from trekking across the Amazon to trekking across the street to a cow pasture. Genome Management Information System, Oak Ridge National Laboratory Http://genomics.energy.gov What is Bioprospecting?
Bioprospecting, also known as biodiversity
prospecting, is the exploration of biological material for commercially valuable genetic and biochemical properties. In simple terms this means the searching, finding and isolating the particular life form ( Bacteria, fungus, microbial yeast, etc ) And utilise it for betterment of mankind. Concept of Bioprospecting Extreme environments, provide habitats for extremophiles, organisms with unique characteristics developed for survival. The biological processes and materials which enable these extremophiles to survive in extreme temperatures, pressures, salinity etc, and other unique conditions are sources of great potential for scientific advancement and commercial application. These Enzymes derived from extremophiles have been used in detergents, food processing, cleaning, dyeing, medical diagnosis, skin protection products, and forensics. Bioprospecting of marine environments is conducted almost exclusively in regions at extreme depths specifically around submarine trenches, cold seeps, seamounts and hydrothermal vents. Examples Thermus aquaticus PCR Aequorea victoria GFP for glofish Antarctic ice fish anti freeze protein LAL - Limulus amebocyte lysate (Rapid microbiological test) Why is it needed? The underlying aim of bio prospecting is to find new resources and products from nature that can be used by humans. Improving human health, through both medicine and better nutrition are key focal areas. It plays a dominant role in discovering leads for drug development, since existing/known compounds for developing drugs for human use are limited. A study showed that between 1983 and 2003, almost two thirds of anti-cancer agents being investigated as drug candidates were derived from natural products.. Other related sectors, such as crop plant biotechnology, screen natural resources for useful traits, such as disease resistance. Where? Although bioprospecting can happen wherever there is biodiversity, it tends to be focused where biodiversity is at its richest, as this raises the chances of finding something useful. Statistically, the chance of a successful hit is one in 10,000 for synthetic compounds and one in 30,000 or 40,000 for natural products. Extreme environments and unique ecological niches are also good sources for diversity, such as Antarctica. Yet, only a tiny fraction of the worlds biodiversity has actually been explored and the richest areas of biodiversity tend to be in developing countries. Process of Bioprospecting As a process, it generally consists of four phases: Phase 1: on-site collection of samples; Phase 2: isolation, charactisation and culture of specific compounds; Phase 3: screening for potential uses, such as pharmaceutical or other uses; and, Phase 4: product development and commercialisation, including patenting, trials, sales and marketing. Who does bioprospecting? Pharmaceutical, agribusiness (biotechnology, seed, crop protection and horticulture), cosmetic and personal care, fragrance, botanicals, and the food and beverage industries. The pharmaceutical and agri-business sectors are more involved. Natural products research is very resource intensive requiring lots of money, people and expertise, making large companies reluctant to get involved again significantly. Added potential environmental impacts of Bioprospectging
In situ experiments in and around the Deep Seabed can
introduce light and noise or change water temperature, which, in-turn, can affect procreation and the survival of organisms in these areas. Bioprospecting activities can also produce pollution in the form of debris or discharge from vessels and equipment. Additionally, inadvertant movement of organisms through disrupting currents or discarding of scientific samples can lead to biological contamination. Finally, there is the usual possibility of over-exploitation in harvesting organisms in these regions and the flow on environmental impacts. Key issues & challenges
Conservation versus exploitation:
Conservation is not always the top priority of nations, and some seek to make a quick profit from their natural resources rather than preserving them. As a result, the biodiversity they wish to exploit is disappearing. Lack of legal clarity: There is a need for clearer, more specific rules on how origins of samples and IK are recorded and their benefits shared, both nationally and abroad. The commercial benefit should be accrue to those who discovered the active ingredient or the biotech company able to identify/ improve on this key ingredient Greater sector involvement: Many sectors actively involved in bioprospecting remain ignorant of the regulations, and are committing biopiracy. Education and participation in relevant international and national discussions is needed to ensure regulation across all sectors. Sea Squirt and Spiny dogfish Ecteinascidin 743 and Aplidinen isolated from the Sea Squirt Ecteinascidia turbinate from the Carribean Sea are undergoing trials for use as an anti cancer medication. Squalamine isolated from the Spiny dogfish Squalus acanthias found in the Atlantic and Pacific Oceans is an antibiotic substance under development. Tunicates Aplidine,isolated from the Mediterranean tunicate, Aplidium albicans, has shown activity against certain types of tumor.