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EPITOMES

sensori-neural or cochlear on the basis of the pure The Significance of Post-irradiation


tone audiogram. This, however, does not describe Edema of the Larynx
the site of lesion other than to exclude middle or
outer ear involvement. Retrocochlear lesions may VARIABLE DEGREES of laryngeal edema often ac-
company curative dose, full course radiation ther-
occur at any point beyond the cochlea on the
apy for cancer of the larynx. This edema usually
auditory pathways such as the 8th nerve, brain
stem or auditory cortex. Various audiometric tests subsides within a month or two. However, persis-
have been designed to differentiate between these tence of significant edema of the larynx beyond
pathologic conditions. Each presents a specific six months after completion of radiation therapy
listening task which increases in difficulty. Otol- makes careful inspection and evaluation of the
ogists and audiologists have been encouraged by larynx difficult. A thorough search for tumor in
finding that there is a high correlation between such cases appears warranted. In 11 of our 14
these clinical tests results and the medical-surgi- most recent cases of "persistent edema," residual
or recurrence eventually was proved to be present.
cal findings. SEYMOUR J. BROCKMAN, MD
The edema is believed to be secondary to in-
REFERENCES creased vascular permeability and obstruction of
Smith BB, Resnick DM: An auditory test for assessing brain the small veins and lymph channels from hyaline
stem integrity. Preliminary report. Laryngoscope 82:414-424, Mar
1972 degeneration of their walls. These radiation
Berlin C: Dichotic speech perception. An interpretation of right
ear advantage and temporal offset effects. J Acoust Soc Am 53,
Mar 1973
changes facilitate the obstruction to the passage
Jerger J: Clinical experience with impedance audiometry. Arch of tumor cells through the lymphatic channels.
Otolaryngol 92:311-324, 1970 Less likely factors that may be responsible for
"persistent postradiation edema" are previous
A Protocol for Evaluating Dizziness laryngeal operation, infection, and perichondritis.
A PROTOCOL has been established for the evalua- Keeping the delayed development of edematous
tion of a dizzy patient when there is any suggestion larynx under observation until tumor manifesta-
that the dizziness may be related to the inner ear. tions are clinically apparent diminishes the chance
This protocol includes hearing tests, vestibular for curative operation. Diligence is called for
tests and x-rays of the inner ear. If these tests fail when confronted with the diagnostic dilemma of
to show an otologic reason for the dizziness, then "delayed edema." When evaluating such a pa-
it is suggested that the patient have a five-hour tient, repeated biopsy, then exploration via laryn-
glucose tolerance test, thyroid studies, FTA/Abs gofissure are indicated in order to confirm the
studies and, in some cases, an allergic evaluation. high diagnostic probability of residual or recurrent
carcinoma.
These studies will often give a clue to a treatable PAUL H. WARD, MD
cause of dizziness. WILLIAM F. HOUSE, MD REFERENCES
REFERENCES Calcaterra TC, Stern F, Ward PH: Dilemma of delayed radia-
tion injury of the larynx. Ann Otol Rhinol Laryngol 81:501-507,
Sheehy JL: The neuro-otologic evaluation. Arch Otolaryngol 88: Aug 1972
592-597, 1968 Manara G: Histological changes of the human larynx irradiated
Powers HP, House WF: The dizzy patient-allergic aspect. with various technical therapeutic methods. Arch Ital Otol 79:
Laryngoscope 79:1330-1339, 1969 596-635, 1968

ADVISORY PANEL TO THE SECTION ON OTOLARYNGOLOGY


HERBERT DEDO, MD, Chairman, San Francisco
RICHARD GOODE, MD F. BLAIR SIMMONS, MD FRANCIS A. Sooy, MD
CMA Section on Otolaryngology Stanford University University of California, San Francisco
Chairman LESLIE BERNSTEIN, MD
Stanford University ALDEN H. MILLER, MD
University of California, Davis University of Southern California
WILLIAM SIMPSON, MD HOWARD HOUSE, MD Los Angeles
CMA Section on Otolaryngology Los Angeles
Secretary SEYMOUR BROCKMAN, MD
Los Angeles ROBERT I. KOHUT, MD CMA Scientific Board
MANSFIELD SMITH, MD University of California, Irvine
California College of Medicine DALE TIPTON, MD
CMA Section on Otolaryngology San Francisco
Assistant Secretary PAUL H. WARD, MD
San Jose University of California, Los Angeles MAURICE SCHIFF, MD
La Jolla
ROBERT ROWE, MD ALAN NAHUM, MD
Loma Linda University University of California, San Diego

66 JANUARY 1974 * 120 * 1

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