Trichuriasis Can Induce the Development of Intestinal Neoplasia

1
Rangga Okta Sadewa and 2Yudha Nurdian

1
Students, Faculty of Medicine, University of Jember, Indonesia.
2
Faculty of Medicine, University of Jember, Indonesia.
Corresponding: Rangga Okta Sadewa, ranggaoktasadewa@gmail.com, 152010101075@students.unej.ac.id

Abstract
Background
Trichuriasis is a disease that caused by infestation of Trichuris trichiura. An estimated of 800 million
or more people worldwide especially in tropics and subtropics area are infested by this worm. The
highest prevalence occurs in areas where sanitation is inadequate and water supplies are unsafe. T.
trichiura reside in the cecum and ascending colon and with heavy infestation extend to the lower
colon and rectum. Most people with trichuriasis have no symptoms or only have eosinofilia. Severe
trichuriasis can cause inflammation of colon and also, recurrent rectal prolapse. New researches
suggest that trichuriasis potentially can lead the formation of neoplasma in intestine, especially in
colon. A research study has been held to understanding of tumour development caused by trichuriasis.
This study uses wild type mice and mice as colon cancer model (APC min/+). T. muris, a whipworm
that known as a parasite of mice and other rodent are used to be a good model for effect of trichuriasis
in human because of its homology with T. trichiura in human. The results of the study are the
infestation of T. muris in wild type mice promotes the development of intestinal neoplasia. The
infestation of T. muris in colon cancer model mice (APC min/+) also increase development of colon
cancer. The mechanism of trichuriasis-induced intestinal neoplasia is unclear. It may be caused by the
chronic infestation of Trichuris that induces the activation of T regulatory cell type. T regulatory cell
type has an important role in protecting the host from chronic infestation of parasite. Otherwise, this
cell can cause a negative impact for the host, especially in the development of intestinal neoplasms.

Conclusion
Trichuriasis is a disease that caused by infestation of T. trichiura. A new study suggests that
trichuriasis can induce the development of neoplasia in mice model infested by T. muris. It may
because of response of T regulatory cell type that induce the development of neoplasia. Another
studies and researches must be held to understanding the mechanism of trichuriasis-induced neoplasia.

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2017 Chronic Trichuris muris Infection Causes Neoplastic Change in the Intestine and Exacerbates
Tumour Formation in APC min/+ mice. PLoS Neglected Tropical Diseases, 11(6): e0005708. doi:
10.1371/journal.pntd.0005708