Académique Documents
Professionnel Documents
Culture Documents
CFU-GM
CFU-M
Monoblast
Promonocyte
Monocyte
Macrophage
MONOBLAST
________________
12-20 µm
Basophilic cytoplasm
________________
NC ratio 4:1-3:1
1-2 nucleoli
PROMONOCYTE
- 12 to 18 µm in diameter
- chromatin pattern is delicate,
- at least one nucleolus is apparent
- Cytoplasm is blue ____________________
MONOCYTE
15 to 20 µm
Larger than neutrophil
_______________________
Nucleus:
____________________________________
Chromatin: _____________
Cytoplasm: __________________________
___________of circulating leukocytes, with an
absolute number of up to _______________
Monocytes
Stays in PB for _______then move to tses to
become macrophage and probably not to
return
_____________________for months or
years
_______________________________
MONOCYTE/MACROPHAGE KINETICS
__________________________
Macrophages = ______________
Fc receptors = __________________________
___________________________
FUNCTIONS OF MONO&MACRO
2. ADAPTIVE IMMUNITY
Ag presenting cells – _____________________
Destruction of _______________
Maintains ___________________
Synthesis of ________________
LEUKOPOIESIS
2 Major Categories
Humoral immunity = _______________
FUNCTION
______________
Ag presentation _________
Necessary for ____________
Produce _________
PLASMA CELLS
Deeply basophilic cytoplasm
________________
Eccentric nucleus
Condensed and coarse chromatin
Nucleoli not visible
T LYMPHOCYTES
_________
Progenitor cells = BM thymic cortex
PRO-T, PRE-T, and IMMATURE T CELLS
Undergo rearrangement = _________________
2 major categories:
______________________________________
Immature T cells ________________
Remaining immat T cell _______ =
__________________________________
T LYMPHOCYTES
FUNCTION
CD4
______ = against intracellular pathogens
______ = against extracellular parasites, induction
of asthma and other allergies
______ = against extracellular bacteria and fungi
______ = maintaining self tolerance by regulating
immune response
T LYMPHOCYTES
FUNCTION
CD8 – secrete granules with
______________________________
- activate ______________on target
cells
- _______________________
NK CELLS
_______________
Heterogeneous grp of cells with respect to
their surface Ag
Majority: ____. ______, ______ and ______
Mature cell – relatively large compared with
other resting lymph
_______________
Killing certain tumor cells and virus infected
cells ____________________
____________of circulating lymphocytes
LYMPHOCYTES
Major role in maintaining health and in response to and
recovery from disease
Not obligate end cells- continuous supply of inc
differentiated cells then transform
Heterogenous group of cells- Tcells, Bcells,NK cells,
non-T and non-B cells
Predestined to migrate- other cells (one direction
migration) but both T and B cells freely migrate to and
from body tissues
Lifespan- short lived B cells (3-4 days), long lived T cells
(average 4 yrs some up to 20 yrs)