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Aluminum
atomic no. 13, atomic wt. 26.98, metal, row 4, col.3A, val. 3, orbits 2-8-3
Aluminum. Al; at. wt. 26.98; at. no. 13; valence 3. Discovered by Wöhler in
1827. Obtained from cryolite (double sod. and aluminum fluoride) or bauxite
(native aluminum hydroxide) by electrolysis in electric furnace.
Reduces the cations of many heavy metals to the metallic state. Solns. of the
metal in dil. HCl or neutral or slightly acid solns. of most aluminum salts, yield
with Na2S a white ppt. soluble in excess of Na2S. Dil. neutral soln. of aluminum
salts yield white gelatinous ppt. on boiling with sod. acetate.
Use: As the pure metal or as alloys (magnalium, aluminum bronze, etc.) for
aircraft, utensils, apparatus, electrical conductors; instead of copper in dental
alloys. The coarse powder is used in aluminothermics (thermite process); the
fine powder as flashlight in Photography, in explosives, fireworks and in
aluminum paints; for absorbing occluded gases in manuf. of steel. In testing
for Au, As, Hg; coagulating colloidal solns. of As or Sb; pptg. Cu; reducer for
determining nitrates and nitrites; instead of Zn for generating hydrogen in
testing for As.
Aluminum Toxicity
The following information was compiled and submitted by Frank Hartman.
"From the earliest days of food regulation, the use of alum (aluminum
sulphate) in foods has been condemned. It is universally acknowledged as a
poison in all countries. If the Bureau of Chemistry had been permitted to
enforce the law ... no food product in the country would have any trace of ...
any aluminum or saccarin. No soft drink would contain caffeine or hebromin;
no bleached flour would be in interstate commerce. Our food and drugs would
be wholly without adulteration ... and the health of our people would be vastly
improved and their life greatly extended."
From History of crime against the Food Laws (1929) by Dr. Wiley, the prime
mover behind the original Pure Food Law and Director of the FDA. He resigned
in disgust in 1912 over exceptions granted to the law and lack of enforcement.
Aluminum has been exempted from tesitng for safety by the FDA under a
convoluted logic wherein it is classified as GRAS. (Generally Regarded As
Safe.) It has never been tested by the FDA on its safety and there are NO
restrictions whatever on the amount or use of aluminum.
There are over 2000 references in the National Library of Medicine on adverse
effects of alumium. The following were extracted to provide a small sample of
the range of toxicity of aluminum.
Chemical Registry
Cells appear to take up aluminum from transferrin rather than from citrate.
Purified preparations of ferritin from brain and liver have been found to
contain aluminum.
It is not known if ferritin has a specific binding site for aluminum. Factors
regulating the migration of aluminum across the blood–brain barrier are not
well understood.
Serum aluminum correlates with encephalopathy; red cell aluminum correlates
with microcytic anemia, and bone aluminum correlates with aluminum bone
disease.
Basal PTH when elevated appears to protect bone and thereby favor CNS
toxicity.
Other factors favoring one form of toxicity over another are not well
understood.
Aluminum toxicity has been reported to impair the formation and release of
parathyroid hormone. The parathyroid glands concentrate aluminum above
levels in surrounding tissues. Treatment of aluminum toxicity in renal failure
patients often reactivates hyperparathyroidism, which to a certain extent is
helpful for bone remodeling and healing.
Distilled water was placed in metal containers and the amount of the "Metal
Can" that disolved into the distilled water was measured daily using Specific
Conductance readings. You can divide the SC number by 2 to get the
approxamite amount of atoms in ppm ( mg / l ).
RESULTS: The 90 infants who received the standard feeding solutions had a
mean (± SD) Bayley Mental Development Index of 95 ±22, as compared with 98
±20 for the 92 infants who received the aluminum-depleted solutions (P=0.39).
The former were significantly more likely (39 percent, vs. 17 percent of the
latter group; P=0.03) to have a Mental Development Index of less than 85,
increasing their risk of subsequent educational problems. For all 157 infants
without neuromotor impairment, increasing aluminum exposure was
associated with a reduction in the Mental Development Index (P=0.03), with an
adjusted loss of one point per day of intravenous feeding for infants receiving
the standard solutions. In preterm infants, prolonged intravenous feeding with
solutions containing aluminum is associated with impaired neurologic
development.
Klein G.L.
It has been a dozen years since aluminum was first shown to contaminate
parenteral nutrition solutions and to be a contributing factor in the
pathogenesis of metabolic bone disease in parenteral nutrition patients as well
as in uremic patients. However, there are no regulations in place to effectively
reduce aluminum contamination of various parenterally administered
nutrients, drugs, and biologic products. The purpose of this review is fourfold:
1.) to summarize our knowledge of the adverse effects of aluminum on bone
formation and mineralization in parenteral nutrition patients; 2.) to discuss the
possible role of aluminum in the osteopenic bone disease of preterm infants;
3.) to show how lack of regulations covering aluminum content of parenteral
solutions can lead to vulnerability of new groups of patients to aluminum
toxicity, the example being given here is that of burn patients
Aluminum-induced anemia.
Hendrick M.J. – Goldschmidt M.H. – Shofer F.S. – Wang Y.Y. – Somlyo A.P.
Attention was first drawn to the potential role of aluminum as a toxic metal
over 50 years ago, but was dismissed as a toxic agent as recently as 15 years
ago. The accumulation of aluminum, in some patients with chronic renal
failure, is associated with the development of toxic phenomena; dialysis
encephalopathy, osteomalacic dialysis osteodystrophy, and an anemia.
Aluminum accumulation also occurs in patients who are not on dialysis,
predominantly infants and children with immature or impaired renal function.
Aluminum has also been implicated as a toxic agent in the etiology of
Alzheimer's disease, Guamiam amyotrophic lateral sclerosis, and
parkinsonism-dementia.
Soft tissue sarcoma associated with aluminum oxide ceramic total hip
arthroplasty. A case report.
Aluminum was the only nonorganic element present in the test site tissue.
This is the first report of confirmed aluminum-induced, delayed-
hypersensitivity granulomas in a tattoo.
Wounds were treated either with 30% aluminum chloride solution or ferric
subsulfate solution or were allowed to clot with minimal pressure from a gauze
pad. Delay in reepithelialization was noted histologically both in wounds
treated with aluminum chloride and in those treated with ferric subsulfate
compared to controls. Presumably this delay was the result of tissue necrosis
caused by these hemostatic agents, resulting in slightly larger and less
cosmetically acceptable scars. Plots of evaporimetry data revealed a biphasic
pattern of water loss during healing, with an initial rapid decline in water loss
followed by a much slower decline.
AlCl3 or GaCl3 was added to artificial cerebrospinal fluid and perfused through
the cerebral ventricles of the rat. Depending on the metal and its concentration
(1-10 mM) the pH of the perfusate ranged from 7.2 to 3.5. At 10 mM metal
chloride, yielding pH 4.7 (Al) or 3.5 (Ga), formation of cerebrospinal fluid was
suppressed 100%. This mechanism may also account for the antiperspirant
action of Al salts.
Kelly A.T. – Short B.L. – Rains T.C. – May J.C. – Progar J.J.
Mark A. – Granstrom M.
Heyer N.J.
In five patients aluminium crystals were found scattered between the cells and,
in addition, the phagosomes of the macrophages contained aluminium. Patch
tests for aluminium were positive in four of the six patients.
This data defines a new model in which aluminum kills liver cells by a
mechanisms distinct from previously recognized pathways of lethal cell injury.
It is hypothesized that aluminum binds to cytoskeletal proteins intimately
associated with the plasma membrane. This interaction eventually disrupts the
permeability barrier function of the cell membrane, an event that heralds the
death of the hepatocyte.
Aluminium allergy causes false positive patch test reactions and we propose
methods of patch testing patients with symptoms at vaccination sites in order
to avoid this problem.
Aluminium allergy.
13 children ranging in age from 1 to 13 years and 1 adult patient had positive
patch tests to 2% AlCl3 in water. 13 of them had pruritic excoriated papules, 9
at sites of hyposensitization therapy with aluminium-bound pollen extracts,
and 4 at sites of childhood immunization with an aluminium-bound vaccine
(Di-Te-Pol).
Minimal effects were observed in the control and acid zones whilst large
mortalities and reduced feeding were recorded in the acid and aluminium
zone.
E. Meiri
The behavioral deficit was not due to nonspecific effects caused by lower fluid
consumption. Partial reversal of the deficit was produced by discontinuing
aluminum treatment, 2 weeks prior to testing.
Joshi J.G.
In the present study, an attempt has been made to investigate the distribution
of aluminum in different regions of brain and body organs of male albino rats,
following subacute and acute aluminum exposure. Aluminum was observed to
accumulate in all regions of the brain with maximum accumulation in the
hippocampus. Aluminum was also seen to compartmentalize in almost all the
tissues of the body to varying extents, and the highest accumulation was in
the spleen.
These results indicate that ions associated with Ti-6Al-4V alloy inhibited the
normal differentiation of bone marrow stromal cells to mature osteoblasts in
vitro, suggesting that ions released from implants in vivo may contribute to
implant failure by impairing normal bone deposition.
Aluminium release from glass ionomer cements during early water exposure in
vitro.
Banin E. – Meiri H.
Sepsis: a cause of aluminum release from tissue stores associated with acute
neurological dysfunction and mortality.
We report six cases of patients with renal failure and exposure to aluminum
who developed septicemia. In all cases the serum aluminum increased
markedly. This may have contributed to the neurological dysfunction seen in
five, and the deaths of four of the patients. We suggest that the rise in serum
aluminum was due to the release of tissue-bound aluminum, resulting in an
increase in free, diffusable aluminum and that this jeopardized both
neurological function and immunocompetence.
Daily intakes of aluminium were estimated for 14 age-sex groups based on the
Food and Drug Administration's (FDA) Total Diet Study dietary exposure
model. Estimates of aluminium intakes ranged from 0.7 mg/day for 6-11-
month-old infants to 11.5 mg/day for 14-16-year-old males. Average intakes for
adult men and women were 8-9 and 7 mg/day, respectively. The major
contributors to daily intake of aluminium were foods with aluminium-
containing food additives, e.g. grain products and processed cheese.
The bone fractures had occurred suddenly while the patients were going about
their daily work. These observations indicate that Al- or iron- related bone
disease with secondary hyperparathyroidism can induce bone fracture by only
slight stress in patients maintained on hemodialysis.
Risk of aluminum accumulation in patients with burns and ways to reduce it.
Klein G.L. – Herndon D.N. – Rutan T.C. – Barnett J.R. – Miller N.L. – Alfrey A.C.
Substitution with a different brand of albumin and calcium chloride can reduce
the parenteral aluminum load by as much as 95% and minimize any role
aluminum may play in the pathogenesis of this bone lesion.
Canned soft drink fed rats had significantly higher blood, liver and bone
aluminum concentration than rats that were given glass bottled soft drink.
Sources of Aluminum
Over the Counter; Deoderants, vaginal douches, baby wipes, skin creams,
suntan lotions, toothpaste, buffered asprin, some haemorrhoid and diarrhea
products.
Foods; Aluminum cans, foils, containers, baking powder, cake mixes, frozen
dough, pancake mixes, self-rising flour, grains, processed cheese.
Verbost P.M. – Lafeber F.P. – Spanings F.A. – Aarden E.M. – Wendelaar Bonga
S.E.
In carp exposed to pH 5.2 in fresh water, the Ca2+ influx from the water is
reduced by 31% when compared to fish in water of neutral pH. At pH 5.2, the
Ca2+ influx but not Na+ uptake is decreased by aluminum (Al). Al reduces
Ca2+ influx dose-dependently: a maximum 55% reduction was observed after
1-2 h exposure to 200 micrograms .1(-1) (7.4 microM) Al.
Aluminium is acutely toxic to fish in acid waters. The gill is the principal target
organ and death is due to a combination of ionoregulatory, osmoregulatory
and respiratory dysfunction. The mechanism of epithelial cell death is
proposed as a general mechanism of aluminium-induced accelerated cell
death.
Strong M.J. – Garruto R.M. – Joshi J.G. – Mundy W.R. – Shafer T.J.
Institutional address:
London, Canada.
mstrong@julian.uwo.ca
Bugiani O. – Ghetti B.
The injection of aluminum powder into the cerebrospinal fluid of adult rabbits
induced a slowly progressing encephalomyelopathy characterized at first by
alteration of posture and then by myoclonic jerks and muscle weakness.
Neurofibrillary degeneration was the hallmark of the disease and involved
most of the gray areas. Neurogenic muscular atrophy appeared in animals
sacrificed in the second and third month after injection.
ISBN: 0007-1226
Aluminium foil has been found to be an extremely useful and painless way of
dressing wounds prior to delayed skin grafting. However, it is not
recommended for use on skin-graft donor sites as it delays epithelial healing.
by Dr. Riley, the prime mover behind the original Pure Food Law and Director
of the FDA. He resigned in disgust in 1912 over exceptions granted to the law
and lack of enforcement.
Aluminum has been exempted from testing for safety by the FDA under a
convoluted logic wherein it is classified as GRAS. (Generally Regarded As
Safe.) It has never been tested by the FDA on its safety and there are NO
restrictions whatever on the amount or use of aluminum.
Aluminum is known to inhibit cell division during the "S Phase" at levels less
than 4 ppm.
Read more:
http://www.lenntech.com/periodic/elements/al.htm
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