Hepatitis C Drug- Hepcvel(Sofosbuvir/Velpatasvir)

Description Of Hepcvel:
 Hepcvel Combination of Sofosbuvir 400mg&Velpatasvir 100mg which is a Cipla
product get approved by FDA.

 The combination of sofosbuvir & Velpatasvir is highly effective in chronic hepatitis C

viral infection caused by genotypes I to VI.
 Hepcvel is not a curable medication; it is used for diminishing the disease progression by
depleting the multiplication of virus in the body.
 Hepcvel tablets are prescription medicine which is used only under the guidance of
medical practitioner.

Brand name : Hepcvel

Ingredient : Sofosbuvir
400mg/Velpatasvir 100mg

Tablet Count: 28 Tablets

Company Name : Cipla

Hepcvel Tablet Uses:

 Hepcvel(Sofosbuvir/Velpatasvir) used to treat Chronic Hepatitis C,a viral infection of the
liver.
Hepcvel Tablet Side effects:
 Headache
 Fatigue
 Nausea
 Asthenia
 Insomnia
 Diarrhea
Pharmacokinetics of Hepcvel
Absorption
The maximal peak plasma concentration time of;
 Sofosbuvir 0.5 to 1 hour
 Velpatasvir 3 hours
Distribution
After absorption occurs, Hepcvel get binds to human plasma protein by;
 Sofosbuvir 61 to 65%
 Velpatasvir >99.5%
The blood plasma ratio of Hepcvel;
 Sofosbuvir: 0.7; Velpatasvir: 0.52 to 0.67
Metabolism
 The metabolism of Hepcvel is occurs widely in liver
 Sofosbuvir: cathepsin A, carboxyl esterase 1 or HINT1
 Velpatasvir: CYP2B6, CYP2C8, or CYP3A4
Indication of Hepcvel Tablet:
 Hepcvel tablets are primarily indicated for the treatment of chronic hepatitis C viral
infection associated with genotype I to VI.
Hepcvel is indicated for the conditions;
 Patients without cirrhosis or with compensated cirrhosis
 Patients with decompensated cirrhosis
Dosage & Administration of Hepcvel:
Before initiating the treatment;
 Patient’s HBsAg & anti-HBc levels should be examined before starting the therapy with
hepcvel tablets.
The recommended dose of Hepcvel tablets;
 Hepcvel tablets are two medicine fixed dose combination consists of 400mg of
sofosbuvir & 100mg of Velpatasvir.
 Hepcvel is a single use tablet.
Warning & precautions
  This fatal case should be occurred in the patients with HCV/HBV co infection & also
who receiving anti-HCV agents but not getting anti-HBV treatment.
 Before starting the treatment, patient should be tested by measuring HBsAg 7 anti-HBc
counts.
 Monitor the liver function test.
 Initiate the HBV infection management.
Pregnancy & lactation
 Hepcvel pregnancy category is B
 Hepcvel with ribavirin pregnancy category is X
 This combination should not be used in pregnancy period.
 Breast feeding should not be recommended.
Storage
 Hepcvel tablet container should be stored at temperature below 30oC.
 Keep the container away from heat, moisture & light.
Missed dose
 In case of missed dose condition, patients should be consult with medical adviser &
follow the instructions.
 Maintain the regular dosing schedule.
 Avoid self medication.

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