-bulldog calf

Blood Type of Recipient Surface antigen on RBC Compatible Donor -reduced features
-aborted before death
A A antigen 1. A or O
B B antigen B or O Tay-Sachs disease
AB A + B antigen A, AB or O -normal at birth
O H antigen O -before one year old deterioration of the central nervous system
-loss of neuro-muscular control
Type A Anti b bodies -blindness
Type B Anti a bodies -death at 3 or 4 years old
Type AB Neither anti a nor anti b bodies -lacks hexosaminidase A
Type O Anti a and anti b bodies
Xeroderma pigmentosum
- Lacks DNA repair enzyme
Hemolysis- kapag di compatible yung nadonate na blood
- Photosensitive
Agglutination- clumping of blood - If exposed to light will result to intense pigmentation
- Freckling
Paternity suit was filed in court - Warty growths (may become malignant)
- UV can damage the DNA

Lethal Genes 2. Dominant Lethal

Genes that can cause death -lethal when homozygous dominant or heterozygous
-Huntington’s disease (can be expressed to 40-50 years old)
1. Recessive genes -Progressive deterioration of the central nervous system
Lethal when homo recessive -involuntary movement
Could result to a recognizable phenotype when heterozygous -onset of symptoms at 30 years old
Ex. Yellow body color in mouse -death at 40-50 years old
F2 genotype 1 YY : 2 Yy : 1 yy
F2 phenotype 1 YY : 2 Yy : 1 yy
Sept 7 2018
Manx allele
-abnormal spinal development Modifier genes
- extreme developmental abnormality - Gene changes phenotype effect of other genes in a quantitative
-death of the embryo fashion
- Dilution or enhancement effects
Manx allele (tailless)
Dexter cattle
Gene interaction

- Non-allelic interaction of 2 or more genes which results to a

modified phenotypic ratio

Epistasis

- Interaction of 2 or more genes

- F1 is heteroxhetero parent
- Determined by observing certain phenotypic ratios in the
progeny