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Material Safety Datasheet

Safety data sheet


Issue Date 21-Jan-2016 Revision Date 17-Nov-2015 Version 2

SECTION 1: Identification of the substance/mixture and of the company/undertaking


1.1. Product identifier
Product Name Phthalic Anhydride flakes
Chemical Name CAS No EC No REACH registration number
Phthalic anhydride 85-44-9 201-607-5 01-2119457017-41-0011

Pure substance/mixture Substance

1.2. Relevant identified uses of the substance or mixture and uses advised against
Industrial Manufacture of substances. Formulation and (re)packing of substances and mixtures.
Use as an intermediate and as a monomer for polymer formation.
Professional Laboratory chemicals.

Uses advised against Not identified.

1.3. Details of the supplier of the safety data sheet


Manufacturer

Perstorp Oxo AB
SE-444 84 Stenungsund
Sweden
Tel. +46 303 728600
Fax. +46 303 728607
www.perstorp.com

E-mail address productinfo@perstorp.com

1.4. Emergency telephone number


Europe (+)1 760 476 3961 (contract no: 334101)

United Kingdom (+)44 8 08 189 0979 (contract no: 334101)

SECTION 2: Hazards identification


2.1. Classification of the substance or mixture
Classification according to Regulation (EC) No. 1272/2008 [CLP]
Acute toxicity - Oral Category 4 - (H302)
Skin corrosion/irritation Category 2 - (H315)
Serious eye damage/eye irritation Category 1 - (H318)
Respiratory sensitisation Category 1 - (H334)
Skin sensitisation Category 1 - (H317)
Specific target organ toxicity (single exposure) Category 3 - (H335)

2.2. Label elements


Symbols/Pictograms

Signal word
Danger

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Phthalic Anhydride flakes Revision Date 17-Nov-2015
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Hazard statements
H302 - Harmful if swallowed
H315 - Causes skin irritation
H317 - May cause an allergic skin reaction
H318 - Causes serious eye damage
H334 - May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335 - May cause respiratory irritation

Precautionary Statements
P261 - Avoid breathing dust/fume/gas/mist/vapours/spray
P280 - Wear protective gloves/protective clothing/eye protection/face protection
P305 + P351 + P338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and
easy to do. Continue rinsing
P310 - Immediately call a POISON CENTER or doctor
P304 + P340 - IF INHALED: Remove person to fresh air and keep comfortable for breathing
P342 + P311 - If experiencing respiratory symptoms: Call a POISON CENTER or doctor

Contains: Phthalic anhydride

2.3. Other hazards


Risk for dust explosion at concentrations >35 g/m3.

SECTION 3: Composition/information on ingredients


3.1 Substances
Chemical Name EC No CAS No REACH registration Weight-% Classification according to
number Regulation (EC) No. 1272/2008
[CLP]
Phthalic anhydride 201-607-5 85-44-9 01-2119457017-41-0011 100 Acute Tox. 4 (H302)
Skin Irrit. 2 (H315)
Eye Dam. 1 (H318)
Resp. Sens. 1 (H334)
Skin Sens. 1 (H317)
STOT SE 3 (H335)

Full text of H- and EUH-phrases: see section 16

Additional information
No information available.

SECTION 4: First aid measures


4.1. Description of first aid measures
General advice Remove and isolate contaminated clothing and shoes.

Inhalation Remove to fresh air. If breathing is irregular or stopped, administer artificial respiration. If
symptoms persist, call a doctor.

Skin contact Immediately flush skin with water and rinse skin with soap and water for at least 5-10
minutes. Use lukewarm water if possible. Remove contaminated clothing and shoes. Get
medical attention if redness does not disappear.

Eye contact Important! Immediately rinse cautiously with tempered water for at least 15 minutes.
Remove contact lenses, if present and easy to do. Continue rinsing. Get medical
attention.

Ingestion Clean mouth with water and drink afterwards plenty of water. Get medical attention.

4.2. Most important symptoms and effects, both acute and delayed
Inhalation: Inhalation of dust may cause respiratory irriation, allergy or asthma symptoms.
Skin contact: Contact with skin and especially wet skin causes severe irritation. Prolonged exposure may as well cause an
allergic dermatitis.
Eye contact: Causes severe irritation with flood of tears and pain and strong redness and swelling of the eye. Risk of damage
to the conjunctiva and cornea.
Ingestion: May cause irritation of the mouth, throat, esophagus, and stomach including severe pain.
Phthalic Anhydride flakes Revision Date 17-Nov-2015
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4.3. Indication of any immediate medical attention and special treatment needed
Treat symptomatically

SECTION 5: Firefighting measures


5.1. Extinguishing media
Suitable extinguishing media
Use extinguishing measures that are appropriate to local circumstances and the surrounding environment.

Unsuitable extinguishing media


High volume water jet.

5.2. Special hazards arising from the substance or mixture


Thermal decomposition can lead to release of irritating and toxic gases and vapours: Carbon monoxide (CO). Carbon dioxide
(CO2).

5.3. Advice for firefighters


Wear self-contained breathing apparatus and protective suit.

SECTION 6: Accidental release measures


6.1. Personal precautions, protective equipment and emergency procedures
Keep unprotected persons away. Wear tightly sealed goggles, protective gloves and if dusty conditions dust filter mask (P2).
Avoid creating dust. In case of major spill contact the rescue services.

6.2. Environmental precautions


Do not allow into any sewer, on the ground or into any body of water. Local authorities should be advised if significant spillages
cannot be contained.

6.3. Methods and material for containment and cleaning up


Methods for containment
Cover with plastic sheet to prevent spreading.
Methods for cleaning up
Vacuum or sweep up material and place in a designated, labelled waste container. After cleaning, flush away traces with
water.

6.4. Reference to other sections


See Section 7,8,13 for more information.

SECTION 7: Handling and storage


7.1. Precautions for safe handling
Before handling, investigate the hazards and risk of using this product at your work place. Persons with a history of skin
sensitisation problems or asthma, allergies or chronic or recurrent respiratory disease should not handle this product. Ensure
adequate ventilation. Wear personal protective equipment according to section 8 if risk of exposure. In case dust is created
from flakes; dust may form an explosive mixture with air. Any unavoidable deposit of dust must be regularly removed. Use local
exhaust ventilation. Keep away from sources of ignition - No smoking. Take precautionary measures against static discharges.

General Hygiene Considerations


Take off all contaminated clothing and wash it before re-use. Wash hands before breaks and after work. Avoid contact with
skin, eyes or clothing.

7.2. Conditions for safe storage, including any incompatibilities


Keep containers tightly closed in a dry, cool and well-ventilated place.

Suitable container/equipment material: Keep/store only in original container.

7.3. Specific end use(s)


For details, see the separate exposure scenario(s).

SECTION 8: Exposure controls/personal protection


8.1. Control parameters
Exposure Limits
Keep personal exposure levels below Derived No Effect Level (DNEL) and national exposure limit values (if existing).
Chemical Name European Union United Kingdom
Phthalic Anhydride flakes Revision Date 17-Nov-2015
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Phthalic anhydride Not available TWA: 4 mg/m3


85-44-9 STEL: 12 mg/m3

Derived No Effect Level (DNEL) - worker


Phthalic anhydride (85-44-9)
Type Exposure route DNEL Remarks
Chronic effects, systemic Dermal 10 mg/kg bw/d
Chronic effects, systemic Inhalation 32.2 mg/m3

Derived No Effect Level (DNEL) - Consumer


Phthalic anhydride (85-44-9)
Type Exposure route DNEL Remarks
Chronic effects, systemic Oral 5 mg/kg bw/d
Chronic effects, systemic Dermal 5 mg/kg bw/d
Chronic effects, systemic Inhalation 8.6 mg/m3

Phthalic anhydride (85-44-9)


Environmental compartment Predicted No Effect Concentration Remarks
(PNEC)
Freshwater 1 mg/l
Intermittent 5.6 mg/l
Freshwater sediment 3.8 mg/kg dry weight
Marine water 0.1 mg/l
Marine sediment 0.38 mg/kg dry weight
Impact on Sewage Treatment 10 mg/l
Soil 0.173 mg/kg dry weight

8.2. Exposure controls


Appropriate engineering controls
Technical measures: Use only in adequate ventilation. If user operations generate dust, fumes, gas, vapour or mist, use
process enclosures, local exhaust ventilation or other engineering controls to keep worker exposure to airborne contaminants
below any recommended or statutory limits.

Individual protection measures, such as personal protective equipment


Eye/face protection Tight sealing safety goggles.
Hand Protection Wear protective nitrile rubber gloves. Ensure that the breakthrough time of the glove
material is not exceeded. Refer to glove supplier for information on breakthrough time for
specific gloves.
Skin and body protection Body protection must be chosen depending on activity and possible exposure, e.g.
apron, chemical resistant boots, chemical-protection suit.

Respiratory protection In case of brief exposure or low pollution use respiratory filter device. In case of intensive
or longer exposure use self-contained respiratory protective device.

Environmental exposure controls


Further information concerning special risk management measures: see annex of this safety data sheet (exposure scenarios).

SECTION 9: Physical and chemical properties


9.1. Information on basic physical and chemical properties
Appearance
Flakes
white
Odour Slight
Odour threshold No data available

Property Value Remar ks •Met hod


pH Not determined
Melting point / freezing point 131 °C OECD Test No. 102: Melting Point/ Melting Range
Boiling point / boiling range 285 °C OECD Test No. 103: Boiling Point
Flash point Not applicable
Evaporation rate No information available
Phthalic Anhydride flakes Revision Date 17-Nov-2015
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Flammability (solid, gas) Not flammable


Explosive limits
Upper explosive limits 10.5 %
Lower explosive limits 1.7 %
Vapour pressure 0.0006 hPa @ 26.6 °C

Vapour density Not applicable


Relative density 1.49 20°C, ISO 1183-1
Water solubility 5.4 g/L @ 20 °C OECD Test No. 105: Water Solubility
Solubility(ies) No information available
Partition coefficient -0.6 @ 20 °C, OECD Test No. 117: Partition
Coefficient (n-octanol/water), HPLC Method
Autoignition temperature 580 °C
Decomposition temperature Not applicable
Kinematic viscosity Not applicable
Dynamic viscosity Not applicable
Explosive properties Not explosive. May form explosive
mixtures with air
Oxidising properties Not oxidising.
Density No information available
Bulk density No information available

9.2. Other information


No information available.

SECTION 10: Stability and reactivity


10.1. Reactivity
There exists no specific test data for this product. For further information, see the subsequent subsections of this chapter.

10.2. Chemical stability


The product is stable at normal conditions. However, the product reacts with the moisture in the air to form phthalic acid.

10.3. Possibility of hazardous reactions


The product reacts with alkalis, alcohols, oxygen, oxidising agents, acids, nitrite and metallic oxides. Risk for dust explosion at
concentrations >35 g/m3.

10.4. Conditions to avoid


Avoid contact with humid air.

10.5. Incompatible materials


Incompatible with strong oxidizing agents, strong acids and bases, nitric acid and sodium nitrate.

10.6. Hazardous decomposition products


Thermal decomposition can lead to release of irritating and toxic gases and vapours: Carbon monoxide (CO) Carbon dioxide
(CO2)

SECTION 11: Toxicological information

11.1. Information on toxicological effects

Information on likely routes of exposure


Inhalation. Dermal.

Symptoms related to the physical, chemical and toxicological characteristics


See Section 4 for more information.

Numerical measures of toxicity


Acute toxicity
Harmful if swallowed.

Phthalic anhydride (85-44-9)


Method Species Exposure route Effective dose Remarks
Not defined Rat Oral 1530 LD50 (lethal dose)
Phthalic Anhydride flakes Revision Date 17-Nov-2015
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mg/kg
OECD Test No. 403: Acute Rat Inhalation >2.14 LC50 mg/l Aerosol
Inhalation Toxicity Maximum attainable
concentration

Skin corrosion/irritation
Irritating to skin.

Phthalic anhydride (85-44-9)


Method Species Exposure route Results:
OECD Test No. 404: Acute Dermal Rabbit Dermal Slightly irritating.
Irritation/Corrosion

Serious eye damage/eye irritation


Causes serious eye irritation. Risk of serious damage to eyes.

Phthalic anhydride (85-44-9)


Method Species Exposure route Results:
Not defined Rabbit Eye Irritating to eyes

Respiratory or skin sensitisation


May cause sensitisation by inhalation and skin contact.

Phthalic anhydride (85-44-9)


Method Species Exposure route Results:
OECD Test No. 406: Skin Guinea pig Skin Skin sensitization test (OECD
Sensitisation 406) on guinea pigs:
extremely sensitising
OECD Test No. 429: Skin Mouse Skin Skin sensitisation test Local
Sensitisation: Local Lymph Node Lymph Node Assay (OECD
Assay 429): sensitising
Not defined Guinea pig Inhalation Sensitising

Germ cell mutagenicity


Not mutagenic.

Phthalic anhydride (85-44-9)


Method Species Results:
OECD Test No. 471: Bacterial Reverse in vitro Negative
Mutation Test
OECD Test No. 476: In vitro Mammalian Cell in vitro Negative
Gene Mutation Test
In vitro Mammalian Chromosome Aberration in vitro Negative
Test

Carcinogenicity
Animal studies have not shown any carcinogenic potential.

Phthalic anhydride (85-44-9)


Method Species Exposure route Effective dose Remarks
Not defined 104w Mouse male Oral 3570 NOAEL mg/kg bw/d
Not defined 104w Mouse female Oral 1785 NOAEL mg/kg bw/d
Not defined 2y Rat Oral 1000 NOAEL mg/kg bw/d

Reproductive toxicity
There is no fertility study with phthalic anhydride available. No effects on reproductive organs were however observed in a oral
carcinogenicity study in rats and mice.

Phthalic anhydride (85-44-9)


Method Species Exposure route Effective dose Remarks
Not defined 104w Mouse male Oral 3570 NOAEL mg/kg bw/d
Results: Negative
Not defined 104w Mouse female Oral 1785 NOAEL mg/kg bw/d
Results: Negative
Not defined 2y Rat Oral 1000 NOAEL mg/kg bw/d
Phthalic Anhydride flakes Revision Date 17-Nov-2015
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STOT - single exposure Irritating to respiratory system

Phthalic anhydride (85-44-9)


Method Species Exposure route Effective dose Remarks
Not defined human data Inhalation - Irritating to respiratory
system

STOT - repeated exposure

Phthalic anhydride (85-44-9)


Method Species Exposure route Effective dose Remarks
Not defined 105w Rat Oral 500 NOAEL mg/kg bw/d

Aspiration hazard
No hazard from product as supplied.

SECTION 12: Ecological information


12.1. Toxicity
Low toxicity to aquatic organisms.

Phthalic anhydride (85-44-9)


Method Species Exposure route Effective dose Exposure time Remarks
OECD Test No. 210: Fish, Brachydanio rerio Freshwater 560 7d LC50 (lethal
Early-Life Stage Toxicity concentration) mg/l
Test
Not defined Cyprinus carpio Freshwater >500 48h LC50 (lethal
concentration) mg/l
EPA 660/3-75-009 Daphnia magna Freshwater >640 48h EC50 (effective
concentration) mg/l
Regulation (EC) No. Scenedesmus Freshwater >100 72h EC0 mg/l
440/2008, Annex, C.3 subspicatus
OECD Test No. 210: Fish, Oncorhynchus Freshwater 10 60d NOEC mg/l
Early-Life Stage Toxicity mykiss (rainbow
Test trout)
OECD Test No. 211: Daphnia magna Freshwater 16 21d NOEC mg/l
Daphnia magna
Reproduction Test

12.2. Persistence and degradability


Readily biodegradable.

Phthalic anhydride (85-44-9)


Method Value Exposure time Results:
Hydrolysis as a Function of pH 0.7 - Half-life time minutes pH:4,
25°C
Hydrolysis as a Function of pH 0.3 - Half-life time minutes pH 7,
25°C
Hydrolysis as a Function of pH 0.02 - Half-life time minutes pH 9,
25°C
OECD Test No. 301D: Ready 74% 30d Readily biodegradable
Biodegradability: Closed Bottle Test
(TG 301 D)
OECD Test No. 301C: Ready 85% 14d Readily biodegradable
Biodegradability: Modified MITI Test
(I) (TG 301 C)

12.3. Bioaccumulative potential


Not potentially bioaccumulable.

Chemical Name Partition coefficient Bioconcentration factor (BCF)


Phthalic anhydride -0.6 3.16

12.4. Mobility in soil


Phthalic Anhydride flakes Revision Date 17-Nov-2015
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The substance does not adsorb to suspended solids and sediment based upon the Koc which indicates a high mobility in soil.

Phthalic anhydride (85-44-9)


Method Koc Remarks
OECD 106 2-31

12.5. Results of PBT and vPvB assessment


This substance does not meet the criteria for classification as PBT or vPvB.

12.6. Other adverse effects


Emissions to water lowers the pH. This may cause local damage to fish and aquatic organisms in the discharge area.

SECTION 13: Disposal considerations


13.1. Waste treatment methods
Waste from residues/unused products
The product is classified as hazardous waste and must be disposed of as such. Incinerate at a licensed installation.

Contaminated packaging
Contaminated packaging materials must be disposed of in the same manner as the product.

Waste codes / waste designations according to EWC / AVV


Waste from residues/unused products: 16 03 05*.

Other Information
Waste codes should be assigned by the user based on the application for which the product was used.

SECTION 14: Transport information

ADR Road transport


14.1 UN number Not regulated
14.2 UN proper shipping name Not regulated
14.3 Transport hazard class(es) Not regulated
14.4 Packing Group Not regulated
14.5 Environmental hazard Not applicable
14.6 Special precautions for user None

RID Rail transport


14.1 UN number Not regulated
14.2 UN proper shipping name Not regulated
14.3 Transport hazard class(es) Not regulated
14.4 Packing Group Not regulated
14.5 Environmental hazard Not applicable
14.6 Special precautions for user None

IMDG Sea transport


14.1 UN number Not regulated
14.2 UN proper shipping name Not regulated
14.3 Transport hazard class(es) Not regulated
14.4 Packing Group Not regulated
14.5 Marine pollutant Not applicable
14.6 Special precautions for user None
14.7 Transport in bulk according No information available
to Annex II of MARPOL 73/78 and
the IBC Code

IATA Air transport


14.1 UN number Not regulated
14.2 UN proper shipping name Not regulated
14.3 Transport hazard class(es) Not regulated
14.4 Packing Group Not regulated
14.5 Environmental hazard Not applicable
14.6 Special precautions for user None
Phthalic Anhydride flakes Revision Date 17-Nov-2015
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SECTION 15: Regulatory information


15.1. Safety, health and environmental regulations/legislation specific for the substance or
mixture
International Regulations
European Union
Take note of Directive 98/24/EC on the protection of the health and safety of workers from the risks related to chemical agents
at work
Take note of Directive 94/33/EC on the protection of young people at work
Comply with Directive 94/9/EC concerning equipment and protective systems intended for use in potentially explosive
atmospheres and, Directive 1999/92/EC regarding minimum requirements for improving the safety and health protection of
workers potentially at risk from explosive atmospheres.

France
Chemical Name French RG number
Phthalic anhydride RG 66,RG 66bis
85-44-9
Germany
Water hazard class (WGK) slightly hazardous to water (WGK 1)
TA Luft (German Air Pollution Control Regulation)
Chemical Name Type Class
Phthalic anhydride - 85-44-9 5.2.5 0.10 kg/h Mass flow (Class I); 20 mg/m3
Mass concentration (Class I)
I

15.2. Chemical safety assessment


A Chemical Safety Assessment has been carried out for this substance.

SECTION 16: Other information


Key or legend to abbreviations and acronyms used in the safety data sheet

Full text of H-Statements referred to under section 3


H302 - Harmful if swallowed
H315 - Causes skin irritation
H318 - Causes serious eye damage
H334 - May cause allergy or asthma symptoms or breathing difficulties if inhaled
H317 - May cause an allergic skin reaction
H335 - May cause respiratory irritation

Issue Date 21-Jan-2016

Revision Date 17-Nov-2015

Revision Note SDS sections updated: 1.

This safety data sheet complies with the requirements of: Regulation (EC) No. 1907/2006, COMMISSION REGULATION
(EU) No. 453/2010 of 20 May 2010.

Disclaimer
The information provided in this Safety Data Sheet is correct to the best of our knowledge, information and belief at the date of its publication.
The information given is designed only as a guidance for safe handling, use, processing, storage, transportation, disposal and release and is
not to be considered a warranty or quality specification. The information relates only to the specific material designated and may not be valid
for such material used in combination with any other materials or in any process, unless specified in the text.

End of Safety Data Sheet


Annex to the Safety Data Sheet according to Regulation (EC) No 1907/2006
[REACH]
Product Name Phthalic Anhydride flakes
Chemical Name Phthalic anhydride
CAS No 85-44-9
EC No 201-607-5
REACH registration number 01-2119457017-41-0011
Pure substance/mixture Substance

Exposure scenario
Section 1 - Title
Title ES1 - Manufacture of substances.
Version 2
Product Name Phthalic Anhydride flakes
Revision Date 21-Jan-2016

Section 2 - Operational conditions and risk management measures


Section 2.1 - Control of environmental exposure

Environmental release category(ies) ERC1 - Manufacture of substances

Control of environmental exposure


Title Contributing Scenario [CS]
Environment
Environmental release categories ERC1 - Manufacture of substances
[ERC]
Remarks Sewage treatment plant used
Assumed domestic sewage treatment 2000 m3/d
plant flow
Removal efficiency (total) 87.3%
Sludge treatment No application of sewage sludge to soil
Can be landfilled or incinerated, when in compliance with local regulations
Technical onsite conditions and Wet scrubber - gas removal
measures to reduce or limit or
discharges, air emissions Incineration
Receiving surface water flow 20 000 m3/d

Section 2.2 - Control of worker exposure


Control of worker exposure
Title Contributing Scenario [CS]
worker
Process category(ies) PROC1 - Use in closed process, no likelihood of exposure
PROC2 - Use in closed, continuous process with occasional controlled exposure
PROC8b - Transfer of substance or preparation (charging/discharging) from/to
vessels/large containers at dedicated facilities
PROC9 - Transfer of substance or preparation into small containers (dedicated filling
line, including weighing)
Covers concentrations up to 100%
Physical form of product Flakes
Exposure duration Avoid carrying out operation for more than
8h/day
Use frequency 220
Product Name Phthalic Anhydride flakes
Version 2
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days per year


Technical conditions and measures Use in contained systems
to control dispersion from source Enclosed equipment
towards the worker Ensure that the worker is in a separated (control) room with independent air supply
PROC2, PROC8b, PROC9:
Use with local exhaust ventilation
Conditions and measures related to Use in contained systems
personal protection, hygiene and Personal measures have to be applied in case of potential exposure only
health evaluation Sampling
and
Material transfers
:
Worst case assumption
Protective clothing
Respiratory protection
See section 8 for more information
Organisational measures to prevent Ensure operatives are trained to minimise exposures
/limit releases, dispersion and Assumes a good basic standard of occupational hygiene is implemented
exposure Pre-employment screening and appropriate health surveillance
Indoor/Outdoor use Indoor

Section 3 - Exposure estimation


Environmental exposure

Environmental release category(ies) ERC1 - Manufacture of substances

Calculation method Used EUSES model


Environmental compartment predicted exposure level Risk characterisation ratio (RCR)
Freshwater 0.257
Freshwater sediment 0.316
Marine water 0.258
Marine sediment 0.312
Soil 0.015
Sewage treatment plant 0.253

Control of worker exposure

Calculation method Risk management measures are based on qualitative risk characterization
The ECETOC TRA tool has been used to estimate workplace exposures unless
otherwise indicated
Title Exposure route Calculation method predicted exposure Risk characterisation
level ratio (RCR)
Contributing Scenario [CS] Worker - dermal, 0.003
PROC1 long-term - systemic
Contributing Scenario [CS] Worker - inhalative, 0.000
PROC1 long-term - systemic
Contributing Scenario [CS] Worker - combined, 0.034
PROC1 long-term - systemic
Contributing Scenario [CS] Worker - dermal, 0.014
PROC2 long-term - systemic
Contributing Scenario [CS] Worker - inhalative, 0.000
PROC2 long-term - systemic
Contributing Scenario [CS] Worker - combined, 0.014
PROC2 long-term - systemic
Contributing Scenario [CS] Worker - dermal, 0.069
PROC8b long-term - systemic
Contributing Scenario [CS] Worker - inhalative, 0.000
PROC8b long-term - systemic
Contributing Scenario [CS] Worker - combined, 0.069
PROC8b long-term - systemic
Product Name Phthalic Anhydride flakes
Version 2
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Contributing Scenario [CS] Worker - dermal, 0.069


PROC9 long-term - systemic
Contributing Scenario [CS] Worker - inhalative, 0.000
PROC9 long-term - systemic
Contributing Scenario [CS] Worker - combined, 0.069
PROC9 long-term - systemic

Section 4 - Guidance to check compliance with the exposure scenario


Predicted exposures are not expected to exceed the applicable exposure limits (given in section 8 of the SDS) when the
operational conditions/risk management measures given in section 2 are implemented. Where other risk management
measures/operational conditions are adopted, then users should ensure that risks are managed to at least equivalent levels.
Guidance is based on assumed operating conditions which may not be applicable to all sites; thus, scaling may be necessary
to define appropriate site-specific risk management measures.
Annex to the Safety Data Sheet according to Regulation (EC) No 1907/2006
[REACH]
Product Name Phthalic Anhydride flakes
Chemical Name Phthalic anhydride
CAS No 85-44-9
EC No 201-607-5
REACH registration number 01-2119457017-41-0011
Pure substance/mixture Substance

Exposure scenario
Section 1 - Title
Title ES2 - Use as an intermediate. Industrial.
Version 2
Product Name Phthalic Anhydride flakes
Revision Date 21-Jan-2016
Sector(s) of use SU3 - Industrial uses: Uses of substances as such or in preparations at industrial sites
SU8 - Manufacture of bulk, large scale chemicals (including petroleum products)
SU9 - Manufacture of fine chemicals
Product category(ies) PC19 - Intermediate

Section 2 - Operational conditions and risk management measures


Section 2.1 - Control of environmental exposure

Environmental release category(ies) ERC6a - Industrial use resulting in manufacture of another


substance (use of intermediates)

Control of environmental exposure


Title Contributing Scenario [CS]
Environment
Environmental release categories ERC6a - Industrial use resulting in manufacture of another substance (use of
[ERC] intermediates)
Maximum daily site tonnage max 360 days/year, total: 579 500 tonnes/year
Remarks Sewage treatment plant used
Assumed domestic sewage treatment 2000 m3/day
plant flow
Removal efficiency (total) 87.3%
Sludge treatment No application of sewage sludge to soil
Can be landfilled or incinerated, when in compliance with local regulations
Technical onsite conditions and Wet scrubber - gas removal
measures to reduce or limit or
discharges, air emissions Incineration
Receiving surface water flow 20 000 m3/d

Section 2.2 - Control of worker exposure


Control of worker exposure
Title Contributing Scenario [CS]
worker
Process category(ies) PROC1 - Use in closed process, no likelihood of exposure
PROC2 - Use in closed, continuous process with occasional controlled exposure
PROC3 - Use in closed batch process (synthesis or formulation)
PROC4 - Use in batch and other process (synthesis) where opportunity for exposure
arises
Product Name Phthalic Anhydride flakes
Version 2
___________________________________________________________________________________________

PROC8b - Transfer of substance or preparation (charging/discharging) from/to


vessels/large containers at dedicated facilities
PROC9 - Transfer of substance or preparation into small containers (dedicated filling
line, including weighing)
Covers concentrations up to 100%
Physical form of product Flakes
Exposure duration Avoid carrying out operation for more than
8h/day
Use frequency 220
days per year
Technical conditions and measures Use in contained systems
to control dispersion from source Enclosed equipment
towards the worker Ensure that the worker is in a separated (control) room with independent air supply
PROC2, PROC3, PROC4, PROC8b, PROC9:
Use with local exhaust ventilation
Conditions and measures related to Use in contained systems
personal protection, hygiene and Personal measures have to be applied in case of potential exposure only
health evaluation Sampling
and
Material transfers
:
Worst case assumption
Protective clothing
Respiratory protection
See section 8 for more information
Organisational measures to prevent Ensure operatives are trained to minimise exposures
/limit releases, dispersion and Assumes a good basic standard of occupational hygiene is implemented
exposure Pre-employment screening and appropriate health surveillance
Indoor/Outdoor use Indoor

Section 3 - Exposure estimation


Environmental exposure

Environmental release category(ies) ERC6a - Industrial use resulting in manufacture of another


substance (use of intermediates)

Calculation method Used EUSES model


Environmental compartment predicted exposure level Risk characterisation ratio (RCR)
Freshwater 0.216
Freshwater sediment 0.266
Marine water 0.216
Marine sediment 0.266
Soil 0.026
Sewage treatment plant 0.253

Control of worker exposure

Calculation method Risk management measures are based on qualitative risk characterization
The ECETOC TRA tool has been used to estimate workplace exposures unless
otherwise indicated
Title Exposure route Calculation method predicted exposure Risk characterisation
level ratio (RCR)
Contributing Scenario [CS] Worker - dermal, 0.003
PROC1 long-term - systemic
Contributing Scenario [CS] Worker - inhalative, 0.000
PROC1 long-term - systemic
Contributing Scenario [CS] Worker - combined, 0.034
PROC1 long-term - systemic
Contributing Scenario [CS] Worker - dermal, 0.014
PROC2 long-term - systemic
Product Name Phthalic Anhydride flakes
Version 2
___________________________________________________________________________________________

Contributing Scenario [CS] Worker - inhalative, 0.000


PROC2 long-term - systemic
Contributing Scenario [CS] Worker - combined, 0.014
PROC2 long-term - systemic
Contributing Scenario [CS] Worker - dermal, 0.003
PROC3 long-term - systemic
Contributing Scenario [CS] Worker - inhalative, 0.000
PROC3 long-term - systemic
Contributing Scenario [CS] Worker - combined, 0.004
PROC3 long-term - systemic
Contributing Scenario [CS] Worker - dermal, 0.686
PROC4 long-term - systemic
Contributing Scenario [CS] Worker - inhalative, 0.002
PROC4 long-term - systemic
Contributing Scenario [CS] Worker - combined, 0.069
PROC4 long-term - systemic
Contributing Scenario [CS] Worker - dermal, 0.069
PROC8b long-term - systemic
Contributing Scenario [CS] Worker - inhalative, 0.000
PROC8b long-term - systemic
Contributing Scenario [CS] Worker - combined, 0.069
PROC8b long-term - systemic
Contributing Scenario [CS] Worker - dermal, 0.069
PROC9 long-term - systemic
Contributing Scenario [CS] Worker - inhalative, 0.000
PROC9 long-term - systemic
Contributing Scenario [CS] Worker - combined, 0.069
PROC9 long-term - systemic

Section 4 - Guidance to check compliance with the exposure scenario


Predicted exposures are not expected to exceed the applicable exposure limits (given in section 8 of the SDS) when the
operational conditions/risk management measures given in section 2 are implemented. Where other risk management
measures/operational conditions are adopted, then users should ensure that risks are managed to at least equivalent levels.
Guidance is based on assumed operating conditions which may not be applicable to all sites; thus, scaling may be necessary
to define appropriate site-specific risk management measures.
Annex to the Safety Data Sheet according to Regulation (EC) No 1907/2006
[REACH]
Product Name Phthalic Anhydride flakes
Chemical Name Phthalic anhydride
CAS No 85-44-9
EC No 201-607-5
REACH registration number 01-2119457017-41-0011
Pure substance/mixture Substance

Exposure scenario
Section 1 - Title
Title ES3 - Use as a monomer for polymer formation. Industrial.
Version 2
Product Name Phthalic Anhydride flakes
Revision Date 21-Jan-2016
Sector(s) of use SU3 - Industrial uses: Uses of substances as such or in preparations at industrial sites
SU10 - Formulation [mixing] of preparations and/or re-packaging (excluding alloys)
SU12 - Manufacture of plastics products, including compounding and conversion
Product category(ies) PC32 - Polymer preparations and compounds

Section 2 - Operational conditions and risk management measures


Section 2.1 - Control of environmental exposure

Environmental release category(ies) ERC6c - Industrial use of monomers for manufacture of


thermoplastics
ERC6d - Industrial use of process regulators for polymerisation
processes in production of resins, rubbers, polymers

Control of environmental exposure


Title Contributing Scenario [CS]
Environment
Environmental release categories ERC6c - Industrial use of monomers for manufacture of thermoplastics
[ERC] ERC6d - Industrial use of process regulators for polymerisation processes in production
of resins, rubbers, polymers
Maximum daily site tonnage max 360 days/year, total: 37 500 tonnes/year
Remarks Sewage treatment plant used
Assumed domestic sewage treatment 2000 m3/day
plant flow
Removal efficiency (total) 87.3%
Sludge treatment No application of sewage sludge to soil
Can be landfilled or incinerated, when in compliance with local regulations
Technical onsite conditions and Wet scrubber - gas removal
measures to reduce or limit or
discharges, air emissions Incineration
Receiving surface water flow 20 000 m3/d

Section 2.2 - Control of worker exposure


Control of worker exposure
Title Contributing Scenario [CS]
worker
Process category(ies) PROC1 - Use in closed process, no likelihood of exposure
PROC2 - Use in closed, continuous process with occasional controlled exposure
Product Name Phthalic Anhydride flakes
Version 2
___________________________________________________________________________________________

PROC3 - Use in closed batch process (synthesis or formulation)


PROC4 - Use in batch and other process (synthesis) where opportunity for exposure
arises
PROC8b - Transfer of substance or preparation (charging/discharging) from/to
vessels/large containers at dedicated facilities
PROC9 - Transfer of substance or preparation into small containers (dedicated filling
line, including weighing)
Covers concentrations up to 100%
Physical form of product Flakes
Exposure duration Avoid carrying out operation for more than
8h/day
Use frequency 220
days per year
Technical conditions and measures Use in contained systems
to control dispersion from source Enclosed equipment
towards the worker Ensure that the worker is in a separated (control) room with independent air supply
PROC2, PROC3, PROC4, PROC8b, PROC9:
Use with local exhaust ventilation
Conditions and measures related to Use in contained systems
personal protection, hygiene and Personal measures have to be applied in case of potential exposure only
health evaluation Sampling
and
Material transfers
:
Worst case assumption
Protective clothing
Respiratory protection
See section 8 for more information
Organisational measures to prevent Ensure operatives are trained to minimise exposures
/limit releases, dispersion and Assumes a good basic standard of occupational hygiene is implemented
exposure Pre-employment screening and appropriate health surveillance
Indoor/Outdoor use Indoor

Section 3 - Exposure estimation


Environmental exposure

Environmental release category(ies) ERC6c - Industrial use of monomers for manufacture of


thermoplastics
ERC6d - Industrial use of process regulators for polymerisation
processes in production of resins, rubbers, polymers

Calculation method Used EUSES model


Environmental compartment predicted exposure level Risk characterisation ratio (RCR)
Freshwater ERC6C 0.253
Freshwater sediment ERC6C 0.314
Marine water ERC6C 0.253
Marine sediment ERC6C 0.315
Soil ERC6C 0.352
Sewage treatment plant ERC6C 0.253
Freshwater ERC6D 0.39
Freshwater sediment ERC6D 0.489
Marine water ERC6D 0.39
Marine sediment ERC6D 0.484
Soil ERC6D 0.533
Sewage treatment plant ERC6D 0.39

Control of worker exposure

Calculation method Risk management measures are based on qualitative risk characterization
The ECETOC TRA tool has been used to estimate workplace exposures unless
Product Name Phthalic Anhydride flakes
Version 2
___________________________________________________________________________________________

otherwise indicated
Title Exposure route Calculation method predicted exposure Risk characterisation
level ratio (RCR)
Contributing Scenario [CS] Worker - dermal, 0.003
PROC1 long-term - systemic
Contributing Scenario [CS] Worker - inhalative, 0.000
PROC1 long-term - systemic
Contributing Scenario [CS] Worker - combined, 0.034
PROC1 long-term - systemic
Contributing Scenario [CS] Worker - dermal, 0.014
PROC2 long-term - systemic
Contributing Scenario [CS] Worker - inhalative, 0.000
PROC2 long-term - systemic
Contributing Scenario [CS] Worker - combined, 0.014
PROC2 long-term - systemic
Contributing Scenario [CS] Worker - dermal, 0.003
PROC3 long-term - systemic
Contributing Scenario [CS] Worker - inhalative, 0.000
PROC3 long-term - systemic
Contributing Scenario [CS] Worker - combined, 0.004
PROC3 long-term - systemic
Contributing Scenario [CS] Worker - dermal, 0.686
PROC4 long-term - systemic
Contributing Scenario [CS] Worker - inhalative, 0.002
PROC4 long-term - systemic
Contributing Scenario [CS] Worker - combined, 0.069
PROC4 long-term - systemic
Contributing Scenario [CS] Worker - dermal, 0.069
PROC8b long-term - systemic
Contributing Scenario [CS] Worker - inhalative, 0.000
PROC8b long-term - systemic
Contributing Scenario [CS] Worker - combined, 0.069
PROC8b long-term - systemic
Contributing Scenario [CS] Worker - dermal, 0.069
PROC9 long-term - systemic
Contributing Scenario [CS] Worker - inhalative, 0.000
PROC9 long-term - systemic
Contributing Scenario [CS] Worker - combined, 0.069
PROC9 long-term - systemic

Section 4 - Guidance to check compliance with the exposure scenario


Predicted exposures are not expected to exceed the applicable exposure limits (given in section 8 of the SDS) when the
operational conditions/risk management measures given in section 2 are implemented. Where other risk management
measures/operational conditions are adopted, then users should ensure that risks are managed to at least equivalent levels.
Guidance is based on assumed operating conditions which may not be applicable to all sites; thus, scaling may be necessary
to define appropriate site-specific risk management measures.
Annex to the Safety Data Sheet according to Regulation (EC) No 1907/2006
[REACH]
Product Name Phthalic Anhydride flakes
Chemical Name Phthalic anhydride
CAS No 85-44-9
EC No 201-607-5
REACH registration number 01-2119457017-41-0011
Pure substance/mixture Substance

Exposure scenario
Section 1 - Title
Title ES4 - Formulation and (re)packing of substances and mixtures.
Version 2
Product Name Phthalic Anhydride flakes
Revision Date 21-Jan-2016
Sector(s) of use SU3 - Industrial uses: Uses of substances as such or in preparations at industrial sites
SU10 - Formulation [mixing] of preparations and/or re-packaging (excluding alloys)

Section 2 - Operational conditions and risk management measures


Section 2.1 - Control of environmental exposure

Environmental release category(ies) ERC2 - Formulation of preparations (mixtures)

Control of environmental exposure


Title Contributing Scenario [CS]
Environment
Environmental release categories ERC2 - Formulation of preparations (mixtures)
[ERC]
Maximum daily site tonnage max 360 days/year, total: 47 500 tonnes/year
Remarks Sewage treatment plant used
Assumed domestic sewage treatment 2000 m3/d
plant flow
Removal efficiency (total) 87.3%
Sludge treatment No application of sewage sludge to soil
Can be landfilled or incinerated, when in compliance with local regulations
Technical onsite conditions and Wet scrubber - gas removal
measures to reduce or limit or
discharges, air emissions Incineration
Receiving surface water flow 20 000 m3/d

Section 2.2 - Control of worker exposure


Control of worker exposure
Title Contributing Scenario [CS]
worker
Process category(ies) PROC1 - Use in closed process, no likelihood of exposure
PROC2 - Use in closed, continuous process with occasional controlled exposure
PROC3 - Use in closed batch process (synthesis or formulation)
PROC4 - Use in batch and other process (synthesis) where opportunity for exposure
arises
PROC5 - Mixing or blending in batch processes for formulation of preparations and
articles (multi-stage and/or significant contact)
PROC8b - Transfer of substance or preparation (charging/discharging) from/to
Product Name Phthalic Anhydride flakes
Version 2
___________________________________________________________________________________________

vessels/large containers at dedicated facilities


PROC9 - Transfer of substance or preparation into small containers (dedicated filling
line, including weighing)
Covers concentrations up to 100%
Physical form of product Flakes
Exposure duration Avoid carrying out operation for more than
8h/day
Use frequency 220
days per year
Technical conditions and measures Use in contained systems
to control dispersion from source Enclosed equipment
towards the worker Ensure that the worker is in a separated (control) room with independent air supply
PROC2, PROC3, PROC4, PROC5, PROC8b, PROC9:
Use with local exhaust ventilation
Conditions and measures related to Use in contained systems
personal protection, hygiene and Personal measures have to be applied in case of potential exposure only
health evaluation Sampling
and
Material transfers
:
Worst case assumption
Protective clothing
Respiratory protection
See section 8 for more information
Organisational measures to prevent Ensure operatives are trained to minimise exposures
/limit releases, dispersion and Assumes a good basic standard of occupational hygiene is implemented
exposure Pre-employment screening and appropriate health surveillance
Indoor/Outdoor use Indoor

Section 3 - Exposure estimation


Environmental exposure

Environmental release category(ies) ERC2 - Formulation of preparations (mixtures)

Calculation method Used EUSES model


Environmental compartment predicted exposure level Risk characterisation ratio (RCR)
Freshwater 0.253
Freshwater sediment 0.308
Marine water 0.253
Marine sediment 0.303
Soil 0.36
Sewage treatment plant 0.253

Control of worker exposure

Calculation method Risk management measures are based on qualitative risk characterization
The ECETOC TRA tool has been used to estimate workplace exposures unless
otherwise indicated
Title Exposure route Calculation method predicted exposure Risk characterisation
level ratio (RCR)
Contributing Scenario [CS] Worker - dermal, 0.003
PROC1 long-term - systemic
Contributing Scenario [CS] Worker - inhalative, 0.000
PROC1 long-term - systemic
Contributing Scenario [CS] Worker - combined, 0.034
PROC1 long-term - systemic
Contributing Scenario [CS] Worker - dermal, 0.014
PROC2 long-term - systemic
Contributing Scenario [CS] Worker - inhalative, 0.000
PROC2 long-term - systemic
Product Name Phthalic Anhydride flakes
Version 2
___________________________________________________________________________________________

Contributing Scenario [CS] Worker - combined, 0.014


PROC2 long-term - systemic
Contributing Scenario [CS] Worker - dermal, 0.003
PROC3 long-term - systemic
Contributing Scenario [CS] Worker - inhalative, 0.000
PROC3 long-term - systemic
Contributing Scenario [CS] Worker - combined, 0.004
PROC3 long-term - systemic
Contributing Scenario [CS] Worker - dermal, 0.686
PROC4 long-term - systemic
Contributing Scenario [CS] Worker - inhalative, 0.002
PROC4 long-term - systemic
Contributing Scenario [CS] Worker - combined, 0.069
PROC4 long-term - systemic
Contributing Scenario [CS] Worker - dermal, 0.007
PROC5 long-term - systemic
Contributing Scenario [CS] Worker - inhalative, 0.002
PROC5 long-term - systemic
Contributing Scenario [CS] Worker - combined, 0.008
PROC5 long-term - systemic
Contributing Scenario [CS] Worker - dermal, 0.069
PROC8b long-term - systemic
Contributing Scenario [CS] Worker - inhalative, 0.000
PROC8b long-term - systemic
Contributing Scenario [CS] Worker - combined, 0.069
PROC8b long-term - systemic
Contributing Scenario [CS] Worker - dermal, 0.069
PROC9 long-term - systemic
Contributing Scenario [CS] Worker - inhalative, 0.000
PROC9 long-term - systemic
Contributing Scenario [CS] Worker - combined, 0.069
PROC9 long-term - systemic

Section 4 - Guidance to check compliance with the exposure scenario


Predicted exposures are not expected to exceed the applicable exposure limits (given in section 8 of the SDS) when the
operational conditions/risk management measures given in section 2 are implemented. Where other risk management
measures/operational conditions are adopted, then users should ensure that risks are managed to at least equivalent levels.
Guidance is based on assumed operating conditions which may not be applicable to all sites; thus, scaling may be necessary
to define appropriate site-specific risk management measures.
Annex to the Safety Data Sheet according to Regulation (EC) No 1907/2006
[REACH]
Product Name Phthalic Anhydride flakes
Chemical Name Phthalic anhydride
CAS No 85-44-9
EC No 201-607-5
REACH registration number 01-2119457017-41-0011
Pure substance/mixture Substance

Exposure scenario
Section 1 - Title
Title ES5 - Laboratory chemicals. Professional.
Version 2
Product Name Phthalic Anhydride flakes
Revision Date 21-Jan-2016
Sector(s) of use SU22 - Professional uses: Public domain (administration, education, entertainment,
services, craftsmen)
Product category(ies) PC21 - Laboratory chemicals

Section 2 - Operational conditions and risk management measures


Section 2.1 - Control of environmental exposure

Environmental release category(ies) ERC8a - Wide dispersive indoor use of processing aids in open
systems
ERC8b - Wide dispersive indoor use of reactive substances in
open systems

Control of environmental exposure


Title Contributing Scenario [CS]
Environment
Environmental release categories ERC8a - Wide dispersive indoor use of processing aids in open systems
[ERC] ERC8b - Wide dispersive indoor use of reactive substances in open systems
Waste management See Section 13 for additional waste treatment information

Section 2.2 - Control of worker exposure


Control of worker exposure
Title Contributing Scenario [CS]
worker
Process category(ies) PROC15 - Use as laboratory reagent
Covers concentrations up to 100%
Physical form of product Flakes
Exposure duration Avoid carrying out operation for more than
8h/day
Use frequency 220
days per year
Technical conditions and measures Use with local exhaust ventilation
to control dispersion from source
towards the worker
Conditions and measures related to Worst case assumption
personal protection, hygiene and Protective clothing
health evaluation Respiratory protection
See section 8 for more information
Product Name Phthalic Anhydride flakes
Version 2
___________________________________________________________________________________________

Organisational measures to prevent Ensure operatives are trained to minimise exposures


/limit releases, dispersion and Assumes a good basic standard of occupational hygiene is implemented
exposure
Indoor/Outdoor use Indoor

Section 3 - Exposure estimation


Environmental exposure

Environmental release category(ies) ERC8a - Wide dispersive indoor use of processing aids in open
systems
ERC8b - Wide dispersive indoor use of reactive substances in
open systems

Calculation method Used EUSES model


Environmental compartment predicted exposure level Risk characterisation ratio (RCR)
Freshwater ERC8a 0.002
Freshwater sediment ERC8a 0.002
Marine water ERC8a 0.013
Marine sediment ERC8a 0.0013
Soil ERC8a 0.622
Sewage treatment plant ERC8a 0.439
Freshwater ERC8b 0.000
Freshwater sediment ERC8b 0.000
Marine water ERC8b 0.000
Marine sediment ERC8b 0.000
Soil ERC8b 0.026
Sewage treatment plant ERC8b 0.015

Control of worker exposure

Calculation method Risk management measures are based on qualitative risk characterization
The ECETOC TRA tool has been used to estimate workplace exposures unless
otherwise indicated
Title Exposure route Calculation method predicted exposure Risk characterisation
level ratio (RCR)
Contributing Scenario [CS] Worker - dermal, 0.003
PROC15 long-term - systemic
Contributing Scenario [CS] Worker - inhalative, 0.000
PROC15 long-term - systemic
Contributing Scenario [CS] Worker - combined, 0.004
PROC15 long-term - systemic

Section 4 - Guidance to check compliance with the exposure scenario


Predicted exposures are not expected to exceed the applicable exposure limits (given in section 8 of the SDS) when the
operational conditions/risk management measures given in section 2 are implemented. Where other risk management
measures/operational conditions are adopted, then users should ensure that risks are managed to at least equivalent levels.
Guidance is based on assumed operating conditions which may not be applicable to all sites; thus, scaling may be necessary
to define appropriate site-specific risk management measures.