The most common method is to effectively create an infinite periodic array.

Create a box around

your single metamaterial element, such as an split ring resonator (SRR). Assign the front and
back faces of the box as waveport excitations with vertically oriented E-fields. Assign the top and
bottom faces as PEC. Assign the two side faces of the box as PMC. Set the solution frequency as
the highest frequency that you wish to simulate. Run HFSS simulation until you hit a reasonable
converge criteria. Run frequency sweep over a given frequency range given range using the Fast
Sweep. Plot two-port S-parameters.