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General Biochemistry I
TuTh 11:30-1:00, SW102
James M. Briggs, Ph.D. Purdue University.
C
Computer modeling;
d li computer-aided
id d drug
d design;
d i
Protein structure/function
http://adrik.bchs.uh.edu/bchs3304
p ((course home ppage)
g )
Office Room 402D Houston Science Center
Office hours M:10:30-11:30, Tu:10:30-11:30 or by appointment
Office phone: 713-743-8366 E-mail jbriggs@uh
jbriggs@uh.edu
edu
E-mail is the best way to reach me!
3 Exams and a Comprehensive Final (See Syllabus)
100 90 A;
100-90 A 8989.9-89.0
9 89 0 A-;
A 88.9-88.0
88 9 88 0 B+;
B 87.9-80
87 9 80 B;
B 79.9-79.0
79 9 79 0 B-;
B 78.9-
78 9
78.0 C+; 77.9-70 C; 69.9-69.0 C-; 68.9-68.0 D+; 67.9-60 D; and < 60 F.
Weekly Homework - to be COMPLETED but not turned in!!!
Good performance on the Final Exam can reduce poorer 1
performance on ONE earlier exam
Letters of Recommendation
•Think about this NOW! From whom will you ask for letters in the
future?
•Asking for a letter from an instructor who does not know you hurts your
application!
•Make sure that your future potential letter writers know you,
you inside
AND outside of class.
•Discuss your future career plans with your potential letter writers.
I i
•Investigate the
h review
i criteria
i i forf applications
li i andd make
k sure that
h your
resume and your letter writers have information about you in those
categories,
g for example:
p
•Leadership
•Communication (written and verbal)
Professionalism
•Professionalism
•Ability to adapt
2
•I will NOT write a letter for a student whom I do not know.
The Exams are based on the book, class notes, and homework.
Those who do the homework honestly and persistently will earn the
better grades.
I encourage group homework and study sections (groups of 3-4 are the
best size). But each person in a group must pull their own weight.
C
Copying
i theh homework
h k andd not fully
f ll participating
i i i cheats
h yourself.
lf
You will need to know the material! You can not just be familiar with it.
it
You will need to study about 2-3 hours a day!
This is an upper-level PROFESSIONAL COURSE
Virtually all figures used in these class notes were taken from the
i t t CD provided
instructor id d with
ith the
th class
l textbook
t tb k (Voet,
(V t Voet,
V t andd Pratt).
P tt)
3
I am not, in any way, taking credit for having created these figures!
Scantron answer keys to the exams may be placed on the course web
site.
site
Worked exams may be placed in glass cabinets in the hallway on the way
to my office.
S
Scores ffor th
the exams will
ill be
b placed
l d on the
th course webb site.
it
Please take advantage of the tutoring and review services in the Dept. of
Biology and Biochemistry - visit the Advising Office located in the Old
Science Building, Room, 116.
Iw
will TRY,, bu
but do not
o promise,
p o se, too have
ve thee course
cou se notes
o es available
v b e on o thee
class web site by 5:00 in the afternoon the day before the lecture is given.
You MUST attend everyy lecture! Chronic lack of attendance will
severely impact your course grade.
You MUST take ALL exams. NO exams are dropped. There are NO
makeups. There is NO extra credit.
4
Chapter 1: Intro to the Chemistry of Life
Biochemistry is the study of the chemistry of life.
Biochemistryy is an interdisciplinary
p y science overlapping
pp g with chemistry,
y,
cell biology, genetics, immunology, microbiology, pharmacology, and
physiology.
Main issues of Biochemistry
These physical laws describe several axioms that make up the Molecular
Logic of Life. These axioms define
7
Prebiotic World
Early atmosphere probably consisted of H2O, O N2, CO2,
with small amounts of CH4, NH3, SO2, and H2
Sparking of a mixture of CH4, NH3, H2O, and H2 for 1
weekk yielded
i ld d (Stanley
(St l Miller
Mill andd Harold
H ld Urey)
U )
•Acids (formic, glycolic, lactic, propionic, acetic,
succinic, aspartic, glutamic, etc.)
•Amino acids (glycine, alanine, aspartic, glutamic)
•Others (urea, sarcosine, N-methyl-alanine, N-methyl-
urea etc.)
urea, etc )
12
E. coli
13
Prokaryotes and Eukaryotes
•All
All modern organisms are based on the same morphological unit,
unit the
cell
•Prokaryotes
P k t – lack
l k a nucleus
l (e.g.,
( b t i archaea)
bacteria, h )
•Eukaryotes – membrane enclosed nucleus encapsulating their DNA,
animals, plants, fungi
•Viruses are not cells and are not living since they lack the apparatus to
reproduce outside of their host cells
16
Eukaryotic Cell
17
Taxonomy:
biological
g
classification
Phylogeny:
evolutionary
18
history
How do organisms evolve?
1. Evolution is not directed toward a particular goal.
It proceeds via random changes. Organisms that are better suited
to their environment flourish.
2. Evolution requires
q some built-in sloppiness.
pp
This is the source of the “random changes”. It allows for
adjustment to unforeseen changes in the environment.
4. Evolution is ongoing.
Not always
y toward increasingg complexity.
p y
19
Physical Units of Space, Time, and Energy.
LENGTH
Y mustt know
You k thi andd be
this b comfortable
f t bl using
i them.
th
aA bB cC dD
[C ]c [ D ]d
G G 0 RT ln
[ A]a [ B ]b
At equilibrium, G=0 so G0 = -RT ln Keq
[C ]ceq [ D]eq
d
K eq e G 0 / RT
[ A]eq
a [ B ]b
eq 27
Each step of a biochemical process is not
required
i d to be
b exergonic.
i
As long as the overall pathway is exergonic,
it will operate in a forward manner.
• Work assigned
g Chapter
p 1 pproblems.
– Book: 1, 5-14
Companion: 14, 16a, 16c
• We will work some of them next time in class
• Read Chapter 2 - We will cover most of it next
time in class.
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