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Universidad Autónoma de Guadalajara A.C.© 2017
Objectives
■ State the Fick’s law for diffusion and
determine the limitations of gas transfer
■ Define oxygen diffusing capacity, and
describe the use of carbon monoxide to
determine oxygen diffusion capacity.
■ Name the factors that affect diffusive
transfer of gas.
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Universidad Autónoma de Guadalajara A.C.© 2017
CHARACTERISTICS
■ Area of blood-gas
barrier in the lung: 50
to 100 m2
■ Thickness: only 0.3 µ
in many places
■ The rate of transfer is
proportional to a
diffusion constant,
which depends on the
properties of the tissue
and the particular gas
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Universidad Autónoma de Guadalajara A.C.© 2017
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Universidad Autónoma de Guadalajara A.C.© 2017
FICK’S LAW
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Universidad Autónoma de Guadalajara A.C.© 2017
PAO2 = 105
PACO2 = 40
CO2 O2
PvO2 40
PvCO2 45
0 time/sec 0.75
105
PaO2
40
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Universidad Autónoma de Guadalajara A.C.© 2017
Picture from Respiratory Physiology, West
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Universidad Autónoma de Guadalajara A.C.© 2017
DIFFUSION VS PERFUSION LIMITED
1. Diffusion limited 2. Perfusion limited
PaO2
B
No
exercise
40
0 time
Universidad Autónoma de Guadalajara A.C.© 2017 .75 10
Picture from Respiratory Physiology,West
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Universidad Autónoma de Guadalajara A.C.© 2017
Venous mix
blood
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Universidad Autónoma de Guadalajara A.C.© Picture
2017 from Respiratory Physiology,West
DIFFUSING CAPACITY
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Universidad Autónoma de Guadalajara A.C.© 2017
MEASUREMENT OF DIFFUSING CAPACITY
Carbon Monoxide is used because is diffusion limited
DL = VCO
PACO
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Universidad Autónoma de Guadalajara A.C.© 2017
REACTION RATES WITH Hb
Not all the resistance for O2 and CO2 diffusion is at the level
of the blood-gas barrier
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Universidad Autónoma de Guadalajara A.C.© 2017
DL = Vgas
P1 – P2
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Universidad Autónoma de Guadalajara A.C.© 2017