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Second, as we alluded to earlier, a variety of different types of neoplasms can arise in the
pancreas, such as ductal adenocarcinoma and pancreatic neuroendocrine tumor, and these
different tumor types are important to recognize because they are often treated differently, and
because they are associated with different prognoses (predicted outcomes).
Trained expert pathologists usually establish the diagnosis of a specific type of neoplasm. They
do this either from biopsies of the tumor or by examining resected (removed) tumors.
Adenocarcinomas (most common) - Just as the normal exocrine cells of the pancreas do,
adenocarcinomas form microscopic glands (collections of cells surrounding an empty space).
Adenocarcinomas can grow large enough to invade nerves which can cause back pain. They also
frequently spread (metastasize) to the liver or lymph nodes. If this happens the tumor may be
considered unresectable.
Adenocarcinoma: This is a gland-forming (it makes tubes) cancer.
In this example, the adenocarinoma has wrapped around a nerve (center of the image).
The following rare exocrine neoplasms of the pancreas are listed alphabetically.
Acinar Cell Carcinomas - These rare cancers may produce excess amounts of the digestive
enzymes normally produced by the pancreas. This increase in enzymes causes distinct symptoms
in 20% of patients with an acinar cell carcinoma. These symptoms may include unusual skin
rashes, joint pain and an increased number of eosinophils, a type of white blood cell, in the
blood.
Microscopically, the cytoplasm of the cancerous cells in acinar cell carcinoma has a
characteristic granular appearance. This is because the cancerous cells contain large amounts of a
cell organelle called the zymogen granule. Special tests performed by pathologists on
microscope slides, including immunohistochemistry, can often be used to diagnose this type of
cancer.
Colloid Carcinomas - Colloid carcinoma is a distinctive cancer of the pancreas associated with
a better prognosis than the more common ductal adenocarcinoma. Under the microscope small
nests of cancer cells appear to be "floating" in pools of extracellular mucin. Many colloid
carcinomas arise in association with another type of tumor, the intraductal papillary mucinous
neoplasm (IPMN) of the pancreas.
Hepatoid Carcinomas - Hepatoid carcinomas of the pancreas have been reported only
extremely rarely in the pancreas. Under the microscope, the cells that form this type of cancer
look like the cells of a liver cancer (hepatoid means liver-like).
Intraductal Papillary Mucinous Neoplasms - These neoplasms are also known as "IPMNs."
They are important to recognize because they represent a potentially curable precursor lesion to
invasive pancreatic cancer. IPMNs characteristically grow in the larger ducts of the pancreas
(hence the name "intraductal!").
Under the microscope they usually appear as finger-like structures (papillae, hence the name
papillary) projecting into the pancreatic duct. IPMNs are believed to start as curable
precancerous lesions, and some, if untreated, may progress to invasive adenocarcinomas.
Mucinous Cystic Neoplasms - This is a rare, cystic (containing collections of fluid), neoplasm
of the pancreas. Most are found in the tail of the pancreas in women. The spaces within this
neoplasm are filled with a thick fluid called mucin. Unlike the serous cystadenomas (see below),
these neoplasms can progress into an invasive cancer over time.
Serous Cystadenomas - These rare tumors are usually benign (noncancerous) growths.
However, they can grow to be quite large and may need to be surgically removed if symptoms
such as pain and weight loss occur. They are cystic, fluid containing, tumors with a sponge-like
appearance.
Serous cystadenoma: This benign tumor forms spaces (cysts), giving the tumor a "sponge-like" appearance.
Signet Ring Cell Carcinoma - This rare form of pancreatic cancer has a characteristic
microscopic appearance. Signet ring cell carcinomas are composed of individual cells with a
large mucin globule. This mucin globule pushes the nucleus of the cell to the side, giving the cell
a "signet" or ring-like appearance.
Undifferentiated Carcinoma with Osteoclast-like Giant Cells - These cancers are extremely
rare. As the name "undifferentiated carcinomas with osteoclast-like giant cells" indicates, these
cancers have unusually large "giant" cells. This does not mean that the cancer itself is larger than
other types of cancer, only that individual cells in this form of cancer are so unusually large that
they look like some very large cells (osteoclasts) found in the normal bone.
Undifferentiated carcinoma with osteoclast-like giant cells: This tumor is composed of two cell types.
The cancerous cells are the big cells on the right of this image. The large osteoclast-like cells (center of the image)
contain lots of nuclei and are the body's non-tumorous cells reacting to the cancer.
The neuroendocrine neoplasms may produce highly active hormones and therefore have very
dramatic symptoms.
Glucagonomas produce the hormone glucagon which can result in a very striking skin rash
(necrolytic migratory erythema.)
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