2 atau 3 alasan pemberian ranitidin injeksi adalah relevan pada semua pasien yang dirawat di RS,

apapun penyakit dan betapapun pasien itu belum di endoskopi.

Journal A Comparison of Sucralfate and Ranitidine for the prevention of upper

Gastrointestinal Bleeding in patients requiring Mecahnical Ventilation. Deborah Cook,M.D,
Gordon Guyat, M.D, John Marshall, M.D. March19, 1998

Konklusi: Diantara pasien kritis yang membutuhkan ventilasi mekanis, mereka yang menerima
ranitidin memiliki tingkat perdarahan gastrointestinal yang jauh lebih rendah daripada yang
diobati dengan sukralfat. tidak ada perbedaan yang signifikan dalam tingkat pneumonia terkaint
ventilator, durasi tinggal di ICU, atau kematian

Journal New England Journal Of Medicine

A Controlled Study of Raniditine for the prevention of recurrrent hemorrhage from duodenal
ulcer. Dennis M. Jense, Sucie Cheng , Thomas Kovacs, Gayle Randall. et all. February 1994

Konklusi :

bagi pasien yang mengalami ulkus duodenal setelah perdarahan berat, terapi pemeliharaan
jangka panjang dengan ranitidin aman dan mengurangi risiko perdarahan berulang

Is Ranitiine Therapy Sufficient sufficient for healing peptic associated with non steroidal anti-
inflammatory drug use ?. N.D. Yeomans, L.E Svedberg, J. Naesdal. School of Medicine,
University of Western Sydney, NSW Australia.2006

Konklusinon:

The result of this review show that, in patients with NSAID-associated GU for whom
discontinuation of NSAID therapu is not appropriate, PPI's which offer more substansial acid
suppression than H2RAs, are associated high rates healing than ranitidine at the standard dose
of 150 mg bid

Omeprazole versus ranitidine as adjunct therapy to endoscopic injection bleeding ulcers : a

prospective and randomized study

Villanueva, Balanzo, Torras. May 1995

Konklusi :
our result suggest that omeprazole does not improve the efficacy of ranitidine afer endoscopic
injection therpay with an active arterial bleeding ulcer

Use of Acid Suppresive drugsand risk of pneumonia: a systematic reviewand meta-analysis.

Chun-Sick Eom, MD MPH, Kang-Sook Lee, MD PhD. Canadian Medical Association Journal.

Konklusion

Clnicians should carefully consider any decision to prescribe acid suppressive drugs, especially
for patient who are already at risk for pneumonia. since it unnecessary to achieve an
achlorhydric stae in order to resolve symptoms, we recommend using the optimal effective dose
of the drug necessary to achieve desired therapeutic goals

Cook, DJ, Reeve BK, Guyat GH et al. Stress Ulcer prophylaxis in critically ill patients. resolving
discordant meta-analysis. JAMA.1996

Cook and associates showed that rate of pneumonia was higher among patients taking
histamine2 receptor anatagonists than among controls, but the difference was not statistically
significant

Pongprasobchaiand coworkers reported that the incidence of nosocomial pneumonia did not
differ between patients receiving proton pump inhibitors