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(2) Nowicky JW. Cancer Treatment Using Anticancer Preparation Alkaloid Derivative Ukrain.
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(6) Nowicky JW. Biological and physiological effects of Ukrain. Journal of Cancer Research
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(9) Nowicky JW, Liepins A, Zbroja-Sontag W, Staniszewski A, Danilos J. Evaluation of clinical
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Evaluation of Thiophosphoric acid alkaloid derivatives from Chelidonium Majus L.
(''Ukrain'') as an immunostimulant in patients with Various Carcinomas. Drugs Exptl.
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W, Danilos J. Evaluation of clinical studies of Ukrain in cancer patients. Journal of
Chemotherapy, Supplement n. 4, 522, 1991.
(12) Liepins A, Nowicky JW. Ukrain is Selectively Cytostatic and/or Cytotoxic to Human Tumor
and HIV-Infected Cells but not to Human Normal Cells. Recent Advances in
Chemotherapy, Anticancer Section, Proceedings of the 17th International Congress of
Chemotherapy, Berlin, 2660, 1991.
(13) Vatanasapt V, Wongpratoom W, Mairiang P, Mairiang E, Chaiyakam C, Buddhisawasd V,
Pairojkul C, Nowicky JW. Preliminary report on clinical experience in the use of Ukrain.
Thai Cancer Journal, Volume 17 No. 1-2, 20, 1991.
(14) Nowicky JW, Liepins A, Staniszewski A, Slezak B, Nowicky W, Hiesmayr W. The
malignotoxic and immune modulating property of the alkaloid derivative Ukrain. Journal
of Cancer Research and Clinical Oncology, Suppl. Vol. 118, V1. 09. 05, 1992.
(15) Kleinrok Z, Jagiello-Wojtowicz E, Matuszek B, Chodkowska A. Basic Central
Pharmacological Properties of Thiophosphoric acid alkaloid derivatives from
Chelidonium Majus L. Pol. J. Pharmacol. Pharm., Vol. 44, 227, 1992.

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(16) Remiszewska M, Wutkiewicz M, Jastrzebski Z, Czyzewska-Szafran H, Danysz A.
Pharmacological Effects of Ukrain in Rats and Rabbits. Acta Poloniae Pharmaceutica-
Drug Research, Vol. 49 no. 4, 43, 1992.
(17) Liepins A, Nowicky JW. Activation of Spleen Cell Lytic Activity by the Alkaloid
Thiophophoric Acid Derivative: Ukrain. International Journal of Immunopharmacology,
14, 8, 1437-1442, 1992.
(18) Slesak B, Nowicky JW, Harlozinska A. In Vitro Effects of Chelidonium Majus L. Alkaloid
Thiophosphoric Acid Conjugates (Ukrain) on the Phenotype of Normal Human
Lymphocytes. Drugs Exptl. Clin. Res., XVIII, 17, 1992.
(19) Chlopkiewicz B, Marczewska J, Ejchart A, Anuszewska E, Koziorowska J. Evaluation of
Mutagenic; Genotoxic and Transforming Properties of Ukrain. Drugs Exptl. Clin. Res.,
XVIII, 31, 1992.
(20) Kleinrok Z, Jagiello-Wojtowicz E, Nowicky JW, Chodkowska A, Feldo M. Interaction
between Ukrain and Aminophenazone in Analgesic Test in Rodents. Drugs Exptl. Clin.
Res., XVIII, 97, 1992.
(21) Musianowycz J, Judmajer F, Manfreda D, Spängler P, Albrecht H, Hoffmann J, Meijer D.
Clinical Studies of Ukrain in Terminal Cancer Patients (Phase II). Drugs Exptl. Clin. Res.,
XVIII, 45, 1992.
(22) Danilos J, Zbroja-Sontag W, Baran E, Kurylcio L, Kondratowicz L, Jusiak L. Preliminary
studies on the effect of Ukrain (Tris {2-{[5BS-(5BA,6B, 12BA)]-5B,6,7,12B,13,14-
hexahydro-13-methyl[1,3] benzodioxolo [5,6-C]-1-3-dioxolo[4,5,-i] phenanthri-dinium-6-
ol]-ethaneaminyl} phosphinesulfide.6HCl) on the immunological response in patients
with malignant tumours. Drugs Exptl. Clin. Res., XVIII, 55, 1992.
(23) Wyczolkowska J, Czuwaj M, Maslinski C. The immunomodulating preparation Ukrain
does not induce anaphylactic sensitization in mice and guinea pigs. Drugs Exptl. Clin.
Res., XVIII, 35, 1992.
(24) Nowicky JW, Manolakis G, Meijer D, Vatanasapt V, Brzosko WJ. Ukrain both as an
anticancer and immunoregulatory agent. Drugs Exptl. Clin. Res., XVIII, 51, 1992.
(25) Staniszewski A, Slesak B, Kolodziej J, Harlozinska-Szmyrka A, Nowicky JW. Lymphocyte
subsets in patients with lung cancer treated with thiophosphoric acid alkaloid derivatives
from Chelidonium majus L. (Ukrain). Drugs Exptl. Clin. Res., XVIII, 63, 1992.
(26) Sotomayor E, Rao K, Lopez DM, Liepins A. Enhancement of macrophage tumouricidal
activity by the alkaloid derivative Ukrain. In vitro and in vivo studies. Drugs Exptl. Clin.
Res., XVIII, 5, 1992.
(27) Pengsaa P, Wongpratoom W, Vatanasapt V, Udomthavornsuk B, Mairieng E,
Tangvorapongchai V, Pesi M, Krusan S, Boonvisoot V, Nowicky JW. The effects of
thiophosphoric acid (Ukrain) on cervical cancer, stage IB bulky. Drugs Exptl. Clin. Res.,
XVIII, 69, 1992.
(28) Lohninger A, Hamler F. Chelidonium majus L. (Ukrain) in the treatment of cancer patients.
Drugs Exptl. Clin. Res., XVIII, 73, 1992.
(29) Kleinrok Z, Jagiello-Wojtowicz E, Nowicky JW, Chodkowska A, Feldo M, Matuszek B.
Some pharmacological properties of prolonged administration of Ukrain in rodents.
Drugs Exptl. Clin. Res., XVIII, 93, 1992.
(30) Juszkiewicz T, Minta M, Wlodarczyk B, Biernacki B. Teratological evaluation of Ukrain in
hamsters and rats. Drugs Exptl. Clin. Res., XVIII, 23, 1992.
(31) Jagiello-Wojtowicz E, Kleinrok Z, Surmaczynska B, Baran E, Feldo M, Nowicky JW. Effect
of single and three months treatment with Ukrain on amino-transferases (ALT and AST)
and on the serum protein level in rodents. Drugs Exptl. Clin. Res., XVIII, 85, 1992.

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(32) Jagiello-Wojtowicz E, Kleinrok Z, Nowicky JW, Matuszek B, Baran E, Surmaczynska B.
Effect of single and prolonged administration of Ukrain on prolactin concentration in rats.
Drugs Exptl. Clin. Res., XVIII, 89, 1992.
(33) Jagiello-Wojtowicz E., Kleinrok Z., Matuszek B., Surmaczynska B., Baran E., Nowicky W.,
Nowicky J.W. Effect of three months treatment with Ukrain on peripheral blood
morphology in rodents. Drugs Exptl. Clin. Res., XVIII, 79, 1992.
(34) Jagiello-Wojtowicz E., Kleinrok Z., Feldo M., Chodkowska A., Nowicky J.W. Effect of
Ukrain on the efficacy of anti-epileptic drugs against maximal electroshock-induced
seizures in mice. Drugs Exptl. Clin. Res., XVIII, 107, 1992.
(35) Jagiello-Wojtowicz E., Kleinrok Z., Chodkowska A., Feldo M., Nowicky J.W. Modification
of antinociceptive action of morphine by Ukrain in rodents. Drugs Exptl. Clin. Res., XVIII,
101, 1992.
(36) Hohenwarter O., Strutzenberger K., Katinger H., Liepins A., Nowicky J.W. Selective
inhibition of in vitro cell growth by the anti-tumour drug Ukrain. Drugs Exptl. Clin. Res.,
XVIII, 1, 1992.
(37) Danysz A., Kokoschinegg M., Hamler F. Clinical studies of Ukrain in healthy volunteers
(phase I). Drugs Exptl. Clin. Res., XVIII, 39, 1992.
(38) Brüller W. Studies concerning the effect of Ukrain in vivo and in vitro. Drugs Exptl. Clin.
Res., XVIII, 13, 1992.
(39) Nowicky J.W. Biological Properties of Ukrain in Experimental and Clinical Investigations.
International Medical Reviews, Avalanche Ltd. St. Petersburg, Russia, 1, 1, 5, 1993.
(40) Nowicky J.W., Nowicky W., Liepins A. Cytostatic and cytotoxic effects of Ukrain on
malignant cells. VIII Mediterranean Congress of Chemotherapy, 24-29 May 1992,
Athens, Greece, Journal of Chemotherapy, Supplement n. 1, Volume 5, 797, 1993.
(41) Nowicky J.W. Ukrain Antineoplastic Immunomostimulant. E09/029, NSC-631570, NSC-
B238865, UKSR-222, W122, Drugs of the Future, Prous Science Publishers, Copyright
Prous Science, 18 (11), 1015, November 1993.
(42) Kamyshentsev M.V., Voltchek I.V., Btailovskaya I.V., Leschev A.L., Lavinsky Y.C. and
Nowicky J. W. Testing Ukrain as an Anti-Influenza Remedy. Recent Advances in
Chemotherapy, American Society for Microbiology, Proceedings of the 18th International
Congress of Chemotherapy, Stockholm, Sweden, June 27-July 2, 645, 1993.
(43) Liepins A., Sotomayor E. M., Lopez D. M. and J.W. Nowicky. Biological Response-
Modifying Properties of the Alkaloid Derivative Ukrain (NSC 631570). Recent Advances
in Chemotherapy, American Society for Microbiology, Proceedings of the 18th
International Congress of Chemotherapy, Stockholm, Sweden, June 27-July 2, 783,
1993.
(44) Nowicky J. W., Manolakis G., Meijer D., Vatanasapt V., Brzosko W.J. and Lohninger A.
Immunological and Tumoricidal Properties of Ukrain. Recent Advances in
Chemotherapy, American Society for Microbiology, Proceedings of the 18th International
Congress of Chemotherapy, Stockholm, Sweden, June 27-July 2, 793, 1993.
(45) Lohninger A., Musianowyc J., Judmaier F., Manfreda D., Spängler P., Albrecht H.,
Hoffmann J. and Mejer D. Results of Phase II Clinical Studies with Ukrain. Recent
Advances in Chemotherapy, American Society for Microbiology, Proceedings of the 18th
International Congress of Chemotherapy, Stockholm, Sweden, June 27-July 2, 794,
1993.
(46) Voltchek I.V., Nowicky J.W., Zolotukhin N.N., Kamyshentsev M.V., Miroshnichenko A.G.,
Leschev A.L. and Belskikh A.N. Some Immunohematological Effects of Ukrain. Recent
Advances in Chemotherapy, American Society for Microbiology, Proceedings of the 18th
International Congress of Chemotherapy, Stockholm, Sweden, June 27-July 2, 798,
1993.

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(47) Nowicky Jaroslaw W., Markowska Janina and Brzosko Witold J. Ukrain and Natural Killer
Cells. Recent Advances in Chemotherapy, American Society for Microbiology,
Proceedings of the 18th International Congress of Chemotherapy, Stockholm, Sweden,
June 27-July 2, 863, 1993.
(48) Zemskov V.S., Yaremchuk O.Ya., Susak Ya.M., Deneka E.R., Kravchenco O.V. and
Kamenets L.Ya. Experience of the Application of Ukrain in Oncological Practice in
Ukraine. Recent Advances in Chemotherapy, American Society for Microbiology,
Proceedings of the 18th International Congress of Chemotherapy, Stockholm, Sweden,
June 27-July 2, 870, 1993.
(49) Nowicky J.W., Cisak E., Liepins A., Susak Ja.M., Semskow W. Stimulation of phagocytic
activity in vitro, in vivo and in the clinic by Ukrain. 11th Future Trends in Chemotherapy,
Interdisciplinary World Congress on Antimicrobial and Anticancer Drugs, 24-27 April
1994, Palexpo Geneva (Switzerland), Abstracts: abs. 68, April 1994.

(50) Kurik M.V., Susak Y.M., Kravchenko O.V. Some biophysical properties of Ukrain. 11th
Future Trends in Chemotherapy, Interdisciplinary World Congress on Antimicrobial and
Anticancer Drugs, 24-27 April 1994, Palexpo Geneva (Switzerland), Abstracts: abs. 79,
April 1994.
(51) Lisnyak O.I., Lozjuk R. M. Biological activity of some thiophosphamide derivatives of
alkaloids with respect to influenza virus. 11th Future Trends in Chemotherapy,
Interdisciplinary World Congress on Antimicrobial and Anticancer Drugs, 24-27 April
1994, Palexpo Geneva (Switzerland), Abstracts: abs. 96, April 1994.
(52) Lozjuk R.M., Lisnyak O.I., Lozjuk L.V. Theoretical grounds and experimental confirmation
of antiviral effect of the preparation Ukrain. 11th Future Trends in Chemotherapy,
Interdisciplinary World Congress on Antimicrobial and Anticancer Drugs, 24-27 April
1994, Palexpo Geneva (Switzerland), Abstracts: abs. 95, April 1994.
(53) Brzosko W.J., Graczyk A., Konarski J., Nowicky J.W. Synergic influence of Ukrain and
protoporphyrine amino conjugates on human malignant cell lines. 11th Future Trends in
Chemotherapy, Interdisciplinary World Congress on Antimicrobial and Anticancer Drugs,
24-27 April 1994, Palexpo Geneva (Switzerland), Abstracts: abs. 110, April 1994.
(54) Brzosko W.J., Uglianica K., Fomin K., Nowicky J.W. Influence of Ukrain on breast
cancers. 11th Future Trends in Chemotherapy, Interdisciplinary World Congress on
Antimicrobial and Anticancer Drugs, 24-27 April 1994, Palexpo Geneva (Switzerland),
Abstracts: abs. 109, April 1994.
(55) Zemskov V.S., Susak Ya.M., Zemskov S.V. Ukrain monotheraphy for treatment of
colorectal cancer. 11th Future Trends in Chemotherapy, Interdisciplinary World
Congress on Antimicrobial and Anticancer Drugs, 24-27 April 1994, Palexpo Geneva
(Switzerland), Abstracts: abs. 78, April 1994.
(56) Liepins A., Nowicky J.W. Selective induction of programmed cell death (apoptosis) in
malignant cells by the alkaloid derivative Ukrain (NSC-613570). 11th Future Trends in
Chemotherapy, Interdisciplinary World Congress on Antimicrobial and Anticancer Drugs,
24-27 April 1994, Palexpo Geneva (Switzerland), Abstracts: abs. 93, April 1994.
(57) Jagiello-Wojtowicz E., Kleinrok Z., Nowicky J., Hodkowska A., Feldo M., Matuszek B.,
Jablonska M., Gorzelak M. Effect of six month treatment with Ukrain on early
osteoporosis induced by ovariectomy in rats. 11th Future Trends in Chemotherapy,
Interdisciplinary World Congress on Antimicrobial and Anticancer Drugs, 24-27 April
1994, Palexpo Geneva (Switzerland), Abstracts: abs. 49, April 1994.

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(58) Nowicky J.W., Wladyslawa Nowicky, Hiesmayr W., Potopalsky A.. Alterations of DNA;
RNA and protein synthesis in malignant cells under the influence of Ukrain. XVI
International Cancer Congress 1994, 30 October - 5 November 1994, New Delhi, India,
abs. PSB 15 -17, 319.
(59) Voltchek I. Ukrain - Drug of the Future in the Cancer Treatment? Terra Medica, Nr. 1,
1995, 24 - 25 (in Russian).
(60) Ciebiada I., Korczak E., Denys A., Nowicky J. W. Effect of Ukrain preparation on immune
response in mice affected by influenza virus. Journal of Chemotherapy, Vol. 7 (Suppl.),
n. 4, 1995 101-104.
(61) Voltchek I., Kamyshentsev M., Lavinsky Y., Nowicky J., Medvedev Y., Litvinchuk L.
Comparative Study of the Cytostatic Effects of Oliphen and Ukrain. Journal of
Chemotherapy, Vol. 8 - n. 2, 1996, 144-146.
(62) Liepins A., Nowicky J.W., Bustamante J.O., Lam E. Induction of Bimodal Programmed
Cell Death in Malignant Cells by the Derivative Ukrain (NSC-631570). Drugs Exptl. Clin.
Res., Vol. XXII (Suppl.), 1996, 1 - 7.
(63) Nowicky JW, Hiesmayr W, Nowicky W, Liepins A. Influence of Ukrain on DNA, RNA and
Protein Synthesis in Malignant Cells. Drugs Exptl. Clin. Res., XXII (Suppl.), 1996, 9-19.
(64) Nowicky J.W., Hiesmayr W., Influence of Ukrain on Human Xenografts in vitro. Drugs
Exptl. Clin. Res., Vol. XXII (Suppl.), 1996, 21 - 25.
(65) Jin Y.M., Nowicky J.W., Liepins A. Mitogenic Properties of Ukrain (NSC-631570) on
Human Peripheral Blood Monocytes: Clinical Implications. Drugs Exptl. Clin. Res., Vol.
XXII (Suppl.), 1996, 27 - 30.
(66) Liepins A., Nowicky J.W. Modulation of Immune Effector Cell Cytolytic Activity and
Tumour Growth Inhibition in vivo by Ukrain (NSC-631570). Drugs Exptl. Clin. Res., Vol.
XXII (Suppl.), 1996, 31 - 42.
(67) Susak Y.M., Zemskov V.S., Yaremchuk O.Y., Kravchenko O.B., Yatsyk I.M., Korsh O.B.
Comparison of Chemotherapy and X-ray Therapy with Ukrain Monotherapy for
Colorectal Cancer. Drugs Exptl. Clin. Res., Vol. XXII (Suppl.), 1996, 43 - 50.
(68) Uglanica K.N., Fomin K.A., Nefyodov L.I., Nowicky J.W., Brzosko W.J., Jankowski A.
Influence of Ukrain on Patients with Surgically Treated Breast Cancer (Introductory
Remarks). Drugs Exptl. Clin. Res., Vol. XXII (Suppl.), 1996, 51 - 54.
(69) Brzosko W.J, Uglanica K.N., Fomin K.A., Nowicky J.W. Influence of Ukrain on Breast
Cancer. Drugs Exptl. Clin. Res., Vol. XXII (Suppl.), 1996, 55 - 62.
(70) Uglanica K.N., Fomin K.A., Nefyodov L.I., Nowicky J.W., Brzosko W.J., Jankowski A.
Influence of Ukrain on Patients with Surgically Treated Breast Cancer. Part I. Clinical
and Laboratory Parameters. Drugs Exptl. Clin. Res., Vol. XXII (Suppl.), 1996, 63 - 66.
(71) Uglanica K.N., Fomin K.A., Nefyodov L.I., Vilkiewich T.W., Nowicky J.W., Brzosko W.J.,
Jankowski A. Influence of Ukrain on Patients with Surgically Treated Breast Cancer. Part
II. Hormonal Profile. Drugs Exptl. Clin. Res., Vol. XXII (Suppl.), 1996, 67 - 70.
(72) Uglanica K.N., Fomin K.A., Nefyodov L.I., Djurd T.I., Nowicky J.W., Brzosko W.J.,
Jankowski A. Influence of Ukrain on Patients with Surgically Treated Breast Cancer. Part
III. The Immune System. Drugs Exptl. Clin. Res., Vol. XXII (Suppl.), 1996, 71 -74.
(73) Uglanica K.N., Maciuk J.R., Fomin K.A., Nefyodov L.I., Kravchuk R.I., Vinogradova L. M.,
Nowicky J.W., Brzosko W.J. Influence of Ukrain on Patients with Surgically Treated
Breast Cancer. Part IV. Electromicroscopic and Cytochemical Evaluation. Drugs Exptl.
Clin. Res., Vol. XXII (Suppl.), 1996, 75 - 82.
(74) Nefyodov L.I., Uglanica K.N., Smirnov V.Y., Doroshenko Y.M., Fomin K.A., Nowicky J.W.,
Brzosko W.J. Amino Acids and Their Derivatives in Blood Plasma of Patients with Breast
Cancer Treated with Ukrain. Part V. Drugs Exptl. Clin. Res., Vol. XXII (Suppl.), 1996, 83
- 86.
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(75) Nefyodov L.I., Uglanica K.N., Smirnov V.Y., Doroshenko Y.M., Fomin K.A., Nowicky J.W.,
Brzosko W.J. Amino Acids and Their Derivatives in Tumour Tissue from Patients with
Breast Cancer Treated with Ukrain. Part VI. Drugs Exptl. Clin. Res., Vol. XXII (Suppl.),
1996, 87 - 90.
(76) Nowicky J.W., Hiesmayr W., Liepins A. Influence of Ukrain on Immunological Blood
Parameters in vitro and in vivo. Drugs Exptl. Clin. Res., Vol. XXII (Suppl.), 1996, 91 - 94.
(77) Boyko V.N., Voltchek I.V., Petrov A.S., Bubnov V.P. Action of Ukrain, a Cytostatic and
Immunomodulating Drug, on Effects of Irradiation. Drugs Exptl. Clin. Res., Vol. XXII
(Suppl.), 1996, 95 - 100.
(78) Jagiello-Wojtowicz E., Kleinrok Z., Nowicky J.W., Jablonski M., Gorzelak M., Chodkowska
A., Feldo M., Matuszek B. Effect of Six-Month Treatment with Ukrain on Early
Osteoporosis Induced by Ovariectomy in Rats. Part I: Preliminary Studies of Bone
Parameters. Drugs Exptl. Clin. Res., Vol. XXII (Suppl.), 1996, 101- 104.
(79) Jagiello-Wojtowicz E., Kleinrok Z., Nowicky J.W., Chodkowska A., Feldo M.,
Surmaczynska B., Gorzelak M., Jablonski M. Effect of Six-Month Treatment with Ukrain
on Early Osteoporosis Induced by Ovariectomy in Rats. Part II: Preliminary Studies of
Peripheral Blood Parameters. Drugs Exptl. Clin. Res., Vol. XXII (Suppl.), 1996, 105-108.
(80) Jagiello-Wojtowicz E., Kleinrok Z., Nowicky J.W., Baran E. Effect of Six-Month Treatment
with Ukrain on Early Osteoporosis Induced by Ovariectomy in Rats. Part III: Preliminary
Studies of Some Hormone Levels. Drugs Exptl. Clin. Res., XXII (Suppl.), 1996, 109-113.
(81) Susak Y.M., Kurik M.V., Kravchenko O.V., Zemskov S.V. Certain Biophysical Properties of
Ukrain. Drugs Exptl. Clin. Res., Vol. XXII (Suppl.), 1996, 113 - 116.
(82) Zhalilo LI, Susak YM, Zemskov SV, Susak IA. Influence of Ukrain on the Redox
Processes of Hepatocytes. Drugs Exptl. Clin. Res., Vol. XXII (Suppl.), 1996, 117-120.
(83) Brzosko W.J., Graczyk A., Konarski J., Nowicky J.W. Synergic Influence of Ukrain and
protoporphyrin Amino Acids Conjugates on Human Malignant Cell Lines. Drugs Exptl.
Clin. Res., Vol. XXII (Suppl.), 1996, 121 - 122.
(84) Wyczólkowska J., Michon T., Nowicky J.W. Inhibitory Effect of Thiophosphoric Acid
Alkaloid Derivatives from Chelidonium majus L. (Ukrain) on Ovalbumin Antigenicity and
Antiovalbumin IgE Antibody Response in Mice. Drugs Exptl. Clin. Res., Vol. XXII
(Suppl.), 1996, 123 - 128.
(85) Jagiello-Wojtowicz E., Kleinrok Z., Chodkowska A., Nowicky J.W., Piper H., Kubiatowski
T. Antinociceptive Effect of Ten Day Administration of Ukrain in Mice and Interaction of
the Treatment with Morphine. Drugs Exptl. Clin. Res., Vol. XXII (Suppl.), 1996, 129 -
132.
(86) Jagiello-Wojtowicz E., Kleinrok Z., Nowicky J.W., Chodkowska A., Kubiatowski T, Piper H.
Interaction Between Ukrain and Morphine in Their Ten-Day Treatment in Mice in the
Writhing Syndrome Test. Drugs Exptl. Clin. Res., Vol. XXII (Suppl.), 1996, 133 - 134.
(87) Ciebiada I, Korczak E., Nowicky JW, Denys A. Does the Ukrain Preparation Protect Mice
Against Lethal Doses of Bacteria? Drugs Exptl Clin Res, XXII (Suppl), 1996, 135-140.
(88) Lozjuk R.M., Lisnyak O.I., Lozjuk L.V. Theoretical Grounds and Experimental
Confirmation of the Antiviral Effect of the Preparation Ukrain. Drugs Exptl. Clin. Res.,
Vol. XXII (Suppl.), 1996, 141 - 146.
(89) Ciebiada I., Korczak E., Nowicky J.W., Denys A. Estimation of Direct Influence of Ukrain
Preparation on Influenza Viruses and the Bacteria E. coli and S. aureus. Drugs Exptl.
Clin. Res., Vol. XXII (Suppl.), 1996, 147 - 152.
(90) Lisnyak OI, Lozjuk RM. Biological Activity of Some Thiophosphamide Derivatives of
Alkaloids with Respect to Influenza Virus. Drugs Exptl. Clin. Res., XXII (Suppl.), 1996,
153-156.

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(91) Stabuc B., Benedicic D. Ukrain with Chemotherapy in Malignant Melanoma (Case
Report). Drugs Exptl. Clin. Res., Vol. XXII (Suppl.), 1996, 159-162.
(92) Hamler F., Hiesmayr W., Korsh O.B., Melnyk A. Ukrain Monotherapy in Malignant
Melanoma (Case Report). Drugs Exptl. Clin. Res., Vol. XXII (Suppl.), 1996, 163 - 166.
(93) Kotsay B., Lisnyak O., Myndiuk O., Romanyshyn J., Fabri O. Ukrain Treatment of
Rhabdomyosarcoma (Case Report). Drugs Exptl. Clin. Res., Vol. XXII (Suppl.), 1996,
167 - 170.
(94) Kadan P., Korsh OB, Melnyk A. Ukrain Therapy of Recurrent Breast Cancer with Lung
Metastases (Case Report). Drugs Exptl. Clin. Res., Vol. XXII (Suppl.), 1996, 171-174.
(95) Nowicky J.W., Schramm E., Godysh Y. Biophysical Effects of Ukrain Therapy in a Patient
with Breast Cancer (Case Report). Drugs Exptl Clin Res., Vol XXII (Suppl), 1996, 175-
182.
(96) Kroiss T., Melnyk A., Korsh O.B. Ukrain Treatment in Carcinoma of the Cervix (Case
Report). Drugs Exptl. Clin. Res., Vol. XXII (Suppl.), 1996, 183 - 186.
(97) Lohninger A, Korsh OB, Melnyk A. Combined Therapy with Ukrain and Chemotherapy in
Ovarian Cancer (Case Report). Drugs Exptl. Clin. Res., Vol. XXII (Suppl.), 1996, 187 -
190.
(98) Sakalo V.S., Korsh O.B., Melnyk A. Ukrain Treatment in a Patient with Non-
Seminomatous Germ-Cell Tumour of Testis (Case Report). Drugs Exptl. Clin. Res., Vol.
XXII (Suppl.), 1996, 191 - 194.
(99) Vyas J.J., Jain V.K. Ukrain Treatment in Carcinoma of the Oesophagus (Case Report).
Drugs Exptl. Clin. Res., Vol. XXII (Suppl.), 1996, 195 - 198.
(100) Kadan P., Korsh O.B., Hiesmayr W. Ukrain in the Treatment of Urethral Recurrent
Carcinoma (Case Report). Drugs Exptl. Clin. Res., Vol. XXII (Suppl.), 1996, 199 - 202.
(101) Steinacker J., Kroiss T., Korsh O.B., Melnyk A. Ukrain Treatment in a Frontal Anaplastic
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(203) Sologub TV, Voltchek IV, Kivisepp NA, Grigoryeva T. Efficacy and safety of the drug
Ukrain in chronic hepatitis C patients. Int J Immunother 2003, XIX(2-4): 55-59.
(204) Usova TA, Poteryaeva ON, Pospelova TI, Korolenko TA. Serum cystatin C in patients with
hemoblastosis. Int J Immunother 2003, XIX(2-4): 61-65.
(205) Gansauge F. Treatment of pancreatic cancer patients with Ukrain: four case reports. Int J
Immunother 2003, XIX(2-4): 67-71.
(206) Susak Y. Ukrain stimulates fibrotic and sclerotic transformations of pancreatic cancer
tissue: comparative description of six cases. Int J Immunother 2003, XIX(2-4): 73-80.
(207) Aschhoff B. Retrospective study of Ukrain treatment in 28 patients with unresectable
pancreatic cancer. Int J Immunother 2003, XIX(2-4): 81-85.
(208) Kleef R. Ukrain (NSC 631570) in combination with locoregional hyperthermia in the
treatment of pancreatic cancer with liver metastases: a case report. Int J Immunother
2003, XIX(2-4): 87-90.
(209) Kroiss T. Ukrain in the therapy of advanced metastatic pancreatic cancer: a case report.
Int J Immunother 2003, XIX(2-4): 91-94.

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(210) Nowicki G, Zahriychuk O. Ukrain treatment of astrocytomas in girl with tuberous sclerosis:
a case report. Int J Immunother 2003, XIX(2-4): 95-97.
(211) Langer A, Zahriychuk O, Hodysh Y. Treatment of generalized lymphangiomatosis with
Ukrain: a case report. Int J Immunother 2003, XIX(2-4): 99-103.
(212) Aschhoff B. Clinical improvement of a patient with xeroderma pigmentosum after
treatment with Ukrain. Int J Immunother 2003, XIX(2-4): a case report. Int J Immunother
2003, XIX(2-4): 105-108.
(213) Nefyodov LI, Doroshenko YM, Smirnov VY, Uglyanitsa KN, Nowicky W. Metabolic control
and treatment of malignant growth: tumor development, patterns of amino acid
imbalance and Ukrain. Int J Immunother 2003, XIX(2-4): 109-114.
(214) Melnichenko N, Sundikovich E, Makarchikov A, Zverinsky I. Antioxidative status and lipid
peroxidation in rats after administration of Ukrain. Int J Immunother 2003, XIX(2-4): 115-
119.
(215) Zverinsky I, Maximchuk Y, Melnichenko N, Zaloga I. Effect of Ukrain on hepatic drug-
metabolizing enzymes in rats: pilot studies. Int J Immunother 2003, XIX(2-4): 121-124.
(216) Egorov A., Belanovskaya E, Rudyak T, Melnichenko N, Zverinsky I. Assessment of the
functional state and morphological structure of the liver of rats after administration of the
drug Ukrain. Int J Immunother 2003, XIX(2-4): 125-128.
(217) Levina OA, Goncharova IA, Filatova TG, Nadeev AP, Nowicky W, Sukhenko TG,
Kolesnikova OP, Korolenko TA. Protective effect of Ukrain against acute
acetaminophen-induced hepatitis in rats. Int J Immunother 2003, XIX(2-4): 129-134.
(218) Usova TA, Poteryaeva ON, Falameyeva OV, Zhanaeva SY, Levina OA, Yarygina ES,
Korolenko TA, Nowicky W. Serum cystatin C in murine tumors treated by combinations
of cyclophosphamide with Ukrain or glucans. Int J Immunother 2003, XIX(2-4): 135-140.
(219) Zhanaeva SJ, Falameyeva OV, Filatova TG, Goncharova IA, Sukhenko TG, Kolesnikova
OP, Kaledin VI, Korolenko TA, Nowicky WM. Effect of different biological response
modifiers on growth and metastazing of murine Lewis adenocarcinoma. Int J
Immunother 2003, XIX(2-4): 141-150.
(220) Korolenko TA, Falameyeva OV, Poteryaeva OM, Zhanaeva SY, Levina OA, Nowicky W.
Cysteine protease inhibitor stefin A in murine tumors during treatment by Ukrain and/or
cyclophosphamide. Int J Immunother 2003, XIX(2-4): 151-157.
(221) Todor I. The effect of the antineoplastic drug Ukrain on the electrokinetic potential of
malignant and normal cells. Int J Immunother 2003, XIX(2-4): 159-167.
(222) Andrievsky A, Smalyukh N, Krivitsky A, Zahriychuk O. In vitro effects of Ukrain on the
activity of trypsin-like proteases. Int J Immunother 2003, XIX(2-4): 169-175.
(223) Jablonski M. Selected calciotropic hormones in serum of sexually mature female rats
treated with Ukrain. Int J Immunother 2003, XIX(2-4): 177-182.
(224) Jablonski M. Serum levels of corticosterone, progesterone, parathyroid hormone and
calcitonin in ovariectomized rats after 3-month treatment with Ukrain. Int J Immunother
2003, XIX(2-4): 183-188.
(225) Wielosz-Tokarewska E, Jagiello-Wojtowicz E. The effect of Ukrain on the serum
vasoactive intestinal polypeptide level in diabetic mice. Int J Immunother 2003, XIX(2-4):
189-191.
(226) Jagiello-Wojtowicz E, Kleinrok A, Jurek D. Effects of Ukrain in acute intoxication with
streptozotocin in rats. Int J Immunother 2003, XIX(2-4): 193-196.
(227) Jagiello-Wojtowicz E, Izdebska M, Piatkowska-Chmiel I. Effect of Ukrain on selected
biochemical parameters in the serum of methanol-intoxicated rats. Int J Immunother
2003, XIX(2-4): 197-200.

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(228) Jagiello-Wojtowicz E., Izdebska M.: Effect of CNS-631570 (Ukrain) on selected
biochemical parameters indicating liver dysfunction in acute methanol intoxication of
rats. Pol. J. Environ., 2004 w druku
(229) Jagiello-Wojtowicz E., Piatkowska-Chmiel I.: Effects of chelidonine on some biochemical
parameters in the serum of rats subacutely intoxicated by copper. Herba Polonica, 2004,
Vol. 50, No 3/4, 2004.
(230) Zemskov S.V. Efficacy of adjuvant treatment with combination of Ukrain (NSC-631570)
and Gemcitabin in cases of pancreas cancer. Ukrainian Chemotherapeutic Journal
2005, #1-2
(231) Mozhenok T.P., Belyaeva T.N., Leontieva E.A., Faddejeva M.D. Modulation of vesicular
membrane fusion and of actin cytoskeleton in mouse macrophages inducing by alkaloid
sanguinarine and a derivative drug Ukrain. Cytology 2005, #10. Institute of Cytology,
RAS, St. Petersburg, Russia.
(232) Tomaszewski M., Olchowik M. Influence of Ukrain on some parameters in pelvis bone
tissue of rats exposed to subacute microwave radiation. Krajowe Sympozjum
Studenckich Kół Naukowych Akademii Medycznych, Lublin, 15 stycznia 2005.
(233) Olchowik M., Tomaszewski M. Effect of Ukrain on biochemical parameters of rats
subjected to subacute microwave radiation (mW). Krajowe Sympozjum Studenckich
Kół Naukowych Akademii Medycznych, Lublin, 15 stycznia 2005.
(234) Piątkowska-Chmiel I. Porównanie działania chelidoniny i leku Ukrain w ostrych zatruciach
miedzią i cyną u szczurów. Krajowe Sympozjum Studenckich Kół Naukowych Akademii
Medycznych, Lublin, 15 stycznia 2005.
(235) Izdebska M., Jagiełło-Wójtowicz E. Protective effects of NSC-631570 in rats acutely
intoxicated by ethylene glycol. VII Sympozjum „Postępy Toksykologii Klinicznej i
Sądowej", Kraków, 2-4 czerwca 2005, Przegl. Lek., 2005, t. 62, 6, s. 638.
(236) Piątkowska-Chmiel I., Jagiełło-Wójtowicz E. Comparison of actions of Chelidonine and
Ukrain in acute copper chloride intoxication in rats. VII Sympozjum „Postępy
Toksykologii Klinicznej i Sądowej", Kraków, 2-4 czerwca 2005, Przegl. Lek., 2005, t. 62,
6, s. 638.
(237) Izdebska M., Jagiełło-Wójtowicz E. Effect of single or 10-day treatment with Ukrain on
some biochemical parameters in the serum of rats acutely intoxicated with alcohols.
42nd Congress of Toxicology, EUROTOX, Kraków, 11-14 September 2005, Vol. 158,
Suppl. 1, s. 56-57.
(238) Ernst E, Schmidt K: Ukrain – a new cancer cure? A systematic review of randomised
clinical trials. BMC Cancer. 2005; 5: 69. doi: 10.1186/1471-2407-5-69.
(239) Kleinrok A., Jagiełło-Wójtowicz E. Effects of Ukrain on some biochemical parameters In
mice pretreated with streptozotocin. IV Lwowsko-Lubelska Konferencja Biochemii
Eksperymentalnej i Klinicznej, Lublin, 11-13 maja 2006.
(240) Izdebska M., Jagiełło-Wójtowicz E. Effect of thiophosphoric acid alkaloid derivatives from
Chelidonium majus L. on some biochemical parameters in the serum of rats acutely
intoxicated by ethylene glycol. 5th International Symposium on Chromatography of
Natural Products (ISCNP). The Application of Chromatographic Methods in
Phytochemical & Biomedical analysis, Lublin -Kazimierz Dolny, June 19-22, 2006, P-58,
s. 110.
(241) Jagiełło-Wójtowicz E., Piątkowska-Chmiel I. Protective effects of chelidonine and Ukrain
in rats acutely intoxicated with tin chloride. 5th International Symposium on
Chromatography of Natural Products (ISCNP). The Application of Chromatographic
Methods in Phytochemical & Biomedical analysis, Lublin -Kazimierz Dolny, June 19-22,
2006, P-60, s. 112.

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(242) Jagiełło-Wójtowicz E., Chodkowska A. Estimation of biochemical parameters in blood
serum of rats subjected to 10-day treatment with alkaloid thiophosphoric acid derivative
of Chelidonium majus L. (Ukrain) with simultaneous exposition to ionizing
radiation. 5th International Symposium on Chromatography of Natural Products
(ISCNP). The Application of Chromatographic Methods in Phytochemical & Biomedical
analysis, Lublin -Kazimierz Dolny, June 19-22, 2006, P-61, s. 113.
(243) Lanvers-Kaminsky C, Nolting DM, Köster J, Schröder A, Sandkötter J, Boos J (2006): In-
vitro toxicity of Ukrain against human Ewing tumor cell lines. Anticancer Drugs 17(9):
1025-1030
(244) Ernst E. Why there will never be an alternative cancer cure. Anti-Cancer Drugs 2006, 17:
1023-1024
(245) Gagliano N, Moscheni C, Torri C, Magnani I, Bertelli AAE, Nowicky W and Gioia M (2006):
Effect of Ukrain on matrix metalloproteinase-2 and Secreted Protein Acidic and Rich in
Cysteine (SPARC) expression in human glioblastoma cells. Anti-Cancer Drugs 17:189-
194.
(246) Habermehl D, Kammerer B, Handrick R, Eldh T, Gruber C, Cordes N, Daniel PT,
Plasswilm L, Bamberg M, Belka C, Jendrossek V: Proapoptotic activity of Ukrain is
based on Chelidonium majus L. alkaloids and mediated via a mitochondrial death
pathway. BMC Cancer 2006; 6:14, http://www.biomedcentral.com/1471-2407/6/14.
(247) Gansauge F, Ramadani M, Schwarz M, Beger HG, Lotspeich E, Poch B: The Clinical
Efficacy of Adjuvant Systemic Chemotherapy with Gemcitabine and NSC-631570 in
Advanced Pancreatic Cancer. Hepato-Gastroenterology 2007; 54:917-920
(248) Jagiełło-Wójtowicz E., Izdebska M.: Effect of thiophosphoric acid alkaloids derivative from
Chelidonium majus (L.) on antioxidant status in alcohol -intoxicated rats. J.
Ethnopharmacol., 2007 - submitted
(249) Jagiełło-Wójtowicz E., Chodkowska A., Jabłoński M., Olchowik G.: Serum RANKL in rats
treated with Ukrain and simultaneous exposition to ionizing radiation. J.
Ethnopharmacol., 2007 - submitted
(250) Gagliano N, Moscheni C, Torri C, Donetti E, Magnani I, Costa F, Nowicky W and Gioia M
(2007): Ukrain modulates glial fibrillary acidic protein, but not connexion 43 expression,
and induces apoptosis in human cultured glioblastoma cells. Anti-Cancer Drugs 2007,
18: 669-676.
(251) Rebscher H: Off-label use in oncology. Quackery or progress? MMW Fortschr Med. 2002
Oct 10; 144(41): 25-6. German.
(252) Kuznetsova LP, Sochilina EE, Faddeeva MD, Iagodina OV: Effect of some isoquinoline
alkaloids on enzymatic activity of acetylcholinesterase and monoamine oxidase. Ukr
Biokhim Zh. 2005 Mar-Apr; 77(2): 147-53. Russian
(253) Dudka J, Burdan F, Szumilo J, Tokarska E, Korobowicz A, Klepacz R, Gieroba R, Madej
B, Korobowicz E: Effect of selected alcohol dehydrogenase inhibitors on human hepatic
lactate dehydrogenase activity – an in vitro study. J Appl Toxicol. 2005 Nov-Dec; 25 (6):
549-53.
(254) Grinevich Y, Shalimov S, Bendyuh G, Zahriychuk O, Hodysh Y: Effect of Ukrain on the
growth and metastasizing of Lewis carcinoma in C57BL/6 mice. Drugs Exp Clin Res.
2005; 31(2): 59-70.
(255) Mendoza J., Zamora R., Gallardo J., Ceballos G., Aldana A., Espinosa M., Maldonado V.,
Melendez-Zajgla: NF-kappaB Does Not Influence the Induction of Apoptosis by Ukrain.
Cancer Biology & Therapy 5:7, July 2006: 788-793.
(256) Izdebska M, Jagiello-Wojtowicz E. Evaluation of antioxidative activity of Ukrain in alcohol-
intoxicated rats. Ann Universitatis Mariae Curie-Sklodowska, Vol. XX No.2, 22.

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(257) Izdebska M, Piatkowska-Chmiel I, Jagiello-Wojtowicz E. Effect of Ukrain on selected
biochemical parameters indicating kidney functioning of rats pretreated with ethanol.
Farm Przegl Nauk, 2008, 11-12: 42-44.
(258) Shvets Yu, Yemskov S, Skachkova O, Rivis O, Khranovska N. Anticancer drug „ukrain“
stimulates dendritic cells maturation in vitro. Immunology & Allergology 4:2008, 24-27.
(259) Wolanska E, Bachanek T, Jarmolinska K, Jagiello-Wojtowicz E, Radzki S. Influence of
Ukrain and strontium on the rat tooth intertubular dentine. I. XRF microprobe study. Bull
Vets Inst Pulawy 52, 655-657, 2008.
(260) Wolanska E, Bachanek T, Jarmolinska K, Jagiello-Wojtowicz E, Radzki S. Influence of
Ukrain and strontium on the rat tooth intertubular dentine. II. Atomic force microscopy
study. Bull Vets Inst Pulawy 52, 659-665, 2008.
(261) Skivka LM, Trompak OO, Kudryavets YI, Bezdenezhnykh NA, Susak YM. The effect of
NSC-631570 (Ukrain) alone in combination with pathogen-associated molecules on cell
cycle distribution and apoptosis induction of mouse melanoma cells with different
biological properties. Experimental Oncology, 2010, 32, 2:92-96.
(262) Susak YM, Skivka LM, Rudik MP, Pozur VV, Liubunya AV. Comparative investigation of
the effect of Ukrain on growth of ascite and solid forms of Ehrlich’s carcinoma.
Experimental Oncology, 2010, 32, 2:107-110.
(263) Skivka L, Susak Y, Trompak O, Kudryavets Y, Bezdenezhnykh N, Semesiuk N, Lykhova
O. The effect of monotherapy and combined therapy with NSC-631570 (Ukrain) on
growth of low- and high-metastasizing B16 melanoma in mice. J Oncol Pharm Pract.,
2010, Sep 3.
(264) Funel N, Giovannetti E, Nowicky W, Pollina LE, Del Chiaro M, Nowicky B, Mosca F,
Peters GJ, Campani D, Boggi U. Molecular mechanisms Molecular mechanisms
underlying the synergistic interaction of the novel anticancer drug Ukrain with
gemcitabine in preclinical models of pancreatic cancer. Proceedings of the 34th National
Congress of the Italian Association for the Study of the Pancreas (AISP) 2010, Journal
of Pancreas, 2010.
(265) Funel N, Giovannetti E, Nowicky W, Pollina LE, Del Chiaro M, Peters GJ, Nowicky B,
Mosca F, Boggi U, Campani D. Different uptake of Ukrain can explain the selective effect
against pancreatic adenocarcinoma cell cultures in vitro. Proceedings of the 34th
National Congress of the Italian Association for the Study of the Pancreas (AISP) 2010,
Journal of Pancreas, 2010.
(266) Funel N, Costa F, Pettinari L, Taddeo A, Sala A, Chiriva-Internati M, Cobos E, Colombo G,
Milzani A, Campani D, Dalle-Donne I, Gagliano N. Ukrain Affects Pancreas Cancer Cell
Phenotype in vitro by Targeting MMP-9 and Intra-/Extracellular SPARC Expression.
Pancreatology 2010;10:545–552, Published online: October 23, 2010

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