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Syndrome Information
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Synonym(s):   Fisher Syndrome

Table of Contents (click to jump

to sections)
What is Miller Fisher Syndrome?
Is there any treatment?
What is the prognosis?
What research is being done?
Clinical Trials

What is Miller Fisher Syndrome?

Miller Fisher syndrome is a rare, acquired nerve disease that is
considered to be a variant of Guillain-Barré syndrome. It is
characterized by abnormal muscle coordination, paralysis of the eye
muscles, and absence of the tendon reflexes. Like Guillain-Barré
syndrome, symptoms may be preceded by a viral illness. Additional
symptoms include generalized muscle weakness and respiratory
failure. The majority of individuals with Miller Fisher syndrome have
a unique antibody that characterizes the disorder.

Is there any treatment?

Treatment for Miller Fisher syndrome is identical to treatment for
Guillain-Barré syndrome: intravenous immunoglobulin (IVIg) or
plasmapheresis (a procedure in which antibodies are removed from
the blood) and supportive care.

What is the prognosis?

The prognosis for most individuals with Miller Fisher syndrome is
good. In most cases, recovery begins within 2 to 4 weeks of the
onset of symptoms, and may be almost complete within 6 months.
Some individuals are left with residual deficits. Relapses may occur
rarely (in less than 3 percent of cases).

What research is being done?

The NINDS supports research aimed at discovering new ways to
diagnose, treat, and, ultimately, cure neuropathies such as Miller
Fisher syndrome.
NIH Patient Recruitment for
Miller Fisher Syndrome Clinical
At NIH Clinical Center
Throughout the U.S. and Worldwide
NINDS Clinical Research Collaboration Trials


GBS/CIDP Foundation International

The Holly Building 104 1/2 Forrest
Narberth, PA   19072
Tel: 610-667-0131 866-224-3301
Fax: 610-667-7036

Related NINDS Publications and Information

NINDS Guillain-Barré Syndrome Information Page

Guillain-Barre Syndrome information sheet compiled by NINDS.

Guillain-Barré Syndrome Fact Sheet

Guillain-Barré Syndrome (GBS) fact sheet produced by the

National Institute of Neurological Disorders and Stroke (NINDS).

Publicaciones en Español

Síndrome de Guillain-Barré
Prepared by:
Office of Communications and Public Liaison
National Institute of Neurological Disorders and Stroke
National Institutes of Health
Bethesda, MD 20892

NINDS health-related material is provided for information purposes

only and does not necessarily represent endorsement by or an
official position of the National Institute of Neurological Disorders
and Stroke or any other Federal agency. Advice on the treatment or
care of an individual patient should be obtained through consultation
with a physician who has examined that patient or is familiar with
that patient's medical history.

All NINDS-prepared information is in the public domain and may be

freely copied. Credit to the NINDS or the NIH is appreciated.

Last updated May 06, 2010

National Institute of Neurological Disorders and Stroke

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