MICROBIOLOGY Microbiology: RIDLEY AND JOPLING CLASSIFICATION OF LEPROSY

Prelim Quiz #

TT BT IL BB BL LL
MAJOR CLASSN Paucibacillary Multibacillary
MACULES/PAPULES Single to few - Similar to TT Hypopigmented More lesions than BT Multiple macules, Multiple non-
anesthetic - >5 skin lesions or red macules Added punch-out papules and anesthetic macular and
Hypopigmented + satellite lesions plaques papular lesions
lesions around
(central) Symmetric lesions
larger lesions
BORDER Well-defined Less-distinct Ill- defined More indistinct Vague
PERIPH. NERVE Common Earlier +/- sensory Assymetric - No anesthesia No neural lesions until
INVOLVEMENT Localized deficit (more common very late
Assymetric of tuberculoid)
- Neuritis late
than neural
lesions

BACILLARY DENSITY None to scanty Mild Scant Moderate Heavy Heavy

LEPROMIN RXN Strongly (+) Scant Weak Weakly (+) (-) (-)
GRANULOMA - Formed by Mixed granuloma - Typically globi
inflammatory under the
cells microscope
- Tend to follow - Do not form good
the course of granuloma
peripheral - Lepra cells = foamy
nerves macrophages
- Epitheloid cells packed with bacilli
surrounded by - Grenz zone = area
a rim of separating the
lymphocytes epidermis from the
dermis
OTHER FEATURES - Hair loss Surface smooth Late complications:
- Anhydrosis and shiny with ill- - Madarosis
Most common type defined borders - Leonine facies
of leprosy (clinically) Leprae in neurons - Testicular damage
enlargement
#MICROteam Special thanks to: TACLOBAO, April Grayle M. & HAFALLA, Marvin Kurt F.