1.

Comparative antiulcer effect of Bisdemethoxycurcumin and Curcumin in a gastric ulcer model

system

In an animal model, intraduodenal administration of bisdemethoxycurcumin (5–80 mg/kg

body wt.) showed a strong inhibitory effect on gastric acid secretion in pylorus-ligated rats
whereas curcumin (5–20 mg/kg body wt.) showed a less inhibitory effect, with maximum potency
at a dose of 20 mg/kg body wt.
Moreover, oral administration of bisdemethoxycurcumin at doses of 20–80 mg/kg body wt. twice
daily for 10 days showed a significant curative efficacy in accelerating the healing of acetic acid-
induced chronic gastric ulcer and promotion of mucosal regeneration in the ulcerated portion in
a dose-related manner with potency equal to curcumin

Dalam model binatang, administrasi intraduodenal dari bisdemethoxycurcumin (5-80 mg / kg

body wt.) menunjukkan efek penghambatan yang kuat pada sekresi asam lambung pada tikus
yang dialiri pilorus sedangkan kurkumin (5-20 mg / kg berat badan) menunjukkan efek kurang
penghambatan, dengan potensi maksimum dengan dosis 20 mg / kg berat badan.
Selain itu, pemberian oral bisdemethoxycurcumin pada dosis 20–80 mg / kg berat badan. dua kali
sehari selama 10 hari menunjukkan khasiat kuratif yang signifikan dalam mempercepat
penyembuhan ulkus lambung kronis yang diinduksi asam dan promosi regenerasi mukosa di
bagian ulserasi dengan cara yang berhubungan dengan dosis yang sama dengan kurkumin

2. Antiulcer Activity of Curcumin on Experimental Gastric Ulcer in Rats and Its Effect on Oxidative
Stress/Antioxidant, IL6 and Enzyme Activities

Rats received different doses

of curcumin (20, 40, and 80 mg/kg) or vehicle by oral gavage. All doses of curcumin significantly
reduced gastric acid output into the gastric lumen. The level of gastric juice acidity was
significantly decreased from 38.60±3.516 mEq/L in the control group to 27.50±2.609 mEq/L,
13.10±0.8750 mEq/L and 6.400±0.6000 mEq/L in the treatment groups receiving 20, 40, and 40
mg/kg curcumin.

3. Turmeric (curcumin) remedies gastroprotective action

Curcumin has been shown to protect the stomach from the ulcerogenic effects of phenylbutazone
in guinea pigs at 50 mg/kg doses.[39,40] It also protects from 5‑hydroxytryptamine‑induced
ulceration at 20 mg/kg doses.[39] Recently, it was confirmed that curcumin can block
indomethacin, ethanol, and stress‑induced gastric ulcer and can prevent pylorus‑ligation‑induced
acid secretion.[40] Rafatullah et al. (1990) reported that an oral dose of 500 mg/kg of the ethanol
extract of turmeric produced significant antiulcerogenic activity in rats subjected to hypothermic
restraint stress, pyloric ligation indomethacin, and reserpine administration. He suggested that
turmeric extract not only increased gastric wall mucus but also restored the non‑protein
sulfhydryl content in the glandular stomachs of rats, and finally concluded that the extract has
significant antiulcer, antisecretory, and gastroprotective effects in rats.[2]
4. Comparative Evaluation of the Anti-ulcer Activity of Curcumin and Omeprazole during the Acute
Phase of Gastric Ulcer

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