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The Egyptian Society of Chest Diseases and Tuberculosis
ORIGINAL ARTICLE
a
Chest Department, Ain Shams University, Cairo, Egypt
b
Ain Shams University Specialized Hospital, Cairo, Egypt
KEYWORDS Abstract Background: Platelets have been increasingly recognized as an important component of
Community acquired innate and adaptive immunity. Platelet response in antimicrobial host defense is similar, in many
pneumonia; ways, to the leukocyte response: both cell types contain antimicrobial peptides that act against a
Platelet count; broad range of pathogens.
Ain Shams University Objective: The aim of this study was to detect whether platelet count could be used as a marker
Hospital; for severity of community acquired pneumonia or not.
Respiratory intensive care Subjects and methods: The study included 40 cases of community acquired pneumonia admitted at
unit Chest Department and Respiratory ICU at Ain Shams University Hospital, as well as, Chest Depart-
ment and Respiratory ICU at Ain Shams University Specialized Hospital. All cases were subjected to
the following: full history taking, thorough clinical examination including general and local examina-
tion, arterial blood gases, electrocardiography, radiological work up, routine laboratory investiga-
tions including compete blood picture and CURB-65 score as a marker for severity of pneumonia.
Results: The results showed that there was a significant relation between the occurrence of respi-
ratory complications and both thrombocytopenia and thrombocytosis. Also, there was a significant
relation between both thrombocytopenia and thrombocytosis and the CURB-65 score as a score
for severity of CAP. There was a significant relation between both thrombocytopenia and thrombo-
cytosis and mortality among the patients with CAP. Finally, platelet count is considered better pos-
itive than a negative predictor value to the outcome.
Conclusion: A better understanding of the role of platelets in the outcomes of patients with com-
munity acquired pneumonia may generate new prognostic and therapeutic modalities for patients
with severe disease.
Ó 2015 The Authors. Production and hosting by Elsevier B.V. on behalf of The Egyptian Society of Chest
Diseases and Tuberculosis. This is an open access article under the CC BY-NC-ND license (http://
creativecommons.org/licenses/by-nc-nd/4.0/).
leukocyte response: both cell types contain antimicrobial All cases were subjected to the following:
peptides that act against a broad range of pathogens. After
platelets and neutrophils are activated, they accumulate at 1. Full history taking.
the site of infection to produce direct contact between their 2. Thorough clinical examination including general and local
antimicrobial peptides and invading bacteria. Leukocytes need examination.
to phagocytize bacteria to achieve interaction with intracellu- 3. Arterial blood gases.
lar peptides; platelets can also internalize microorganisms into 4. Electrocardiography.
phagosome-like vacuoles, enhancing pathogen clearance. 5. Radiological work up (conventional CXR, CT scan and/or
Antimicrobial peptides from both cells exert a rapid, potent, chest ultrasound).
and direct antimicrobial effect that contributes to limiting 6. Routine laboratory investigations including compete blood
the infection [1]. picture.
Clinicians have always evaluated the degree of leucocytosis 7. CURB-65 score tool.
in patients with pneumonia as an indication of systemic
inflammatory response and severity of disease. Thrombocy- CURB-65 Mortality Prediction Tool for Patients with
topenia is also a recognized marker of poor outcomes in Community-Acquired Pneumonia [5].
patients with pneumonia due to the association of low platelet
counts with disseminated intravascular coagulation and severe
sepsis. Abnormalities in the coagulation system can be due to
Prognostic variables*
low as well as high platelet count. However, the association
Confusion
between thrombocytosis and clinical outcomes in adult
Blood urea nitrogen level >20 mg per dL (7.14 mmol per L)
patients with community-acquired pneumonia (CAP) has not Respiratory rate P30 breaths per minute
been investigated [2]. Blood pressure (systolic <90 mmHg or diastolic 660 mmHg)
Considering that platelets play a crucial role in antimicro- Age P65 years
bial host defenses and the coagulate system, it is hypothesized Score Inpatient vs. outpatient 30-day mortality (%)
that an abnormal platelet count may be an important marker 0 or 1 point Treat as outpatient 0.7–2.1
to assess severity of disease in patients with CAP [3,4]. 2 points Treat as inpatient 9.2
P3 points Treat in intensive care unit 15–40
*
Assign 1 point for each variable
Subjects and methods
n = 8), while in patients with thrombocytosis, the cause of cardiopulmonary and humoral immune function as well as
death was mostly related to complications of ICU stay or asso- specific pathogen data, the platelet count is necessarily an
ciated co morbidity. Thus, they believed that thrombocytope- imprecise prognostic indicator. In immunocompetent adults,
nia remains an important predictor of outcome in patients it would seem that thrombocytopenia and thrombocytosis,
with severe CAP. In these patients, thrombocytosis is not asso- rather than having a prognostic significance, may be more
ciated with worse outcome. The difference between the results important diagnostically in suggesting a specific CAP
of our study and those of Georges et al. might be due to the pathogen.
obvious discrepancy in the number of enrolled patients with
thrombocytosis in both studies. On the contrary, Prina et al. Conclusion
[10] prospectively analyzed 2423 consecutive, hospitalized
patients with CAP. They found that fifty-three patients (2%) A better understanding of the role of platelets in the outcomes
presented with thrombocytopenia, 204 (8%) with thrombocy- of patients with pneumonia may generate new prognostic and
tosis, and 2166 (90%) had normal platelet counts. Patients therapeutic modalities for patients with severe disease.
with thrombocytosis presented more frequently with respira-
tory complications, such as complicated pleural effusion and
Recommendations
empyema, whereas those with thrombocytopenia presented
more often with severe sepsis, septic shock, need for invasive
mechanical ventilation and ICU admission. Patients with 1. Future research is needed to assess whether abnormality in
thrombocytosis and patients with thrombocytopenia had platelet counts in patients with CAP is just a marker of the
longer hospital stays and higher 30-day mortality and readmis- inflammatory response or is in part responsible for
sion rates than those with normal platelet counts. Multivariate mortality. In particular, future research should focus on
analysis confirmed a significant association between thrombo- investigating the cause of death for patients with abnormal
cytosis and 30-day mortality. Adding thrombocytosis to the platelet counts.
confusion, respiratory rate, and BP plus age P65 years score 2. Also, future researches should focus on the relation
slightly improved the accuracy to predict mortality (area under between platelet count abnormality and the causative
the receiver operating characteristic curve increased from 0.634 pathogen of CAP.
to 0.654, P = .049). They concluded that thrombocytosis in 3. When evaluating a complete blood count report in patients
patients with CAP is associated with poor outcome, with CAP, platelet count may be informative for predicting
complicated pleural effusion, and empyema. The presence of patient poor outcomes in addition to the commonly used
thrombocytosis in CAP should encourage ruling out respira- leukocyte count.
tory complication and could be considered for severity
evaluation. References
The results of our study are supported with those of Mir-
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