Name of Drug Classification and
(Dosage, Route, Mechanism of Action
Frequency, Timing)
Generic Name: Classification:
Ceftriaxone
3rd generation
cephalosporin
Brand Name:
Forgram Mechanism of Action:
Works by inhibiting the
mucopeptide synthesis in
Dosage: the bacterial cell wall. The
685mg beta-lactam moiety of
Ceftriaxone binds to
carboxypeptidases,
endopeptidases, and
Route: transpeptidasesin the
IV bacterial cytoplasmic
membrane. These enzymes
are involved in cell-wall
synthesis and cell division.
Frequency: By binding to these
Q12H enzymes, Ceftriaxone results
in the formation of defective
cell walls and cell death.
Timing:
Indication and Side Effects or Adverse Nursing Responsibilities
Contraindication Reactions
 Pain  Assess patient’s
Indication:  Phlebitis previous sensitivity
. Indicated in patients with  Rash reaction to penicillin
neurologic complications,  Diarrhea or other
carditis and arthritis. It is  Thrombocytosis cephalosporins.
also effective in Gram  Leucopenia  Assess patient for
negative infections; signs and symptoms
 Glossitis
Meningitis, Gonorrhea. It is of infection before
also for Bone and joint and during the
infections, Lower treatment
respiratory tract infections,  Report signs such as
middle ear infection, PID, petechiae,
Septicemia and Urinary Tract ecchymotic areas,
infections. epistaxis or other
forms of
Contraindication: unexplained
Hypersenstive to bleeding.
cephalosporins,  Monitor
penicillins and related hematologic,
antibiotics. elctrolytes, renal and
hepatic function.