HOST AGENT ENVIRONMENT

Age : <15 years old

Genetic alteration

ALVEOLAR (ARMS)
EMBRYONIC
(ERMS)
Cytogenic translocation

85% [t(2:13] 10% [t(1:13)]

Affects biologic activity

at the level of:
- protein function
- gene expression

- control of cell growth

- apoptosis
BIOPSY :
- differentiation
MRI :
- motility

Tumorigenic behavior

Painless growth of tumor

Skeletal (striated) muscle

24% GUT 20% Extremities 20% Head & Neck 16% parameningeal 22% other sites