Cancer risk among firefighters: a review and meta-analysis of 32 studies. - PubMed - NCBI Page 1 of 2 PubMed vy Format: Abstract Full toxt links ®@ Wolters kiuwer| J Occup Environ Med, 2006 Nov;48(11):1189-202. Cancer risk among firefighters: a review and meta-analysis of 32 studies. LeMasters GK', Genaidy AM, Succop P, Deddens J, Sobeih T, Barriera-Viruet H, Dunning K, Lockey J. Author information Abstract OBJECTIVE: The objective of this study was to review 32 studies on firefighters and to quantitatively and qualitatively determine the cancer risk using a meta-analysis. METHODS: A comprehensive search of computerized databases and bibliographies from identified articles was performed, Three criteria used to assess the probable, possible, or unlikely risk for 21 cancers included pattern of mete-relative risks, study type, and heterogeneity testing. RESULTS: The findings indicated that firefighters had a probable cancer risk for multiple myeloma with a summary risk estimate (SRE) of 1.53 and 95% confidence interval (Cl) of 1.21-1.84, non-Hodgkin lymphoma (SRE = 1.51, 95% Cl = 1.31-1.73), and prostate (SRE = 1.28; 95% Cl = 1.15-1.43). Testicular cancer was upgraded to probable because it had the highest summary risk estimate (SRE = 2.02; 95% Cl = 1.30-3.13). Eight additional cancers were listed as having a "possible" association with firefighting. CONCLUSIONS: Our results confirm previous findings of an elevated metarelative risk for multiple myeloma among firefighters. In addition, a probable association with non-Hodgkin lymphoma, prostate, and testicular cancer was demonstrated. wid: 17099456 DOI: 10,1097/01,4om,0000246229.68607,00 {Indexed for MEDLINE] Publication types, MeSH terms https://www.nebi.nlm.nih. gow/pubmed/17099456 8/14/2017Risk of cancer among firefighters in California, 1988-2007. - PubMed - NCBI Page 1 of 2 PubMed v Format: Abstract Full toxt links rc. HS PMC cull text Risk of cancer among firefighters in California, 1988-2007. , Deapen DM, Calvert GM ‘Amu Ind Med, 2015 JulS8(7):715-29, de: 10.1002/ajm.22466. Epub 268 ‘Tsai Ru", Luckhaupt SE, Schumacher P', Cress RD’ Author information Abstract BACKGROUND: Most studies of firefighter cancer risks were conducted prior to 1990 and do not reflect risk from advances in building materials. METHODS: A case-control study using California Cancer Registry data (1988-2007) was conducted to evaluate the risk of cancer among firefighters, stratified by race. RESULTS: This study identified 3,996 male firefighters with cancer. Firefighters were found to have a significantly elevated risk for melanoma (odds ratio [OR] = 1.8; 95% confidence interval [Cl] 1.4-2.1), multiple myeloma (OR 1.4; 95%CI 1.0-1.8), acute myeloid leukemia (OR 1.4; 95%CI 1.0-2.0), and cancers of the esophagus (OR 1.6; 95%CI 1.2-2.1), prostate (OR 1.5; 95%CI 1.3-1.7), brain (OR 1.5; 95%CI 1.2-2.0), and kidney (OR 1.3; 95% C1 1.0-1.6). CONCLUSIONS: In addition to observing cancer findings consistent with previous research, this study generated novel findings for firefighters with race/ethnicity other than white. It provides additional evidence to support the association between firefighting and several specific cancers (© 2015 This article has been contributed to by US Goverment employees and their work is in the public domain in the USA, KEYWORDS: cancer; firefighters; occupation; registry; risk PMID: 25943908 PMCID: PMC4527530 DO!: 10.1002faiim.22466 Indexed for MEDLINE] Free PMC Article Publication types, MeSH terms, Grant support hittps:lAvww.nebi.nim.nih.gov/pubmed/25943908 8/14/2017Cancer incidence among male Massachusetts firefighters, 1987-2003.-PubMed-NCBI Page 1 of 2 PubMed v Format: Abstract Full text links. ‘Am ind Med, 2008 May;51(5):329-35. doi: 10. 1002/ajim.20849, Cancer incidence among male Massachusetts fire’ 1987-2003. Kang D', Davis LK, Hunt P, Kriebel D. Author information Abstract BACKGROUND: Firefighters are known to be exposed to recognized or probable carcinogens. Previous studies have found elevated risks of several types of cancers in firefighters. METHODS: Standardized morbidity odds ratio (SMORs) were used to evaluate the cancer risk in white, male firefighters compared to police and all other occupations in the Massachusetts Cancer Registry from 1986 to 2003, Firefighters and police were identified by text search of the usual occupation field. All other occupations included cases with identifiable usual occupations not police or firefighter. Control cancers were those not associated with firefighters in previous studies, RESULTS: Risks were moderately elevated among firefighters for colon cancer (SMOR = 1.36, 95% Cl: 1.04-1.79), and brain cancer (SMOR = 1.90, 95% Cl: 1.10-3.26). Weaker evidence of increased risk was observed for bladder cancer (SMOR = 1.22, 95% Cl 0,89-1.69), kidney cancer (SMOR = 1.34, 95% Cl: 0.90-2.01), and Hodgkin's lymphoma (SMOR = 1.81, 95% Cl: 0.72-4.53). CONCLUSIONS: These findings are compatible with previous reports, adding to the evidence that firefighters are at increased risk of a number of types of cancer. (c) 2008 Wiley-Liss, Inc. PMID: 18808327 DOI: 10,1092/alim.20549 [Indexed for MEDLINE] https://www.nebi.nlm.nih.gov/pubmed/18306327 8/14/2017Mortality and cancer incidence in a pooled cohort of US firefighters from San Francisco, .. Page 1 of 2 PubMed v Format: Abstract Full text links 3 I ruutext Occup Environ Med, 2014 Jun;71(6):388-97. doi: 10.1136/cemed-2013- Mortality and cancer incidence in a pooled cohort of US firefighters from San Francisco, Chicago and Philadelphia (1950-2009). Janiels RD', Kubale TL, Ylin JH, Dahm MM, Hales TR, Baris D, Zahm SH, Beaumont JJ, Waters KM, Pinkerton LE. Author information Abstract OBJECTIVES: To examine mortality patterns and cancer incidence in a pooled cohort of 29 993 US career firefighters employed since 1950 and followed through 2009. METHODS: Mortality and cancer incidence were evaluated by life table methods with the US population referent. Standardised mortality (SMR) and incidence (SIR) ratios were determined for 82 causes of death and 41 cancer incidence groupings. Analyses focused on 15 outcomes of a priori interest. Sensitivity analyses were conducted to examine the potential for significant bias. RESULTS: Person-years at risk totalled 858 938 and 403 152 for mortality and incidence analyses, respectively. All-cause mortality was at expectation (SMR=0.99, 95% Cl 0.97 to 1.01, n=12 028). There was excess cancer mortality (SMR=1.14, 95% Cl 1.10 to 1.18, 1n=3285) and incidence (SIR=1.09, 95% Cl 1.06 to 1.12, n=4461) comprised mainly of digestive (SMR=1.26, 98% Cl 1.18 to 1.34, n=928; SIR=1.17, 95% Cl 1.10 to 1.25, n=930) and respiratory (SMR=1.10, 95% Cl 1.04 to 1.17, n=1096; SIR=1.16, 95% Cl 1.08 to 1.24, n=813) cancers. Consistent with previous reports, modest elevations were observed in several solid cancers; however, evidence of excess lymphatic or haematopoietic cancers was lacking. This study is the first to report excess malignant mesothelioma (SMR=2.00, 95% Cl 1.03 to 3.49, n=12; SIR=2.28, 95% Cl 1.60 to 3.19, n=35) among US firefighters. Results appeared robust under differing assumptions and analytic techniques. CONCLUSIONS: Our results provide evidence of a relation between firefighting and cancer. The new finding of excess malignant mesothelioma is noteworthy, given that asbestos exposure is a known hazard of firefighting. KEYWORDS: Longitudinal studies < Methodology, speciality httpsi/www.ncbi.alm.nih. gov/pubmed/24142974 8/14/2017Perfluoroalkyl acids including perfluorooctane sulfonate and perfluorohexane sulfonate in... Page 1 of PubMed v Format: Abstract Full text links [ewes Perfluoroalkyl acids including perfluorooctane sulfonate and perfluorohexane sulfonate in firefighters. vin C!, Suny, Islam A, Qian Y, Ducatman A. Author information Abstract OBJECTIVE: Firefighters were likely exposed to perfiuorooctane sulfonate since it was a component of extinguishing foams and perfiuorohexane sulfonate (PFHxS), a surfactant coating carpet and other building materials, during firefighting. The objective of the study is to evaluate serum concentrations of perfluoroalkyl acids (PFAAs) in firefighters. METHODS: A total of 8826 male adults, including 37 firefighters, were analyzed. Multivariate analysis was conducted by using a general linear model. The least square mean of serum PFAAs was obtained after adjustment for demographic and socioeconomic variables, RESULTS: Serum concentration of PFHxS was statistically higher in firefighters both before and after adjustment, Perfluorooctane sulfonate and perfiuorononanoic acid were also found higher in firefighters, though not statistically significant. CONCLUSIONS: The study suggests that fighting fire can be a risk of exposure to PFAAs, specifically PFHxS. PMID: 21348631 DOI: 10,1097/JOM,0b01303182041314 [Indexed for MEDLINE] Publication type, MeSH terms, Substances LinkOut - more resources https://www nebi.nlm.nih.govipubmed/21346631 8/14/2017Novel fluorinated surfactants tentatively identified in firefighters using liquid chromatogr.... Page 1 of 2 [PubMed v Format: Abstract Full text links [ACS Pucatons, Environ Sci Technol, 2015 Feb 17:49(4):2434-42. dol: 10.1021/es503653n. Epub 2015 Feb 6; Novel fluorinated surfactants tentatively identified in firefighters using liquid chromatography quadrupole time-of- flight tandem mass spectrometry and a case-control approach. Rotander A‘, Karman A, Toms LM, Kay M, Mueller JE, Gémez Ramos M. Author information Abstract Fluorinated surfactant-based aqueous film-forming foams (AFFFs) are made up of per- and polyfiuorinated alkyl substances (PFAS) and are used to extinguish fires involving highly flammable liquids. The use of perfluorooctanesulfonic acid (PFOS) and other perfluoroalkyl acids (PFAAs) in some AFFF formulations has been linked to substantial environmental contamination. Recent studies have identified a large number of novel and infrequently reported fluorinated surfactants in different AFFF formulations. In this study, a strategy based on a case-control approach using quadrupole time-of-flight tandem mass spectrometry (QTOF-MS/MS) and advanced statistical methods has been used to extract and identify known and unknown PFAS in human serum associated with AFFF-exposed firefighters. Two target sulfonic acids [PFOS and perfluorohexanesulfonic acid (PFHxS)], three non-target acids [perfluoropentanesulfonic acid (PFPeS), perfluorcheptanesulfonic acid (PFHpS), and perfluorononanesulfonic acid (PFNS)], and four unknown sulfonic acids (CLPFOS, ketone-PFOS, ether-PFHxS, and Cl-PFHxS) were exclusively or significantly more frequently detected at higher levels in firefighters compared to controls. The application of this strategy has allowed for identification of previously unreported fluorinated chemicals in a timely and cost-efficient way. PMID: 25611076 DOI: 10.102/es503653n [Indexed for MEDLINE] Publication type, MeSH terms, Substances https://www.nebi.nlm.nih.gov/pubmed/25611076 8/14/2017