GENERIC CLASSIFICATION DOSAGE / INDICATIONS MECHANISM OF ACTION ADVERSE REACTION

Furosemide Sulphonamide diuretics .Oral Hypertension Furosemide inhibits reabsorption of Na and chloride Fluid and electrolyte imbalance. Rashes, photosensitivity,
Adult: 40-80 mg daily, alone or in conjunction with other antihypertensives. mainly in the medullary portion of the ascending Loop nausea, diarrhoea, blurred vision, dizziness, headache,
Oral Oedema associated with heart failure Adult: Initially, 20 mg daily or of Henle. Excretion of potassium and ammonia is also hypotension. Bone marrow depression (rare), hepatic
40 mg every other day for mild cases, or 40 mg once daily adjusted increased while uric acid excretion is reduced. It dysfunction. Hyperglycaemia, glycosuria, ototoxicity.
according to response. In some cases, 80 mg or more daily as a single dose increases plasma-renin levels and secondary Potentially Fatal: Rarely, sudden death and cardiac
or in 2 divided doses may be required. Max: 600 mg daily in severe cases. hyperaldosteronism may result. Furosemide reduces arrest. Hypokalaemia and magnesium depletion can cause
IntravenousPulmonary oedema BP in hypertensives as well as in normotensives. It cardiac arrhythmias.
Adult: 40 mg via slow inj. If no adequate response within 1 hr, a further 80 also reduces pulmonary oedema before diuresis has
mg may be given via infusion. set in.
IntravenousOliguria in acute or chronic renal failure
Adult: GFR: 5-20 ml/min: 250 mg diluted to 250 ml in a suitable diluent to
be infused over 1 hr. If urine output is insufficient within the next hr, may
follow by 500 mg added to an appropriate infusion fluid to be infused over 2
hr, total volume depends on the patient's state of hydration. If urine output is
still unsatisfactory within 1 hr after the 2nd infusion then a 3rd dose of 1 g
may be infused over 4 hr. Rate of infusion: ≤4 mg/min. For patients with
significant fluid overload, inj may be given without dilution directly into the
vein, rate of admin ≤4 mg/min. Patients who do not respond to a dose of 1 g
may need dialysis. If the response is satisfactory, the effective dose (of up to
1 g) may be repeated every 24 hr. Subsequently, adjust dose according to
patient's response.
Parenteral
Oedema associated with heart failure Adult: 20-50 mg IM or slow IV Inj
increased by 20-mg increments every 2 hr. Doses >50 mg must be given as
IV