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is a Blood disorders?
Bambang Sudarmanto
Kariadi Academic Medical Centre / Department of Child
Health Medical Faculty Diponegoro University Semarang
Introduction
Severe and recurrent forms of epistaxis constitute a major trouble parent and
doctor
It results from an interaction of factors damaging nasal mucose lining, affect the
vessel walls, or alter the coagulability of the blood, and malignancy
According to the literature, causes of epistaxis look different between adults and
children.
Epidemiology
Epistaxis is
A frequent ED complaint complaint; often causes significant anxiety in patients and cli
nicians
Rarely seen in infant < 2 years old
40% children will have presented with at least 1 episode of epistaxis by the age of 5
In age group 6-10 years 56% incidence rate
NOSEBLEEDS- EPISTAXIS
Cause of epistaxis
ENT
Pediatric
Frequency distribution of hematological patients
according to cause
EPISTAXIS : ADULT vs CHILDREN
ETIOLOGY NOSEBLEEDS
Adult Children
Most common cause: Most common cause:
Medication (NSAIDs, Warfarin,and Vascular fragylity
Aspirin) Alergic rhinitis, trauma
Hypertension Neoplasma (benigna, maligna)
Arteriosclerosis BLOOD DISORDERS
Cardiovascular disorder
Diagnosis
01 HISTORY
Posterior:
Posterior nosebleeds are much less common than anterior noseb
leeds. They tend to occur more often in elderly people.
Complicated, require admision to the hospital.
Nosebleeds in serious ?
Frequent nosebleeds
1. Accur more than once a week.
Platelets disorders
Combination of these
Blood coagulation is localized to surfaces
Primary hemostasis:
platelet adhesion and aggregation
• Secondary hemostasis:
clot formation
Primary hemostasis relies on platelets and von
Willebrand factor
Platelet functions:
– Adhesion (to sub endothelium)
– Release of platelet granules
– Aggregation (platelet-platelet)
Primer hemostasis
Vessel wall damage activation of primary hemostasis followed
by thrombus formation (secondary hemostasis)
VASSEL IN NASAL CAVITY
PLATELETS DISORDERS
Thrombocytopenia
Thrombopathy
THROMBOCYTOPENIA
Inherited Acquired
Hemophilia A Vitamin K deficiency
Comprehensive
Complete family
01 medical and
bleeding history
02 history
Platelet count
Bleeding Time (BT)
Protrhombin Time (PT)
Partial Thromnoplastin Time (PTT)
Thrombin Time (TT)
Approach of bleeding disorders in children (1)
Initial Laboratory Evaluation to Screen for Bleeding Disorders: Analysis and Interpretation
Possible bleeding
PT aPTT Platelet count
disorder
Hemophilia A, Hemophilia B
Normal Prolonged Normal Factor IX deficiency
vWD with F VIII disfunction
Early Vit K deficiency
Prolonged Normal Normal Factor VII deficiency
Warfarin excess
Approach of bleeding disorders in children (2)
Initial Laboratory Evaluation to Screen for Bleeding Disorders: Analysis and Interpretation
Liver diseases
Vit K deficiency
Prolonged Prolonged Normal
Common pathways factors
Dysfibrinogenesis
DIC
Prolonged Prolonged Low
Liver diseases
Acute ITP
Normal Normal Low
Chronic ITP
When we suspect malignancy?
Nosebleeds and Leukemia Nosebleeds and Liver cancer
01 02
Acute leukemia most common Hepatoblastoma and hepatocellular
hematology malignancy in childhood carcinoma most common type of
liver cancer in childhood
03 Repeated nosebleeds
04 Bleeds frequently