Antineoplastic Antibiotics.

Cell cycle phase-nonspecific disrupts DNA transcription and

inhibit DNA & RNA synthesis.

Drug Dosage Uses

Dactinomycin 500mcg/vial Wilm's tumor, rhabdomyosarcoma,

metastatic and nonmetastatic
choriocarcinoma, nonseminomatous testicular
carcinoma, Ewing's sarcoma, nonmetastatic
Ewing's sarcoma, and sarcoma botryoides.

Bleomycin Powder for Squamous cell carcinomas, Hodgkin's disease,

injection: testicular and ovarian carcinoma, and
15unit malignant pleural effusion.
30unit

Mitomycin Powder for Adenocarcinoma of the stomach, colon, or

injection: pancreas.
5mg
20mg
40mg

Plicamycin 25 to 30 mcg Testicular tumors, hypercalcemia and

(0.025-0.030 mg) hypercalciuria associated with advanced
per kilogram of cancer, particularly involving paget’s bone
body weight disease.

Daunorubicin Injectable Acute myelogenous and lymphocytic

solution: leukemias.
5mg/mL
Powder for
injection:
20mg

Doxorubicin Injectable Acute lymphoblastic leukemia, acute

solution: myeloblastic leukemia, Wilms' tumor,
2mg/mL neuroblastoma, soft tissue and bone sarcomas,
 Powder for breast carcinoma, ovarian carcinoma,
injection: transitional cell bladder carcinoma, thyroid
10mg carcinoma, Hodgkin's and non-Hodgkin's
20mg lymphomas, bronchogenic carcinoma, and
50mg gastric carcinoma.

Epirubicin Injectable Breast cancer

solution:
2mg/mL
Powder for
reconstitution:
50 mg
200 mg
 Drug Dosage Toxicity

Dactinomycin 500mcg/vial Renal, hepatic abnormalities, GI

ulcerations, proctitis, anemia, blood
dyscrasias and esophagitis.

Bleomycin Powder for injection: Pulmonary fibrosis

15unit
30unit

Mitomycin Powder for injection: Serious cumulative bone marrow

5mg suppression, thrombocytopenia and
20mg leukopenia that can contribute to the
40mg development of overwhelming infectious
disease. Irreversible renal failure as a
consequence of hemolytic uremic
syndrome. Occasionally adult respiratory
distress syndrome has also been seen.

Plicamycin 25 to 30 mcg (0.025- Severe thrombocytopenia, hemorrhagic

0.030 mg) per tendency, renal impairment, mutagenicity,
kilogram of body and interfere with fertility, anorexia,
weight stomatitits, depression phlebitis, facial
flushing, hepatotoxicity, and electrolyte
disturbances (decrease in serum calcium,
potassium, and phosphate levels) are also
encountered.

Daunorubicin Injectable solution: CHF, secondary leukemia, renal failure,

5mg/mL carcinogenesis, mutagenesis,
Powder for injection: teratogenicity, and fertility impairment.
20mg

Doxorubicin Injectable solution: Hepatic damage

2mg/mL
Powder for injection:
10mg
20mg
50mg