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Evaluation of Insomnia
Insomnia is defined as sleep difficulty (difficulty patient may be diagnosed with different subtypes
initiating or maintaining sleep, early morning by different experienced clinicians. This is not
awakening, or both) that is associated daytime con- surprising, as many patients manifest overlapping
sequences because of night time sleep difficulty, symptoms.
with the proviso that the nighttime or daytime Chronic insomnia disorder (CID) is defined
problems are not explained by an inadequate in the ICSD-3 and encompasses elements of
opportunity to sleep. The International Classifica- psychophysiologic insomnia, idiopathic insom-
tion of Sleep Disorders, Second Edition (ICSD-2) nia, paradoxical insomnia, insomnia associated
defined eight insomnia disorders (Tables F37-1 with mental disorder, inadequate sleep hygiene,
and F37-2).1 Other classifications such as that as well the behavioral insomnias of childhood
by Diagnostic and Statistical Manual of Mental Dis- (limit setting or sleep association disorders)
orders, Fourth Edition (DSM-IV) classified (Box F37-2 and see Table F37-2). The ICSD-
insomnia as primary insomnia and secondary 3 states that CID is characterized by “frequent
insomnia (insomnia associated with a mental dis- and persistent difficulty initiating or maintain-
order, medical disorder, or a drug or substance).2 ing sleep that results in general sleep dissatisfac-
The term comorbid insomnia has often been used tion.” CID may occur in isolation or be a
to refer to “secondary” insomnias, as it is often comorbid condition with a mental disorder,
difficult to define the relationship between medical condition, or substance use. Duration
insomnia and the associated disorder (which dis- of at least 3 months is required for the diagnosis
order is primary and which is secondary?). For of CID, and symptoms must occur on at least
example, insomnia may precede depression, 3 nights per week. Note that in ICSD-2, only
worsen during depression, and persist after a 1-month duration was required for many of
remission from depression. The ICSD-3 defines the insomnia disorders. More details on CID
only three insomnia disorders (see Table F37-1; are provided below. A number of other sleep
Box F37-1),3 and the ICSD-2 insomnia disorders disorders are associated with insomnia com-
have been consolidated into these three disorders. plaints (Table F3-3). These included sleep
The rationale is that previously used subtypes apnea syndromes, circadian rhythm sleep-wake
could not reliably be diagnosed.4 The same disorders, and the restless legs syndrome.
584
FUNDAMENTALS 37 EVALUATION OF INSOMNIA 585
Adapted from Schutte-Rodin S, Broch L, Buysee D, et al: Clinical guideline for the evaluation and management of chronic
insomnia in adults, J Clin Sleep Med 4:487-504, 2008.
Adapted from American Academy of Sleep Medicine: International classification of sleep disorders, ed 3, Darien, IL, 2014, American
Academy of Sleep Medicine.
BOX F37-2 Short-Term Insomnia defined and the duration of the complaint deter-
Disorder mined. The history of the origin of the complaint,
including age of onset should be explored, and
ICSD-3 DIAGNOSTIC CRITERIA particular life events or stressors at the start of
(Criteria A to E must be met) the problem should be identified. For example,
A, B, C. As in Chronic Insomnia Disorder patients with the subtype idiopathic insomnia
D. The sleep disturbance and associated daytime report problems since childhood or adolescence
symptoms have been present for less than with an insidious onset. Patients with psycho-
3 months. physiologic subtype of insomnia may report that
E. The sleep/wake difficulty is not better explained chronic insomnia began after a severe illness.
by another primary sleep disorder. Presleep conditions or activities that could affect
sleep, including the bedroom environment,
activities near bedtime, or mental state near bed-
time should be explored. The bedroom environ-
3. Frequency, duration, adequate sleep ment should be characterized for factors that
opportunity or environment: A frequency might disturb sleep (noise, clock easily seen from
of at least 3 nights per week, a duration of the bed, extreme hot or cold temperature). Activ-
3 months, and the requirement of an ade- ities near bedtime, including working late on the
quate opportunity and environment for sleep computer, drinking caffeinated beverages or
are requirements for the diagnosis of CID. alcohol in the evening, or exercise near bedtime,
The ICSD-3 states that patients with chronic may impair the ability to sleep. The mental status
insomnia characterized by recurrent epi- at bedtime should be explored. Often, patients
sodes of sleep/wake difficulties lasting several began worrying about their stresses and prob-
weeks at a time (<3 months) over several lems when retiring for the night. The presence
years may also qualify for the CID diagnosis. or absence of nocturnal symptoms, including snor-
ing, gasping during sleep, symptoms of restless
legs syndrome (RLS), and body movements
INSOMNIA EVALUATION should be evaluated.
The sleep-wake schedule should be determined
A detailed sleep history is the cornerstone of by report including variability of bedtime and
evaluation of insomnia.5–9 First, the nature of rise time as well as the frequency and duration
the primary sleep complaint (problems with sleep of naps. Factors that worsen or improve sleep
onset, sleep maintenance, or quality) should be should be detailed. For example, some patients
FUNDAMENTALS 37 EVALUATION OF INSOMNIA 587
with insomnia report sleeping better in a novel sleep apnea, insomnia symptoms are more likely
environment (reverse first-night effect).10 to be present in women than in men.1 The circa-
Patient recall may be supplemented by sleep dian sleep-wake rhythm disorders (CSWRDs)
logs, actigraphy, or both, as discussed in a fol- may also be associated with insomnia com-
lowing section. Daytime function should be dis- plaints, including delayed sleep phase syndrome
cussed with emphasis on possible consequences (sleep-onset insomnia) and advanced sleep phase
of insomnia. Reports of daytime fatigue or syndrome (early morning awakening). In delayed
impaired cognition and mood are more sleep phase syndrome, once the affected indi-
common than true daytime sleepiness. True day- viduals are able to fall asleep, they have fairly
time sleepiness should trigger suspicion for additional normal sleep. In advanced sleep phase syndrome,
sleep problems such as sleep apnea, narcolepsy, or individuals fall asleep early but then awaken in the
depression. Daytime activities that may affect sleep early morning hours. In non–24-hour CSWRD,
such as the amount of caffeine, alcohol, exercise, patients may report periods of insomnia alternating
sunlight exposure, and napping should be with hypersomnia.1,3 RLS or periodic limb move-
detailed. A general medical and psychiatric history ment disorder (PLMD) may be associated with
is important to identify mental or medical condi- symptoms of insomnia or nonrestorative sleep.
tions that may affect sleep. A detailed medication A number of medications may also disturb sleep
history including over-the-counter medications quality (e.g., caffeine).
and substances of abuse is extremely important.
A physical examination and appropriate labo-
ratory testing if not recently performed should
rule out obvious medical causes of insomnia. QUESTIONNAIRES, SLEEP LOGS,
Examination of the upper airway showing a high AND ACTIGRAPHY
Mallampati score (upper airway narrowing)11
might trigger suspicions of obstructive sleep Supporting information from questionnaires
apnea (OSA). (mood, cognition about insomnia), sleep logs,
and actigraphy may be helpful in evaluating
patients with insomnia (Box F37-4 and Box
DIFFERENTIAL DIAGNOSIS F37-5). These may supplement other information
obtained from the sleep history. Assessing the
Major characteristics of the insomnia types listed patient’s attitudes about sleep and the sleep prob-
in the ICSD-2 are listed in Table F37-2. Patients lem is as important as documenting the degree of
with CID often have characteristics of more sleep disturbance. In addition, some patients are
than one type. A number of non CID sleep dis- hesitant to admit to feelings of depression. Sleep
orders may be associated with insomnia com- logs and actigraphy provide a more accurate esti-
plaints (Box F37-3). Sleep apnea syndromes mate of the patient’s sleep quantity than is possi-
may be associated with repetitive arousal and ble from patient recall.
sleep-maintenance problems. In patients with The Epworth Sleepiness Scale (ESS; see
Fundamentals 17) is used to assess subjective
estimates of the propensity to fall asleep in
BOX F37-3 Other Sleep Disorders common situations.12 The Pittsburgh Sleep
Associated with Insomnia Quality Index (PSQI) is a 24-item self-report
Complaints measure of general sleep quality that specifically
addresses the preceding 1-month period. The
1. Sleep apnea syndromes PSQI evaluates seven domains, including the
2. Circadian rhythm sleep/wake disorders
duration of sleep, sleep disturbance, sleep-onset
a. Delayed sleep/wake disorder type—sleep-
onset insomnia latency, daytime dysfunction because of sleepi-
b. Advanced sleep/wake disorder—early AM ness, sleep efficiency, need for medications to
awakening sleep, and overall sleep quality. The PSQI
c. Irregular sleep phase type—at least three yields a global score and seven component
sleep episodes per 24 hours scores (poor sleep: global score > 5).13,14 The
d. Non-24 hour sleep phase type—alternating questionnaire has been shown to distinguish
periods of insomnia and hypersomnia among healthy patients, patients with depres-
3. Restless legs syndrome/periodic limb move- sion, and patients with sleep disorders. It was
ment disorders not designed specifically for insomnia but
From American Academy of Sleep Medicine: International
has been used in insomnia assessment and treat-
classification of sleep disorders: diagnostic and coding manual, ed ment studies. Detailed instructions for use and
3, Darien, IL, 2013, American Academy of Sleep Medicine. scoring of the PSQI are available at the
588 FUNDAMENTALS 37 EVALUATION OF INSOMNIA
Strongly Strongly
Disagree Agree
Name 1 2 3 4 5 6 7 8 9 10
1. I need 8 hours of sleep to feel refreshed and function well during the day.
2. When I don’t get a proper amount of sleep on a given night, I need to catch up on the
next day by napping or on the next night by sleeping longer.
6. In order to be alert and function well during the day, I believe would be
better off taking a sleeping pill rather than having a poor nights sleep.
8. When I sleep poorly on one night, I know it will distrub my sleep schedule
for the whole week.
9. Without an adequate night’s sleep I can hardly function the next day.
10. I can’t ever predict whether I’ll have a good or poor night’s sleep.
11. I have little ability to manage the negative consequences of distrubed sleep.
12. When I feel tired, have no energy, or just seem not to function well
during the day, its generally because I did not sleep well the night before.
16. I avoid or cancel obligations (social, family) after a poor night’s sleep.
FIGURE F37-1 n Dysfunctional Beliefs and Attitudes About Sleep (DBAS)-16. (From Morin CM, Vallières A, Ivers H:
Dysfunctional beliefs and attitudes about sleep (DBAS): validation of a brief version (DBAS-16), Sleep 30:1547-1554, 2007.)
insomnia. Sleep logs are often more accurate and also typically provide space to record caffeine
more reliable than patient recall of their chronic consumption, bedtime activities, or medications
sleep patterns. Sleep logs usually follow a ques- taken for sleep as well as estimates of sleep qual-
tion format or time plot graphic format.20 An ity. Sleep logs are very helpful in revealing general
adaptation of a basic consensus sleep log20 is patterns of the sleep-wake cycle such as irregular bed-
shown in Figure F37-2. The reader should look times and wake times and the amount and frequency
at Patient 111 for other examples. The essential of napping. A few characteristic patterns noted in
elements of a sleep log include the ability to sleep logs are listed in Box F37-6.
assess time in bed (TIB), sleep-onset latency
(SOL), total sleep time (TST), and the amount
of wakefulness after sleep onset (WASO). The ACTIGRAPHY
TIB is the period from when the patient gets
in bed until the final time the patient leaves the Actigraphy involves use of a portable device
bed in the morning. WASO includes all wake (often resembling a watch and typically worn
from sleep onset until the patient leaves the on the wrist) that collects movement information
bed in the morning. The patient need report only (activity) over an extended period (Figure F37-3).
three of these four parameters because they are The absence of movement is assumed to be a sur-
related (TIB ¼ SOL + TST + WASO). Sleep effi- rogate of sleep.21 The use of actigraphy is included
ciency can be computed (¼ TST 100/TIB), in the ICSD-3 diagnostic criteria for several circa-
with normal values exceeding 85%. Sleep logs dian sleep wake rhythm disorders.3 Practice
590 FUNDAMENTALS 37 EVALUATION OF INSOMNIA
FIGURE F37-2 n Sleep log. (Adapted from Carney CE, Buysse DJ, Ancoli-Israel S, et al: The consensus sleep diary: standard-
izing prospective sleep self-monitoring, Sleep 35[2]:287-302, 2012.)
FIGURE F37-3 n Actigraphy from a good sleeper and a patient with insomnia. B, Bedtime ready to sleep. The patient
with insomnia had long sleep latency and two prolonged awakenings as well as a nap.
CLINICAL PEARLS
1. The diagnosis of CID requires the presence of (a) sleep difficulty, (b) daytime consequences, (c) difficulty for
at least 3 nights per week for at least 3 months, and (d) adequate opportunity and environment for sleep.
2. Sleep difficulty may include problems initiating or maintaining sleep, and early morning awakening. In chil-
dren, sleep difficulty includes resistance to going to bed and difficulty sleeping without caregiver
intervention.
3. A good sleep history is the essential tool for evaluating insomnia. PSG has only a limited role in this
evaluation.
4. Sleep logs and actigraphy provide complementary information, so the use of both can be valuable.
5. A number of insomnia disorders in ICSD-2 are now included in the ICSD-3 diagnosis of chronic insomnia
disorder.