DAFTAR ISI

DAFTAR ISI .......................................................................................................... ii

DAFTAR TABEL ................................................................................................. ii

DAFTAR GAMBAR ............................................................................................ vi

DAFTAR SINGKATAN .................................................................................... viii

BAB 1 PENDAHULUAN......................................................................................1

1.1Latar Belakang................................................................................................1

1.2Rumusan Masalah...........................................................................................3

1.3Tujuan Penelitian.............................................................................................3

1.3.1Tujuan Umum...........................................................................................3

1.3.2 Tujuan Khusus ........................................................................................ 3

1.4Manfaat Penelitian...........................................................................................4

BAB II TINJAUAN PUSTAKA............................................................................5

2.1.Hiperlipidemi................................................................................................. 5

2.1.1. Klasifikasi Hiperlipidemi....................................................................... 5

2.1.2. Metabolisme Lippoprotein ..................................................................... 6

2.1.3. Evaluasi Laboratorium Parameter Lipid.................................................6

2.1.4.Lipoprotein…..................................................................................................7

2.2 Jalur Pembentukan Kolesterol............................................................................9

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2.3 Pengangkuatn Kolesterol Dalam Jaringan........................................................9

2.4 Ekskresi Kolesterol .......................................................................................... 9

2.5 Rumput Teki....................................................................................................10

2.5.1 Taksonomi Rumput Teki...……….............................................................11

2.5.2 Deskripsi Rumput Teki.............................................................................12

2.5.3 Kandungan Rumput Teki………………………………..........………….12

2.5.4 Manfaat Rumput Teki .............................................................................. 16

2.5 Ekskresi Kolesterol.........................................................................................16

BAB III KERANGKA KONSEPTUAL DAN HIPOTESIS ........................... 22

3.1 Kerangka Konseptual .................................................................................. 22

3.2 Hipotesis ...................................................................................................... 23

BAB IV METODOLOGI PENELITIAN ......................................................... 24

4.1Jenis Penelitian ............................................................................................. 24

4.2 Tempat dan Waktu Penelitian ..................................................................... 24

4.3 Populasi dan Sampel ................................................................................... 24

4.3.1Populasi.................................................................................................. 24

4.3.2 Sampel .................................................................................................. 24

4.3.3 Besar Sampel ........................................................................................ 24

4.3.4 Teknik Pengambilan Sampel ................................................................ 27

4.3.5 Karakteristik Sampel Penelitian............................................................ 28

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 4.3.6Variabel Penelitian ................................................................................. 28

4.3.7 Definisi Operasional ............................................................................. 28

4.4.Alat dan Bahan Penelitian ........................................................................... 29

4.4.1 Alat........................................................................................................ 29

4.4.2 Bahan .................................................................................................... 29

4.5Prosedur Penelitian ....................................................................................... 29

4.5.1. Proses Adaptasi .................................................................................... 29

4.5.2 Pembagian kelompok dan pembagian tikus.......................................... 29

4.5.3. Cara Pembuatan Ekstrak Umbi Rumput Teki (Cyperus Rotundus L) . 30

4.5.4. Dasar Penentuan Dosis Ekstrak Umbi Rumput Teki…………………32

4.5.5 Proses Anastesi dan Pengambilan Sampel Darah ................................. 35

4.5.6Pemberian Diet Hiperlipidemi ............................................................... 35

4.5.7Proses Anastesi dan Pembedahan Hewan Coba .................................... 35

4.5.8Pengukuran Kadar Kolesterol HDL ....................................................... 35

4.6 Alur Penelitian ................................................................................................ 39

4.7Analisis Data .................................................................................................... 39

DAFTAR PUSTAKA .......................................................................................... 40

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 DAFTAR TABEL

Tabel 2.1 Senyawa tertinggi pada Cyperus rotundus L..............................8

Tabel 2.2 Kadar Kolesterol Normal dalam Darah.....................................17

Tabel 4.3Definisi Operasional..................................................................34

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 DAFTAR GAMBAR

Gambar 2.1 Morfologi Rumput Teki .......................................................... 5

Gambar 2.2 Struktur Kolesterol .................................................................. 7

Gambar 2.3Jalur Metabolisme Eksogen pada Kolesterol ........................... 19

Gambar 2.4 Jalur Metabolisme Endogen pada Kolesterol .......................... 19

Gambar 2.5 Jalur Reverse Cholesterol Transport ....................................... 19

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 DAFTAR SINGKATAN

CVD = Chronic Vascular Diseases

VLDL = Very Low Density Lippoprotein

IDL = Intermediate Density Lippoprotein

LDL = Low Density Lippoprotein

HDL = High Density Lippoprotein

RCT = Reverse Cholesterol Transport

ABCA 1 = ATP-Binding Cassette Transporter A1

LCAT = Lecithin Cholesterol Acyltransferase

LPL = lipolitik lipoprotein lipase

CETP = Cholesterol Esther Transfer Protein

CE = Cholesterol Esther

Apo = Apolippoprotein

FFA = Free Fatty Acid

NEFA = Non-Esterified Fatty Acid

NECP = National Cholesterol Education Program

FCR = Fractional Catabolic Rate

SR-B1 = Scavenger Reseptor Class B type 1

TGrL = Trigliserida Reach Lippoprotein

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