Aspirin in Dogs

Variables #1 #2 #3 #4
60
Route IV IV PO PO
Dose (mg/kg) 10.0 10.0 10.0 10.0 50
Weight (kg) 24 24 24 24
Total Dose (mg)

µg/ml
240 240 240 240 40
Number of Doses 1 1 1 1
Dose Interval (Hrs) 30
12 12 12 12
Clt (l/hr/kg) 0.25 0.25 0.25 0.25
20
Vz (l/kg) 0.42 0.42 0.42 0.42
ka ( / hr) NA NA 3.5 3.5 10
F NA NA 0.99 0.99
Target Concentrations 0
MEC (µg/ml) 0 1 2 3 4 5 6 7 8 9 10
10
MTC (µg/ml) 50 Hours
Calculated Values
Iz ( / hr) 0.60 0.60 0.60 0.60
100
T1/2 (hrs) 1.16 1.16 1.16 1.16
Steady-State Calculated Values
Tmax (hrs) NA NA 0.71 0.71 10
µg/ml

Cmax (µg/ml) 23.8 23.8 16.3 16.3

Cave (µg/ml) 3.3 3.3 3.3 3.3
1
Cmin (µg/ml) 0.02 0.02 0.02 0.02
AUC (µg*hr / ml) 40.0 40.0 39.6 39.6
0.1

0.01
0 1 2 3 4 5 6 7 8 9 10

Hours

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