SINUFORTE ® (SINUFORTE) - instructions for use. http://lekarstwo.ru/2017/en/18_c/02/page90.

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Universal reference book VERMESSUNGSINGENIEUR/IN (GIS- VERMESSUNGSINGENIEUR/-TECHNIKER

for medicines MANAGER/-IN SENIOR) (M/W)

Mainova AG Vermessungsbüro Mayer

Zum Job Zum Job

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Product name:SINUFORTE ® (SINUFORTE)

Active substance: nonappropriate Alphabetical index of medicines:

Type: Phytopreparation with secretolitic and secretory- A B V G D E J
motor action for topical application in diseases of the
paranasal sinuses
Z I Y K L M N
Manufacturer: INVAR (Russia) manufactured by O P R S T U F
LABIANA PHARMACEUTICALS (Spain) manufactured H C CH SH E U Y
by Iveriapharma (Georgia) manufactured by FARMA
MEDITERRANIA (Spain)

Composition, form of production and packaging VERMESSUNGSTECH

NIKER UND
? Lyophilizate for the preparation of a solution for intranasal administration from white to light brown, hygroscopic; the VERMESSUNGSINGEN
IEURE (M/W)
prepared solution is from colorless to light yellow color. intermetric Gesellschaft für

1 f. Ingenieurmessung und
raumbezogene Informatio…

lyophilizate juice and extract of fresh cyclamen European tubers (hemolytic index 1: 6000-1: 12000) 50 mg
Stuttgart, Berlin, Ditzingen, …
Solvent: water d / u - 5 ml.
50 mg - bottles of colorless glass (1) complete with a solvent (1 x plastic polyethylene) and a nozzle-sprayer - plastic pallets (1) Zum Job
- cardboard packs.
INSTRUCTION FOR THE SPECIALIST.
Description of the drug approved by the manufacturer for the printed edition of 2014.
PHARMACHOLOGIC EFFECT
Vegetable preparation for the treatment of inflammatory diseases of the paranasal sinuses (NNP) and the nasal cavity.The drug VERMESSUNGSINGEN
acts on sensitive receptors of the trigeminal nerve in the region of the middle nasal passage and causes reflex secretion in the IEUR/IN (GIS-
MANAGER/-IN
mucosa of the nasal cavity and the ONP. Stimulated hypersecretion is accompanied by a change in the rheological properties of SENIOR)

the secret and normalization of its viscosity.Reflex hypersecretion in combination with the anti-edematous effect of the drug Mainova AG

leads to the evacuation of secretions from the sinuses to the nasopharynx and provides physiological drainage of all sinuses
simultaneously.The drug promotes the restoration of mucociliary transport in the nasal cavity and ONP by increasing the Frankfurt am Main
presence of the liquid part of the secretion in the surface layer of the mucus. Sinuforte ® enhances blood microcirculation in the Zum Job
nasal mucosa and ONP. This is due to the fact that parasympathetic stimulation, which activates the secretion, also causes
vasodilation of the vessels supplying the glands.
Intensified reflex secretion in the form of serous-mucosal secretions is detected after a few minutes and can last from 30 to 120
Privacy policy:
minutes, depending on the individual characteristics of the organism. Privacy policy:
PHARMACOKINETICS
The effect of the Sinuforte ® preparation is due to the combined effects of cyclamen components, the most studied of which are
triterpene saponins.Carrying out kinetic studies is not possible, since all together the components can not be traced with the
help of markers or bio-studies. For the same reason, it is impossible to detect metabolites of the drug.
INDICATIONS
- complex therapy of acute and chronic sinusitis: sinusitis, frontal, etmoiditis and sphenoiditis (in the case of purulent sinusitis,
occurring with the generalization of infection and / or orbital complications, Sinuforte ® should be used only in combination
with antibiotics).In uncomplicated course of the disease, it is possible to use the drug as a monotherapy under the supervision
of a doctor;
- complex therapy of rhinosinusitis accompanied by exudative otitis media;
- the period of early postoperative rehabilitation after endoscopic surgical interventions on the paranasal sinuses.
DOSING MODE
Intranasally.
Adults and children over 5 years of age:
- Each time the dispenser dispenses 0.13 ml (2-3 drops) of the drug, which is about 1.3 mg of the drug (single dose).
- The preparation prepared by the above method is administered once a day by single spraying into each nasal passage.
Preliminary it is recommended to make 2-3 test sprays in the air.
- The drug is recommended to be used daily, if necessary, it is also allowed to use it every other day.
- The duration of one course of treatment is 12-16 days with the administration of the drug every other day or 6-8 days with
daily use.
SIDE EFFECT
There may be a feeling of mild or moderate burning in the nasal cavity, saliva and / or lacrimation in response to irritation of
sensitive receptors of the trigeminal nerve.
In some cases, reddening of the face, a brief headache in the frontal region, or a pale pink color discharge from the nose as a
result of capillary diapedesis may occur.The aforementioned short-term physiological reactions confirm the reflex mechanism
of action of the drug and do not require discontinuation of treatment.
Allergic reactions are possible (including skin rash, dyspnea, etc.).In these cases, it is recommended to stop taking the drug and
consult a specialist.
CONTRAINDICATIONS
- hypersensitivity to the components of the drug;
- Polyposis rhinosinusitis;
cysts of the paranasal sinuses;
- allergic rhinosinusopathy;
- allergic reactions (delayed and immediate);
- Arterial hypertension II-III st .;
- pregnancy and lactation period (safety of use in these periods has not been studied);
- Children under 5 years old (use in children under 5 years old has not been studied).
PREGNANCY AND LACTATION
Contraindicated in pregnancy and lactation.
APPLICATION FOR CHILDREN
Contraindicated for children under 5 years.

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