DRUG DOSAGE MECHANISM OF INDICATIONS & SIDE EFFECTS & NURSING RESPONSIBILITY

ACTION CONTRAINDICATIONS ADVERSE EFFECTS

Generic Name: 2.25g TIV QID It is similar to that of Indication: Side Effects: - Obtain history of
Piperacillin (q6) other penicillins. - Nosocomial - Diarrhea hypersensitivity to
Tazobactam Interfere with Pneumonia - Nausea penicillins,
bacterial cell wall Contraindication: - Vomiting cephalosporins, or other
Brand Name: synthesis promotes - History of allergic drugs prior to
Piptaz loss of membrane reactions to any of Adverse Effects: administration.
integrity and leads to the penicillins, - Agitation
Functional Class: death of the cephalosporins, or - Bruising - Lab tests: C&S prior to
Antiinfective organism. β-lactamase - Cough first dose of the drug;
inhibitors. start drug pending results.
Chemical Class: Tazobactam is an
Penicillin inhibitor of a wide - Monitor hematologic
variety of bacterial status with prolonged
beta–lactamases. It therapy (Hct and Hgb, CBC
has little antibacterial with differential and
activity itself; platelet count).
however, in
combination with
piperacillin, it extends
the spectrum of
bacteria that are
susceptible to
piperacillin. Two-drug - Monitor patient carefully
combination has during the first 30 min
antibiotic activity after initiation of the
against an extremely infusion for signs of
broad spectrum of hypersensitivity.
gram-positive, gram-
negative and
anaerobic bacteria.