iron is hemochromatosis, peptic Ascorbic acid 200 mg For infants and young diarrhea, gastric
absorbed from the ulcer, regional enteritis, or more, increases iron children, administer irritation, and abdominal
duodenum and upper and ulcerative colitis. absorption liquid preparations with a cramps.
jejunum by an active pyridoxine-responsive dropper. Deposit liquid
mechanism through anemia, and cirrhosis of the Calcium salts/ well back against the Review form of iron
the mucosal cells liver. Use in those with decreases GI check. prescribed, frequency of
where it combines normal iron balance. absorption of iron; administration.
with the protein separate administration Ingestion of calcium and
transferring. Iron is times iron supplements with Take with meals to
stored in the body as food can decrease iron reduce gastric irritation.
hemosiderin or Methyldopa/ decrease absorption by one-third; Taking with citrus juices
aggregated ferritin Methyldopa absorption iron absorption is not enhances iron absorption.
which is found in from GI tract decrease if calcium Milk products, eggs, and
reticuloendothelial carbonate is used and antacids inhibit
cells of the liver, taken between meals. absorption so avoid
spleen, and bone unless taking ferrous
marrow. About two- lactate.
thirds of total body
iron is in the
circulating RBCs in
hemoglobin.
 San Beda College
COLLEGE OF NURSING

DRUG STUDY

GENERIC NAME: Mefenamic Acid Dosage: 500 mg 1 tablet Q6 BRAND NAME: Algicap
Route of Administration: P.O. Available Stock: 250 mg, 500 mg
DRUG CLASS MODE OF ACTION INDICATION/ ADVERSE DRUG NURSING HEALTH TEACHING
CONTRAINDICATION REACTIONS TO INTERACTIONS CONSIDERATIONS
WATCH OUT FOR
Anti- Binds the Indications: Gastrointestinal Alendronate Increased Check for doctor’s order Advise the patient if self-
inflammatory prostaglandin For the treatment of experience including – risk of gastric toxicity administered, use exactly
agent, non- synthetase receptors rheumatoid arthritis, abdominal pain, Advise patient to report as directed, do not
steroidal; COX-1 and COX-2, osteoarthritis, constipation, diarrhea, Methotrexate Increases any discomfort increase dose
cycloxygenase inhibiting the action dysmenorrheal, and mild to dyspepsia, flaturence, the effect and toxicity
inhibitors of prostaglandin moderate pain, gross bleeding, of methotrexate Monitor v/s Educate the patient that
synthesis. As these inflammation and fever heartburn, nausea, GI adverse reactions can
receptors have a role ulcers, vomiting, Anisindione, Do not give to the patient occur
as a major mediator Contraindications: abnormal renal Dicumarol and who have active
of inflammation Contraindicated in patients function, anemia, Acenocoumarol ulceration or hronic Instruct the patient to
with known Increases the inflammation of either take it with or without
and/or a role for dizziness, edema,
hypersensitivity to anticoagulant effect the upper or lower GI food.
prostanoid signaling elevated liverenzymes,
mefenamic acid. Should tract
in activity-dependent headache, increased
not be given to patients Aspirin: increased
plasticity, the who have experienced bleeding time, pruritus, Should not be used in
symptoms of pain are rashes and tinnitus. adverse effect.
asthma, uritcaria, or patients with preexisting
temporarily reduced. allergic-type reactions after renal diseases.
ACE Inhibitors: can
taking aspirin or other reduce the natriuretic
NSAIDs. Severe, rarely effect of furosemide
fatal, anaphylactic-like and thiazides in some
reaction. patients.
 San Beda College
COLLEGE OF NURSING

DRUG STUDY

GENERIC NAME: Tranexamic Acid Dosage: 500 mg/tab; 2 tablets Q6 BRAND NAME: Hemostan
Route of Administration: P.O. Available Stock: 250 mg
DRUG CLASS MODE OF ACTION INDICATION/ ADVERSE DRUG NURSING HEALTH TEACHING
CONTRAINDICATION REACTIONS TO INTERACTIONS CONSIDERATIONS
WATCH OUT FOR
Anti- Inhibits breakdown of Indications: Dizziness, headache, Increase risk of clotting Check for doctor’s order Advise the patient to take
hemophilic fibrin clots; inhibits Anti-hemorrhagic and anti- nausea, vomiting, when used with it with or without food
agent activation of fibrinolytic for effective anorexia, diarrhea, estrogen-containing OC Should not be given if
plasminogen, thereby hemostasis in various hypotension, positive skin test Advise the patient if self-
preventing the surgical clinical cases, thromboembolism, administered use exactly
conversion of traumatic injuries, thrombosis Advise patient to report as directed, do not
plasminogen to hematuria, prevent any discomfort increase dose
plasmin excessive bleeding
Monitor v/s
Contraindications:
Hypersensitivity, patients Caution patient to avoid
exposed with prolonged products containing
thrombosis, active aspirin or NSAIDs
intravascular clotting without consulting health
care professionals

Dosage modification
required in patient with
renal impairment

Watch out for any signs

of bleeding
 San Beda College
COLLEGE OF NURSING

DRUG STUDY

GENERIC NAME: Methylergonovine maleate Dosage: 1 tablet 0.2 mg x 3-4 daily for 1 week BRAND NAME: Methergine
Route of Administration: P.O., IM, IV Available Stock: Tablets: 0.2 mg
 San Beda College
COLLEGE OF NURSING

DRUG STUDY

GENERIC NAME: Diclofenac Sodium Dosage: 50 mg 1 tablet TID x 10 day BRAND NAME: Voltaren
Route of Administration: P.O. Available Stock: 50 mg, 100 mg
DRUG CLASS MODE OF ACTION INDICATION/ ADVERSE DRUG NURSING HEALTH TEACHING
CONTRAINDICATION REACTIONS TO INTERACTIONS CONSIDERATIONS
WATCH OUT FOR
Nonsteriodal Inhibits cyclo- Indications: Headache, dizziness, There are no reported The lowest dose should Advise the patient if self-
anti- oxygenase release Arthritis, osteiarthritis abdominal significant interactions be sought for the client. administered, use exactly
inflammatory which results in pain/cramps, nausea, with this medicine as directed, do not
drugs decreased Contraindications: diarrhea, constipation, May be used up to 3 increase dose
prostaglandin Perioperative pain follow- and weeks to attain beneficial
synthesis. up coronary artery bypass. dyspepsia/indigestion effects for rheumatoid Educate the patient that
Prostaglandin causes Contraindicated to patients arthritis. adverse reactions can
inflammation. with cardiovascular occur
Therefore this is conditions. Assess for V/S, CBC,
effective in reducing renal and LFTs Instruct the patient to
swelling. take it with or without
food.