Assignment 1: Chapter 2 – States of Matter Related to Pharmaceutical Calculations

Name: _________________________Yr./Sec.________ Seat no._________Date:___________________

Answer the following:

_____________________1. Forces of attraction or repulsion between molecules.

_____________________2. Force of attraction between unlike molecules.

_____________________3. Force of attraction between like molecules.

Types of Intermolecular forces:

_____________________4. Relatively weak forces compared to covalent forces. It include dipole-dipole,

dipole-induced dipole and induced dipole-induced dipole.

_____________________5. Force of attraction between an ionized drug molecule and a counterion which
may be an inorganic salt ion or organic species.

_____________________6. Strong type of dipole-dipole attraction that results from the interaction
between the hydrogen atom and electronegative atom.

_____________________7. Force of attraction arises from the inability of non-polar molecules to interact
with water.

8. Differentiate the states of matter based on the following criteria:

Intermolecular
States Characteristics Kinetic energy
forces
Solid

Liquid

Gas

9. Three main types of solids:

Types Characteristics
Crystalline

Amorphous

Polymeric
Assignment 1: Chapter 2 – States of Matter Related to Pharmaceutical Calculations

Name: _________________________Yr./Sec.________ Seat no._________Date:___________________

_____________________10 They are drugs that exist in more than one crystalline shape.

_____________________11. Most drugs exist in the _____ form.

_____________________12. and _____________________13. Crystals are defined by the ___ and ___ of
the lattice.

_____________________14 Crystal system which exhibits the highest symmetry.

_____________________15 Crystal system which exhibits the lowest symmetry.

_____________________16.and ______________________17. Chemical degradation of crystals may be

accelerated under___ conditions and presence of ___.

_____________________18. and _____________________19. Polymorphic crystals differ in ___ and ___

due to difference in molecular interactions.

_____________________20. Differences in solubility of the drug may to lead to differences in ____.

_____________________21. It is the study of the factors influencing the bioavailability of a drug in humans
and animals and the use of this information to optimize therapeutic activity.

_____________________22. It is the study of the absorption, distribution, metabolism and excretion of

drugs in the body.

_____________________23. It deals with the art and science of formulation and manufacture of dosage
forms and drug delivery system.

_____________________24. Amorphous solids can be converted to crystalline state.

25-28. Which type of solid exhibits the following characteristics?

A. Crystalline
B. Amorphous

______25. Faster chemical degradation

______26. Physically more stable

______27. Dissolves faster

______28. Less soluble