Xenopus (4BIO5-1: Betia, Duenas, Emmanuel, Gosengfiao, Sindayen)

GENES & PROTEINS FUNCTION / ACTIVITY Helps to generate the activation of rho and rac through its
VegT Maternal mRNA that acts as endodermal determinant cytoplasmic determination
mRNA responsible for the formation of ectoderm and
Sox17a Ectodermin
contributes in the inhibition of the formation of mesoderm
mix1 Bone morphogenetic Responsible for fate development and induces expression of
Gata4 Group of transcription factors that express endoderm proteins (BMP) ventral characteristics
Homeodomain mixer Chordin
factor Inhibits BMP pathway and are responsible in the
Follistatin
Transcription factor genes for future intestine (posterior dorsalization and neuralization of the embryo
Cdx Noggin
endoderm)
Transcription factor genes for future foregut (anterior N-cam Transcription factors that expresses neural
Pdx1 plate/neuroepithelium
endoderm) Sox2
hex Formation of anterior endoderm Stem cell leukemia Transcription factor needed for hematopoietic
Brachyury Transcription factor that expresses mesoderm factor (SCL) differentiation
Transcription factors that express the ventralization of the Wnt8 Involved in the normal dorsalization process of the embryo
Vent
embryo Tcf3 Transcription factor that expresses a dorsalizing character
vent1+2 Specify lateral plate Lef1 Transcription factor that expresses a ventralizing character
vent2 Specify somitic regions Myf5 Myogenic factors
Transforming growth antidorsalizing
factor beta-super morphogenetic Ventralization
Inducing factors that forms mesoderm
family (nodal related protein (ADMP)
factors) otx2 Forebrain/midbrain development
Smad Upregulate target genes to form mesoderm (via induction) ag1 Cement gland formation
Cerberus short Inhibit nodal related factors Cerberus
Maternally encoded gene that regulate and coordinates cell- Anterior patterning
dickkopf
cell adhesion and has a synergistic response with nodal-
Beta catenine Wnt
related factors that unregulated genes for the Spemann's Posterior patterning
organizer FGF
Goosecoid krox20 A Zn finger transcription factor expressed in the hindbrain
Lim1 A homeodomain transcription factor expressed at the
Transcription factors that express the Spemann's organizer engrailed
Not midbrainhindbrain boundary
rho Small GTP exchange proteins needed for convergent
Siamos
rac extensions
Vg1 Inducing factor for mesoderm formation
Dominant ligand that activates the noncanonical Wnt
Wnt pcp pathway Responsible for convergent extensions
wnt5a signaling pathways, which are defined as being independent
Sprouty Inhibits wnt pathway from the -catenin pathway
Paraxial proto Inhibits sprouty gene Cat2 present in germ plasm
cadherin Expressed in paraxial mesoderm
Gsk3 inhibited by lithium