Antibiotic MoA MoR Indication Formulation/ Typical Adverse effects Interactions Other info

dose sensitivities
B-Lactams (Time dependent killing)
Ampicillin b-lactamases, Susceptible infections 0.5-1g QID N/V, diarrhea, Allopurinol (risk of Not with food
Inhibit cell penetration, Rash/anaphylaxis- rashes),
wall alteration of discontinue Methotrexate
Amoxicillin synthesis -> target site, Susceptible infections, H. 500mg TID N/V, diarrhea, (excretion reduced), H.Pylori: with metronidazole & omeprazole/lansoprazole and
no cross link Pylori Rash/anaphylaxis- Warfarin, Venlafaxine ? clarithromycin &omeprazole/eso,rabe,pantoprazole
discontinue
Can take with food if pt experiences stomach problems
(Broad)
Natural Penicillins- PEN-
Penicillins

V,G,VK
(narrow)
Penicillinase-Resistant
Nafcillin
Oxacillin
Dicloxacillin
(very narrow)
Flucloxacillin +Penicillinase b-lactamase producing QID GI disturbances Caution: administration of 2+ weeks and age: cholestatic jaundice and
resistant Staph hepatitis plausible.
Not to be used if pt has Hx of hepatic dysfunction with this AB
Not to be used in pt with hepatic impairment
1st GENERATION -Sus infections due to -BID Hypersensitivity, Cross Anticoagulants- H2-R antagonist, PPIs but O.K. if AB taken with food.
Cefadroxil GRAM+ &- sensitivity with other B- Coumarins.
-Skin infections lactams (0.5-6%) Inactivate Oral Typhoid
-OD Vaccine
Cefalexin GRAM+ &-
UTIs
Cefadrine GRAM+ &- QID
2ND GENERATION GRAM+ &- TID Protracted skin rxn
Cefaclor
Cefuroxime GRAM+ &- BID
Cephalosporins

Same as PENs

Same as PENs

Lyme
UTI
3rd GENERATION GRAM+ &- OD/BID
Cefixime ORAL
Cefotaxime Uncomplicated OD
gonorrhoea
GRAM+ &- IV
Ceftazidime TID -Paraesthesia
BNF
IV -Taste disturbances
Ceftriaxone OD -Calcium ceftriaxone -IV-Calcium
IV precipitates in gall -Hx of kidney stones
BNF bladder, urine -Hx of hypercalciuria
-Reduce dose in hepatic
impairment -Ciclosporin [C]
Ertapenem Abdominal/gynaecological OD -Diarrhea Allergy/cross sensitivity: b-lactam
Com acquired pneumonia -headache
IV -N/V
-pruritis
-raised platelet count
Imipenem with cilastatin QID -N/V
Carbapenems

Resist
IV -Diarrhea
hydrolysis by
Carbapenemases -rash
most b-
-eosinophilia
lactamases
Meropenem Hospital acquired TID -abd pain -Valproate?
infections IV -N/V
-Diarrhea
-headaches
-pruritis
-rash
Monobactams
Carbapenems