Académique Documents
Professionnel Documents
Culture Documents
Legend:
Insulin resistance
Disease process
Laboratory Values
↓ Insulin production in the beta cells of the pancreas
Signs and
symptoms Look: Cellular starvation
↓ Absorption of glucose by the cells
manifested by
the patient
Surgical
intervention
↑ Serum glucose level
Metformin
↑ Serum osmolarity
Numbness at
When glucose levels exceeds renal threshold affected site
Impaired renal
function Polyuria
Hypertension BUN: 55.3 (N. V: 4.6- 23.3 Hgb: 9.7 (N.V: 12-16 gms %), Hct:
mg/dL), Creatinine in serum: 27.4 (N.V: 37-47 vol%)
Blood pressure: 2.6 (N. V: 0.5-1.1 mg/dL)
160 / 90 mmHg
↓ Absorption of glucose by the cells
Cellular starvation
Gluconeogenesis
If it worsens: Breakdown of fat stores which is When fat is broken down in the body, it uses
normally stored in the cells more energy as compared to glucose
Free fatty acids are broken down Body goes in negative calorie effect
When the body needs energy, and glucose or fat are not
through beta oxidation pathway
available, proteins are broken down into amino acids Fatigue
Formation of ketone
bodies in the liver Nausea, vomiting,
poor appetite
Amino acids can be Amino acids can be
converted to glucose converted into energy Ketosis Domperidone
(gluconeogenesis)
worsening Acid-base balance:
hyperglycemia Use of proteins as decrease pH
energy will cause the
muscles or other
Metabolic acidosis
organs to breakdown
Nausea and vomiting,
abdominal pain, rapid
respirations (RR > 20 cpm)
Domperidone