Vous êtes sur la page 1sur 6

-$\XUYHGD,QWHJU0HG-DQ0DU  ± 30&,'30&

GRL

3UDNULWLDQGLWVDVVRFLDWLRQVZLWKPHWDEROLVPFKURQLFGLVHDVHVDQGJHQRW\SHV3RVVLELOLWLHVRIQHZERUQ
VFUHHQLQJDQGDOLIHWLPHRISHUVRQDOL]HGSUHYHQWLRQ
6XEKRMLW'H\DQG3DULND3DKZD

'HSDUWPHQWRI(SLGHPLRORJ\,QGLDQ,QVWLWXWHRI3XEOLF+HDOWK'HOKL,QGLD

'LVWULFW,PSURYHPHQW&RRUGLQDWRU85&86$,'$66,673URMHFW/XGKLDQD3XQMDE,QGLD
$GGUHVVIRUFRUUHVSRQGHQFH'U6XEKRMLW'H\$VVRFLDWH3URIHVVRU,QGLDQ,QVWLWXWHRI3XEOLF+HDOWK'HOKL3ORW6HFWRU,QVWLWXWLRQDO$UHD*XUJDRQ+DU\DQD,QGLD(
PDLOVXEKRMLWGH\#LLSKGRUJ

5HFHLYHG6HS5HYLVHG1RY$FFHSWHG1RY

&RS\ULJKW‹-RXUQDORI$\XUYHGDDQG,QWHJUDWLYH0HGLFLQH

7KLVLVDQRSHQDFFHVVDUWLFOHGLVWULEXWHGXQGHUWKHWHUPVRIWKH&UHDWLYH&RPPRQV$WWULEXWLRQ1RQFRPPHUFLDO6KDUH$OLNH8QSRUWHGZKLFKSHUPLWVXQUHVWULFWHGXVHGLVWULEXWLRQDQG
UHSURGXFWLRQLQDQ\PHGLXPSURYLGHGWKHRULJLQDOZRUNLVSURSHUO\FLWHG

7KLVDUWLFOHKDVEHHQFLWHGE\RWKHUDUWLFOHVLQ30&

$EVWUDFW *RWR

$\XUYHGDLVRQHRIWKHROGHVWKHDOWKVFLHQFHVRIWKHZRUOGZLWKFRQFHSWVRItridoshaDQGprakritiEHLQJFRUHSKLORVRSKLHV7KHVHFRUHFRQFHSWV
DOORZLPSOHPHQWDWLRQRIZD\VIRUQRWRQO\SHUVRQDOL]HGPHGLFLQHDQGWUHDWPHQWEXWDOVRSHUVRQDOL]HGSUHYHQWLRQ,QWKHOLJKWRIPRGHUQRU
FXUUHQWVFLHQFHHYLGHQFHKDVVXUIDFHGFRQQHFWLQJWKHFRQFHSWVRItridoshaDQGprakritiZLWKPHWDEROLFSDWKZD\VFKURQLFGLVHDVHVDQGYDULRXV
JHQRW\SHV6XFKHYLGHQFHKDVWKURZQXSLQVLJKWVDERXWWKHXQLYHUVDOLW\RI$\XUYHGLFFRQFHSWVDVZHOODVWKHLUDSSDUHQWDVVRFLDWLRQZLWK
FRQFHSWVLQFXUUHQWVFLHQFH7KLVUHYLHZZDVXQGHUWDNHQWRFRQVROLGDWHWKHHYLGHQFHRIVXFKDVVRFLDWLRQVZKLFKH[LVWEHWZHHQprakritiDQG
PHWDEROLFV\VWHPVFKURQLFGLVHDVHVDQGJHQRW\SHVZLWKWKHREMHFWLYHWKDWDFDVHFDQEHPDGHIRUGUDZLQJRXWWKHFOHDUOLQNDJHVWKDWPLJKW
H[LVWIRUprakritisEHLQJGLVWLQFWSKHQRW\SHVUHSUHVHQWLQJFHUWDLQJHQRW\SHV$FRUROODU\WRVXFKGLVFRYHULHVFDQEHWKHSRVVLELOLW\RIQHZERUQV
EHLQJVFUHHQHGIRUWKHLUprakritiE\JHQHWLFWHVWLQJZKLFKZLOOHQDEOHWKHSUHYHQWLRQRIYDULRXVFKURQLFGLVHDVHVIRUVXFKFKLOGUHQYLDWKH
LPSOHPHQWDWLRQRIYDULRXVGLHWDU\OLIHVW\OHDQGKDELWXDOFKDQJHVDVUHTXLUHGIURPDQHDUO\DJH7KLVLPSOHPHQWDWLRQRISUHYHQWLYHSUDFWLFHV
IURPDQHDUO\DJHPD\UHVXOWLQVXFKFKLOGUHQOHDGLQJKHDOWK\GLVHDVHIUHHPRUHSURGXFWLYHOLYHV7KXVHYHQWXDOO\WKLVFDQEHDQRSSRUWXQLW\
WRSUDFWLFHSHUVRQDOL]HGSUHYHQWLYHKHDOWKZKLFKLVQRWDSRVVLELOLW\LQRWKHUV\VWHPVRIPHGLFLQHHVSHFLDOO\ZHVWHUQV\VWHPVRIPHGLFLQH
3HUVRQDOL]HGSUHYHQWLYHKHDOWKLVRQHVWHSIXUWKHUWKDQSHUVRQDOL]HGPHGLFLQHDQGLVDYHU\QRYHOLGHDZLWKIDUUHDFKLQJLPSOLFDWLRQV

Keywords: $\XUJHQRPLFVQHZERUQVFUHHQLQJSHUVRQDOL]HGSUHYHQWLRQprakritiTridosha

,1752'8&7,21 *RWR

$\XUYHGDLVWKHDQFLHQWPHGLFDOVFLHQFHSUHYDOHQWIRUWKRXVDQGVRI\HDUVLQWKH,QGLDQVXEFRQWLQHQW2QHRIWKHNH\IXQGDPHQWDOWKHRULHVRI
$\XUYHGDLQYROYHVDV\VWHPRIXQGHUVWDQGLQJKHDOWKDQGGLVHDVHNQRZQDVWKHtridosha>@7KLVFRQFHSWRItridoshaLQYROYLQJWKHWKUHHdoshas
RIvatapittaDQGkaphaLVDFHQWUDOGRFWULQHRI$\XUYHGDDQGIROORZVIURPWKHILUVWFKDSWHURIWKHHDUOLHVWWH[WRQ$\XUYHGDWKHCharaka
Samhita>@7KHDQFLHQWWH[WVRI$\XUYHGDPHQWLRQQXPHURXVSURSHUWLHVRIdoshasDQGKRZWKH\DIIHFWDKXPDQEHLQJ
VSK\VLRORJ\RUprakriti
EDVHGRQWKHGRPLQDQFHRIRQHRUPRUHdoshas7KHprakritiRIDSHUVRQLVTXLWHFDSDEOHRISURYLGLQJDIDLULQGLFDWLRQRISK\VLRORJLFDO
VWUHQJWKVDQGZHDNQHVVHVPHQWDOWHQGHQFLHVDQGVXVFHSWLELOLW\WRLOOQHVVHVRIYDULRXVW\SHV>7DEOH@>@7KHUHH[LVWDQXPEHURIWRROVPDLQO\
TXHVWLRQQDLUHVIRUDVFHUWDLQLQJWKHprakritiRIDQLQGLYLGXDODQGWKHUHKDYHEHHQRQJRLQJDWWHPSWVRIYDOLGDWLQJVXFKDWRROVLQFHWKHV
VXFKDVLQYHVWLJDWLRQLQWRVXFKWRROVGRQHE\-RVKL>@DQG5DVWRJL>@$WWKHPRPHQWTXHVWLRQQDLUHVIRUGHWHUPLQLQJRQH
VGRVKDH[LVWRQOLQH
DVZHOODQGFDQEHUHDGLO\XVHGE\SHRSOHWRGHWHUPLQHWKHLURZQprakriti>@7KHUHDOVRH[LVWVWKHDJHROGPHWKRGRInadi vigyanRUSXOVH
GLDJQRVLVWKURXJKZKLFKDVNLOOHG$\XUYHGLFSK\VLFLDQFDQGHWHUPLQHprakritiDPRQJRWKHUWKLQJV>@+RZHYHUQROLWHUDWXUHVXJJHVWVWKH
SUHVHQFHRIVWDQGDUGL]HGWHFKQLTXHVIRUnadi vigyanRUIRUWKHQHHGWRVWDQGDUGL]HLW

7DEOH
&KDUDFWHULVWLFIHDWXUHVRIWKHWKUHHH[WUHPHprakritiW\SHVVatapittaDQGkaphaDQGWKHLU
VXVFHSWLELOLW\WRGLVHDVHV

,QDGGLWLRQWRDWWHPSWVDWYDOLGDWLQJDWRROWRDVFHUWDLQprakritiWKHUHKDYHDOVREHHQQXPHURXVRQJRLQJDWWHPSWVDWXQGHUVWDQGLQJ$\XUYHGLF
SULQFLSOHVDQGYDOLGDWLQJ$\XUYHGLFWKHRULHVLQWKHOLJKWRIPRGHUQVFLHQFH>@2IODWHOLQNVKDYHEHHQIRUZDUGHGDERXWWKHDVVRFLDWLRQRIWKH
tridoshaWKHRU\ZLWKOLYLQJV\VWHPVRIDOORUJDQLVPVELRORJLFDOIXQFWLRQVLQFHOOVDQGRUJDQLVPVDQGJHQHWLFV>@7KHPRVWUHFHQW
XQGHUVWDQGLQJRI$\XUYHGLFWridoshaWKHRU\LVUHODWHGWRWKHIDFWWKDWdoshasDUHFRQFHUQHGZLWKRUJDQLVPUHJXODWLRQVLQYROYLQJLQSXWRXWSXW
WXUQRYHUDQGVWRUDJH>@$FFRUGLQJWRWKLVXQGHUVWDQGLQJdoshasDUHELRORJLFDOO\XQLYHUVDOPHFKDQLVPVUHJXODWLQJIXQFWLRQVLGHQWLILHGDV
IXQGDPHQWDOE\V\VWHPVWKHRU\LQSXWDQGRXWSXW vata WKURXJKSXWRUWXUQRYHU pitta DQGVWRUDJH kapha $VVXFKLWKDVEHHQH[WUDSRODWHG
WKDWdoshasDUHIXQGDPHQWDOWRDOOOLYLQJV\VWHPVDQGRUJDQLVPVDQGHYHQVLQJOHFHOOV>@7KXVRIODWHWKHUHLVHPHUJLQJDIXOOWKHRU\LQWHUPV
RIDOOPRGHUQVFLHQFHVZKLFKFDQEHVXEMHFWHGWRHPSLULFDOWHVWLQJDQGZHDZDLWIXUWKHUUHVHDUFKWKDWFDQWDNHWKHXQGHUVWDQGLQJRI$\XUYHGD
IRUZDUGLQWHUPVRIPRGHUQVFLHQFH
2QHVXFKDUHDZLWKUHVSHFWWRPRGHUQVFLHQFHLQZKLFKVRPHHYLGHQFHLVEHLQJJHQHUDWHGLVQRZNQRZQDV$\XJHQRPLFV>@7KHEDVLF
FRQFHSWEHKLQG$\XJHQRPLFVLVWKHIDFWWKDWLIWKHV\VWHPRItridoshaLVSUHYDOHQWLQDOORUJDQLVPVWKHQWKHUHPXVWEHZD\VLQZKLFKLWLV
LQKHULWHG6WDWHGVLPSO\prakritiPXVWEHDSKHQRW\SLFSKHQRPHQRQDULVLQJIURPDSDUWLFXODUJHQRW\SH7KHdoshasUHSUHVHQWGLIIHUHQWDVSHFW
RIUHJXODWLRQZLWKLQDQRUJDQLVPDQGVXFKUHJXODWLRQLVDUHVXOWRIPHWDEROLFSDWKZD\VLQYROYLQJPXOWLSOHHQ]\PHV>@7KXVLISURWHLQHQ]\PHV
DUHLQKHULWHGWKHQVRDUHPHWDEROLFSDWKZD\VFRPSULVLQJRIPXOWLSOHHQ]\PHV>@$OWKRXJKWKHUHDUHHQRUPRXVGLIILFXOWLHVLQXQGHUVWDQGLQJWKH
SDWWHUQRILQKHULWDQFHRIHQ]\PHVLQYROYHGLQFRPSOH[PHWDEROLFSDWKZD\VVRPHKHDGZD\KDVEHHQPDGHLQLGHQWLI\LQJPHWDEROLFSDWKZD\V
RIFHUWDLQGLVHDVHVDVZHOODVFHUWDLQJHQHVUHODWHGWRprakritiW\SHV>@

6LQFHprakritiLVUHODWHGWRFHUWDLQSK\VLFDODQGPHQWDOWHQGHQFLHVWKDWGHWHUPLQHVXVFHSWLELOLW\WRGLVHDVHVWKHDQFLHQWWH[WVRI$\XUYHGDDOVR
SURYLGHJXLGHOLQHVIRUPDLQWDLQLQJOLIHVW\OHVLQDFFRUGDQFHZLWKRQH
VprakritiIRUFRQWLQXHGKHDOWK\OLYLQJLQDSHUVRQDOL]HGPDQQHU>@
$OWKRXJKQXPHURXVSXEOLFDWLRQVH[LVWLQDOOWKHDERYHPHQWLRQHGWRSLFVRQDVVHVVLQJWKHSUHVHQWOLWHUDWXUHZHIHOWWKHQHHGIRUV\QWKHVL]LQJWKH
FXUUHQWVWDWHRIHYLGHQFHUHJDUGLQJ$\XUYHGLFprakritiLWVUHODWLRQWRPHWDEROLVPFKURQLFGLVHDVHDQGJHQRW\SHVDQGWKHIXWXUHGLUHFWLRQ,Q
WKLVUHYLHZZHKDYHDWWHPSWHGWRFROODWHHYLGHQFHZLWKUHJDUGVWRWKHUHODWLRQRIprakritiZLWKPHWDEROLVPFKURQLFGLVHDVHDQGJHQRW\SHV
NQRZQVRIDU:HDOVRWDNHWKLVNQRZOHGJHIXUWKHUWRSUHGLFWDIXWXUHZKHUHLWZLOOEHSRVVLEOHWRVFUHHQQHZERUQVXVLQJWKHLUJHQRW\SHDQG
WKXVGHWHUPLQHWKHLUprakritiZKLFKFDQWKHQKHOSXVGHFLGHWKHW\SHRIPRVWKHDOWK\DQGVXLWDEOHOLIHVW\OHIRUVXFKQHZERUQVWROHDGDGLVHDVH
IUHHDQGSURGXFWLYHOLIH7KLVZLOOEHDQRYHOVWHSWRZDUGVSHUVRQDOL]HGSUHYHQWLYHPHGLFLQHIRUKXPDQV

0$7(5,$/6$1'0(7+2'6 *RWR

$VHDUFKZDVXQGHUWDNHQLQ0('/,1( ZZZSXEPHGFRP RUWKH3XE0HGGDWDEDVHXVLQJNH\ZRUGVOLNHprakritiGRVKDprakriti


JHQRW\SHVprakritiFKURQLFGLVHDVHprakritiPHWDEROLVPprakritiSHUVRQDOL]HGPHGLFLQH$\XUYHGDprakriti$\XUYHGDGRVKD$\XUYHGD
prakritiJHQRW\SHV$\XUYHGDprakritiFKURQLFGLVHDVH$\XUYHGDprakritiPHWDEROLVPDQG$\XUYHGDprakritiSHUVRQDOL]HGPHGLFLQHZLWKWKHLU
FRUUHVSRQGLQJPHVKWHUPVLQFRPELQDWLRQOLNH25$1'7KHIROORZLQJDUHWKHSURFHVVDQGHOLJLELOLW\FULWHULDIRUWKHLQFOXVLRQRIDUWLFOHVLQ
WKLVUHYLHZ7KHVHDUFKZDVOLPLWHGWRRQO\(QJOLVKOLWHUDWXUHLQFOXGLQJWKRVHVWXGLHVZKLFKZHUHSXEOLVKHGIURPWR7KLVVHDUFK
\LHOGHGDWRWDORIDUWLFOHVIURPWKH3XE0HGVRXUFHDQGDUWLFOHVIURPRWKHUVRXUFHVVXFKDV*RRJOH6FKRODU29,'0('6&$3(
&$%,%0&DQG6FLHQFH'LUHFW>)LJXUH@)LIW\HLJKWDUWLFOHVZHUHVHOHFWHGDIWHUUHPRYLQJDOOWKHGXSOLFDWHV$IWHUVFUHHQLQJDOOWKHVH
DUWLFOHVDUWLFOHVZHUHLQFOXGHGDVRWKHUDUWLFOHVZHUHXQUHODWHGWRWKHWRSLFFRQFHUQHG2XWRIWKHVHDUWLFOHVWKUHHPRUHDUWLFOHVZHUH
H[FOXGHGDVWKHVHGLGQRWKDYHWKHUHOHYDQWLQIRUPDWLRQUHODWHGWRRXUUHYLHZREMHFWLYHV$WRWDORIDUWLFOHVIXOILOOHGWKHLQFOXVLRQFULWHULD>
7DEOH@7KLVVHDUFKZDVXQGHUWDNHQLQ)HEUXDU\

)LJXUH
)ORZRILQIRUPDWLRQLQWHUPVRIQXPEHURIDUWLFOHVWKURXJKGLIIHUHQWSKDVHVRIOLWHUDWXUHVHDUFKIRU
WKLVUHYLHZ

7DEOH
'HWDLOHGOLVWRIDUWLFOHVXVHGIRUWKLVUHYLHZ

3UDNULWLDQGPHWDEROLVP

:HGLVFRYHUHGDWRWDORIVHYHQDUWLFOHVUHODWHGWRprakritiDQGPHWDEROLVPLQRXUUHYLHZ $UWLFOHVDQG >7DEOH@


PrakritiOLWHUDOO\PHDQLQJFRQVWLWXWLRQRUQDWXUHDQGFRQVLVWVRIWKHtridoshas vatapittaDQGkapha >@7KHWKUHHVWULNLQJFRQVWLWXWLRQVRI
prakriti vatapittaDQGkapha SUHVHQWDVHWRIPHWDEROLFWHQGHQFLHVZKLFKKHOSLQGHWHUPLQLQJWKHUHDFWLRQRIERG\DQGPLQGZKHQ
FRQIURQWHGE\DVWLPXOXV(DFKGRVKDKDVLWVGLVWLQFWSURSHUWLHVDQGIXQFWLRQVZKLFKDUHXQLYHUVDOWROLYLQJV\VWHPVDQGDUHSUHVHQWLQDOO
RUJDQLVPV>@,Q$\XUYHGDWKHWKUHHdoshasDUHXQGHUVWRRGWRKDYHWKHLUUHJLRQVZLWKLQWKHERG\ZKHUHWKH\SUHGRPLQDWHvataEHORZWKH
QDYHOpittaEHWZHHQWKHFODYLFOHDQGQDYHODQGkaphaDERYHWKHFODYLFOH>@*HQHUDOO\WKHUHLVDQDWXUDOSUHGRPLQDQFHRIRQHRUPRUHdoshas
LQDQLQGLYLGXDO,QKXPDQERG\IXQFWLRQVOLNHFHOOGLYLVLRQPRYHPHQWDQGH[FUHWLRQRIZDVWHVDUHPDLQO\JRYHUQHGE\vata prakritiZKLOH
DQDEROLVPJURZWKPDLQWHQDQFHRIVWUXFWXUHVWRUDJHDQGVWDELOLW\DUHFRQWULEXWHGE\kaphaDQGpittaLVSULPDULO\UHVSRQVLEOHIRUPHWDEROLVP
WKHUPDOUHJXODWLRQDQGKRPHRVWDVLV>@(DFKprakritiKDVVSHFLILFSK\VLFDOSK\VLRORJLFDODQGSV\FKRORJLFDODWWULEXWHV gunas ZKLFKWRWDOO\
GHSHQGVXSRQLQYROYHPHQWRIHDFKGRVKDLQDQLQGLYLGXDO>@(YHU\LQGLYLGXDOPXVWPDLQWDLQWKHLUEDODQFHRIdoshasDVGHWHUPLQHGE\WKHLU
prakritiLQRUGHUWRUHPDLQKHDOWK\

PrakritiLVEHOLHYHGWREHGHWHUPLQHGDWWKHWLPHRIFRQFHSWLRQDQGUHPDLQXQDOWHUHGGXULQJWKHOLIHWLPHZLWKFRQWULEXWLRQVIURPHQYLURQPHQWDO
IDFWRUVLQFOXGLQJPDWHUQDOGLHWDQGOLIHVW\OH>@(YHU\LQGLYLGXDOFDQEHFDWHJRUL]HGLQWRYDULRXVFRPELQDWLRQVRIvatapittaDQGkapha
prakritiGHSHQGLQJXSRQWKHSUHGRPLQDQFHRIHDFKGRVKDDQGLVLQGHSHQGHQWRIUDFHHWKQLFLW\ODQJXDJHDQGJHRJUDSK\ZKLFKZLOOEH
VSHFLILFIRUHDFKLQGLYLGXDO7KHVXVFHSWLELOLW\WRGLIIHUHQWGLVHDVHVGHSHQGVXSRQWKHW\SHRIprakritiFRQVWLWXWLRQLQDQLQGLYLGXDO7KHUHIRUH
DVVHVVPHQWRIprakritiDQDO\VLVZLOOQRWRQO\KHOSLQXQGHUVWDQGLQJWKHSK\VLFDODQGPHQWDOFRQVWLWXWLRQRISDWLHQWEXWDOVRSOD\VDYLWDOUROHLQ
SURJQRVLVGLDJQRVLVWUHDWPHQWDQGSUHYHQWLRQRIPDQ\FRPSOH[GLVHDVHV

VatapittaDQGkapha prakritiDUHIRXQGWRKDYHXQLTXHPHWDEROLFDFWLYLWLHV$FFRUGLQJWR$\XUYHGDkaphaLVVORZpittaLVIDVWDQGvataLV
FRQVLGHUHGWRKDYHYDULDEOHPHWDEROLVP9DULRXVVWXGLHVKDYHWULHGWRHVWDEOLVKFRUUHODWLRQEHWZHHQVSHFLILFprakritiW\SHVDQGGLIIHUHQW
PHWDEROLFDFWLYLWLHVRFFXUULQJLQWKHERG\5HFHQWO\DVWXG\UHSRUWHGWKDWERG\PDVVLQGH[ %0, LQvata­pitta prakritiZDVVLJQLILFDQWO\OHVVDV
FRPSDUHGWRkapha­pitta prakritiDQGWKHvata­pitta prakritiLQGLYLGXDOVZHUHIRXQGWREHKDYLQJPD[LPXPSODWHOHWDJJUHJDWLRQ>@2QHRIWKH
DVVRFLDWLRQVRItridoshasKDVEHHQK\SRWKHVL]HGE\+DQNH\  LQZKLFKLWZDVVXJJHVWHGWKDWWKHSHSWLGHFRHQ]\PH$ZKLFKRFFXUVLQDOO
FHOOVDFURVVDOOVSHFLHVSUHVHUYHGWKURXJKHYROXWLRQDQGLVDVVRFLDWHGZLWKOLSLGPHWDEROLVPLVOLQNHGZLWKWKHtridoshasDWWKHFHOOXODUOHYHO>@
2QHPRUHVWXG\GHVFULEHVWKHFRQFHSWRIprakritiLQDJLQJVWDWLQJWKDWWKHpittaSUHGRPLQDQFHprakritiW\SHLQGLYLGXDOVKDYHKLJKEDVDO
PHWDEROLFUDWH %05 DQGHQHUJ\FRQVXPSWLRQOHDGLQJWRWLVVXHGHVWUXFWLRQDQGSUHPDWXUHDJLQJDQGDYHUDJHOLIHVSDQZKLOHkapha
SUHGRPLQDQFHprakritiW\SHKDYHDWHQGHQF\WRGHOD\HGPDQLIHVWDWLRQRIDJLQJDQGORQJHUOLIHVSDQ>@

*KRGNHet al  GHPRQVWUDWHDSUREDEOHJHQRPLFEDVLVIRUPHWDEROLFGLIIHUHQFHVDWWULEXWHGE\prakritiDQGFRQFOXGHGWKDWpitta prakriti


DUHIDVWPHWDEROL]HUVDQGkaphaRQHVDUHVORZDQGDUHLQIOXHQFHGE\GLIIHUHQWGRVHVRI&<3&,VXEVWUDWHV>@7KXVLWZDVDSSDUHQWIURPWKLV
VWXG\WKDWIDVWDQGVORZPHWDEROLVPZDVRQHRIWKHPDMRUGLIIHUHQWLDWLQJSKHQRPHQDZLWKUHVSHFWWRFRUUHODWLRQVEHWZHHQ&<3&JHQRW\SHV
DQGprakriti(YLGHQFHIURPRWKHUVWXGLHVDOVRLQGLFDWHVSUREDEOHGLIIHUHQFHVLQRWKHUELRPDUNHUVUHODWHGWRWKHtridoshaV\VWHP6LHUUD 
PDNHVWKHFRQQHFWLRQEHWZHHQ$\XUYHGDtridoshaV\VWHPZLWKSV\FKRORJLFDODQGHQGRFULQRORJLFDOFRPSRQHQWVRIDKXPDQEHLQJDQGVXJJHVWV
SRVVLEOHELRPDUNHUVUHODWHGWRWKHWKUHHERG\W\SHV>@+HSURIIHUVWKDWWKHJHQRSV\FKRVRPDWRW\SLQJRIKXPDQVDVFRPSULVHGE\WKHtridosha
WKHRU\RI$\XUYHGDLVPHGLDWHGE\FHUWDLQQXFOHDUUHFHSWRUVPDLQO\WKRVHUHODWHGWRDQGURJHQ7FHOOVDQGWK\UR[LQHZKLFKDUHUHODWHGWRpitta
PHVRPRUSKLFRUDQGUXV kapha HQGRPRUSKLFRUWK\PXV DQGvata HFWRPRUSKLFRUWK\UXV UHVSHFWLYHO\7KHVHUHFHSWRUVUHJXODWHWKH
H[SUHVVLRQRIFHUWDLQJHQHVDQGWKXVKDYHDQRYHUDOOFRQWURORYHUHPEU\RQLFGHYHORSPHQWDGXOWKRPHRVWDVLVDQGILQDOO\WKHPHWDEROLVPRIDQ
RUJDQLVP$QGURJHQVDUHQRWUHIHUUHGWRRQO\DVPDOHKRUPRQHVEXWDVDEURDGHUWHUPFRQVLVWLQJRIYDULRXVVWHURLGKRUPRQHVZKLFKGHWHUPLQH
WKHSK\VLFDOFRQVWLWXWLRQRIKXPDQV6XFKVWHURLGKRUPRQHVKDYHEHHQNQRZQWRPRGLI\EUDLQVWUXFWXUHVLQYDULRXVVSHFLHVDQGDOVREHWZHHQ
JHQGHUVZLWKLPSOLFDWLRQVIRUYDULRXVEHKDYLRUVVXFKDVDJJUHVVLRQGRPLQDQFHFRXUDJHDQGOLELGRDQGFDQEHILUVWPDUNHUIRUtridosha
V\VWHP>@$QRWKHUFRPSRQHQWLVWKDWRIFHOOPHGLDWHGLPPXQLW\ZKLFKDFWVLQGHSHQGHQWRIDQWLERGLHVRUFRPSOHPHQWVDQGFDQWKXVEHD
VHFRQGELRPDUNHUUHODWHGWRWKHtridoshaV\VWHP/DVWEXWQRWWKHOHDVWLVWKHWK\URLGKRUPRQHVZKLFKDUHSULPDULO\UHVSRQVLEOHIRUDERG\
VUDWH
RIPHWDEROLVPKRZTXLFNO\DERG\XVHVHQHUJ\PDNHVSURWHLQVDQGFRQWUROVVHQVLWLYHQHVVRIERG\WRRWKHUKRUPRQHV*LYHQWKHLPSRUWDQFH
RIWK\URLGKRUPRQHVLQFUHDWLQJHVVHQWLDOPHWDEROLFGLIIHUHQFHEHWZHHQKXPDQVWKLVKDVEHHQVXJJHVWHGDVDWKLUGPDUNHUUHODWHGWRWKH
tridoshaV\VWHP>@)LQDOO\WKHSLWXLWDU\DQGWKHPHODQRF\WHVWLPXODWLQJKRUPRQH 06+ FDQPRGLI\WKHHIIHFWVRIWKHDERYHWKUHHPDUNHUVWR
SURGXFHIXUWKHUQXDQFHGGLIIHUHQFHVEHWZHHQWKHWKUHHERG\W\SHV>@

7KXVDQXPEHURIVWXGLHVKDYHGHPRQVWUDWHGRUK\SRWKHVL]HGWKHOLQNVRIWKH$\XUYHGLFtridoshaWKHRU\ZLWKYDULRXVPHWDEROLFV\VWHPVDQG
ELRPDUNHUVDPRQJZKLFKVRPHKDYHHYHQGHPRQVWUDWHGWKHJHQRPLFOLQNDJHVDVZHOO+RZHYHUDQXPEHURIWKHVHDVVRFLDWLRQVQHHGWREH
IXUWKHUYHULILHGE\PRUHGLUHFWHYLGHQFH

3UDNULWLDQGFKURQLFGLVHDVH

:HKDYHOLVWHGDWRWDORIILYHDUWLFOHVUHODWHGWRprakritiDQGFKURQLFGLVHDVHVLQWKLVUHYLHZ DUWLFOHVDQG >7DEOH@PrakritiRUD


SHUVRQ
VFRQVWLWXWLRQRIKLVKHUtridoshasDOVRKDVDFOHDUOLQNWRWKHVXVFHSWLELOLW\RQHKDVIRUFKURQLFGLVHDVHV7KLVLVTXLWHZLGHO\NQRZQLQ
$\XUYHGDEXWLVDOVRQRZEHFRPLQJPRUHDSSDUHQWLQWKHZLGHUNQRZOHGJHVFDSHRIKHDOWKLQWKHOLJKWRIUHFHQWHYLGHQFHIURPPRGHUQRU
FXUUHQWKHDOWKVFLHQFH%DVHGRQWKHSURSHUWLHVRIWKHWKUHHERG\W\SHVWKHSUHGRPLQDQFHRIkaphaERG\W\SHVIRUJDLQLQJZHLJKWLVTXLWHZHOO
NQRZQ>7DEOH@7KLVSURSHQVLW\WRJDLQZHLJKWDQGIRUREHVLW\LVLQWXUQOLQNHGZLWKDQXPEHURIFKURQLFGLVHDVHVVXFKDVKHDUWGLVHDVH
K\SHUWHQVLRQDQGGLDEHWHVDOORIZKLFKDUHLQFUHDVLQJO\YLHZHGFROOHFWLYHO\DVPHWDEROLFV\QGURPH6LPLODUO\ORRNLQJDWWKHSURSHUWLHVRIpitta
ERG\W\SHLWFDQEHSUHGLFWHGWKDWVXFKLQGLYLGXDOVFDQKDYHDSURSHQVLW\WRGHYHORSXOFHUVEOHHGLQJGLVRUGHUVDQGVNLQGLVRUGHUVPRUH
FRPPRQ>7DEOH@VataERG\W\SHVFDQKDYHSURSHQVLW\WRGHYHORSQHXURORJLFDOSUREOHPVGHPHQWLDPRYHPHQWDQGVSHHFKGLVRUGHUV
DUUK\WKPLDVDQGUHODWHGFKURQLFGLVHDVHVDVZHOO>7DEOH@+RZHYHURIWKHWKUHHERG\W\SHVFODVVLFDOWH[WVVXJJHVWWKDWvataW\SHLQGLYLGXDOV
ZLOOKDYHPD[LPXPSURSHQVLW\IRUFKURQLFGLVHDVH>@

0DKDOOHet al  >@KDYHGLVFRYHUHGLQWKHLUVWXG\WKDWELRPDUNHUVRIFRURQDU\DUWHU\GLVHDVH &$' VXFKDVYHU\ORZGHQVLW\OLSRSURWHLQ


9/'/ DQGORZGHQVLW\OLSRSURWHLQV /'/ ZHUHVLJQLILFDQWO\KLJKHUZKLOHKLJKGHQVLW\OLSRSURWHLQ +'/ ZDVVLJQLILFDQWO\ORZHUDPRQJ
&$'SDWLHQWVZKRZHUHvata kapha 9. ZKHQFRPSDUHGWRRWKHUERG\W\SHV9.ERG\W\SHZDVDOVRVLJQLILFDQWO\FRUUHODWHGZLWKGLDEHWHV
PHOOLWXVK\SHUWHQVLRQDQGG\VOLSLGHPLDZLWKKLJKHVWOHYHOVRILQIODPPDWRU\PDUNHUVVXFKDV,/71)DOSKDKV&53DQG+20$,57KHVH
LQIODPPDWRU\PDUNHUVZHUHDOVRIRXQGWREHKLJKHULQkaphaERG\W\SH>@7KXVWKHSDWWHUQVRIDVVRFLDWLRQWKDWPLJKWEHH[SHFWHGIURP
$\XUYHGLFtridoshaWKHRU\KDYHEHHQVKRZQWRKDYHFOHDUOLQNVZLWKFHUWDLQFKURQLFGLVHDVHFRQGLWLRQV$VDSDUWRIDQRWKHUVWXG\ZKLFK
ORRNHGDWWKHHIIHFWRIZDONLQJRQYDULRXVPDUNHUV>@LWZDVQRWHGWKDWWKHUHZDVDIDYRUDEOHFKDQJHLQPXOWLSOHPDUNHUVUHODWHGWREORRG
SUHVVXUHDQGEORRGJOXFRVHDPRQJvata­pitta 93 DQGpitta­kapha 3. LQGLYLGXDOVGXHWRH[HUFLVH6LPLODUO\IDYRUDEOHHIIHFWVRIH[HUFLVHWR
VRPHH[WHQWZDVDOVRWUXHIRU9.LQGLYLGXDOV>@

,QDGGLWLRQWRREHVLW\DQGUHODWHGGLVRUGHUVRIKHDUWEORRGSUHVVXUHDQGGLDEHWHVdoshasKDYHEHHQOLQNHGWRRWKHUW\SHVRIFKURQLFGLVHDVHDV
ZHOOVXFKDVUKHXPDWRLGDUWKULWLV 5$ >@-X\DOet al  GLVFRYHUHGWKDWLQIODPPDWRU\JHQHVZHUHPRUHDVVRFLDWHGZLWKvataVXEJURXSRI
SDWLHQWVZKLOHR[LGDWLYHVWUHVVSDWKZD\JHQHVZHUHPRUHREVHUYHGLQpittaDQGWRVRPHH[WHQWkaphaVXEJURXS7KLVVWXG\GHOLQHDWHGWKHIDFW
WKDWWKHUHZHUHGLVFUHHWSDWKZD\VIRUWKHVDPHGLVHDVHIRU5$HWLRORJ\LQGLIIHUHQWprakritiEDVHGVXEJURXSVZKLFKDFFRUGLQJWRWKHPWRRNXV
FORVHUWRYDOLGDWLQJFRQFHSWVRIprakritiDQGSHUVRQDOL]HGPHGLFLQHDVGHILQHGE\$\XUYHGD>@

/LQNVRIprakritiKDVDOVREHHQPDGHZLWKDJLQJDQGFDQFHU3XUYDDQG0HHQD  LQWKHLUSDSHURXWOLQHGWKHIDFWWKDWWKHDJLQJSURFHVVZDV


DVVRFLDWHGZLWKWKHprakritiRIDQLQGLYLGXDOZLWKWKHpittaSUHGRPLQDQWLQGLYLGXDOVVXSSRUWHGE\vataEHLQJSURQHWRSUHPDWXUHDJLQJVLQFHWKH\
KDYHLQFUHDVHG%05DQGWKLVWHQGVWRGHVWUR\WKHWLVVXHVIDVWHUFRPSDUHGWRWKHRWKHUWZRdoshas>@+RZHYHUWKHRYHUDOOXQGHUVWDQGLQJLV
WKDWLWLVvataSUHGRPLQDQWLQGLYLGXDOVZKRDJHDWWKHIDVWHVWUDWH>7DEOH@,QDQRWKHUDUWLFOHE\9HQNDWUDJKDYDQet al  LQDVWXG\ZLWK
DVPDOOVDPSOHVL]HLWZDVLQIHUUHGWKDWFDQFHUSDWLHQWVKDGSULPDULO\pittaGRPLQDQFHIROORZHGE\kaphaGRPLQDQFHFRPSDUHGWRQRUPDO
FRQWUROV>@VataLVDVVRFLDWHGZLWKERQHpittaZLWKEORRGZKLOHkaphaLVDVVRFLDWHGZLWKRWKHUWLVVXHVUHODWHGWRVWUXFWXUHDQGVWRUDJHVXFKDV
DGLSRVHWLVVXH$VVXFKLWLVGLIILFXOWWRWUHDWZKHQSHRSOHZLWKvata prakritiGHYHORSERQHFDQFHUSHRSOHZLWKpitta prakritiGHYHORSOHXNHPLDV
DQGSHRSOHZLWKkapha prakritiGHYHORSFDQFHURIVRIWWLVVXHVDFFRUGLQJWR$\XUYHGD>@$OVRLWKDVEHHQVXJJHVWHGWKDWLQWUHDWPHQWRI
FDQFHULWZLOOVHUYHZHOOWRUHGXFHpittaDQGkapha doshasERWKSK\VLFDOO\DQGSV\FKRORJLFDOO\LQDOOSDWLHQWVRIFDQFHUZLWKPRGLILFDWLRQV
EDVHGRQDSHUVRQ
VprakritiDQGWKHW\SHRIFDQFHU

3UDNULWLDQGJHQRW\SHV
2QVHDUFKLQJIRUOLQNVRIprakritiDQGJHQHWLFVRUJHQRPLFVRUJHQRW\SHVZHGLVFRYHUHGDWRWDORIQLQHDUWLFOHV DUWLFOHV
 >7DEOH@-RLQWUHVHDUFKEHLQJFDUULHGRXWZLWK$\XUYHGDDQGFXUUHQWVFLHQFHVLVHQWHULQJQRYHOWHUULWRU\HYHU\GD\2QHVXFKLQLWLDWLYH
KDVEHHQE\WKH'HSDUWPHQWRI6FLHQFHDQG7HFKQRORJ\ '67 ZLWKWKH$6,,$ $6FLHQFH,QLWLDWLYHLQ$\XUYHGD SURMHFWZKLFKKDVEHJXQ
VWXGLHVRI$\XUYHGDprakritiDQGJHQHWLFV>@7KHQHHGRIWKHKRXULVDOVRWREULGJHWKHRQWRORJLFGLYLGHEHWZHHQ$\XUYHGDDQGFXUUHQW
VFLHQFHVZLWKWKHGHYHORSPHQWRIFRPPRQYRFDEXODU\>@7KHJDSLVFORVLQJIDVWDQGVRIDUZHKDYHGLVFRYHUHGWKHYDULRXVZD\VLQZKLFK
prakritiLVDVVRFLDWHGZLWKPHWDEROLFV\VWHPVZLWKLQWKHERG\DQGDOVRZLWKFKURQLFGLVHDVHFRQGLWLRQV(YLGHQFHLVSUHVHQWDQGPRXQWLQJ
UHJDUGLQJWKHOLQNVEHWZHHQprakritiDQGYDULRXVJHQHVWKURXJKZKLFKWKHVHDVVRFLDWLRQVZRUN>@6XFKOLQNVEHWZHHQprakritiDQGJHQHWLFV
KDYHEHHQFOHDUO\HODERUDWHGE\3DWZDUGKDQDQG%RGHFNHU  >@ZKLFKKDYHQRZEHFRPHWKHEDVLVIRUVFLHQWLILFLQYHVWLJDWLRQUHODWHGWR
³$\XUYHGLFELRORJ\´DQG³$\XJHQRPLFV´7KHEDVLVIRUWKLVZDVDQHDUOLHUZRUNGRQHE\3DWZDUGKDQet al  >@LQZKLFKWKH\
GHPRQVWUDWHGDVLJQLILFDQWFRUUHODWLRQEHWZHHQYDULRXVDOOHOHVRIKXPDQOHXNRF\WHDQWLJHQ +/$ JHQRW\SHDQGprakritiSURYLGLQJUDWLRQDOH
DQGSUHOLPLQDU\H[SHULPHQWDOVXSSRUWIRUWKHFRQFHSWRIDQDVVRFLDWLRQEHWZHHQ+/$DOOHOHVDQG$\XUYHGLFtridoshaWKHRU\RILQGLYLGXDO
prakritiW\SHV>@,QRWKHUVWXGLHVDVVRFLDWLRQVKDYHEHHQGLVFRYHUHGEHWZHHQYDULRXVJHQHVUHODWHGWRLQIODPPDWRU\SDWKZD\VDQGR[LGDWLYH
VWUHVVSDWKZD\VLQ5$SDWLHQWVDQGprakriti>@2WKHUDVVRFLDWLRQVEHWZHHQJHQHWLFVDQGprakritiKDYHEHHQGUDZQRXWIRUJHQHVUHODWHGWR
GUXJPHWDEROLVPVXFKDV&<3&>@ZKHUHWKHJHQRW\SHUHODWHGWRH[WHQVLYHPHWDEROL]HUVZDVDVVRFLDWHGZLWKpitta prakritiZKLOHWKH
JHQRW\SHDVVRFLDWHGZLWKSRRUPHWDEROL]HUZDVKLJKHVWLQkapha prakriti>@2WKHUVWXGLHVORRNLQJDWJHQRPHZLGHH[SUHVVLRQGLIIHUHQFHV
EHWZHHQWKHWKUHHprakritiW\SHVKDYHGLVFRYHUHGVLJQLILFDQWHQULFKPHQWRIKRXVHNHHSLQJGLVHDVHUHODWHGDQGKXEJHQHVDVVRFLDWHGZLWKWKH
WKUHHH[WUHPHprakritis>@$SURSRVWRWKHDERYHHYLGHQFHUHJDUGLQJUHODWLRQVRIJHQHWLFVDQGprakriti-RVKLet al  >@KDYHSURYLGHGD
FRPSUHKHQVLYHUHYLHZRIVXFKVWXGLHVZKLFKKDYHLQYHVWLJDWHGWKHEDVLVRIWKHtridoshaWKHRU\RI$\XUYHGDLQOLJKWRIPRGHUQVFLHQWLILF
JHQHWLFVWXGLHV7KH\KDYHUHYLHZHGQRWRQO\JHQHWLFVWXGLHVUHODWHGWR$\XUYHGDEXWDOVRWKRVHUHODWHGWRRWKHUWUDGLWLRQDOIRUPVRIPHGLFLQH
IURP.RUHD&KLQDDQG-DSDQ>@/LQNVKDYHDOVREHHQGLVFRYHUHGEHWZHHQDJHQH(*/1ZKLFKZDVMXVWRQHDPRQJRWKHU
GLIIHUHQWLDOO\H[SUHVVHGJHQHVEHWZHHQYDULRXVH[WUHPHprakritiW\SHV>@(*/1JHQHYDULDWLRQVDUHUHVSRQVLEOHIRUKLJKDOWLWXGHDGDSWDWLRQ
LQKXPDQVDQGWKH77JHQRW\SHRIWKLVJHQHZDVPRUHIUHTXHQWLQWKHkapha prakritiZKLFKZDVDVVRFLDWHGZLWKKLJKHUH[SUHVVLRQRI(*/1
DQGKLJKHULQFLGHQFHRISXOPRQDU\HGHPDZKLOHWKLVJHQRW\SHZDVVLJQLILFDQWO\ORZHULQpitta prakritiW\SH>@$FFXPXODWLQJILQGLQJVKDYH
LQUHFHQWWLPHVOHGWRSURSRVDOVE\FHUWDLQUHVHDUFKHUVWKDWWKLVMRLQWILHOGRIJHQHWLFVDQG$\XUYHGDZKLFKKDVQRZEHHQQDPHG$\XJHQRPLFV
FDQEHXWLOL]HGWRFUHDWHDV\VWHPRISUHGLFWLYHSUHYHQWLYHDQGSHUVRQDOL]HGPHGLFLQHVRWKDWLQVWHDGRIDJHQHUDOL]HGV\PSWRPDWLFDSSURDFK
WKHSUDFWLFHRIPHGLFLQHWDNHVDQLQGLYLGXDODSSURDFKEDVHGRQRQH
VJHQHWLFPDNHXS>@

3UDNULWLQHZERUQJHQHWLFVFUHHQLQJDQGSHUVRQDOL]HGSUHYHQWLRQ3RVVLELOLWLHVIRUWKHIXWXUH

1HZERUQJHQHWLFVFUHHQLQJKDVLWVKLVWRU\LQVLQWKH8QLWHG6WDWHVZKHUHLWZDVVWDUWHGDVDSXEOLFKHDOWKSURJUDP>@7KHILUVWJHQHWLF
GLVRUGHUWREHGHWHFWHGE\QHZERUQJHQHWLFVFUHHQLQJZDVSKHQ\ONHWRQXULD:LWKWLPHWKHOLVWRIGLVRUGHUVWKDWFDQEHGHWHFWHGE\QHZERUQ
JHQHWLFVFUHHQLQJKDVH[SDQGHGZLWKGLIIHUHQWFRXQWULHVKDYLQJGLIIHUHQWOLVWRIGLVRUGHUVWKDWWKH\VFUHHQIRU>@7KH$PHULFDQ&ROOHJHRI
0HGLFDO*HQHWLFVUHFRPPHQGVWHVWVWREHSHUIRUPHGRQWKHQHZERUQ>@0RVWRIWKHWHVWVLQYROYHXVLQJKHHOSULFNEORRGVDPSOHVRUWHVWLQJ
IRUKHDULQJVLJKWRUFRQJHQLWDOKHDUWGHIHFWV+RZHYHUWKHNLQGRIQHZERUQJHQHWLFVFUHHQLQJWKDWZHHQYLVDJHLQWKLVUHYLHZGLIIHUVIURPMXVW
WHVWLQJIRUSRVVLEOHJHQHWLFGLVRUGHUV

1HZERUQJHQHWLFVFUHHQLQJIRUSUDNULWL

$VDSDUWRIWKLVUHYLHZLWKDVEHHQDSSDUHQWWKDWprakritiW\SHVDVGHVFULEHGLQ$\XUYHGDFDQEHFRQVLGHUHGDVSKHQRW\SHVWKDWKDYHGLVWLQFW
OLQNVZLWKYDULRXVPHWDEROLFSDWKZD\VGLVHDVHVXVFHSWLELOLW\HVSHFLDOO\WKDWZLWKFKURQLFGLVHDVHVDQGODVWEXWQRWWKHOHDVWZLWKGLIIHULQJ
JHQRW\SHV$VWKHVHOLQNVRIprakritiEHFRPHIXUWKHUGHILQHGLWLVQRWGLIILFXOWWRLPDJLQHDWLPHLQWKHQHDUIXWXUHZKHQLWZLOOEHSRVVLEOHWR
LGHQWLI\VSHFLILFJHQRW\SHVWKDWDUHOLQNHGWRDQ\JLYHQprakritiW\SH1RWRQO\JHQRW\SHVEXWVWXGLHVVRIDUKDYHDOVRVKRZQWKDWQRUPDO
KHDOWK\LQGLYLGXDOVIURPWKHWKUHHPRVWFRQWUDVWLQJprakritisH[KLELWVWULNLQJGLIIHUHQFHVLQELRFKHPLFDODQGKHPDWRFULWSDUDPHWHUVPHDVXULQJ
XVLQJSHULSKHUDOEORRG>@7KHVHLQFOXGHOLSLGSURILOHVXULFDFLGKHPRJORELQEORRGFORWWLQJWLPHDQGVHUXP]LQFOHYHOV$WWKHH[SUHVVLRQ
OHYHOWKHUHLVHQULFKPHQWLQFRUHELRORJLFDOSURFHVVHVVXFKDVWUDQVSRUWLPPXQHUHVSRQVHEORRGFRDJXODWLRQHWF$OVRKLJKHUOHYHOVRI
PDUNHUVIRUPHWDEROLFV\QGURPHVXFKDVWULJO\FHULGH 7* WRWDOFKROHVWHURO/'/9/'/+'/HWFZHUHVHHQLQSHUVRQVZLWKkapha
prakriti6LPLODUO\KLJKHUOHYHOVRIH[SUHVVLRQRIKHPRJORELQJHQHVZHUHREVHUYHGLQpittaFRPSDUHGWRkaphaRUvata>@

$\XUYHGLFPHWKRGRIprakritiFODVVLILFDWLRQKDVWKXVOHGVFLHQWLVWVWRLGHQWLI\ELRFKHPLFDODQGJHQHH[SUHVVLRQGLIIHUHQFHVDPRQJQRUPDO
LQGLYLGXDOV²VRPHWKLQJZKLFKLVQRWSRVVLEOHLQZHVWHUQV\VWHPRIPHGLFLQH7KXVLWFDQEHDQWLFLSDWHGWKDWLQQHDUIXWXUHJHQRW\SH
DVFHUWDLQPHQWFDQEHXVHGDSUHGLFWLYHPDUNHUVIRUprakriti7KLVRSHQVWKHGRRUIRUDQLGHDWKDWKDVQRWEHHQSURSRVHGEHIRUH,WLVTXLWH
SRVVLEOHWKDWLQQHDUIXWXUHQHZERUQVFDQEHVFUHHQHGULJKWDWWKHWLPHRIELUWKIRUWKHLUprakritiXVLQJWKHLUJHQHWLFSURILOHZKLFKLVIXUWKHU
FRUUHODWHGE\RWKHUELRFKHPLFDOSDUDPHWHUV7KXVVSHFLILFVHWRIFULWHULDXVLQJJHQHWLFPDUNHUVDQGELRFKHPLFDOPDUNHUVFDQEHVHWXSQRWRQO\
WRLGHQWLI\H[WUHPHprakritiW\SHVEXWHYHQPL[HGprakritiW\SHV

$OLIHWLPHRISHUVRQDOL]HGSUHYHQWLRQ

7KHFRQFHSWVRI$\XUYHGDDUHQRW,QGLDVSHFLILFDQGFDQDSSO\WRDOORIKXPDQSRSXODWLRQLQWKHZRUOG:HDUHDOVRZHOODZDUHWKDWDSHUVRQ
V
prakritiLVFRQVLGHUHGWREHQRUPDOIRUWKDWSHUVRQDQGDQ\GHUDQJHPHQWRIWKHdoshasRIWKHSHUVRQ
VFRQVWLWXWLRQOHDGVWRGLVHDVHV$VVXFK
WKHMRERIDQ$\XUYHGLFSK\VLFLDQLVWRGHWHFWWKHH[WHQWRIGHUDQJHPHQWDQGEULQJEDFNWKHdoshasWRWKHQRUPDOVWDWHZKLFKFDQEHGRQHXVLQJ
GUXJVGLHWOLIHVW\OHFKDQJHVRUHQYLURQPHQWDOFKDQJHV>@$VDSDUWRI$\XUYHGDWKHYDULRXVWUDLWVWKDWHDFKprakritiW\SHKDVLQWHUPVRIWKHLU
ERG\VWUXFWXUHPHQWDOPDNHXSWROHUDQFHWRYDULRXVW\SHVRIIRRGDQGHQYLURQPHQWDQGVXVFHSWLELOLW\WRYDULRXVGLVHDVHVLQFOXGLQJWKH
SURJQRVLVLVZHOOHVWDEOLVKHG>7DEOH@,QDGGLWLRQDOVRZHOOHVWDEOLVKHGLVWKHNQRZOHGJHUHJDUGLQJWKHHIIHFWVWKDWYDULRXVGLHWOLIHVW\OH
HQYLURQPHQWDQGWUHDWPHQWZLOOKDYHRQGLIIHUHQWprakritis>@$OVRZHNQRZE\QRZWKDWZHVWHUQDOORSDWKLFPHGLFLQHH[FHOVZKHQLWLV
UHTXLUHGIRUWUHDWLQJDFXWHGLVRUGHUV&KURQLFGLVRUGHUVRQWKHRWKHUKDQGFDQQRWEHPDQDJHGZHOOE\DOORSDWKLFPHGLFLQHDQG$\XUYHGDLV
PRUHHIIHFWLYHLQWUHDWLQJVXFKFKURQLFQRQFRPPXQLFDEOHGLVHDVHVPDLQO\E\ahara GLHW vihara OLIHVW\OH DQGILQDOO\aushadhi
PHGLFDWLRQ 7KHDERYHWKUHHSLOODUVRI$\XUYHGLFPHGLFLQHLQFRQMXQFWLRQZLWKWKHtridoshaWKHRU\SURYLGHDGLIIHUHQWSDUDGLJPWRPHGLFDO
SUDFWLWLRQHUVIRUXQGHUVWDQGLQJDGLVHDVHDQGPDNH$\XUYHGDFDSDEOHRIGHOLYHULQJSHUVRQDOL]HGPHGLFLQHIRUHYHU\RQH>@

$VVXFKGHWHFWLQJWKHVFUHHQLQJQHZERUQVWRGHWHFWWKHLUprakritiULJKWDIWHUWKHWLPHRIWKHLUELUWKFDQKDYHYHU\VLJQLILFDQWDQGIDUUHDFKLQJ
LPSOLFDWLRQV.QRZLQJWKHprakritiRIDQHZERUQFDQOHDGWRLQFXOFDWLRQDQGDGRSWLRQRIOLIHVW\OHVRIDQHZERUQWKDWZLOOUHVXOWLQSUHYHQWLRQRI
FKURQLFGLVHDVHVDQGPRUHKHDOWK\KLJKTXDOLW\OLIHIRUDQLQGLYLGXDO>@)RUH[DPSOHLILWLVNQRZQWKDWDQHZERUQKDVkapha prakritiWKHQ
ULJKWIURPWKHEHJLQQLQJWKHFKLOGFDQEHHQFRXUDJHGWRSDUWLFLSDWHLQVSRUWVDQGSK\VLFDODFWLYLW\6LQFHkapha prakritiSHUVRQVKDYHDQDWXUDO
WHQGHQF\IRUUHGXFHGPRYHPHQWLQFXOFDWLRQRIKDELWVWKDWOHDGVDkapha prakritiSHUVRQWRSDUWLFLSDWHLQVSRUWVIURPFKLOGKRRGZLOOOHDGWRD
KHDOWKLHUOLIHDQGZLOOSUHYHQWPRVWRIWKHFKURQLFGLVHDVHVUHODWHGWRREHVLW\WKDWDkaphaSHUVRQLVRWKHUZLVHVXVFHSWLEOHWR6LPLODUO\LILW
NQRZQWKDWDFKLOGKDVpitta prakritiVWHSVFDQEHWDNHQULJKWIURPFKLOGKRRGWRPDNHVXUHVXFKDFKLOGLQFXOFDWHVKDELWVWKDWPDNHKLPPRUH
SDWLHQWDQGQRWORRVHRQH
VDQJHU,QDGGLWLRQVSLF\RUDFLGLFIRRGPD\QRWEHVHUYHGWRVXFKDFKLOGVLQFHpitta prakritiLQGLYLGXDOVKDYHPRUH
SURSHQVLWLHVWRGHYHORSJDVWULFXOFHUVDQGUHODWHGGLVRUGHUV

7KXVLQFRQFOXVLRQLWLVDSSDUHQWWKDWPXOWLSOHOLQNDJHVRI$\XUYHGLFtridoshaSULQFLSOHZLWKPRGHUQVFLHQWLILFELRFKHPLFDODQGJHQHWLF
PDUNHUVDUHEHLQJXQHDUWKHG7KLVLVDYHU\VLJQLILFDQWVWHSWRZDUGVLQWHJUDWLQJ$\XUYHGLFWKHRULHVZLWKPRGHUQVFLHQWLILFILQGLQJVDQGLWLV
TXLWHOLNHO\WKDWOLQNLQJWKHtridoshaWKHRU\RI$\XUYHGDZLWKFXUUHQWPHGLFDOSUDFWLFHVFDQLPSURYHKHDOWKRXWFRPHV>@$VDVWHSIXUWKHULW
FDQEHHQYLVDJHGWKDWLQIXWXUHQHZERUQVFDQEHVFUHHQHGIRUYDULRXVprakritiW\SHVZKLFKZLOORSHQXSSRVVLELOLWLHVRIFUHDWLQJOLIHVW\OHVDQG
HQYLURQPHQWVWKDWOHDGWRSUHYHQWLRQRIGLVHDVHVWKDWSDUWLFXODUprakritiW\SHVDUHSURQHWR7KLVWDNHVWKHFRQFHSWRISHUVRQDOL]HGPHGLFLQH
IXUWKHUDQGHQWHUVWKHDUHQDRISHUVRQDOL]HGSUHYHQWLYHKHDOWKRUSHUVRQDOL]HGSUHYHQWLYHPHGLFLQH6XFKSHUVRQDOL]HGSUHYHQWLYHKHDOWKZLOO
UHVXOWLQKHDOWK\DQGPRUHSURGXFWLYHOLYHVIRUVXFKFKLOGUHQZKLFKKDVDOVRWKHSRWHQWLDOWRUHGXFHWKHEXUGHQRIGLVHDVHDVZHOODVLQFUHDVLQJ
FRVWVIDFHGE\KHDOWKV\VWHPVGXHWRULVLQJLQFLGHQFHRIFKURQLFGLVHDVHV

)RRWQRWHV *RWR

6RXUFHRI6XSSRUW1LO

&RQIOLFWRI,QWHUHVW1RQHGHFODUHG

5()(5(1&(6 *RWR

+DQNH\$7KHVFLHQWLILFYDOXHRI$\XUYHGD-$OW&RPSOHPHQW0HG±>3XE0HG@

6KDUPD39HGLWRUWKHG&K9DUDQDVL&KRZNDPEKD6DQVNULW6HULHV&KDXNDPEKD2ULHQWDOLD&DUDND6DPKLWD

-RVKL55$ELRVWDWLVWLFDODSSURDFKWRD\XUYHGD4XDQWLI\LQJWKHWULGRVKD-$OWHUQ&RPSOHPHQW0HG±>3XE0HG@

5DVWRJL6'HYHORSPHQWDQG9DOLGDWLRQRID3URWRW\SH3UDNULWL$QDO\VLV7RRO 33$7 ,QIHUHQFHVIURPDSLORWVWXG\$\X±


>30&IUHHDUWLFOH@>3XE0HG@

'DEXU
VRQOLQHSUDNULWLWHVW>/DVWDFFHVVHGRQ0DU@$YDLODEOHIURPKWWSZZZGDEXUFRP$\XUYHGD.QRZ\RXU3UDNULWL
3UDNULWL7HVW

2¶6XOOLYDQ&HGLWRUVWHG&KXUFKLOO/LYLQJVWRQH5HVKDSLQJKHUEDOPHGLFLQH.QRZOHGJHHGXFDWLRQDQGSURIHVVLRQDOFXOWXUH

+DQNH\$(VWDEOLVKLQJWKH6FLHQWLILF9DOLGLW\RI7ULGRVKD3DUW'RVKDV6XEGRVKDVDQG'RVKD3UDNULWLV$QF6FL/LIH±
>30&IUHHDUWLFOH@>3XE0HG@

+DQNH\$$\XUYHGLFSK\VLRORJ\DQGHWLRORJ\$\XUYHGR$PULWDQDP7KHGRVKDVDQGWKHLUIXQFWLRQLQJLQWHUPVRIFRQWHPSRUDU\ELRORJ\
DQGSK\VLFDOFKHPLVWU\-$OWHUQ&RPSOHPHQW0HG±>3XE0HG@

+DQNH\$$WHVWRIWKHV\VWHPVDQDO\VLVXQGHUO\LQJWKHVFLHQWLILFWKHRU\RI$\XUYHGD
V7ULGRVKD-$OWHUQ&RPSOHPHQW0HG±
>3XE0HG@

3DWZDUGKDQ%%RGHFNHU*$\XUYHGLFJHQRPLFV(VWDEOLVKLQJDJHQHWLFEDVLVIRUPLQGERG\W\SRORJLHV-$OWHUQ&RPSOHPHQW0HG
±>3XE0HG@

-X\DO5&1HJL6:DNKRGH3%KDW6%KDW%7KHOPD%.3RWHQWLDORID\XUJHQRPLFVDSSURDFKLQFRPSOH[WUDLWUHVHDUFK/HDGVIURPD
SLORWVWXG\RQUKHXPDWRLGDUWKULWLV3ORV2QHH>30&IUHHDUWLFOH@>3XE0HG@

0DKDOOH13.XONDUQL093HQGVH101DLN66$VVRFLDWLRQRIFRQVWLWXWLRQDOW\SHRI$\XUYHGDZLWKFDUGLRYDVFXODUULVNIDFWRUV
LQIODPPDWRU\PDUNHUVDQGLQVXOLQUHVLVWDQFH-$\XUYHGD,QWHJU0HG±>30&IUHHDUWLFOH@>3XE0HG@

%KXVKDQ3.DOSDQD-$UYLQG&&ODVVLILFDWLRQRIKXPDQSRSXODWLRQEDVHGRQ+/$*HQHSRO\SKRUPRUSKLVPDQGWKHFRQFHSWRI3UDNULWL
LQ$\XUYHGD-$OWHUQ&RPSOHPHQW0HG±>3XE0HG@

%KDOHUDR6'HVKSDQGH77KDWWH83UDNULWL $\XUYHGLFFRQFHSWRIFRQVWLWXWLRQ DQGYDULDWLRQVLQ3ODWHOHWDJJUHJDWLRQ%0&&RPSOHPHQW


$OWHUQ0HG>30&IUHHDUWLFOH@>3XE0HG@

3XUYD0&0HHQD06$UHYLHZRQUROHRI3UDNULWLLQDJLQJ$<8 $Q,QWHUQDWLRQDO4XDUWHUO\-RXUQDORI5HVHDUFKLQ$\XUYHGD
±>30&IUHHDUWLFOH@>3XE0HG@

*KRGNH<-RVKL.3DWZDUGKDQ%7UDGLWLRQDO0HGLFLQHWR0RGHUQ3KDUPDFRJHQRPLFV$\XUYHGD3UDNULWL7\SHDQG&<3&*HQH
3RO\PRUSKLVP$VVRFLDWHGZLWK0HWDEROLF9DULDELOLW\(YLG%DVHG&RPSOHPHQW$OWHUQDW0HG>30&IUHHDUWLFOH@
>3XE0HG@

5L]]R6LHUUD&9$\XUYHGLFJHQRPLFVFRQVWLWXWLRQDOSV\FKRORJ\DQGHQGRFULQRORJ\7KHPLVVLQJFRQQHFWLRQ-$OWHUQ&RPSOHPHQW
0HG±>3XE0HG@

7LZDUL6*HKORW67LZDUL6.6LQJK*(IIHFWRIZDONLQJ DHURELFLVRWRQLFH[HUFLVH RQSK\VLRORJLFDOYDULDQWVZLWKVSHFLDOUHIHUHQFHWR


Prameha GLDEHWHVPHOOLWXV DVSHUPrakriti$<8 $Q,QWHUQDWLRQDO4XDUWHUO\-RXUQDORI5HVHDUFKLQ$\XUYHGD ±
>30&IUHHDUWLFOH@>3XE0HG@

9HQNDWUDJKDYDQ66XQGDUHVDQ735DMDJRSDODQ96ULQLYDVQ.&RQVWLWXWLRQDOVWXG\RIFDQFHUSDWLHQWVLWVSURJQRVWLFDQGWKHUDSHXWLF
VFRSH$QF6FL/LIH±>30&IUHHDUWLFOH@>3XE0HG@

1D\DN-$\XUYHGDUHVHDUFK2QWRORJLFDOFKDOOHQJHV-$\XUYHGD,QWHJU0HG±>30&IUHHDUWLFOH@>3XE0HG@

3UDVKHU%1HJL6$JJDUZDO60DQGDO$.6HWKL73'HVKPXNK65HWDO,QGLDQ*HQRPH9DULDWLRQ&RQVRUWLXP:KROHJHQRPH
H[SUHVVLRQDQGELRFKHPLFDOFRUUHODWHVRIH[WUHPHFRQVWLWXWLRQDOW\SHVGHILQHGLQ$\XUYHGD-7UDQVO0HG>30&IUHHDUWLFOH@
>3XE0HG@

-RVKL.*KRGNH<6KLQWUH37UDGLWLRQDOPHGLFLQHDQGJHQRPLFV-$\XUYHGD,QWHJU0HG±>30&IUHHDUWLFOH@>3XE0HG@

$JJDUZDO61HJL6-KD36LQJK3.6WREGDQ73DVKD0$HWDO,QGLDQ*HQRPH9DULDWLRQ&RQVRUWLXP(*/1LQYROYHPHQWLQKLJK
DOWLWXGHDGDSWDWLRQUHYHDOHGWKURXJKJHQHWLFDQDO\VLVRIH[WUHPHFRQVWLWXWLRQW\SHVGHILQHGLQ$\XUYHGD3URF1DWO$FDG6FL86$
±>30&IUHHDUWLFOH@>3XE0HG@

0XNHUML03UDVKHU%$\XUJHQRPLFV$QHZDSSURDFKLQSHUVRQDOL]HGDQGSUHYHQWLYHPHGLFLQH6FL&XOW±

:DWVRQ06/OR\G3XU\HDU0$0DQQ0<5LQDOGR3+RZHOO55$PHULFDQ&ROOHJHRI0HGLFDO*HQHWLFV $&0* >/DVW


DFFHVVHGRQ1RY@1HZERUQVFUHHQLQJWRZDUGDXQLIRUPVFUHHQLQJSDQHODQGV\VWHP>UHSRUWRQWKHLQWHUQHW@$YDLODEOHIURP
KWWSVZZZDFPJQHW$&0*3XEOLFDWLRQV3UDFWLFHB*XLGHOLQHVBGRFV1%6BUHSRUWDVS[

7ULSDWKL-66LQJK5+&RQFHSWRIGHKDSUDNULWLYLVjYLVKXPDQFRQVWLWXWLRQLQ$\XUYHGD$QF6FL/LIH±
>30&IUHHDUWLFOH@>3XE0HG@

&KDWWHUMHH%3DQFKROL-3UDNULWLEDVHGPHGLFLQH$VWHSWRZDUGVSHUVRQDOL]HGPHGLFLQH$\X±>30&IUHHDUWLFOH@
>3XE0HG@

3DWHO.2[IRUG2KLR86$7KHVLV±0LDPL8QLYHUVLW\$\XUYHGDDVWXG\RIHDVWHUQSKLORVRSK\RIPHGLFLQH

$UWLFOHVIURP-RXUQDORI$\XUYHGDDQG,QWHJUDWLYH0HGLFLQHDUHSURYLGHGKHUHFRXUWHV\RI0HGNQRZ3XEOLFDWLRQV