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Respiratory
“There’s so much pollution in the air now that if it weren’t for our lungs, ``Embryology 642
there’d be no place to put it all.”
—Robert Orben ``Anatomy 644
641
RESPIRATORY—EMBRYOLOGY
``
Lung development Occurs in five stages. Initial development includes development of lung bud from distal end of
respiratory diverticulum during week 4. Every Pulmonologist Can See Alveoli.
STAGE STRUCTURAL DEVELOPMENT NOTES
Embryonic Lung bud trachea bronchial buds Errors at this stage can lead to
(weeks 4–7) mainstem bronchi secondary (lobar) tracheoesophageal fistula.
bronchi tertiary (segmental) bronchi.
Pseudoglandular Endodermal tubules terminal bronchioles. Respiration impossible, incompatible with life.
(weeks 5–17) Surrounded by modest capillary network.
Canalicular Terminal bronchioles respiratory bronchioles Airways increase in diameter.
(weeks 16–25) alveolar ducts. Surrounded by prominent Respiration capable at 25 weeks.
capillary network. Pneumocytes develop starting at 20 weeks.
Saccular Alveolar ducts terminal sacs. Terminal sacs
(week 26–birth) separated by 1° septae.
Alveolar Terminal sacs adult alveoli (due to 2° At birth: 20–70 million alveoli.
(week 36–8 years) septation). By 8 years: 300–400 million alveoli.
In utero, “breathing” occurs via aspiration
and expulsion of amniotic fluid vascular
resistance through gestation.
At birth, fluid gets replaced with air in
pulmonary vascular resistance.
Embryonic Fetal Postnatal
period period period
Alveolar
Saccular
Canalicular BIRTH
Pseudoglandular
Embryonic Surfactant
2 4 6 8 10 12 14 16 18 20 22 24 26 28 30 32 34 36 38 40 2 4 6 8
Weeks Years
Club cells Nonciliated; low columnar/cuboidal with secretory granules. Located in bronchioles. Degrade
toxins; secrete component of surfactant; act as reserve cells.
Type I
Neonatal respiratory Surfactant deficiency surface tension Screening tests for fetal lung maturity: lecithin-
distress syndrome alveolar collapse (“ground-glass” appearance sphingomyelin (L/S) ratio in amniotic fluid
A of lung fields) A . (≥ 2 is healthy; < 1.5 predictive of NRDS), foam
Risk factors: prematurity, maternal diabetes (due stability index, surfactant-albumin ratio.
to fetal insulin), C-section delivery ( release Persistently low O2 tension risk of PDA.
of fetal glucocorticoids; less stressful than 3
vaginal delivery). Mature
Concentration (mg %)
L/S ratio
Lec
10 Transitional
exogenous surfactant for infant.
tio Sph 1
Therapeutic supplemental O2 can result in 5 L/S ra ingo
mye
lin Immature
Retinopathy of prematurity, Intraventricular
hemorrhage, Bronchopulmonary dysplasia 20 26 30 35 40
(RIB). Gestational age (wk)
RESPIRATORY—ANATOMY
``
Respiratory tree
Conducting zone Large airways consist of nose, pharynx, larynx, trachea, and bronchi. Small airways consist of
bronchioles that further divide into terminal bronchioles (large numbers in parallel least airway
resistance).
Warms, humidifies, and filters air but does not participate in gas exchange “anatomic dead
space.”
Cartilage and goblet cells extend to the end of bronchi.
Pseudostratified ciliated columnar cells primarily make up epithelium of bronchus and extend to
beginning of terminal bronchioles, then transition to cuboidal cells. Clear mucus and debris from
lungs (mucociliary escalator).
Airway smooth muscle cells extend to end of terminal bronchioles (sparse beyond this point).
Respiratory zone Lung parenchyma; consists of respiratory bronchioles, alveolar ducts, and alveoli. Participates in gas
exchange.
Mostly cuboidal cells in respiratory bronchioles, then simple squamous cells up to alveoli. Cilia
terminate in respiratory bronchioles. Alveolar macrophages clear debris and participate in
immune response.
Conducting zone
Trachea
Goblet cell Basal cell Ciliated cell
Pseudostratified
ciliated columnar
epithelium
Smooth muscle
Bronchi
Cartilage
Simple ciliated
columnar epithelium
Bronchioles
Smooth muscle
Cuboidal
ciliated cells Club cell
Terminal
bronchioles
Simple cuboidal epithelium
Smooth muscle
Respiratory zone
Cuboidal
cells Club cell Squamous cell
Respiratory
bronchioles Simple cuboidal and
squamous epithelium
Smooth muscle
Type I pneumocyte
Type II pneumocyte
Alveolar sacs
Alveolar macrophage
Capillary
Lung anatomy Right lung has 3 lobes; Left has Less Lobes (2) and Lingula (homolog of right middle lobe). Instead
of a middle lobe, left lung has a space occupied by the heart A .
Trachea Upper lobe
Relation of the pulmonary artery to the bronchus at each lung hilum is described by RALS—Right
Anterior; Left Superior. Carina is posterior to ascending aorta and anteromedial to descending
Horizontal
fissure Oblique fissure
aorta B .
Right lung is a more common site for inhaled foreign bodies because right main stem bronchus is
wider, more vertical,
Middle lobe and shorter than the left. If you aspirate a peanut:
Lingula
Carina
While supine—usually enters right lower Lowerlobe. Lower
While Inferior
lying lobe
on right side—usually enters loberight upper lobe. lobe
Right Left
While upright—usually R enters right
L lower lobe. L R
bronchus bronchus Anterior view Posterior view
7 11
Pleura Lingula 8
T12
9 12
10 L1
ICS = intercostal space
11
A B
RUL LUL Ao
SVC PA
Ao
Carina
RML
RLL LLL
RESPIRATORY—PHYSIOLOGY
``
Ventilation
Minute ventilation Total volume of gas entering lungs per minute Normal values:
V E = V T × RR Respiratory rate (RR) = 12–20 breaths/min
Alveolar ventilation Volume of gas that reaches alveoli each minute V T = 500 mL/breath
VA = (V T − VD) × RR VD = 150 mL/breath
Lung and chest wall Elastic recoil—tendency for lungs to collapse Chest wall
inward and chest wall to spring outward. 6 TLC
Volume (L)
At FRC, airway and alveolar pressures equal
TV
atmospheric pressure (called zero), and FRC
intrapleural pressure is negative (prevents 2
atelectasis). The inward pull of the lung is Lung
balanced by the outward pull of the chest wall.
System pressure is atmospheric. PVR is at a 0
−20 −10 0 10 20 30 40
minimum. Transpulmonary static pressure (cmH2O)
Compliance—change in lung volume for a
change in pressure; expressed as ΔV/ΔP and is Compliant lungs comply (cooperate) and fill
inversely proportional to wall stiffness. High easily with air.
compliance = lung easier to fill (emphysema,
normal aging), lower compliance = lung
harder to fill (pulmonary fibrosis, pneumonia,
NRDS, pulmonary edema). Surfactant
increases compliance.
Hysteresis—lung inflation curve follows a
different curve than the lung deflation curve
due to need to overcome surface tension forces
in inflation.
Hemoglobin Hemoglobin (Hb) is composed of 4 polypeptide Fetal Hb (2α and 2γ subunits) has a higher
subunits (2 α and 2 β) and exists in 2 forms: affinity for O2 than adult Hb, driving diffusion
β2 β1
Deoxygenated form has low affinity for O2, of oxygen across the placenta from mother to
thus promoting release/unloading of O2. fetus. O2 affinity results from affinity of
Oxygenated form has high affinity for O2 HbF for 2,3-BPG.
(300×). Hb exhibits positive cooperativity Hemoglobin acts as buffer for H+ ions.
Heme
and negative allostery. Myoglobin is composed of a single polypeptide
α2 α1 Cl−, H+, CO2, 2,3-BPG, and temperature chain associated with one heme moiety.
favor deoxygenated form over oxygenated Higher affinity for oxygen than Hb.
form (shifts dissociation curve right O2
unloading).
Cyanide poisoning Usually due to inhalation injury (eg, fires). Inhibits aerobic metabolism via complex IV
inhibition hypoxia unresponsive to supplemental O2 and anaerobic metabolism. Findings:
almond breath odor, pink skin, cyanosis. Rapidly fatal if untreated. Treat with induced
methemoglobinemia: first give nitrites (oxidize hemoglobin to methemoglobin, which can trap
cyanide as cyanmethemoglobin), then thiosulfates (convert cyanide to thiocyanate, which is
renally excreted).
in
subsequent O2 molecule bound). Myoglobin 90 lob
og
My
is monomeric and thus does not show 80
Hb saturation (%)
Shifting the curve to the right Hb affinity 50 P50
for O2 (facilitates unloading of O2 to tissue)
40
P50 (higher Po2 required to maintain 50%
30
saturation).
Shifting the curve to the left O2 unloading 20
Hb (due to low affinity for 2,3-BPG), so its Left shift Right shift
( O₂ unloading to tissue) ( O₂ unloading to tissues)
dissociation curve is shifted left. Left = Lower Right shift – ACE Bats right handed
H+ ( pH, base) H+ ( pH, Acid)
PCO₂ PCO ₂
Exercise
2,3–BPG 2,3–BPG
High Altitude
Temperature Temperature
PAO₂ PaO₂
Perfusion limited
Partial pressure
PaO₂
Fibrosis (diffusion limited)
PACO₂ PaCO₂
Perfusion limited
PaCO
Diffusion limited
0
Length along pulmonary capillary
Pulmonary vascular Ppulm artery – PL atrium Ppulm artery = pressure in pulmonary artery
resistance PVR = PL atrium ≈ pulmonary capillary wedge pressure
cardiac output
Q = cardiac output (flow)
R = resistance
Remember: ΔP = Q × R, so R = ΔP / Q η = viscosity of blood
R = 8ηl / πr4 l = vessel length
r = vessel radius
Paco2
Alveolar gas equation Pao2 = PIo2 – Pao2 = alveolar Po2 (mm Hg)
R
PIo2 = Po2 in inspired air (mm Hg)
Paco2 Paco2 = arterial Pco2 (mm Hg)
≈ 150 mm Hga –
0.8 R = respiratory quotient = CO2 produced/O2
a At consumed
sea level breathing room air
A-a gradient = Pao2 – Pao2. Normal range =
10–15 mm Hg
A-a gradient may occur in hypoxemia; causes
include shunting, V̇/Q̇ mismatch, fibrosis
(impairs diffusion)
Oxygen deprivation
Hypoxia ( O2 delivery to tissue) Hypoxemia ( Pao2) Ischemia (loss of blood flow)
cardiac output Normal A-a gradient Impeded arterial flow
Hypoxemia High altitude venous drainage
Anemia Hypoventilation (eg, opioid use)
CO poisoning A-a gradient
V̇/Q̇ mismatch
Diffusion limitation (eg, fibrosis)
Right-to-left shunt
Carbon dioxide CO2 is transported from tissues to lungs in 3 In lungs, oxygenation of Hb promotes
transport forms: dissociation of H+ from Hb. This shifts
−
1 HCO (70%). equilibrium toward CO2 formation; therefore,
3
2 Carbaminohemoglobin or HbCO2 CO2 is released from RBCs (Haldane effect).
(21–25%). CO2 bound to Hb at N-terminus In peripheral tissue, H+ from tissue
of globin (not heme). CO2 favors metabolism shifts curve to right, unloading O2
deoxygenated form (O2 unloaded). (Bohr effect).
3 Dissolved CO2 (5–9%). Majority of blood CO2 is carried as HCO3− in
the plasma.
Cl– HCO3– 1
Tissue Plasma RBC
ll
Capillary wa
HHb H+ + Hb–
CO2 + Hb HbCO2 2
Dissolved CO2 3
Response to high atmospheric oxygen (PO2) Pao2 ventilation Paco2 respiratory alkalosis altitude
altitude sickness.
Chronic in ventilation.
erythropoietin Hct and Hb (due to chronic hypoxia).
2,3-BPG (binds to Hb causing left shift so that Hb releases more O2).
Cellular changes ( mitochondria).
renal excretion of HCO3− to compensate for respiratory alkalosis (can augment with
acetazolamide).
Chronic hypoxic pulmonary vasoconstriction results in pulmonary hypertension and RVH.
RESPIRATORY—PATHOLOGY
``
Rhinosinusitis Obstruction of sinus drainage into nasal cavity inflammation and pain over affected area.
A Typically affects maxillary sinuses, which drain against gravity due to ostia located superomedially
(red arrow points to fluid-filled right maxillary sinus in A ).
Orbit
Most common acute cause is viral URI; may lead to superimposed bacterial infection, most
Max
commonly S pneumoniae, H influenzae, M catarrhalis.
Infections in sphenoid or ethmoid sinuses may extend to cavernous sinus and cause complications
(eg, cavernous sinus syndrome).
Epistaxis Nose bleed. Most commonly occurs in anterior segment of nostril (Kiesselbach plexus). Life-
threatening hemorrhages occur in posterior segment (sphenopalatine artery, a branch of maxillary
artery). Common causes include foreign body, trauma, allergic rhinitis, and nasal angiofibromas
(common in adolescent males).
Kiesselbach drives his Lexus with his LEGS: superior Labial artery, anterior and posterior
Ethmoidal arteries, Greater palatine artery, Sphenopalatine artery.
Head and neck cancer Mostly squamous cell carcinoma. Risk factors include tobacco, alcohol, HPV-16 (oropharyngeal),
EBV (nasopharyngeal). Field cancerization: carcinogen damages wide mucosal area multiple
tumors that develop independently after exposure.
Deep venous Blood clot within a deep vein swelling, Most pulmonary emboli arise from proximal
thrombosis redness A , warmth, pain. Predisposed by deep veins of lower extremity.
A Virchow triad (SHE): Use unfractionated heparin or low-molecular-
Stasis (eg, post-op, long drive/flight) weight heparins (eg, enoxaparin) for
Hypercoagulability (eg, defect in prophylaxis and acute management.
coagulation cascade proteins, such as Use oral anticoagulants (eg, warfarin,
factor V Leiden; oral contraceptive use) rivaroxaban) for treatment (long-term
Endothelial damage (exposed collagen prevention).
triggers clotting cascade) Imaging test of choice is compression ultrasound
d-dimer lab test used clinically to rule out DVT with Doppler.
(high sensitivity, low specificity).
Pulmonary emboli V̇/Q̇ mismatch, hypoxemia, respiratory alkalosis. CT pulmonary angiography is imaging test of
Sudden-onset dyspnea, pleuritic chest pain, choice for PE (look for filling defects) C .
tachypnea, tachycardia. Large emboli or May have S1Q3T3 abnormality on ECG.
saddle embolus A may cause sudden death
due to electromechanical dissociation.
Lines of Zahn are interdigitating areas of pink
(platelets, fibrin) and red (RBCs) found only in
thrombi formed before death; help distinguish
pre- and postmortem thrombi B .
Types: Fat, Air, Thrombus, Bacteria, Amniotic An embolus moves like a FAT BAT.
fluid, Tumor.
Fat emboli—associated with long bone fractures
and liposuction; classic triad of hypoxemia,
neurologic abnormalities, petechial rash.
Air emboli—nitrogen bubbles precipitate
in ascending divers (caisson disease/
decompression sickness); treat with hyperbaric
O2; or, can be iatrogenic 2° to invasive
procedures (eg, central line placement).
Amniotic fluid emboli—can lead to DIC,
especially postpartum.
A B C
Flow-volume loops
FLOW-VOLUME PARAMETER Obstructive lung disease Restrictive lung disease
RV
FRC
TLC
FEV1
FVC
FEV1/FVC Normal or
FEV1 decreased more than FVC FEV1 decreased proportionately to FVC
OBSTRUCTIVE NORMAL RESTRICTIVE
Loop shifts to the left Loop shifts to the right
8 8 8
Expiration
4 4 4
Flow (L/sec)
Volume (L)
8 6 4 2 0 8 6 4 2 0 8 6 4 2 0
4 4 4
Inspiration
RV
VC
8 8 8
TLC
Obstructive lung Obstruction of air flow air trapping in lungs. Airways close prematurely at high lung
diseases volumes FRC, RV, TLC. PFTs: FEV1, FVC FEV1/FVC ratio (hallmark),
V̇/Q̇ mismatch. Chronic, hypoxic pulmonary vasoconstriction can lead to cor pulmonale. Chronic
obstructive pulmonary disease (COPD) includes chronic bronchitis and emphysema. “FRiCkin’
RV needs some increased TLC, but it’s hard with COPD!”
TYPE PRESENTATION PATHOLOGY OTHER
Chronic bronchitis Findings: wheezing, crackles, Hypertrophy and hyperplasia Diagnostic criteria: productive
(“blue bloater”) cyanosis (hypoxemia due of mucus-secreting glands cough for > 3 months in a
to shunting), dyspnea, CO2 in bronchi Reid index year for > 2 consecutive years.
retention, 2° polycythemia. (thickness of mucosal gland
layer to thickness of wall
between epithelium and
cartilage) > 50%. DLCO
usually normal.
Emphysema (“pink Findings: barrel-shaped chest Centriacinar—associated with CXR: AP diameter, flattened
puffer”) D , exhalation through pursed smoking A B . Frequently in diaphragm, lung field
lips (increases airway pressure upper lobes (smoke rises up). lucency.
and prevents airway collapse). Panacinar—associated with
α1-antitrypsin deficiency.
Frequently in lower lobes.
Enlargement of air spaces
recoil, compliance,
DLCO from destruction of
alveolar walls (arrow in C ).
Imbalance of proteases and
antiproteases elastase
activity loss of elastic
fibers lung compliance.
Asthma Findings: cough, wheezing, Hyperresponsive bronchi re Type I hypersensitivity
tachypnea, dyspnea, versible bronchoconstriction. reaction.
hypoxemia, inspiratory/ Smooth muscle hypertrophy Aspirin-induced asthma is
expiratory ratio, pulsus and hyperplasia, Curschmann a combination of COX
paradoxus, mucus spirals F (shed epithelium inhibition (leukotriene
plugging E . forms whorled mucous overproduction airway
Triggers: viral URIs, allergens, plugs), and Charcot-Leyden constriction), chronic sinusitis
stress. Diagnosis supported by crystals G (eosinophilic, with nasal polyps, and asthma
spirometry and methacholine hexagonal, double-pointed symptoms.
challenge. crystals formed from
breakdown of eosinophils in
sputum). DLCO normal or .
E F G H
Restrictive lung Restricted lung expansion causes lung volumes ( FVC and TLC). PFTs: FEV1/FVC ratio.
diseases Patient presents with short, shallow breaths.
A Types:
Poor breathing mechanics (extrapulmonary, peripheral hypoventilation, normal A-a gradient):
Poor muscular effort—polio, myasthenia gravis, Guillain-Barré syndrome
Poor structural apparatus—scoliosis, morbid obesity
Interstitial lung diseases (pulmonary diffusing capacity, A-a gradient):
Pneumoconioses (eg, coal workers’ pneumoconiosis, silicosis, asbestosis)
Sarcoidosis: bilateral hilar lymphadenopathy, noncaseating granuloma; ACE and Ca2+
Idiopathic pulmonary fibrosis A (repeated cycles of lung injury and wound healing with
collagen deposition, “honeycomb” lung appearance and digital clubbing)
Goodpasture syndrome
Granulomatosis with polyangiitis (Wegener)
Pulmonary Langerhans cell histiocytosis (eosinophilic granuloma)
Hypersensitivity pneumonitis
Drug toxicity (bleomycin, busulfan, amiodarone, methotrexate)
Hypersensitivity pneumonitis—mixed type III/IV hypersensitivity reaction to environmental
antigen. Causes dyspnea, cough, chest tightness, headache. Often seen in farmers and those
exposed to birds. Reversible in early stages if stimulus is avoided.
Liver
Sp
Pneumoconioses Asbestos is from the roof (was common in insulation), but affects the base (lower lobes).
Silica and coal are from the base (earth), but affect the roof (upper lobes).
Asbestosis Associated with shipbuilding, roofing, Affects lower lobes.
plumbing. “Ivory white,” calcified, Asbestos (ferruginous) bodies are golden-brown
supradiaphragmatic A and pleural B plaques fusiform rods resembling dumbbells C ,
are pathognomonic of asbestosis. found in alveolar sputum sample, visualized
Risk of bronchogenic carcinoma > risk of using Prussian blue stain, often obtained by
mesothelioma. bronchoalveolar lavage.
risk of pleural effusions.
Berylliosis Associated with exposure to beryllium in Affects upper lobes.
aerospace and manufacturing industries.
Granulomatous (noncaseating) D on histology
and therefore occasionally responsive to
steroids. risk of cancer and cor pulmonale.
Coal workers’ Prolonged coal dust exposure macrophages Affects upper lobes.
pneumoconiosis laden with carbon inflammation and Small, rounded nodular opacities seen on
fibrosis. imaging.
Also known as black lung disease. risk for Anthracosis—asymptomatic condition found in
Caplan syndrome (rheumatoid arthritis many urban dwellers exposed to sooty air.
and pneumoconioses with intrapulmonary
nodules).
Silicosis Associated with sandblasting, foundries, Affects upper lobes.
mines. Macrophages respond to silica “Eggshell” calcification of hilar lymph nodes on
and release fibrogenic factors, leading to CXR.
fibrosis. It is thought that silica may disrupt The silly egg sandwich I found is mine!
phagolysosomes and impair macrophages,
increasing susceptibility to TB. risk of
cancer, cor pulmonale, and Caplan syndrome.
A B C D
Mesothelioma Malignancy of the pleura associated with Psammoma bodies seen on histology.
A
asbestosis. May result in hemorrhagic pleural Calretinin ⊕ in almost all mesotheliomas, ⊝ in
effusion (exudative), pleural thickening A . most carcinomas.
Smoking not a risk factor.
Sleep apnea Repeated cessation of breathing > 10 seconds during sleep disrupted sleep daytime
somnolence. Diagnosis confirmed by sleep study. Normal Pao2 during the day.
Nocturnal hypoxia systemic/pulmonary hypertension, arrhythmias (atrial fibrillation/flutter),
sudden death.
Hypoxia EPO release erythropoiesis.
Obstructive sleep Respiratory effort against airway obstruction. Associated with obesity, loud snoring, daytime
apnea sleepiness. Caused by excess parapharyngeal tissue in adults, adenotonsillar hypertrophy in
children. Treatment: weight loss, CPAP, surgery.
Central sleep apnea Impaired respiratory effort due to CNS injury/toxicity, HF, opioids. May be associated with
Cheyne-Stokes respirations (oscillations between apnea and hyperpnea). Treat with positive
airway pressure.
Obesity Obesity (BMI ≥ 30 kg/m2) hypoventilation Paco2 during waking hours (retention); Pao2
hypoventilation and Paco2 during sleep. Also known as Pickwickian syndrome.
syndrome
Pulmonary Normal mean pulmonary artery pressure = 10–14 mm Hg; pulmonary hypertension ≥ 25 mm Hg
hypertension at rest. Results in arteriosclerosis, medial hypertrophy, intimal fibrosis of pulmonary arteries,
plexiform lesions. Course: severe respiratory distress cyanosis and RVH death from
decompensated cor pulmonale.
ETIOLOGIES
Pulmonary arterial Often idiopathic. Heritable PAH can be due to an inactivating mutation in BMPR2 gene (normally
hypertension inhibits vascular smooth muscle proliferation); poor prognosis. Pulmonary vasculature endothelial
dysfunction results in vasoconstrictors (eg, endothelin) and vasodilators (eg, NO and
prostacyclins).
Other causes include drugs (eg, amphetamines, cocaine), connective tissue disease, HIV infection,
portal hypertension, congenital heart disease, schistosomiasis.
Left heart disease Causes include systolic/diastolic dysfunction and valvular disease.
Lung diseases or Destruction of lung parenchyma (eg, COPD), lung inflammation/fibrosis (eg, interstitial lung
hypoxia diseases), hypoxemic vasoconstriction (eg, obstructive sleep apnea, living in high altitude).
Chronic Recurrent microthrombi cross-sectional area of pulmonary vascular bed.
thromboembolic
Multifactorial Causes include hematologic, systemic, and metabolic disorders, along with compression of the
pulmonary vasculature by a tumor.
Lung—physical findings
ABNORMALITY BREATH SOUNDS PERCUSSION FREMITUS TRACHEAL DEVIATION
Pleural effusion Dull None if small
Away from side of lesion
if large
Atelectasis (bronchial Dull Toward side of lesion
obstruction)
Simple pneumothorax Hyperresonant None
Tension Hyperresonant Away from side of lesion
pneumothorax
Consolidation Bronchial breath sounds; Dull None
(lobar pneumonia, late inspiratory crackles,
pulmonary edema) egophony, whispered
pectoriloquy
Pleural effusions Excess accumulation of fluid A between pleural layers restricted lung expansion during
inspiration. Can be treated with thoracentesis to remove/reduce fluid B .
Transudate protein content. Due to hydrostatic pressure (eg, HF) or oncotic pressure (eg, nephrotic
syndrome, cirrhosis).
Exudate protein content, cloudy. Due to malignancy, pneumonia, collagen vascular disease, trauma
(occurs in states of vascular permeability). Must be drained due to risk of infection.
Lymphatic Also known as chylothorax. Due to thoracic duct injury from trauma or malignancy. Milky-
appearing fluid; triglycerides.
A B
Pneumothorax Accumulation of air in pleural space A . Dyspnea, uneven chest expansion. Chest pain, tactile
fremitus, hyperresonance, and diminished breath sounds, all on the affected side.
Primary spontaneous Due to rupture of apical subpleural bleb or cysts. Occurs most frequently in tall, thin, young males
pneumothorax and smokers.
Secondary Due to diseased lung (eg, bullae in emphysema, infections), mechanical ventilation with use of
spontaneous high pressures barotrauma.
pneumothorax
Traumatic Caused by blunt (eg, rib fracture), penetrating (eg, gunshot), or iatrogenic (eg, central line
pneumothorax placement, lung biopsy, barotrauma due to mechanical ventilation) trauma.
Tension Can be from any of the above. Air enters pleural space but cannot exit. Increasing trapped air
pneumothorax tension pneumothorax. Trachea deviates away from affected lung B . Needs immediate needle
decompression and chest tube placement. May lead to intrathoracic pressure venous return
cardiac function.
A B
Pneumonia
TYPE TYPICAL ORGANISMS CHARACTERISTICS
Lobar pneumonia S pneumoniae most frequently, also Legionella, Intra-alveolar exudate consolidation A ; may
Klebsiella involve entire lobe B or the whole lung.
Bronchopneumonia S pneumoniae, S aureus, H influenzae, Acute inflammatory infiltrates C from
Klebsiella bronchioles into adjacent alveoli; patchy
distribution involving ≥ 1 lobe D .
Interstitial (atypical) Mycoplasma, Chlamydophila pneumoniae, Diffuse patchy inflammation localized to
pneumonia Chlamydophila psittaci, Legionella, viruses interstitial areas at alveolar walls; diffuse
(RSV, CMV, influenza, adenovirus) distribution involving ≥ 1 lobe E . Generally
follows a more indolent course (“walking”
pneumonia).
Cryptogenic Etiology unknown. Secondary organizing Formerly known as bronchiolitis obliterans
organizing pneumonia caused by chronic inflammatory organizing pneumonia (BOOP). Noninfectious
pneumonia diseases (eg, rheumatoid arthritis) or pneumonia characterized by inflammation of
medication side effects (eg, amiodarone). ⊝ bronchioles and surrounding structure.
sputum and blood cultures, no response to
antibiotics.
A B C D E
Lung abscess Localized collection of pus within Air-fluid levels B often seen on CXR. Fluid
A
parenchyma A . Caused by aspiration of levels common in cavities; presence suggests
oropharyngeal contents (especially in patients cavitation. Due to anaerobes (eg, Bacteroides,
predisposed to loss of consciousness [eg, Fusobacterium, Peptostreptococcus) or S aureus.
alcoholics, epileptics]) or bronchial obstruction Lung abscess 2° to aspiration is most often found
(eg, cancer). in right lung. Location depends on patient’s
Treatment: antibiotics. position during aspiration.
Pancoast tumor Also known as superior sulcus tumor. Carcinoma that occurs in the apex of lung A may cause
A
Pancoast syndrome by invading cervical sympathetic chain.
Compression of locoregional structures may cause array of findings:
Recurrent laryngeal nerve hoarseness
Stellate ganglion Horner syndrome (ipsilateral ptosis, miosis, anhidrosis)
1st rib
Superior vena cava SVC syndrome
Mass Brachiocephalic vein brachiocephalic syndrome (unilateral symptoms)
Brachial plexus sensorimotor deficits
RESPIRATORY—PHARMACOLOGY
``
N-acetylcysteine Mucolytic—liquifies mucus in chronic bronchopulmonary diseases (eg, COPD, CF) by disrupting
disulfide bonds. Also used as an antidote for acetaminophen overdose.
Dextromethorphan Antitussive (antagonizes NMDA glutamate receptors). Synthetic codeine analog. Has mild opioid
effect when used in excess. Naloxone can be given for overdose. Mild abuse potential. May cause
serotonin syndrome if combined with other serotonergic agents.
Pseudoephedrine, phenylephrine
MECHANISM α-adrenergic agonists, used as nasal decongestants.
CLINICAL USE Reduce hyperemia, edema, nasal congestion; open obstructed eustachian tubes.
ADVERSE EFFECTS Hypertension. Rebound congestion if used more than 4–6 days. Can also cause CNS stimulation/
anxiety (pseudoephedrine).
Asthma drugs Bronchoconstriction is mediated by (1) inflammatory processes and (2) parasympathetic tone;
therapy is directed at these 2 pathways.
β2-agonists Albuterol—relaxes bronchial smooth muscle (short acting β2-agonist). Used during acute
exacerbation.
Salmeterol, formoterol—long-acting agents for prophylaxis. Adverse effects are tremor and
arrhythmia.
Inhaled Fluticasone, budesonide—inhibit the synthesis of virtually all cytokines. Inactivate NF-κB, the
corticosteroids transcription factor that induces production of TNF-α and other inflammatory agents. 1st-line
therapy for chronic asthma. Use a spacer or rinse mouth after use to prevent oral thrush.
Muscarinic Tiotropium, ipratropium—competitively block muscarinic receptors, preventing
antagonists bronchoconstriction. Also used for COPD. Tiotropium is long acting.
Antileukotrienes Montelukast, zafirlukast—block leukotriene Exposure to antigen
receptors (CysLT1). Especially good for (dust, pollen, etc)
aspirin-induced and exercise-induced asthma.
Zileuton—5-lipoxygenase pathway inhibitor. Avoidance
Blocks conversion of arachidonic acid to
leukotrienes. Hepatotoxic.
Antigen and IgE Omalizumab
Anti-IgE monoclonal Omalizumab—binds mostly unbound serum on mast cells
therapy IgE and blocks binding to FcεRI. Used in
allergic asthma with IgE levels resistant to
Steroids
inhaled steroids and long-acting β2-agonists.
Bronchodilation AC β-agonists
Bronchial
Symptoms
hyperreactivity
cAMP
Bronchial tone
PDE Theophylline
AMP
ACh Adenosine
Muscarinic Theophylline
antagonists
Bronchoconstriction
Methacholine Nonselective muscarinic receptor (M3) agonist. Used in bronchial challenge test to help diagnose
asthma.