IR - PERPUSTAKAAN UNIVERSITAS AIRLANGGA

THE EFFECTS OF ROTAVIRUS VACCINE TO HISTOPATHOLOGICAL

OVERVIEW OF FEMALE RATS (Rattus norvegicus)
REPRODUCTIVE SYSTEM

Habba Nahril Labana Addafiqi

ABSTRACT

The purpose of this study is to determine the impact of giving rotavirus

vaccine against the overview of histopathological ovaries and uterus of female rats.
This study used 20 female rats as laboratory animals were divided into two
treatment groups, control group namely P0 that was given 1 ml solution of sucrose
and the treatment group namely P1 which was given 1 ml rotavirus vaccine.
Observation of histopathological description using scoring method according to the
Reproductive Toxicology journals with a few modifications. Analysis of the data
used non parametric statistics Mann-Whitney U test. The result showed that giving
of rotavirus vaccines there was histopathological changes in the endometrial of
uterus but not significant. In conclusion, that giving of rotavirus vaccines there was
not histopathological changes in the ovaries and uterus rats (Rattus norvegicus).

Keywords: vaccines, rotavirus, ovarium, uterus, pathology

vi

SKRIPSI PENGARUH PEMBERIAN VAKSIN ... HABBA NAHRIL LABANA ADDAFIQI