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The oculomotor nucleus lies in the ventromedial part. The nuclei of two sides fuse together forming a
single complex having a triangular outline. The emerging fibres of oculomotor nerve pass ventrally
and medial part of the substantia nigra and emerge in the posterior part of the interpeduncular fossa
through the sulcus on the medial aspect of crus through the tegmentum, intersecting red nucleus cerebri.
Germinal center:
• Contains predominantly B lymphocytes (including centroblasts and centrocytes)
and scattered follicular T helper cells and T regs
• Also tingible-body macrophages and follicular dendritic cells
Mantle zone:
• Tightly packed small B lymphocytes of the primary follicles, pushed aside by the
germinal centers
Marginal zone:
• Less packed small B lymphocytes with more cytoplasm
• Light zone on outer rim of mantle zone
• Contains a mix of post-follicular memory B cells derived after stimulation of
recirculating cells from T cell dependent antigen and naïve B cells
• Often not well developed in lymph nodes
Paracortex:
• Tissue between cortical follicles and medulla (see below)
• Contains predominantly dark staining mature T cells, B immunoblasts,
interdigitating dendritic cells, plasmacytoid dendritic cells, histiocytes, and high
endothelial venules (post capillary venules lined by plump endothelial cells that
express leukocyte adhesion molecules and contain intraluminal lymphocytes)
• Expands during cell-mediated immunological reactions
• Has coarse network of reticulin fibers