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Sarah Tebeka, Yann Le Strat, Caroline Dubertret,

Parity and bipolar disorder: New analyses,

Journal of Affective Disorders,

Volume 238,

2018,

Pages 489-490,

ISSN 0165-0327,

https://doi.org/10.1016/j.jad.2018.05.039.

(http://www.sciencedirect.com/science/article/pii/S0165032718308814)

Keywords: Bipolar disorder; Pregnancy; Postpartum; Mood disorder; Psychotropic

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I-Kuan Wang, Li-Ming Lien, Jiunn-Tay Lee, Chung-Hsiang Liu, Chih-Hung Chen, Ching-Huang Lin,
Jiann-Shing Jeng, Chaur-Jong Hu, Tzung-Hai Yen, Sien-Tsong Chen, Hou-Chang Chiu, I-Ju Tsai,
Fung-Chang Sung, Chung Y. Hsu,

Renal dysfunction increases the risk of recurrent stroke in patients with acute ischemic stroke,

Atherosclerosis,

Volume 277,

2018,

Pages 15-20,

ISSN 0021-9150,
https://doi.org/10.1016/j.atherosclerosis.2018.07.033.

(http://www.sciencedirect.com/science/article/pii/S0021915018312401)

Abstract: Background and aims

This study investigated risks of short-term (1 and 3 months) and long-term (1-year) recurrent stroke
associated with glomerular filtration rate (eGFR) in patients with acute ischemic stroke.

Methods

From the Taiwan Stroke Registry data, we identified 45,876 acute ischemic stroke patients from April
2006 to April 2014 and classified them into 4 groups based on the eGFR at admission: ≥ 90, 60–89,
30–59, and <30 mL/min/1.73 m2 or on dialysis. The risks of 1-month, 3-month and 1-year recurrent
stroke related to the eGFR levels were investigated.

Results

Both the risks of short-term and long-term recurrent stroke increased as the eGFR levels declined. The
1-month recurrent incidence rates increased steadily from 0.54 to 0.59, 0.84 and 0.89 per 1000
person-days, as the eGFR declined from ≥90 to 60–89, 30–59, and <30 mL/min/1.73 m2 or on dialysis,
respectively. Compared to patients with eGFR ≥90 mL/min/1.73 m2, the adjusted subhazard ratio of
1-month recurrent stroke decreased from 1.69 (95% confidence interval (CI) = 1.24–2.31) for patients
with eGFR < 30 mL/min/1.73 m2 or on dialysis to 1.14 (95% CI = 0.91–1.43) for patients with eGFRs of
60–89 mL/min/1.73 m2, considering the competing risk of deaths. Similar patterns were also
observed for the adjusted HRs of 3-month and 1-year recurrent stroke, but with reduced hazard
values, by the corresponding eGFR levels.

Conclusions

There is an independent graded association between an increased risk of recurrent stroke and
declining eGFR levels in patients with acute ischemic stroke.

Keywords: Estimated glomerular filtration rate; Ischemic stroke; Recurrent stroke; Renal function

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