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(Key words: Guidelines of Sri Lanka College of Paediatricians, congenital hypothyroidism, management)
Neonatal screening for congenital hypothyroidism Decision to start treatment based on the venous
blood TFTs
• All babies should have a heel prick blood
screening test for thyroid stimulating • If venous fT4 concentration is below the
hormone (TSH) before discharge from the normal range for age, treatment should be
institution at which the birth took place. started immediately.
• Abnormal heel prick results should be • If venous TSH concentration is >20 mIU/L,
notified over the phone to the parents and the treatment should be started even if the fT4
relevant paediatrician, as soon as such results concentration is normal.
are available. • If venous TSH concentration is between 6-20
• Parents/Paediatrician should be notified mIU/L in a well-baby with a fT4
when the TSH level is over 20 mIU/L. concentration in the normal range for age,
• Preterm neonates, low-birth weight (LBW) o Repeat TFT in 2 weeks.
and very low-birth weight (VLBW) neonates o Perform an ultrasound scan (USS)
and ill preterm neonates admitted to neonatal of the thyroid gland.
intensive care units should have their o If a small/ectopic thyroid gland is
screening either before discharge or before 4 seen with TSH 6-20 mIU/L, then
weeks of age, whichever comes earlier. irrespective of fT4value, thyroxine
• Neonates treated with dopamine or therapy should be started.
dobutamine should have their screening test o If the thyroid gland is normal on
two weeks after stopping dopamine/ USS with a TSH 6-20 mIU/L and a
dobutamine.
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Guidelines on management of congenital hypothyroidism in Sri Lanka Sri Lanka J. Child Health 2015; 44(2):75-76
normal fT4, repeat TFT every two o 6 months to 12 months of life - fT4
weeks till TSH normalizes and TSH should be checked every 8
Imaging weeks.
o 1 year to 3 years of life - fT4 and
• All children with CH should have an USS of TSH should be checked every 3
the thyroid gland. months.
• If facilities are available, radioisotope o After 3 years till growth is
scanning should be done before starting completed - fT4 and TSH should be
treatment or within 3 days of starting checked every 6-12 months.
treatment. • Additional evaluations should be carried out
• Initiation of treatment should never be 4-6 weeks after any change in L-T4 dose.
delayed pending imaging. • Adequate treatment throughout childhood is
essential for normal growth and
Treatment and monitoring of CH development.
• Over-treatment should be avoided.
• Levothyroxine (L-T4) is the medication of • Anthropometry, including occipitofrontal
choice. circumference (OFC) measurements, and
• L-T4 should be initiated as soon as possible developmental assessments should be
and during the first 2 weeks after birth or monitored at each clinic visit.
immediately after confirmatory serum test
results are available. Thyroid re-evaluation
• Initial dose of L-T4 is 10-15µg/kg per day.
• L-T4 tablet should be crushed and given Thyroid re-evaluation should be considered in the
dissolved in a few millilitres of breast milk or following group of patients:
water.
• Thyroxine should be given early morning on • Those who had initial TSH >20 mIU/L with
an empty stomach and breast milk should be normal fT4 and normal USS.
withheld for 30-45 minutes after the • All preterm and sick babies who required
medication is administered. treatment.
• Parents should be provided with written • Those who had normal TSH levels
instructions regarding L-T4 treatment. immediately after commencing treatment.
Monitoring of dose and follow-up In these patients treatment should be continued till 3
years of age with regular clinical and biochemical
• Serum or plasma fT4 and TSH concentrations monitoring. In general transient hypothyroidism is
should be determined between 8.00-9.00 a.m. characterized by a marginally elevated TSH on
before the morning dose of L-T4. repeated testing, slightly low or normal fT4 and a low
• At the first follow-up visit 2 weeks after dose of L-T4 is required to maintain euthyroid status.
starting L-T4, the fT4 level should be checked
and the dose adjusted accordingly. Suggested procedure for re-evaluation is as follows:
• fT4 concentration should be maintained in the • Reduce dose of L-T4 by 30%.
upper half of the age-specific reference • Check TSH/ fT4 after 3 weeks.
range. • Repeat an USS of the thyroid gland.
• TSH should be maintained in the age-specific • If TSH >10mIU/L, CH is confirmed and
reference range. lifelong treatment needs to be given.
• Any reduction of L-T4 should not be based on • If CH is not confirmed, reduce L-T4 dose
a single increase in fT4 concentration during gradually with repeat TFTs at 3 weekly
treatment. intervals and stop treatment thereafter.
• Once TSH/ fT4 levels have normalized the • Repeat TFT after 3 months of stopping
suggested follow-up is as follows:- treatment.
o During the first 6 months of life - fT4
and TSH should be checked every 6
weeks.
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