KENDRIYA VIDYALAYA

KAMPTEE
Chemistry Investigatory
Project
Session 2012-13

Study of the given sample

of Antacid
Made by:- Gopal Mishra
of class 12th ‘B’
Roll no.:-29
 Acknowledgements
I would like to express my special thanks of gratitude to
my chemistry teacher Mr. Nandeshwar as well as our
principal Mr. S.S. Upadhyay who gave me the golden
opportunity to do this wonderful project on the topic Study
of given sample of Antacids, which also helped me in doing
a lot of Research and I came to know about so many new
things. I am really thankful to them.

Secondly I would also like to thank my parents and friends

who helped me a lot in finishing this project within the
limited time.

Thirdly I also want to thank my chemistry lab assistant

Mr. Sajan for helping me to make this project successful.

Thanks Again To All Who Helped Me In Making Of This

Project.

-Gopal Mishra

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 Contents
Acknowledgements …………………………………2
Certificate……………………………………………4
Aim ………………………………………...............5
Introduction…………………………………………6
Apparatus Required…………………………………8
Procedure ……………………………………..........9
Observation ………………………………………...11
Conclusion……………………………………..…..14
Remarks…………………………………………….15

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 Certificate

T h i s i s to c e r t i f y t ha t G o p a l Mis h r a ha s
s a t i s fa c to r i l y c o mp l et e d th e c o u r s e
o f C h e m i s tr y I n v e s t i g a t o r y
P r o j e c t prescribed by the CBSE under the
AISSCE course in the laboratory of K.V. Kamptee
school in the year of 2012-13.

Signatures
CHEMISTRY TEACHER PRINCIPAL

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AIM:-

To analyze the given samples of

commercial antacids by determining the
amount of hydrochloric acid they can
neutralize.

INTRODUCTION:-

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Antacids:-
An Antacid is any substance, generally a base or
basic salt, which neutralizes stomach acidity. They are
used to relieve acid indigestion, upset stomach, sour
stomach, and heartburn.
Action mechanism:-
Antacids perform a neutralization reaction, i.e. they
buffer gastric acid, raising the pH to reduce acidity in the
stomach. When gastric hydrochloric acid reaches the
nerves in the gastrointestinal mucosa, they signal pain to
the central nervous system. This happens when these
nerves are exposed, as in peptic ulcers. The gastric acid
may also reach ulcers in the esophagus or the
duodenum. Other mechanisms may contribute, such as
the effect of aluminium ions inhibiting smooth muscle
cell contraction and delaying gastric emptying.

Indications:-

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 Antacids are taken by mouth to relieve heartburn,
the major symptom of gastro esophageal reflux disease,
or acid indigestion. Treatment with antacids alone is
symptomatic and only justified for minor symptoms.
Peptic ulcers may require H2-receptor antagonists or
proton pump inhibitors. The utility of many combinations
of antacids is not clear, although the combination of
magnesium and aluminium salts may prevent alteration
of bowel habits.
Some famous antacid brands:-
1. Milk of Magnesia – Mg(OH)2
2. Equate – Al(OH)3 and Mg(OH)2
3. Gaviscon – Al(OH)3
4. Maalox (liquid) – Al(OH)3 and Mg(OH)2
5.Maalox (tablet) – CaCO3
6. Digene – Al(OH)3 and Mg(OH)2
7. Gelusil – Al(OH)3

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APPARATUS REQUIRED:-

Burettes, pipettes, titration flasks,

measuring flasks, beakers, weight box, fractional
weights, sodium hydroxide, sodium carbonate,
hydrochloric acid, phenolphthalein.

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PROCEDURE :-

1. Prepare 1 litre of approximately HCl solution

by diluting 10 ml of the concentrated acid for one
litre.

2. Similarly, make 1 litre of approximately NaOH

solution by dissolving4.0g of NaOH to prepare one
litre of solution.

3. Prepare Na2CO3 solution by weighing exactly

1.325 g of anhydrous sodium carbonate and then
dissolving it in water to prepare exactly 0.25
litres (250 ml) of solution.

4. Standardize the HCl solution by titrating it

against the standard Na2CO3 solution using
methyl orange as indicator.

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5. Similarly, standardize NaOH solution by
titrating it against standardized HCl solution using
phenolphthalein as indicator.

6. Powder the various samples of antacid tablets

and weigh 1.0 g of each.

7. Add a specific volume of standardised HCl to

each of the weighed sample is taken in conical
flasks. The acid should be in slight excess, so that
it can neutralize all the alkaline component of the
tablet.

8. Add 2 drops of phenolphthalein and warm the

flask till most of powder dissolves. Filter off the
insoluble material.
9. Titrate this solution against the standardized
NaOH solution, till a permanent pinkish tinge is
obtained. Repeat this experiment with different
antacids.
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OBSERVATIONS AND CALCULATIONS :-

Standardization of HCl solution :-

Volume of Na2CO3 solution taken = 20.0 ml

Burette readings Volume of

S. No. (ml) acid used
Initial Final (ml)

Concordant reading = …… ml

Applying molarity equation, N1V1 = N2V2

N1 * …… = ……* 20

Normality of HCl, N1 = 2/…… N

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Standardization of NaOH solution :-

Volume of the given NaOH solution taken =

20.0 ml

Burette readings Volume of

S. No. (ml) acid used
Initial Final (ml)

Concordant volume = …… ml

Applying normality equation,

N1’V1’ (ACID)= N2’V2’ (BASE)

= (2/……)(……)

Normality of NaOH, N2’ ……/10*…… N

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Analysis of antacid tablet :

Weight of antacid tablet powder = 1.0 g

Volume of HCl solution added = …… ml

Volume of Volume of HCl

NaoH solution solution used
used for for neutralizing
S.No. Antacid
neutralizing 1.0 g of an
unused HCl antacid matter
(ml) (ml)
1. Gelusil

2. Digene

3. Visco

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CONCLUSION :-

The antacid which has maximum volume of

HCl is used for neutralizing i.e.
………………………………….is more effective.

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 Thanks For
Viewing
Your Remarks Please…

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