144
Conclusions: This is the first translational research aimed to focus
on other contributing pathway, PDGF signaling pathway, in the pathogen-
esis of OSA/CIH-associated PH. As the results, CIH induces increased
mean PAP, pulmonary vascular remodeling and RVH. Moreover, PDGF
signalling pathway may be associated with the development of OSA/CIH-
associated PH proven by beneficial effects of imatinib on pulmonary
hemodynamics and pulmonary vascular remodelling.
AP153
CHRONIC LUNG DISEASE AND THE PULMONARY
HEMODYNAMICS: A SINGLE CENTER RETROSPECTIVE
STUDY
TAMAKI KAKUWA1, MANABU SUZUKI1, KONOMI KOBAYASHI1,
AYAKO SHIOZAWA1, YOSHIE TSUJIMOTO1, SACHI MATSUBAYASHI1,
NAOKO NAGANO1, KEITA SAKAMOTO1, MASAO HASHIMOTO1,
MOTOYASU IIKURA1, SHINYU IZUMI1, HARUTO SUGIYAMA1
1
Respiratory department, National Center for Global Health and
Medicine, Tokyo, Japan
Background and Aims: Once chronic lung disease (CLD) patients
develop pulmonary hypertension (PH), their prognosis worsen. To investi-
gate the tendency of pulmonary hemodynamics in CLD, we conducted a
single center retrospective observational study.
Methods: From March 2014 to December 2016, CLD patients who
had characteristic symptoms of PH such as dyspnea on exertion under-
went transthoracic echocardiography (TTE). We performed right heart
catheterization (RHC) to those with high estimated right ventricular pres-
sure (eRVP) to measure mean pulmonary artery pressure (PAPm) and
analyzed the correlation with other indexes; arterial blood gas (ABG)
parameters and radiographic findings.
Results: Twenty four patients were enrolled (median age; 70.5 year-
old, male; 58%). Median eRVP was 38mmHg (29-100mmHg) and median
PAPm was 20.5mmHg. Patient distribution by PAPm was as follows:
≥25mmHg, 16%, 20-24mmHg, 33% and <20mmHg, 50%. There were
high correlation between eRVP and PAPm. Radiographic findings; diame-
ter of right descending pulmonary artery (PA), abrupt tapering of the
peripheral vessels in chest X-ray and diameter of PA and PA/ aorta diam-
eter ratio in chest computer tomography and ABG; PaO2, PaCO2 and
HCO3 parameters showed middle to strong correlations with PAPm.
Conclusions: In this study, patients who met the criteria of PH
were limited to 13%. However, there were 50% patients showing
PAPm≥20mmHg. Since previous studies showed poor prognosis for patients
with PAPm ≥20mmHg, we should concern early intervention for this certain
amount of population. In our patients, not only eRVP but other indexes
showed correlation with PAPm. Along with TTE, radiographic and ABG find-
ings may be simple daily objective parameters of PH in CLD patients.
AP154
RELATIONSHIP BETWEEN CD4 COUNT WITH TROPONIN I
(CTNI) LEVEL IN HIV/AIDS PATIENTS
MUZAKKIR AMIR1, H CIPTA, P KABO
1
Department of Cardiology, Faculty of Medicine, Hasanuddin University,
Makassar, Indonesia, and 2Wahidin Sudirohusodo Hospital, Makassar,
Indonesia
Background: Several studies have shown that an increasing inci-
dence of cardiovascular disease in HIV patients associated with tradi-
tional risk factors for cardiovascular disease, antiviral treatment, low HDL
levels, and HIV-inflammatory status itself. CD4 lymphocytes are the main
target of HIV infection because the virus has an affinity for the CD4
Editorial material and organization © 2017 Asian Pacific Society of Respirology.
Copyright of individual abstracts remains with the authors
Abstracts
surface molecule. Cardiac troponin (cTn) has been used generally as a
sensitive and specific marker in the detection of myocardial injury.
The aim of this study is to evaluate relationship between CD4 count
and troponin I levels in HIV / AIDS patients.
Method: This research is a descriptive analytical research with cross
sectional method. The study was conducted in Inpatient, Outpatient instal-
lation and Pathology Laboratory Clinic of Dr. dr. Wahidin Sudirohusodo
Hospital Makassar starting from March 2017 until sufficient number of
samples.
Results: During the sampling period from March 2017 to April 2017,
the number of samples fulfilled the inclusion criteria was 43 patients.
Groups with elevated troponin had lower CD4 levels than those with nor-
mal troponin (144.9
118.3 vs. 293.9
111.3, p <0.001). In this study
found a significant relationship between CD4 count with troponin I levels,
where the direction of the relationship is reversed (p <0.005). The most
common cardiac abnormality found by echocardiography is ventricular
diastolic dysfunction (72.2%). Groups with cardiac abnormalities had
lower CD4 counts compared with those without cardiac abnormalities. In
addition, there is a relationship between the two, where the greater the
CD4 count, the less likely to find cardiac abnormalities (OR 0.99,
p <0.034).
Conclusion: There is relationship between CD4 count and troponin I
levels in HIV / AIDS patients.
Respiratory Neurobiology Sleep
AP155
AWARENESS AND KNOWLEDGE OF OBSTRUCTIVE SLEEP
APNEA AMONG THE GENERAL POPULATION
ADELINE TAN1, CHING-HUI SIA2, LINDA WL TAN3, ROB M VAN DAM3,
CHI-HANG LEE4
1
Department of Respiratory Medicine, Ng Teng Fong General Hospital,
Singapore, 2Internal Medicine Residency, National University Health
System, Singapore, 3Saw Swee Hock School of Public Health, National
University of Singapore, Singapore, and 4Department of Cardiology,
National University Heart Centre, Singapore
Background and Aims: Obstructive sleep apnea (OSA) is an
increasingly prevalent condition that remains largely undiagnosed. Strate-
gies to optimize diagnosis and treatment of OSA are dependent on public
awareness of the disease.
Methods: We aimed to assess the level of awareness and knowl-
edge of OSA among the general population. The Singapore Health 2 was
a population-based study that comprised interview and health screening
components. Out of 2,720 subjects who completed the interview compo-
nent, 2080 subjects gave consent for further health surveys. We con-
tacted these subjects and conducted a structured telephone interview.
Results: We completed 1306 telephone interviews (response rate
62.8%). The mean age (standard deviation) of the respondents was 47.1
(14.8) years and 567 (43.4%) were males. Two hundred and eighty-one
(21.5%) respondents were aware of OSA, but only 170 (13.0%) respon-
dents could define OSA correctly. A total of 77 (5.9%), 158 (12.1%),
150 (11.5%) and 110 (8.4%) respondents were able to correctly list at
least one risk factor, symptom, health consequence and treatment options
for OSA, respectively. The most common sources of information about
OSA were traditional media such as newspapers (42.0%), internet
(14.2%) or relatives and friends (14.6%). On multivariate analysis, respon-
dents were more likely to define OSA correctly if they were older (≥
61years), (odds ratio of 2.99, 95% Confidence Interval [CI]: 1.66-5.41),
were Chinese as compared to Indians (odds ratio 2.63, 95% CI: 1.46-
4.72), had higher levels of income (odds ratio 2.18, 95% CI 1.16-4.10)
and post-secondary education (odds ratio 2.87, 95% CI: 1.28-6.45).
Respirology (2017) 22 (Suppl. 3), 88–278