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(40%) in group A had an ejection fraction <50% versus 8 of 24 patients excised and mounted in a Langendorf retrograde perfussion system and
(33%) in group B . The number of patients with an ejection fraction <50% perfused for 30 minutes with Krebs-Henseleit buffer(stabilization period),
was significantly reduced in group A compared with group B at 1 and 3 and then applying 30 minutes ischemia followed by 60 minutes reperfu-
months after PCI, i.e. 11% versus 16% (p ¼ 0.046) at 1 month and 4% versus sion at 37C,pH 7.6 supplimented with 10mM glucose.Left ventricular
16% (p ¼ 0.017) at 3 months. developed pressure(LVDP),heart rate(H.R.) and coronary flow(C.F.) have
Conclusions: NAC, appears to minimize myocardial reperfusion injury been measured. Another objective of our study was evaluation of
during PCI and improves global and regional wall motion at 1 and 3 biochemical parameters of cardiac metabolism in hyperthyroid rat heart
months after PCI. i.e.: LDH,CK,SOD,GSH,GGT,plasma cholesterol, and total lipids
Results: There is a decrease in coronary flow in hyperthyroid rat heart
versus controls.In both cases there is a decrease of this parameter during
EAS16-0154, VASCULAR BIOLOGY: MYOCARDIAL INFARCTION, STROKE, reperfusion with lower values in controls and a tendency of reaching a
PERIPHERAL VASCULAR DISEASE. platau value. Hyperthyroidism is reflected by modification of plasma LDH 4
RELATIONSHIP BETWEEN LIPID DISORDERS AND SEVERITY AND times higher than in controls accounting for an increase in plasma and
NATURE OF CORONARY ARTERY LESIONS IN MALE PATIENTS WITH myocardial CK, but a decrease of SOD activity in myocardium may be in
CORONARY ARTERY DISEASE part serves as energy support for accelerated metabolism and installing
oxidative stress at this level.There is a decrease in GGT and an increase in
V. Kashtalap 1, O. Barbarash 2, O. Hryachkova 3, A. Novitskaya 4. 1 Research total lipids.
Institute for Complex Issues of Cardiovascular Diseases - Russian Acade, Conclusions: Because of low levels of total plasma cholesterol and of
Polyvascular atherosclerosis pathophysiology laboratory, Kemerovo, Russia; absence of a significant modification of lipid peroxides,hyperthyroid rat
2
Research Institute for Complex Issues of Cardiovascular Diseases - Russian heart is not a target for the atherogenic factors present in other forms of
Acade, Director, Kemerovo, Russia; 3 Research Institute for Complex Issues arterial hyperthension.
of Cardiovascular Diseases - Russian Acade, Laboratory of cells technology,
Kemerovo, Russia; 4 Research Institute for Complex Issues of Cardiovascular
Diseases - Russian Acade, Cardilogy department, Kemerovo, Russia EAS16-1019, VASCULAR BIOLOGY: MYOCARDIAL INFARCTION, STROKE,
PERIPHERAL VASCULAR DISEASE.
Objectives: To study the relationship between lipid disorders and the ACUTE ARTERIAL OCCLUSION OF APPARENTLY HEALTHY ARTERIES e A
severity and nature of coronary lesions in patients with coronary artery CONCLUSIVE EXPLANATION USING FRACTAL PHYSICS
disease.
D. Tesloianu 1, M. Agop 2, I. Nedelciuc 3. 1 Clinical Emergency Hospital “Sf.
Methods: 119 consecutive male patients admitted to the clinic with veri- Spiridon” Iasi, Cardiology, Iasi, Romania; 2 GH. Asachi Technical University
fied stable coronary artery disease were included in the study. The median Iasi, Physics, Iasi, Romania; 3 Institute of Cardiovascular Disease Iasi,
of patients age was 61 (55.5; 66.0) years. All patients underwent coronary Interventional Cardiology, Iasi, Romania
angiography with the severity assessment of coronary atherosclerosis ac-
cording to the number of diseased vessels and the SYNTAX score, and Objectives: The acute arterial occlusion of an artery that has no significant
multislice computed tomography with the quantitative calcium scoring preexistent lesions usually leads to dramatic consequences. In the present
index (CACS) calculation according to the Agatston method. The parame- paper, we propose the scale e relativity approach to analyze the blood flow
ters of lipid profile (total cholesterol and fractions) were measured in all dynamics.
patients. All patients received statins.
Results: The comparative analysis of lipid profile and number of the Methods: We prove through mathematical modeling that the blocking of
damaged coronary arteries was revealed the patients with three-vessels the lumen of an absolutely healthy artery can happen as a result of the
damage of coronary arteries the high-density lipoprotein cholesterol “stopping effect”, in the conditions of a normal sanguine circulation. This
(HDL-C) level was significant lower than in patients with one - and two- happens due to the fact that blood is a complex non-Newtonian fluid,
vessel damages. There was weak contradictory positive correlation be- travelling into the complex structure of the arterial system, with nonlinear
tween HDL-C level and CACS index. There were no significant relationships particle dynamics. In this context the hypothesis according to which blood
between the parameters of lipid profile (total cholesterol and its fractions) entities move on continuous yet non-differentiable curves (and particu-
and the severity of coronary lesions, assessed by the number of affected larly on fractal curves) becomes natural and moreover, lacking any con-
arteries and by the SYNTAX score, as well as coronary artery calcium tradictions. Analyzing these types of dynamic implies a scale-relativity
scoring. (SR) type of physics.
Conclusions: The further search for biomarkers in patients with coronary Results: Mathematical models prove the existence of the stopping effect in
artery disease with statin therapy, that reflect the severity of atheroscle- a normal arterial portion, an effect which appears through the auto
rosis and coronary calcification, is required because the traditional pa- structure of the normal sanguine flux. This happens in the absence of any
rameters of lipid profile have restrictions for the assessment of lesion of the arterial wall. Taking into consideration the temperature and
cardiovascular risk in these patients. viscosity variations that define the normal functioning of the human body,
we can easily understand the described phenomenon.
Conclusions: The purpose theory does not want to annul the classic
EAS16-0768, VASCULAR BIOLOGY: MYOCARDIAL INFARCTION, STROKE, modeling of the cracking of an atheroma plaque with major thrombosis
PERIPHERAL VASCULAR DISEASE. added in explaining the acute arterial occlusion, but we consider that the
PHYSIOLOGICAL AND BIOCHEMICAL PARAMETERS OF HYPERTHYROID mathematical modeling offers at least a thoroughly explained and hard to
RAT HEART DURING ISCHEMIA REPERFUSION contradict alternative.
Methods: Our study has been done on 10 male Wistar rats treated with Objectives: Autolysis is a mechanism to dispose the excessive blood clot in
T3(i.p. injections 4.5mg/kg body weight) for 4 weeks.Rat hearts have been our circulation. It is regulated by plasma protein called plasmin.Thrombus
e186 Abstracts / Atherosclerosis 252 (2016) e1ee196
autolysis in acute myocardial infarction can be recognized from the ECG Objectives: Cardiovascular morbidity is associated with dyslipidaemia,
that shows premature ventricular contraction, accelerated ventricular determined by serum lipids and lipoproteins. Conventional lipid profiling
rhytm, and couplet that resembles the reperfusion rhytm. This case report lacks analytical accuracy, particularly in hypertriglyceridemic (HTG) pa-
become important because served as a evidence of autolysis in STEMI tients. A quantitative proteomics assay was developed for detection and
patient that well documented from the ECG and proved by angiography quantification of six serum apolipoproteins, among them apolipoprotein
that rarely been documented before B100 (apoB), and qualitative apoE phenotyping. The total number of
atherogenic lipoprotein particles is reflected by serum apoB concentration.
Methods: Our patient 51-years-old male came with chief complain of This study aims to assess the value of quantitative serum apoB on long-
typical angina onset 11 hours accompanied by diaphoresis and nausea term re-infarction in HTG ST-elevated myocardial infarction (STEMI)
with no complication of the acute myocardial infarction. The risk factors patients.
for coronary artery disease in this patient were dyslipidemia, smoking, and
family history with CAD. The ECG showed STEMI in anteroseptoapico- Methods: Patients with STEMI from the MISSION! Intervention Study in
lateral wall with evolution and VES unifocal frequent with episode of 2004-2005 were analyzed. Patients with previous statin use or >65 years
couplet. While the patient being observed in the emergency room, the ECG were excluded. The association between baseline serum apoB and long-
rhytm turned into accelerated idioventricular that latter assesed as term re-infarction in HTG patients in comparison with LDLc according to
reperfusion rhytm that happen from autolysis mechanism in a patient that Friedewald (LDL-F) was investigated.
hasn’t been given trombolytic therapy. Results: In total, 55 (34%) of 161 included patients had triglyceride levels
Results: This autolysis then confirmed by angiography that done the next >2.0 mmol/L. Corrected for sex, both LDL-F [HR 2.2 (CI 1.1-4.7) p-val-
day which show multiple stenosis 80-90% in proximal-mid LAD from ue¼0.04] and apoB [HR 1.3 (CI 1.0-1.8) p-value¼0.04] are associated with
which in STEMI patient the stenosis use to be 100%. long-term re-infarction in normal triglyceride (NTG) patients. In HTG pa-
Conclusions: Autolysis doesn’t happen in all STEMI patient. There are tients, LDL-F was not associated with long-term re-infarction [HR 1.8 (CI
several factors that influence the incidence of autolysis such as the fre- 0.8-4.0) p-value¼0.13], whereas apoB association was borderline signifi-
quency of physical exercise and endothelial dysfunction (caused by dia- cant [HR 1.3 (CI 1.0-1.7) p-value¼0.08].
betes, smoking, hypertension). Conclusions: Baseline quantitative serum apoB is associated with long-
term re-infarction in NTG and borderline significant in HTG STEMI pa-
tients. LDL-F is associated with long-term re-infarction in NTG STEMI pa-
EAS16-0326, VASCULAR BIOLOGY: MYOCARDIAL INFARCTION, STROKE, tients only.
PERIPHERAL VASCULAR DISEASE.
VENOUS THROMBOEMBOLISM AND CORONARY SYNDROME