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“..and don’t you remember Keats proposing “Confusion to the memory of Newton”, and upon your
insisting on an explanation before you drank it, his saying “Because he destroyed the poetry of the
rainbow by reducing it to a prism?” Ah my dear old friend you and I shall never see such days
again…”
Benjamin Haydon, letter to his friend William Wordsworth, mid Nineteenth Century.
In December 1817, Benjamin Haydon, the English painter and critic hosted a famous dinner. He
would in later years refer to it as the “immortal” dinner. He invited the cream of the artistic and
literary genius of Georgian London to view his latest allegorical work, “Christ entering Jerusalem”.
In it was featured Sir Isaac Newton, as a believer and Voltaire as a sceptic. Among the guests were
John Keats, William Wordsworth and Charles Lamb. After much drinking and merriment the
conversation turned to Haydon’s painting thereupon which the gathering was somewhat stunned to
hear Keats propose a rather derogatory toast to the memory of Sir Isaac Newton. When William
Wordsworth demanded an explanation for the apparent slight on one of England’s greatest heroes,
Keats explained that Newton had forever destroyed the wonder and beauty of a rainbow by reducing
it to a set of physical laws. He recorded this sentiment, years later in his poem “Lamia” in which he
accuses Newton of destroying the wonder of nature, by “unweaving the rainbow”. Many, of the
early Nineteenth century agreed with him, including Haydon who echoed this sentiment to his friend
Wordsworth many years later in a letter recalling the memory of Keats.
It is an argument still familiar to us today, many prefer the idea of a rainbow that is made and sent
by God as opposed to a set of mundane “physical laws”. The natural wonder of childhood has been
replaced by the reality of a brutal and unthinking universe. The magisterial Richard Dawkins takes a
different view. He argues that the incredible insights and scientific discoveries of the Enlightenment
that had barely preceded Keats’s own time should only increase our wonder and marvel of the
natural world. In the words of the brilliant 20th century physicist Richard Feynman…
“…The beauty that is there for you is also available for me too. But I see a deeper beauty that isn’t
so readily available to others. I can see the complicated interactions of the flower. The color of the
flower is red. Does the fact that the plant has color mean that it evolved to attract insects? This adds
a further question. Can insects see color? Do they have an aesthetic sense? And so on. I don’t see
how studying a flower ever detracts from its beauty, it only adds…”
Richard Dawkins passionately argues that we can still maintain our childhood wonder in the natural
world even when we understand much of how it works, indeed as we learn more it should only
increase this wonder to a greater degree than any child even could think possible. By blending the
two aspects of all humanity, the innate wonder of the world we find ourselves so temporarily and
miraculously part of, together with a sense of never ending enquiry as to the actual explanation for
our existence, great and wonderful strides have been made. In the words of Richard Dawkins, “A
Keats and a Newton listening to each other might hear the galaxies sing”
Newton’s childhood wonder of nature combined with his relentless thirst to understand the marvels
of the world around him have led to scientific advances that would have been undreamed of by even
himself. In the field of 21st century medicine one of the “dull catalogue of common things” that we
process is the pulse oximeter. By this device we can monitor the oxygen saturation levels of our
patients and though we have “unweaved its rainbow” we should never fail to appreciate the wonder
of the fact that we are able to do this.
PULSE OXIMETRY
Introduction
● The oxygen reserves of the body are very limited and life threatening hypoxemia can
development rapidly within minutes and with few initial clinical signs to warn of this.
● The availability therefore of reliable pulse oximeters has revolutionized the safe monitoring
of patients with unstable cardiorespiratory conditions as well as patients undergoing
anaesthesia or sedation.
● Pulse oximetry is an easy to use, non-invasive, continuous real time monitor of a patient’s
level, (percentage) of oxygenated haemoglobin.
● It reduces the need for frequent and invasive measurement of arterial PaO 2 levels required to
monitor unstable or sedated or anesthetised patients.
● It is important to note that whilst the oxygen saturation is a very important component of
tissue oxygenation, it is in fact only one component of a range of factors which determine the
overall oxygen delivery to the tissues.
The total oxygen delivery (or “oxygen flux”) to the tissues is determined by the following equation:
= CO (mls /min) x (1.39 Hb gm / 100 mls x SAT % + 0.3 / 100mls at PaO2 of 100 mmHg)
O2 carrying capacity of Hb = 1.39 x 15gm / 100mls blood x 100 / 100, (assuming 100% saturation)
Assuming: 1 gm of Hb binds 1.39 mls of O 2 and that the Hb level is 15gm/ 100mls. This comes to
20.8 mls O2 per 10 mls of blood.
The amount of dissolved O2 = Solubility x PaO2 (Henry’s law: the amount of O2 dissolved in blood is
a to its partial pressure)
The solubility of O2 in blood = 0.003 mls / 100 mls / mm Hg of O2
Therefore the oxygen content of blood = 20.8 mls / 100 mls blood + 0.3 mls / 100mls blood. This
comes to 21.1 mls O2 / 100 mls blood.
Assuming the average adult at rest has a CO of 5 liters / min
Therefore, in summary, adequate tissue oxygenation depends not only on the PaO 2, but also on an
adequate cardiac output, and hemoglobin level.
Pulse oximeters function on the basis of the physics of absorption spectroscopy, and 3 principles that
stem from this:
● The differences in absorption (and hence transmission) of light of differing wavelengths for
OxyHb and DeoxyHb.
● The assumption that no other Hb forms exist apart from OxyHb and DeoxyHb.
Absorbed light
Wavelength (nanometres)
Pulse oximeters have 2 LED (light emitting diode) sources. One is of 660 nm wavelength, (visible
red light) whilst the other is of 940nm wavelength, (invisible infra-red light).
The absorption and transmission of light through different media varies according to the exact
wavelength of the light that is traversing the media.
At 660nm, DeoxyHb is absorbed much more than OxyHb, (ie OxyHb transmits red light to a much
greater degree than DeoxyHb)
At 940nm DeoxyHb is absorbed about the same as OxyHb, (ie, OxyHb and DeoxyHb are
transmitted to about the same degree)
Therefore:
Therefore:
And:
The Beer Lambert law relates the OxyHb level as a function of the amount of transmitted light, (at
constant light intensity and Hb). This law therefore allows the microprocessors to convert a
transmitted light reading into an OxyHb level.
The total amount of light that is transmitted through the tissues will depend on the sum of the light
that is transmitted through the pulsatile (or arterial) component and the non-pulsatile (venous and
tissue) component.
The detecting microprocessors of the pulse oximeter are able to differentiate the pulsatile component
of light that is transmitted from the total non-pulsatile plus pulsatile component of light that is
transmitted.
The pulsatile component of transmitted light will therefore provide a reading for the arterial oxygen
saturation level.
Oxygen saturation values are calculated in this way by the detecting microprocessors many hundreds
of times a second, and the result is then time averaged over approximately 5 seconds.
Indications
1. Pulse oximeters are now considered mandatory for the monitoring of all patients who:
Interpretation
Once a reading is given in terms of the patient’s arterial oxygen saturation an assessment can be
made of the patient’s oxygenation status (but not necessarily of the adequacy of the total oxygen
delivery to the tissues)
By using the oxygen-dissociation curve function an estimate can be made of the patient’s PaO2 level.
The Oxygen Dissociation Curve, showing the factors that can affect it.
Interpretation of SaO2 levels: 2
Note that a saturation of 90%, represent the beginning of the steep descent of the oxygen-
dissociation curve and so within this region, even small decreases in the SaO 2 will represent a
profound decrease in the PaO2. It is the PaO2 which determines the flow of oxygen down the
“oxygen cascade” from alveoli to mitochondria. For this reason a saturation level below 90%
represents imminent respiratory failure.
Normal limitations:
● As mentioned above whilst giving a reading for a patient’s oxygenation status, the adequacy
of the total oxygen delivery to the tissues is not necessarily determined, as this will further
depend on functional haemoglobin levels and the cardiac output.
● The pulse oximeter will not provide any information on the important parameters of PaCO 2
and acid-base status.
● A normal SaO2 reading especially in cases of increased inspired oxygen concentrations will
not necessarily indicate an adequate ventilatory effort. Hypoventilation may not become
apparent till late because of falsely reassuring SaO2 readings.
1. Anemia:
● This will reduce the oxygen carrying capacity of the blood, but the recorded SaO 2 will
remain unaltered.
2. Dysfunctional haemoglobins:
● CO, there may be “normal” readings despite the existence of severe tissue hypoxia.
● Methemoglobinemia, this absorbs similarly in the red and infra-red bands and results
in pulse oximeter readings of around 85% irrespective of the degree of actual
oxygenation.
● Conditions that shift the oxygen-dissociation curve will make interpretation of results
more problematic.
4. Poor perfusion
● Any condition in which there is poor peripheral perfusion (from any cause) will make
readings inaccurate and unreliable. The vascular bed being monitored must be
pulsatile.
1. Accuracy range:
● Readings are accurate within the range of 70-100% SaO2 and reasonable but variable
in the range of 55%-70%. Below 55% they are not accurate. 1
2. Motion artefact.
● Patients with darkly pigmented skin, though careful nail bed placement of the probe
will usually overcome this.
4. Nail polishes:
● Some dark nail polishes, depending on the exact type may cause signal failure.
Technical Aspects
Application
● Pulse oximetry uses light emitting diodes (LEDs) of two wavelengths (red and infrared) that
transmit through a reasonably translucent site with good blood flow.
● Opposite the emitter is a photodetector that receives the light that passes through the tissues.
The photodetector converts the light energy into electrical energy to provide a digital
electronic reading and a visual waveform.
● Typical adult/pediatric sites are the finger, toe, pinna (top) or lobe of the ear. Infant sites
include the foot or palm of the hand and the big toe or thumb.
Features
● Ease of use
● Non-invasive
● No calibration required
● An audible tone for pulse rate with a variable intensity audio capability that correlates with
the level of arterial saturation.
References
Dr J. Hayes.
Dr D. Pescod, Staff Anaesthetist Northern Hospital.
13 June 2007