Dosage,
Route,
Name of Drug Mechanism of Action
Frequency &
Timing
Generic: Dosage: Binds to dihydropyridine
10mg/ day and nondihydropyridine
cell membrane receptor
amlodipine sites on myocardial and
vascular smooth-muscle
Brand: Route: cells and inhibits influx of
extracellular calcium ions
Norvasc Oral across slow calcium
channels. This decreases
Frequency: intracellular calcium
level, inhibiting smooth-
O.D muscle cell contractions
and relaxing coronary
and vascular smooth
Timing: muscles, decreasing
8 peripheral vascular
resistance, and reducing
systolic and diastolic
blood pressure.
Decreased peripheral
vascular resistance also
decreases myocardial
workload, oxygen
demand, and possibly
angina.
Classification
Functional:
Nursing
Indication Adverse Reactions Special Precautions
Responsibilities
Management of CNS: Anxiety, dizziness, Assess if patient is Monitor vital signs
hypertension, fatigue, headache, allergic or
chronic stable lethargy, light- hypersensitive to the Obtain history of
angina, vasospastic headedness, drug. patient’s previous
(Prinzmetal’s or paresthesia, medication to avoid
variant) angina. somnolence, syncope, Patient with heart interactions.
tremor block, heart failure,
CV: Arrhythmias, impaired renal Monitor blood
hypotension, function, hepatic pressure while
palpitations, disorder, or severe adjusting dosage,
peripheral edema aortic stenosis. especially in patients
EENT: Dry mouth, with heart failure or
pharyngitis severe aortic
ENDO: Hot flashes stenosis
GI: Abdominal cramps,
abdominal pain, Educate to take
constipation, diarrhea, missed dose as soon
esophagitis, as remembered and
indigestion,nausea next dose in 24
GU: Decreased libido, hours.
impotence, urinary
frequency Educate to
MS:Myalgia immediately notify
RESP: Dyspnea prescriber of
SKIN: Dermatitis, dizziness, arm or leg
flushing, rash swelling, difficulty
Other:Weight loss breathing, hives, or
Contraindications Side Effects rash.
Hypersensitivity to Frequent (greater than
Take amlodipine
Antihypertensive amlodipine or its 5%): Peripheral edema, with food
components. headache, flushing.
Hepatic impairment, Occasional (5%– Monitor blood
Chemical: aortic stenosis, 1%):Dizziness, pressure to rule out
hypertophic palpitations, nausea, hypotension
Dihydropyridine cardiomyopathy unusual fatigue or
with weakness (asthenia). Ensure compliance
outflow tract Rare (less than 1%): to medication.
obstruction. Chest pain,
bradycardia,orthostatic
hypotension.