Dr Budiono Santoso - Curriculum Vitae

PERSONAL DATA

Name : Budiono Santoso, M.D., Ph.D., SpFK

Date & place of birth : 27 May 1950, Ambarawa, Indonesia.

Present position : Retired (Formerly Team Leader in Essential Medicines and

Health Technology, World Health Organization, Western
Pacific Regional office, until 31 May 2012)

Mailing address : Jalan Ampelgading 415, Concongcatur, Depok, Sleman,

Yogyakarta 55283, Indonesia.

E-mail address : bs2751950@gmail.com:

Home telephone nos : +62274887512. Cell phone : +628125392857

Home address : Ngenthak, Kadipuro, Ngaglik, Sleman, Yogyakarta

Marital status : Married with 3 children
Wife : Murlina Santoso
Son : Aryo Birowo
Wisnu Utomo
Saworo Tino Triatmo (deceased)

EDUCATION

1994: Certified as Specialist in Clinical Pharmacology (Spesialis Farmakologi Klinik,

SpFK)

1983: Ph.D. Degree, University of Newcastle Upon Tyne, U.K.

Thesis: Genetic and environmental influences on polymorphic drug acetylation.
Supervisor: Professor M.D. Rawlins.

1975: Medical Degree (M.D.), Gadjah Mada University, Yogyakarta, Indonesia.

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Dr Budiono Santoso - Curriculum Vitae

EMPLOYMENTS

2012 – Independent consultant in medicines

2010 - 2012 – Team Leader, Essential Medicines and Technologies,

WHO Western Pacific Regional Office, Manila.

2000 (January) – Regional Adviser in Pharmaceuticals, WHO Western Pacific Regional Office,
Manila.

1999 (August) – Short-term Professional & Acting Regional Adviser in Pharmaceuticals, WHO
Western Pacific Regional Office, Manila.

1995 – 1999 Director, Centre for Clinical Pharmacology and Drug Policy Studies, WHO
Collaborating Centre for Research and Training on Rational Drug Use,
Gadjah Mada University, Yogyakarta, Indonesia.
1987 – 1999 Chairman, Department of Clinical Pharmacology, Faculty of Medicine,
Gadjah Mada University.
1988 – 1995 Associate Director, Centre for Research and Development of Traditional
Drugs, Gadjah Mada University.
1994 – 1999 Chairman, Hospital Pharmacy and Therapeutic Committee, Sardjito General
Hospital.
1984 - present Senior Lecturer in Clinical Pharmacology, Faculty of Postgraduate Studies,
Gadjah Mada University.
1987 – 1991 Executive Secretary, Committee for S3-degree (Doctoral/Ph.D.) Programme,
Faculty of Medicine, Gadjah Mada University.
1985 - 1988 Chairman, Committee for Research, Faculty of Medicine, Gadjah Mada
University.
1985 – 1987 Chairman, Section of Clinical Pharmacology, Department of Pharmacology,
Faculty of Medicine, Gadjah Mada University.
1980 – 1983 Rockefeller Fellow at the Wolfson Unit of Clinical Pharmacology, University
of Newcastle Upon Tyne, U.K.
1976 – 1987 Staff of the Department of Pharmacology, Faculty of Medicine, Gadjah
Mada University.

PROFESSIONAL AFFILIATION

 International Network for the Rational Use of Drugs (INRUD) Washington, Executive
Committee, until 1999.
 International Union of Pharmacology (IUPHAR) - Clinical Pharmacology Division:

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Dr Budiono Santoso - Curriculum Vitae

Sub-Committee Chairman on Pharmacoepidemiology, 1992 - 1996.

Sub-Committee Chairman, Clinical Pharmacology for Developing
Countries, 1996-2000, 2000 – 2004.
 Indonesian Society for Pharmacology, Executive Committee (Chairman of the
Research Section), 1983 - 2000.
 Indonesian Medical Association, Member.
 Southeast Asian - Western Pacific Federation of Pharmacology, Member.
 Indonesian Society for Medical Polemology, Executive Secretary, 1984 - 1994.
 Yogyakarta Academy of Sciences, Founder & Member, 1995 - present
 Saworo Consulting for Academic Development (SCAD), Founder, 1996-2000.

INTERESTS/FIELDS OF RESEARCH

1. Access to medicines
2. Rational use of medicines,
3. National medicines policies
4. Clinical pharmacology.
5. Pharmacoepidemiology, drug utilization & promotion of rational drug use.
6. Drug policy & drug evaluation.
7. Pharmacokinetics & pharmacogenetics
8. Institutional and academic developments.
9. Prevention of accidents.
10. Adolescence health.

PREVIOUS ASSIGNMENTS/WORKS WITH THE WORLD HEALTH ORGANIZATION

 WHO contractual partner on STAKEHOLDER MEETING ON PHARMACEUTICAL SYSTEM

STRENGTHENING (PSS) IN THE CONTEXT OF EMERGENCY RESPONSE TO ARTEMISININ RESISTANCE
th th
FOR COUNTRIES OF THE G RATER MEKONG S UB- REGION , PHNOM PENH CAMBODIA , 17 to 19
November, 2014
 WHO contractual partner to devise a strategic document on Improving Access to Good Quality
Medicines in Mekong countries, August 2013.
 WHO Short term consultant on quality assurance of traditional medicines, Cambodia, November
2012.
 Team Leader, Essential Medicines and Technologies, WHO, Western Pacific Regional
Office, Manila, 2010 – 2012.
 WHO WPRO, Manila, Regional Adviser in Pharmaceuticals, January 2000 – 2010
 WHO WPRO, Manila, short term professional, August 1999 – December 2000
 WHO International Working Group on ATC/DDD Classification, 1997
 WHO Expert Advisory Panel on Drug Evaluation; 1991-1995; 1995-1999.
 WHO Expert Committee on the Use of Essential Drugs, 1993, 1995.
 Chairman, WHO Collaborating Centre for Research and Training on Rational Drug Use
(1996-2000), Gadjah Mada University.

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Dr Budiono Santoso - Curriculum Vitae

 WHO Short-term Consultant, Essential Drug Program, Cambodia, 1998, 1999.

 WHO Temporary Adviser, Containment of Antimicrobial Resistance, Geneva, February 1999
 WHO Short-term consultant, National Drug Policy Conference, Kyrgyzstant, November, 1994.
 WHO Short-term Consultant, First International Summer Course Problem-based
Pharmacotherapy Teaching. Groningen, 22 August - 02 September 1994. Organized by the
Department of Pharmacology and Clinical Pharmacology, WHO Collaborating Center; Faculty
of Medicine, University of Groningen, The Netherlands.
 WHO Short-term Consultant, Evaluation of Essential Drug Program in Ceylon, 1993.
 WHO Temporary Adviser, University Workshop on the Introduction of Essential
Drugs and Rational Prescribing Concept into Medical Curricula, WHO Eastern Mediterranean
Regional Office, Pakistan, June 1993.
 WHO Short-term Consultant, Maldives, June - July 1992, Development of the Maldive
Essential Drugs Project.
 WHO Short-term Consultant, Nepal, September 1991, Workshop on Generic Prescribing
vs. Brand Product.
 WHO Temporary Adviser, Review of Model Guide to Good Prescribing, Groningen.
October 1991.
 WHO Short-term Consultant, Myanmar, March 1991, Evaluation of Essential Drug
Program.
 WHO Short-term Consultant, Nepal, December 1989 - January 1990, Development of the
Nepal Drug Information System.
 WHO Temporary adviser, Meeting of the WHO - Drug Utilization Research Group. Oslo,
28 - 30 September 1987

ASSIGNMENTS/WORKS WITH OTHER ORGANIZATION

 Ausaid consultant on pharmaceutical review in Indonesia, December 2013 – June 2014

 MSH consultant on quality antimalarials in Greater Mekong countries, September 2013 – March
2014.
 Chairman, Yogyakarta Academy of Sciences, 2013 – 2015
 Founder and chairman, Medang Heritage Society, 2013 –
 Invited speaker, Asia Pacific Conference on National Medicine Policies, Sydney, 26 – 29
June 2012.
 Recipient, Plaque of Appreciation, Federation of Asian Pharmaceutical Association, 2012.
 Consultant, Asian Development Bank, Assessment of Pharmaceutical Sector in Indonesia,
November 1998.
 International Advisory Board, World Conference in Clinical Pharmacology and Therapeutics ,
Florence, Italy July 2000
 Trainer, INRUD 6th Regional Course of PRDU, Kathmandu, March 1998.
 Invited speaker for Myanmar Medical Conference in Myanmar, 19-21 January
1998.
 Consultant on National Drug Policy through BASICS Project in Asmara, Eritrea, 6-20 October
1997.
 Invited speaker, DIA Workshop – International Policies in Health Economics: State of Play
and Future Direction in Pharmaceuticals, Queensland, 24-26 September 1997.

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Dr Budiono Santoso - Curriculum Vitae

 Invited expert for pharmaceutical supply in Iraq, 27 June-4 July 1997

 Coordinator, Drug Evaluation Committee, Ministry of Health Republic of Indonesia, 1985 - present.
 Consultant, Rational Pharmaceutical Management in Nepal, Management Sciences for Health
(MSH), Washington, 1994, 1995, 1996, 1997, 1998
 Consultant, Rational Pharmaceutical Management (USAID Funded Project) in Bangladesh,
assignment by Management Sciences for Health (MSH, Washington), 1998.
 Trainer, International Course on Promoting Rational Use of Drugs, organized by INRUD and
LATINCLEN, Mexico City, September 17-23 1996
 Editorial Board, Journal of American Medical Association - Southeast Asia (JAMA-SEA).
 Advisory Editorial Board, Socepta Journal (Uganda), 1996 - present.
 Expert Advisory Panel on International Health, The United States Pharmacopeia (USP)
Committee of Revision, 1990-1995; 1995-2000.
 Course Coordinator, International Course on the Promoting Rational Drug Use, Yogyakarta,
19-30 September 1994. Organized by INRUD Indonesia in collaboration with World Health
Organization-Geneva and INRUD Secretariat, Boston.
 International Reference Panel, International Conference on National Medicinal Drug Policies,
Sydney 8-11 October 1995.
 Trainer, INRUD Course on Promoting Rational Use of Drugs, Manila, 27 November - 8
December 1995.
 External examiner, University Malaya, Faculty of Medicine, 1995.
 Founder and Secretary General, Yogyakarta Academy of Sciences. 1995-1996.
 Expert Panel, Pharmacology Section, IV Indonesian Pharmacopeia Committee of Revision.
1991 - 1994.
 Chairman, Asian Conference on Clinical Pharmacology & Therapeutics, Yogyakarta, 31
October - 4 November 1993.
 Recipient of Phytomedica Award for Natural Product Research from Phyto Medica
Foundation. Bandung, September 25, 1993.
 Editorial Advisory Board, MIMS - Asia, 1993.
 Member of Advisory Editorial Panel, Medical Progress (Hongkong), 1989 - now.
 Expert Panel for the Drug Evaluation Committee, Ministry of Health of the Republic
of Indonesia. 1988 - now
 Advisory Editorial Board, Clinical and Experimental Pharmacology (The Netherlands),
1991-present.
 Member of Advisory Editorial Board, Asia Pacific Journal of Pharmacology. Paean Publishing,
Singapore.
 Short-term Consultant for the implementation of the Pharmaceutical Component of Health
Sector Financing Project, Ministry of Health of the Republic of Indonesia. 1991.
 Chairman, Team for Developing the Clinical Trial Protocol of Phytopharmaca, Yayasan Phyto
Medica, Jakarta, Indonesia.
 Editor, Proceedings of the International Symposium on Antipyretic Analgesics - New Insights
1990, Yogyakarta, March 1990.
 Member/consultant of various committees to the Directorate General of Food and Drug
Control, Ministry of Health of the Republic of Indonesia, i.e.,
- Working Group on the evaluation of phytopharmaca.
- Revision of the national essential drug list, 1986, 1990, 1993.

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Dr Budiono Santoso - Curriculum Vitae

- Comparative national standard drug list in Southeast Asia (WHO-funded

project).
 Chief editor, Lembaran Obat dan Pengobatan. A drug and therapeutic bulletin for practitioners
in Indonesia. Published by Yayasan Melati Nusantara, Yogyakarta.
 Resource person for various projects under the Ministry of Health and CHIPPS
(Comprehensive Health Improvement Projects - Province Specific), funded by USAID grant
and Government of the Republic of Indonesia.
- Workshops on epidemiology and management.
- Workshops on drug management.
 Short-term Consultant, International Network for the Rational Use of Drugs, October-
November 1989, Indonesia & Bangladesh Country Assessment for Essential Drug Program.
 Resource person/trainer, International Course on Promoting Rational Use of Drugs,
Yogyakarta, January 1989. Organized jointly by Management Sciences for Health (Boston),
Yayasan Indonesia Sejahtera (Jakarta), Program Analysis for Clinical Strategies - Harvard
Medical School (Boston) and Gadjah Mada University (Yogyakarta).
 Consultant, Health Sector Financing Project - Pharmaceutical Sector, Ministry of Health of the
Republic of Indonesia (a project funded by USAID grant). June - July, 1988
 Resource person in the development of a training module on diarrhoeal diseases for
Kabupaten (regency) drug procurement officers, a project under the Ministry of Health. 1987
 Member, WHO - Drug Utilization Research Group. 1987 - present.
 Consultant, Department of International Health, Charles R. Drew Postgraduate Medical
School, U.S.A., for projects funded by USAID: “Pharmacokinetics of Rifampin amongst
Indonesian Subjects”. May - December 1986
 Organizer, International Symposium on Non-narcotic Analgesics. Current Concept on Risk
and Benefit Assessment. Organized by Gadjah Mada University under the patronage of the
Ministry of Health of Indonesia. Yogyakarta, February 23 - 26, 1986.
 Editor and contributor, Efek Samping Obat (Side-effects of Drugs), first edition, 1988.
Published by Yayasan Melati Nusantara, Yogyakarta.
 Guest editor, Medical Toxicology, Vol. 1 (suppl.1), 1986. Proceedings of the Symposium on
Non-narcotic Analgesics today: an update of benefits and risks.
 Organizer, the II Southeast Asian and Western Pacific - Regional Meeting of Pharmacologists
(II SEAWP-RMP). June, 1979.

IMPORTANT PROJECTS

With WHO

Development of the Regional Strategy for Improving Access to Essential Medicines in the
Western Pacific Region, WHO/WPRO 2005 - 2010. Revised in 2010, and continued with the
Regional Framework on Access to Essential Medicines in the Western Pacific, WHO/WPRO
2011 – 2015. Both serve as guides for WHO, membership and partners on improving
access to essential medicines.

Promoting ethical practices in medicines registration, selection and procurement in the

Western Pacific region in 2004, funded by WHO/Ausaid, which later became a WHO Global
Program on Good Governance in Medicines.

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Dr Budiono Santoso - Curriculum Vitae

WHO Combating Counterfeit Medicines in the Western Pacific in 2004, funded by

WHO/Ausaid.

WHO regional rapid alert system for combating counterfeit medicines in the Western
Pacific in 2005, a web based information reporting on counterfeit medicines.

WHO regional medicines price information exchange (PIE) in 2009.

Operation STORM to combat counterfeit medicines in Greater Mekong countries, a

collaborative projects (INTERPOL, World Healh Organization, World Customs Organization
and medicines regulatory authorities, customs and police of Greater Mekong countries, in
2008 and 2010.

Previous to WHO

Principal Investigator, Evaluation of Indonesian National Drug Policy. Funded by the World
Health Organization, 1997-1998

 Principal Investigator, Preparation of a Problem-based Standard Treatment Guidelines for

Healthcentre Paramedics, Funded by HealthProject IV, Ministry of Health, Indonesia,
1998
 Principal Investigator, The Use of Time Series Methods to Evaluate Interventions to
Improve Drug Use in Developing Countries. Funded by the Harvard University and
INRUD, 1994-1996.
 Principal Investigator, Randomized Double-blind Controlled Clinical Trial of Analgesic
Effect of Floctafenine after Extraction of Lower Impacted Wisdom Tooth, Hoechst AG
Germany, 1993-1995.
 Investigator, dioVan Anthihypertensive Longterm Use Evaluation (VALUE), Novartis, 1998
– 2004.
 Investigator, Interethnic Differences in Rifampin Pharmacokinetics: A comparison
between American and Indonesian healthy volunteers, 1995. Joint research, Department
of Clinical Pharmacology, Gadjah Mada University, Yogyakarta, Indonesia and
Department of Pharmaceutical Sciences, Midwestern University, Downers Grove IL, USA
(on going) .
 Principal Investigator, Development of Self-monitoring Instruments for Drug Use in Health
Facilities at District Level. A Pilot Study. Project funded by the International Network for
the Rational Use of Drugs (INRUD), 1993-1994.
 Principal Investigator, Improving the Rational Use of Drugs in Diarrhoea. The Impact of a
Conventional Form of Formal Group Seminar for Prescribers at District Level vs. a Small
Face to Face Training at Health Centre. A research project funded by Applied Diarrhoeal
Research Project (ADDR), Grant No. 080, 1992-1993
 Investigator, Interactional Group Discussion: A Possible Behavioral Intervention for
Rational Use of Injections. Funded by WHO-DAP, 1992-1993.
 Investigator, Randomized Double Blind, Plazebo Controlled Trial of the Analgesic Effect
of Dipyrone, Mefenamic Acid and Ibuprofen after Extraction of Lower Impacted Wisdom
Tooth, Hoechst AG Germany, 1994-1996.

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Dr Budiono Santoso - Curriculum Vitae

LIST OF PUBLICATIONS/COMMUNICATION

Barber SL, Huang B, Santoso B, Laing R. Paris V and Wu C. The reform of the essential
medicines system in China : a comprehensive approach to universal coverage.
J. Glob Health 2013, June, 3(1).
( http://www.jogh.org/documents/issue201301/V3_Barber.pdf) Accessed 29 July 2013.

Robertson J, Santoso B, Holloway KA, Dartnell J, Tisocki K, McLachlan A, Smith A. Asia

Pacific Conference on National Medicines Policies.
(http://www.australianprescriber.com/magazine/35/6/190/3). Accessed 29 July 2013.

Newton PN, Fernandez FM, Placon A, Mildenhall DC, Green MD, Zyong L, Chrisophel EM,
Phanouvong S, Howells S, McIntosh E, Laurin P, Blum N, Hampton CY, Faure K, Nyadong
L, Soong CWR, Santoso B, Zhiguang W, Newton J and Palmer K. A collaborative
epidemiological investigation into the criminal fake artesunate trade in South East Asia.
PLoS Medicines, February 2008, 5 (2)

Boxtel CJ, Santoso B & Edwards IR. Drugs Benefits and Risks – International Textbookof
Clinical Pharmacology. Publisher : Jon Willey & Sons Ltd. 2001 (1st edition) and 2007 (2nd
edition)

Santoso, B., Suryawati, S., Setyawati, E., Saleh Danu, S. & Rustamaji S. Indicator-based
monitoring to improve the quality use of medicines in primary healthcare and hospital facilities.
CPT 2000, Florence, 2000, abstract no.22.

Santoso, B., Teaching rational therapeutics in emerging countries : problems and solutions. CPT
2000, Florence 2000, abstract. No 270.

SANTOSO, B., Essential drugs in Southeast Asia, JAMA SEA, January/February 2000 : 6 – 8.

SANTOSO, B., 1998, Ethics of Research Involving Human Subjects in Southeast Asia.
JAMA-SEA 14(4):7-8
SANTOSO, B., 1998, Reaffirming the Management of Tuberculosis. Medical Progress, 25(6):
19-22.
SANTOSO, B., 1997, Drug advertisements: a critical lesson for Indonesian students, WHO
Essential Drug Monitor. (23):23.
SANTOSO, B., 1997, Drug interactions in Southeast Asia, Medical Progress 24(5):5-9
SANTOSO, B., 1997, Problems with drug use and the impact on healthcare in Southeast
Asia. JAMA-SEA 13(3):5-6
SANTOSO, B., 1996, Principles of rational prescribing, Medical Progress 23(10):6-9
SANTOSO, B., 1996, Problems of drugs utilization in developing countries and the expected
role of clinical pharmacology. A plenary lecture during the VIth World Conference on
Clinical Pharmacology and Theraupetics, Buenos Aires, August 1996
ASTUTI, L & SANTOSO,B., 1996, The effect of cimetidine co-administration on the renal
clearance of sulfadiazine. Medika 25(5): 350-354

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Dr Budiono Santoso - Curriculum Vitae

DE VRIES, T.P.G.M., HENNING, R.H.,HOGERZEIL , H.V., BAPNA, J.S., BERO, L., KAFLE,
K.K., MABADEJE, A.F.B., SANTOSO, B. & SMITH, A.J., 1995, Impact of a short
course in pharmacotherapy for undergraduate medical students: an international
randomised controlled study. Lancet 346 (2):1454-1457.
SANTOSO B. ,1996, The role of social sciences in drug use studies, Thematic paper
presented at Asia Pacific Conference on Social Sciences and Medicine, Perth, 1996.
SANTOSO B, SURYAWATI S & HADIYONO JEP, 1996, Small group intervention vs formal
seminar for improving appropriate drug use. Social Science and Medicine 42(8): 1163-
1168.
HADIYONO JEP, SURYAWATI S, DANU S & SANTOSO B, 1996, Interactional Group
Discussion: Results of a controlled trial using a behavioural intervention to reduce the
use of injections in public health facilities. Social Science and Medicine 42(8): 1177-
1183.
SANTOSO B., 1995, Promoting Rational Use of Drugs. INRUD experiences from Indonesia.
Presented at the International Conference on Medicinal Drug Policy, Sydney, 9-11
October 1995.
SANTOSO B., 1995, Teaching clinical pharmacology and therapeutics towards rational use of
drugs (Indonesian), Journal of Indonesia Medical Association, 45 (11):662-667.
SANTOSO B. & SURYAWATI S., 1995, The Use of Drugs in Children and Lactation. Seminar
Proceedings, Diponegoro University.
SANTOSO B., 1995, Hospital Pharmacy and Therapeutic Committees in Southeast Asia. Role
and Functions. Medical Progress, 22 (11):5-10.
SANTOSO B., 1995, Misuse of injections. A serious threat to Health Care in Developing
Countries. Medical Progress, April 1995, 22(4):5-8.
SIMATUPANG,A., SURYAWATI,S. & SANTOSO,B., 1994, The influence of cotrimoxazole on
glibenclamide-induced hypoglicemia in healthy volunteers. Medika XX(10), 23-26.
SANTOSO B., 1994, The importance of patient counseling. Medical Progress, 21(11A),
November 1994 (Suppl):5-8.
SANTOSO B., 1994, Problems and priorities of drug utilization in developing countries.
Experiences of intervention studies from Indonesia. Pharmacoepidemiology and Drug
Safety 3(Suppl1):S121.
BIMO, SANTOSO B, SURYAWATI S, HADIYONO JEP & SUNARTONO, 1994, Development
of self-monitoring instruments for drug use in health facilities: a pilot study.
Pharmacoepidemiology and Drug Safety 3(Suppl1):S113.
SIMATUPANG A., SANTOSO B. & SURYAWATI S., 1994, The influence of isoniazid on the
pharmacokinetics and hypoglycaemic effect of glybenclamide in slow and rapid
acetylator subjects. Bulletin of Postgraduate Studies, Gadjah Mada University (BPPS-
UGM) 7(1B):41-54.
SURYAWATI S. & SANTOSO B., 1994, Development an educational intervention module for
the community in improving the quality of self-medication. Pharmacoepidemiology and
Drug Safety 3(Suppl1):S114.
SURYAWATI, S. & SANTOSO, B., 1993, Pharmacokinetic profile of captopril amongst
Indonesian healthy volunteers. Abstract Book, Asian Conference on Clinical
Pharmacology & Therapeutics, Yogyakarta, 1993
SANTOSO B., SURYAWATI S. & SALEH-DANU S., 1993, Implementing MGGP in the
existing curriculum of Clinical Pharmacology. Abstract Book, Asian Conference on
Clinical Pharmacology & Therapeutics, Yogyakarta, 1993

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Dr Budiono Santoso - Curriculum Vitae

HOGERZEIL H.V., BIMO, ROSS-DEGNAN D., LAING R.O., OFORI-ADJEI D., SANTOSO
B., CHOWDHURY A.K., DAS A.M., KAFLE K.K., MABADEJE A.F.B. & MASSELE
A.Y., 1993, Field tests for rational drug use in twelve developing countries, Lancet
342:1408-10.
SANTOSO B., SOELISTIONO H., ROCHIM M. & DWIPRAHASTO I., 1993, Analgesics in
dentistry, In: W.D. Gerber & G. Nappi (eds) Update on Non-Narcotic Analgesics
Research. Birkhauser Verlag, Basel.
SANTOSO B., 1993, Promoting rational presecribing among physicians in Indonesia. Guest
presentation at Intercountry Workshop on the Introduction of Essential Drugs and
Rational Prescribing Concepts Into University Curricula, Islamabad.
SANTOSO B., 1993, Introducing Concept of Rational Prescribing in undergraduate Medical
Curricula. Experiences from Gadjah Mada University. Guest presentation at
Intercountry Workshop on the Introduction of Essential Drugs and Rational Prescribing
Concepts Into University Curricula, Islamabad.
SANTOSO B., 1993, Analgesics for Dental Pain. Guest presentation during International
Conference on Pain, New Delhi.
SANTOSO B., 1993, Clinical Trial of Natural Products for Diabetes Mellitus. Presented at
Seminar on Traditional Drugs for Diabetes, Jakarta.
SANTOSO B., 1993, The needs of social science expertise in health research. Presented at
Seminar on the Role of Social Scientists in Health Research, Inter-University Center
for Social Studies, Gadjah Mada University, Yogyakarta.
ROSS-DEGNAN, D., LAING, R., QUICK, J., ALI, H.M., OFORI-ADJEI, D., SALAKO. L., &
SANTOSO, B., 1992, A strategy for promoting improved pharmaceutical use: The
international network for rational use of drugs. Soc. Sci. Med. 35(11): 1329-1341.
SANTOSO, B., 1992, Bioequivalence studies of generic products. Presented at Vth World
Conference on Clinical Pharmacology and Therapeutics, Yokohama.
SANTOSO, B., SURYAWATI, S., 1992, Teaching medical students to critically assess drug
advertisement. Presented at Vth World Conference on Clinical Pharmacology and
Therapeutics, Yokohama.
SURYAWATI, S., SANTOSO, B., SUNARTINI, HADJAR, M.M.I. & SARDJOKO, 1992,
Pharmacokinetics and cerebrospinal penetration of rifampicin in children with
tuberculous meningitis. Presented at Vth World Conference on Clinical Pharmacology
and Therapeutics, Yokohama.
SURYAWATI, S., SANTOSO, B., HADJAR, M.M.I. & SARDJOKO, 1992, Pharmacokinetics
and metabolite profiles of rifampicin amongst Indonesian healthy and tuberculous
subjects. Presented at Vth World Conference on Clinical Pharmacology and
Therapeutics, Yokohama.
MUSTOFA, KRISTIN, E., SURYAWATI, S., & SANTOSO, B., 1992, Effects of rifampin
pretreatment on the pharmacokinetics of nifedipine in healthy volunteers. Presented at
Vth World Conference on Clinical Pharmacology and Therapeutics, Yokohama.
DONATUS, I.A., SANTOSO, B., HARJONO, S. & DJOJOSAPUTRO, M., 1992, Effects of
rifampin pretreatment on the elimination kinetics of metronidazole and dexamethasone
in healthy volunteers. Presented at Vth World Conference on Clinical Pharmacology
and Therapeutics, Yokohama.
SANTOSO, B., 1991, Irrational use of drugs - the need for international cooperation and
action. Presented in the Symposium on Drug Utilization in the Community and
Hospital, VI Southeast Asian/Western Pacific Regional Meeting of Pharmacologists,
Hong Kong.

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SURYAWATI, S., SANTOSO, B., HADJAR, M.M.I. & SARDJOKO, 1991, Pharmacokinetics
of rifampin in Javanese elderly patients with tuberculosis. Presented at VI Southeast
Asian/Western Pacific Regional Meeting of Pharmacologists, Hong Kong.
MUSTOFA M, SURYAWATI S, KRISTIN E, DWIPRAHASTO I, MULYADI DS & SANTOSO
B., 1991, The effects of propranolol co-administration on the pharmacokinetics and
pharmacodynamics of nifedipine in healthy volunteers. Presented at VI Southeast
Asian/Western Pacific Regional Meeting of Pharmacologists, Hong Kong.
KRISTIN, E., SANTOSO, B., 1991, The effets of isoniazid co-administration and
sulfamethazine doses on the polymorphic acetylation of sulfamethazine in slow and
rapid acetylators. Presented at VI Southeast Asian/Western Pacific Regional Meeting
of Pharmacologists, Hong Kong.
SANTOSO, B., 1991, Lack of erythromycin-theophyline interaction in healthy subjects, the
Indonesian Journal of Pharmacology and Theraupetics. 8(3-4); 64-68.
SIMATUPANG, A., SURYAWATI, S. & SANTOSO, B., 1991, The effect of cotrimoxazole and
the hypoglycaemia induced by glibenclamide in healthy volunteers. Presented at VI
Southeast Asian/Western Pacific Regional Meeting of Pharmacologists, Hong Kong.
MUSTOFA, SURYAWATI, S. & SANTOSO, B., 1991, Pharmacokinetics of metronidazole in
saliva. Int. J. Clin. Pharmac. Ther. Toxic. 29(12):474-478.
SANTOSO, B., 1991, Mechanisms and clinical impacts of drug interactions. Lembaran Obat
& Pengobatan 5(4):25-32.
SANTOSO, B., SUGIYANTO, ASDIE, S. & EFFENDI, R., 1991, Absence of relationship
between isoniazid-induced hepatic disturbances and acetylator phenotype. Berita
Kedokteran Masyarakat, VII/3/113-187:169-178.
SANTOSO, B. & SASTROWIJOTO, S., 1991, Impact of problem-based learning about
therapeutic decision making on drug prescribing. Buletin Pendidikan I(3):70-75
SURYAWATI, S. & SANTOSO, B., 1991, Improving the capability of medical students to
critically assess drug advertisement. Buletin Pendidikan I(3):76-79
MUSTOFA, SURYAWATI, S. & SANTOSO, B., 1991, Bioinequivalence of commercial
nifedipine formulations. Med. Sci. Res. 19:277-278
SURYAWATI, S., SANTOSO, B., HADJAR, M.M.I. & SARDJOKO, 1990, Rifampin
pharmacokinetics in malnourished tuberculous patients. 5th Southeast Asian - Drug
Metabolism Workshop, Manila.
SOELISTIONO, H., ROCHIM, A., DWIPRAHASTO, I., SANTOSO, B. & KALHAMMER, R.,
1990, Randomized double-blind placebo controlled trial of dipyrone and paracetamol in
post-operative dental pain. Pain 5(suppl):S38
DJOJOSAPUTRO, M., MUSTOFA, SURYAWATI, S. & SANTOSO, B., 1990, The effects of
doses and pre-treatment of rifampicin on the elimination kinetics of metronidazole.
European Journal of Pharmacology 138:1870
SUHARMI, S., SANTOSO, B. & MULYONO, 1990, Influence of atenolol on the
pharmacokinetics and diuretic effects of hydrochlorothiazide in healthy volunteers.
European Journal of Pharmacology 138:2375
DONATUS, I.A., SANTOSO, B., HADJAR, M.I. & VERMEULEN, N.P.E., 1990, Preventive
effect of curcumin on paracetamol-induced hepatotoxicity in mice. European Journal
Pharmacology 138:2451
SANTOSO, B., 1990, Problems of drug use in pregnancy. In: S. Suryawati et al. (eds)
Pemakaian Obat pada Kehamilan (Drug Use in Pregnancy). Yayasan Melati
Nusantara, Yogyakarta. (written in Bahasa Indonesia).

11
Dr Budiono Santoso - Curriculum Vitae

SANTOSO, B., 1990, OTC-use of antipyretic analgesics - the need of effective information
and education to consumers. In: B. Santoso & K. Brune (eds): Proceedings of the
International Symposium on Antipyretic Analgesics - New Insights 1990. Birkhauser,
Basel, pp.: 81-88.
SANTOSO, B., 1990, Antibiotics prophylaxis in surgery. In: S. Suryawati et al. (eds)
Pemilihan dan Pemakaian Antibiotika dalam Klinik (The Selection and Use of
Antibiotics in Clinical Practices. Yayasan Melati Nusantara, Yogyakarta. (written in
Bahasa Indonesia, abstract in English).
SANTOSO, B., 1990, Experiences with drug utilization in Indonesia. Inaugural Meeting of
The International Network for the Rational Use of Drugs (INRUD), Yogyakarta.
MUSTOFA, SURYAWATI, S., DWIPRAHASTO, I. & SANTOSO, B., 1990, The relative
bioavailability of diclofenac with respect to time of administration. Br. J. clin.
Pharmacol. 32(2):246-247
SURYAWATI, S., SANTOSO, B., HADJAR, M.M.I. & SARDJOKO, W., 1989, Drug
interactions with rifampin. European Journal of Clinical Pharmacology 36(supp.):A269
SANTOSO, B., SURYAWATI, S., MUSTOFA & DWIPRAHASTO, I., 1989, The influence of
isoniazid pre-treatment on the elimination of dexamethasone. European Journal of
Clinical Pharmacology 36(supp.):A268
DWIPRAHASTO, I., ROCHIM, A., SOELISTIONO, KALHAMMER, R. & SANTOSO, B., 1989,
Randomized double-blind placebo-controlled trial of dipyrone and aspirin in post-
operative dental pain. European Journal of Clinical Pharmacology 36(supp.):A125
SUWADI & SANTOSO, B., 1989, Clinical trial of a phytopharmacon (Herbastres R) for
anxiety. Phyto Medica 1(1):36-42 (written in Bahasa Indonesia)
SANTOSO, B., 1989, Management of clinical trials. Majalah Farmakologi dan Terapi
Indonesia 6(suppl):37
DHARMA KERTI, N., DANU, S.S., DWIPRAHASTO, I. & SANTOSO, B., 1989, Physicians’
knowledge on generic names of drugs. Majalah Farmakologi dan Terapi Indonesia
6(suppl):46
RIYARTO, S., DWIPRAHASTO, I. & SANTOSO, B., 1989, Consumption pattern of sistemic
chloramphenicol in some health centres in Sleman District, Yogyakarta. Majalah
Farmakologi dan Terapi Indonesia 6(suppl):48
DWIPRAHASTO, I., KRISTIN, E., MUSTOFA, SURYAWATI, S. & SANTOSO, B., 1989, The
evaluation of DOPB program at Yogyakarta Special Territory. Majalah Farmakologi
dan Terapi Indonesia 6(suppl):56
DWIPRAHASTO, I., ROCHIM, A., SOELISTIONO, H. & SANTOSO, B., 1989, Clinical trial of
dipyrone vs aspirin in post-extraction dental pain. Majalah Farmakologi dan Terapi
Indonesia 6 (suppl): 76
SANTOSO, B., SURYAWATI, S., MUSTOFA & DWIPRAHASTO, I., 1989, Influence of
isoniazid pretreatment on the elimination kinetics of dexamethasone. Majalah
Farmakologi dan Terapi Indonesia 6 (suppl): 109
MUSTOFA, SURYAWATI, S. DWIPRAHASTO, I., KRISTIN, E. & SANTOSO, B., 1989,
Prednisone pharmacokinetic profile in healthy subjects. Majalah Farmakologi dan
Terapi Indonesia 6(suppl):110
SURYAWATI, S., SANTOSO, B., HADJAR, M.M.I., SARDJOKO, 1989, The effects of
isoniazid, pirazinamide and rifampin pretreatments on the pharmacokinetics of
rifampin. Majalah Farmakologi dan Terapi Indonesia 6(suppl):112

12
Dr Budiono Santoso - Curriculum Vitae

SURYAWATI, S., SANTOSO, B., HADJAR, M.M.I., & SARDJOKO, 1989, Pharmacokinetic
profiles of rifampin at doses of 300, 450 and 600 mg in malnourished pulmonary
tuberculous patients. Majalah Farmakologi dan Terapi Indonesia 6(suppl):113
SUHARMI, S., MULYONO, SANTOSO, B., 1989, Effect of atenolol co-administration on the
pharmacokinetic profile of hydrochlorotiazide in healthy subjects. Majalah Farmakologi
dan Terapi Indonesia 6(suppl):114
MUSTOFA, DJOJOSAPUTRO, M., SURYAWATI, S. & SANTOSO, B., 1989, Elimination
kinetics of metronidazole after 500 mg and 1000 mg intravenously administrations in
healthy subjects. Majalah Farmakologi dan Terapi Indonesia 6(suppl):115.
SANTOSO, B., MUSTOFA, SURYAWATI, S., 1989, Comparative pharmacokinetic profiles
and adverse effects of two slow-release theophylline preparations: 12 hourly vs 24
hourly capsules. Majalah Farmakologi dan Terapi Indonesia 6(suppl):118
KRISTIN, E. & SANTOSO, B., 1989, The influence of isoniazid pretreatment on sulfadimidine
acetylation ratio. Majalah Farmakologi dan Terapi Indonesia 6(suppl):119
SANTOSO, B., RISTANTO, SURYAWATI, S., MUSTOFA, DWIPRAHASTO, I. & KRISTIN,
E., 1989, Comparative bioavailability of ampicilline capsules: anhidrous ampicillin vs.
trihydrate ampicillin. Majalah Farmakologi dan Terapi Indonesia 6(suppl):120
PRAMONO, S., NGATIDJAN & SANTOSO, B., 1989, Identification of active compounds,
pharmacology, toxicology and clinical trial of Oldenlandia corymbosa Linn. Majalah
Farmakologi dan Terapi Indonesia 6(suppl):133
SOETARNO, SANTOSO, B. & MULYONO, 1988, The effect of dose and co-administration
with trimetoprim on the pharmacokinetics of sulfamethoxazole. Bulletin of
Postgraduate Studies, Gadjah Mada University (BPPS - UGM) 2(1):259-272
SUNARSIH, I.M., SANTOSO, B. & MULYONO, 1988, Antibiotic audit at the Department of
Medicine, Sardjito General Hospital. Bulletin of Postgraduate Studies, Gadjah Mada
University (BPPS- UGM) 3(1):433-443
JULI MARJATI, DJOKO WIBOWO & SANTOSO, B., 1988, Survey on the microbiological
quality of food at canteens of primary schools with and without school health program
in Bali. Bulletin of Postgraduate Studies - Gadjah Mada University (BPPS- UGM)
3(1):411-421
ROESJDI GAWAI, MULYONO & SANTOSO B., 1988 ,Acetylation of sulfadiazine in slow and
rapid acetylators. Bulletin of Postgraduate Studies - Gadjah Mada University (BPPS-
UGM) 3(1):445-454
SANTOSO, B. & SURYAWATI, S., 1988, Epidemiology of drug utilization. Its role in
improving health service quality. J. Med. Sci. 20(3):77-86 (written in Bahasa Indonesia,
abstract in English)
SURYAWATI, S., HADJAR, M.M.I., SARDJOKO & SANTOSO, B., 1988, INH - rifampin
interaction. Poster presentation at the XII Congress of Federation of Asian
Pharmaceutical Association (FAPA), Denpasar.
SURYAWATI, S., MUSTOFA, DWIPRAHASTO, I. & SANTOSO, B., 1988, Comparative
bioavailability of diclofenac after slow-release and conventional enteric-coated tablets.
Poster presentation at the II International Conference on Drug Absorption, Edinburgh.
SAMIGUN, MULYONO & SANTOSO, B., 1988, Reduction of theophylline clearance by
isoniazid. Presented at the V Southeast Asian and Western Pacific - Regional Meeting
of Pharmacologists (SEAWP-RMP), Beijing.
SANTOSO, B., 1988, Bed-side teaching in clinical pharmacology. Discussion paper for the
International Consultation on Rational Drug Use in Medical/Pharmacy Education,
Manila.

13
Dr Budiono Santoso - Curriculum Vitae

SANTOSO, B. & SURYAWATI, S., 1987, Bioinequivalence of two commercial piroxicam

formulations. Med. Sci. Res. 15:133-134
SURYAWATI, S., KING, R.C. & SANTOSO, B., 1987, Pharmacokinetic profiles of rifampicin
amongst healthy and tuberculous Javanese-Indonesians. Poster presentation at the II
Southeast Asian Drug Metabolism Workshop, Singapore.
SANTOSO, B. & RAWLINS, M.D., 1987, Dstribution of acetylator phenotype in malnourished
population. A study amongst the Javanese-Indonesians. Poster presentation at the X
International Congress of Pharmacology, Sydney.
SURYAWATI, S. & SANTOSO, B., 1986, Measurement of isoniazid half-life from salivary
samples. Int. J. Clin. Pharmacol. Ther. Tox. 24:18-22
SANTOSO, B., 1986, The clinical significance of drug interaction. Medika 12:94-98
SANTOSO, B. & SURYAWATI, S., 1986, Lack of erythromycin - theophylline interaction.
Poster presentation at the III World Conference on Clinical Pharmacology &
Therapeutics, Stockholm.
SURYAWATI, S. & SANTOSO, B., 1986, The expenditure of antibiotics and chemo-
therapeutics in primary health centres. Poster presentation at the III World Conference
on Clinical Pharmacology & Therapeutics, Stockholm.
SURYAWATI, S. & SANTOSO, B., 1986, Elimination kinetics of rifampicin after the doses of
450 mg and 600 mg. Medika 12:244-247
SANTOSO, B. & WAHAB, A.S., 1986, Penicillin, streptococcal infection and rheumatic fever:
the need for reappraisal and reaffirmation. JAMA-SEA 2(11):5
SANTOSO, B., 1985, Impairment of isoniazid clearance by propranolol. Int.. J. Clin.
Pharmacol. Ther. 23:134-136
SANTOSO, B., 1985, Clinical pharmacokinetics. Its role and pitfalls. Cermin Dunia
Kedokteran 37:8-13 (written in Bahasa Indonesia)
SANTOSO, B., 1985, The influence of malnutrition on the proportion of polymorphic drug
acetylation (dapsone). Proceedings of the National Seminar of Senior Scientists.
pp.341-368. Organized by the Ministry of Education, Bandung. (written in Bahasa
Indonesia, abstract in English)
SURYAWATI, S. & SANTOSO, B., 1985, The reduction of salicylate renal elimination after
propranolol pretreatment. Indon. J. Pharmacol. Ther. 2:101-104 (written in Bahasa
Indonesia, abstract in English).
SANTOSO, B., SUGIYANTO & ASDIE, S., 1985, The liver function tests in tuberculous
patients receiving isoniazid. Internal Report to Gadjah Mada University,
PPPT/UGM/1984-1985/11/53 (written in Bahasa Indonesia, abstract in English).
SURYAWATI, S. & SANTOSO, B., 1985, Differential dose-dependency of the renal
elimination of salicylate, sulfadiazine and sulfamethazine. Medika 12:48-53 (written in
Bahasa Indonesia)
SANTOSO, B., 1985, Design of clinical investigation. Indon. J. Pharmacol. Ther. 2:107-110
(written in Bahasa Indonesia)
SANTOSO, B., 1985, Bed-side consultation in clinical pharmacology. Cermin Dunia
Kedokteran 37:55-57 (written in Bahasa Indonesia)
SARTONO, T., RIDWAN, A.A. & SANTOSO, B., 1983, Measurement of isoniazid in saliva. J.
Indon. Med. Assoc. (MKI) 34:47-50 (written in Bahasa Indonesia)
SANTOSO, B. & RAWLINS, M.D., 1983, Dose-dependent changes in isoniazid clearance in
rapid and slow acetylator phenotypes. Br. J. Clin. Pharmacol. 15:137p
SANTOSO, B., 1983, Genetic and Environmental Influences on Polymorphic Drug
Acetylation. Ph.D. Thesis, University of Newcastle Upon Tyne, U.K.

14
Dr Budiono Santoso - Curriculum Vitae

SANTOSO, B. & MULYONO, 1982, Dose adjusment in renal impairment. Medika 8:226-229
(written in Bahasa Indonesia, abstract in English)
SANTOSO, B., SUHARDJONO,D., DANU, S.S., EFFENDI, R. & ASDIE, S., 1981, Nutritional
status and drug acetylation polymorphism. Medika 7:301-304 (written in Bahasa
Indonesia, abstract in English).
SANTOSO, B., SUHARDJONO, D., DANU, S.S., EFFENDI, R. & ASDIE, S., 1981, The rate
of isoniazid acetylation and the occurence of relapse in tuberculosis. J. Indon. Med.
Assoc. (MKI) 32:2-5 (written in Bahasa Indonesia, abstract in English)
THOM, S., FARROW, P., SANTOSO, B., ALBERTHI, K.G.M.M. & RAWLINS, M.D., 1981,
Effect of oral glucose on isoniazid kinetics. Br. J. Clin. Pharmacol. 11:423p
DJOJODIBROTO, R.D., SANTOSO, B., BUDHIARTO, M. & ARINI SUMANTRI, 1978, The
effects of stool of acute gastroenteritis patients on isolated guinea-pig ileum. Modern
Medicine of Asia 14:43-47

***

Notes : Some missing references

1. Serum Cholinesterase activity in malnutrition (1979)

2. Serum cholinesterase activity in patients with dengue haemorrhagic fever (1978)

15